NASA Spaceline Current Awareness List #726 2 December 2016 (Space Life Science Research Results)

Status Report From: Spaceline
Posted: Friday, December 2, 2016


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Spaceline: Please note: Starting with List #727 on December 9, 2016, SPACELINE Current Awareness Lists will be distributed via the listserv Please add this new address to your contact list. Please do not reply to listserv emails; send any correspondence to Robyn Ertwine, SPACELINE Current Awareness Senior Editor,



Papers deriving from NASA support:



McConnell AM, Yao C, Yeckes AR, Wang Y, Selvaggio AS, Tang J, Kirsch DG, Stripp BR.

p53 regulates progenitor cell quiescence and differentiation in the airway.

Cell Rep. 2016 Nov 22;17(9):2173-82.

PIs: D.G. Kirsch/B.R. Stripp/NSCOR

Note: This article may be obtained online without charge.

Journal Impact Factor: 7.870

Funding: "These studies were supported by NASA NSCOR grant NNX11AC60G (to D.G.K. and B.R.S.) and CIRM grant LA1_C12-06915 (to B.R.S.)."



Gil Del Alcazar CR, Todorova PK, Habib AA, Mukherjee B, Burma S.

Augmented HR repair mediates acquired temozolomide resistance in glioblastoma.

Mol Cancer Res. 2016 Oct;14(10):928-40.

PI: S. Burma

Journal Impact Factor: 4.510

Funding: "S. Burma is supported by grants from the NIH (RO1CA149461, RO1CA197796 and R21CA202403) and the National Aeronautics and Space Administration (NNX16AD78G). C.R. Gil del Alcazar completed this work in partial fulfillment of the requirements for his PhD degree. A.A. Habib is supported in part by a grant from the Department of Veteran's Affairs."



Aravindan N, Aravindan S, Manickam K, Natarajan M.

High energy particle radiation-associated oncogenic transformation in normal mice: Insight into the connection between activation of oncotargets and oncogene addiction.

Sci Rep. 2016 Nov 23;6:37623.

PI: M. Natarajan

Note: This article may be obtained online without charge.

Journal Impact Factor: 5.228

Funding: "This study was supported by the NASA Ground-Based Studies in Space Radiobiology, Grant NNX12-AC32G."



Boerma M.

An introduction to space radiation and its effects on the cardiovascular system.

THREE. 2016 Oct 13:1-12.

Note: This article may be obtained online without charge.

Journal Impact Factor: Not applicable to this publication

Funding: No funding cited. THREE is a publication of the NASA Johnson Space Center Space Radiation Program Element.



Olsen RH, Weber SJ, Akinyeke T, Raber J.

Enhanced cued fear memory following post-training whole body irradiation of 3-month-old mice.

Behav Brain Res. 2016 Nov 16;319:181-7. [Epub ahead of print]

PIs: J. Raber; G.A. Nelson/J. Raber/NSCOR

Journal Impact Factor: 3.002

Funding: "This work was supported by NASA Grants # NNX10AD59G and # NNJ12ZSA001N."



Rodman C, Almeida-Porada G, George S, Moon J, Soker S, Pardee T, Beaty M, Guida P, Sajuthi SP, Langefeld CD, Walker SJ, Wilson PF, Porada CD.

In vitro and in vivo assessment of direct effects of simulated solar and galactic cosmic radiation on human hematopoietic stem/progenitor cells.

Leukemia. 2016 Nov 24. [Epub ahead of print]

PI: C.D. Porada

Journal Impact Factor: 12.104

Funding: "This work was supported by grant #NNX13AB67G from National Aeronautics and Space Administration (NASA)."



Yin L, Gupta R, Vaught L, Grosche A, Okunieff P, Vidyasagar S.

An amino acid-based oral rehydration solution (AA-ORS) enhanced intestinal epithelial proliferation in mice exposed to radiation.

Sci Rep. 2016 Nov 23;6:37220.

PI: S. Vidyasagar

Note: This article may be obtained online without charge.

Journal Impact Factor: 5.228

Funding: "The work was partially funded through grants from the National Space Biomedical Research Institute (NSBRI) through NASA NCC 9-58, RE02901, and a research agreement with the University of Florida."



Silva-Martinez J.

Human systems integration: Process to help minimize human errors, a systems engineering perspective for human space exploration missions.

REACH.  Nov 23. [Article in Press]

Journal Impact Factor: Not available for this journal

Funding: No funding cited. J. Silva-Martinez is affiliated with NASA Johnson Space Center.



Other papers of interest:



Ogneva IV, Belyakin SN, Sarantseva SV.

The development of Drosophila melanogaster under different duration space flight and subsequent adaptation to Earth gravity.

PLoS One. 2016 Nov 18;11(11):e0166885.

Note: Foton-M4 and ISS results. This article may be obtained online without charge.



Proshchina A, Kharlamova A, Barabanov V, Gulimova V, Saveliev S.

Vestibular cerebellum of thick-toed geckos (Chondrodactylus turnery GRAY, 1864) and C57/BL6N mice after the long-term space flight on the biosatellite BION-M1.

J Chem Neuroanat. 2016 Nov 18;79:58-65. [Epub ahead of print]

Note: BION-M1 results.



Cebolla AM, Petieau M, Dan B, Balazs L, McIntyre J, Cheron G.

"Cerebellar contribution to visuo-attentional alpha rhythm: Insights from weightlessness".

Sci Rep. 2016 Nov 24;6:37824.

Note: ISS results. This article may be obtained online without charge.



Sundblad P, Frånberg O, Siebenmann C, Gennser M.

Measuring uptake and elimination of nitrogen in humans at different ambient pressures.

Aerosp Med Hum Perform. 2016 Dec;87(12):1045-50.



Rice GM, Snider D, Moore JL, Lavan JT, Folga R, VanBrunt TB.

Evidence for -Gz adaptation observed with wearable biosensors during high performance jet flight.

Aerosp Med Hum Perform. 2016 Dec;87(12):996-1003.



Zhang C, Zhou L, Zhang F, Lu D, Li N, Zheng L, Xu Y, Li Z, Sun S, Long M.

Mechanical remodeling of normally-sized mammalian cells under a gravity vector.

FASEB J. 2016 Nov 8. [Epub ahead of print]

Note: Mouse MC3T3-E1 preosteoblast cells were grown on rectangular cover slips oriented either upward, downward, or on edge.



Lai S, Panarese A, Lawrence R, Boninger ML, Micera S, Ambrosio F.

A murine model of robotic training to evaluate skeletal muscle recovery after injury.

Med Sci Sports Exerc. 2016 Nov 21. [Epub ahead of print]



Nakanishi R, Hirayama Y, Tanaka M, Maeshige N, Kondo H, Ishihara A, Roy RR, Fujino H.

Nucleoprotein supplementation enhances the recovery of rat soleus mass with reloading after hindlimb unloading-induced atrophy via myonuclei accretion and increased protein synthesis.

Nutr Res. 2016 Oct 23. [Epub ahead of print]

Note: Hindlimb unloading study.



Venturelli M, Cé E, Limonta E, Bisconti AV, Devoto M, Rampichini S, Esposito F.

Central and peripheral responses to static and dynamic stretch of skeletal muscle: mechano- and metabo-reflex implications.

J Appl Physiol (1985). 2016 Nov 17:jap.00721.2016. [Epub ahead of print]



Wang J, Wang F, Zhang P, Liu H, He J, Zhang C, Fan M, Chen X.

PGC-1a over-expression suppresses the skeletal muscle atrophy and myofiber-type composition during hindlimb unloading.

Biosci Biotechnol Biochem. 2016 Nov 21:1-14. [Epub ahead of print]

Note: Hindlimb unloading study.



Metzger TA, Vaughan TJ, McNamara LM, Niebur GL.

Altered architecture and cell populations affect bone marrow mechanobiology in the osteoporotic human femur.

Biomech Model Mechanobiol. 2016 Nov 22. [Epub ahead of print]



Yuan Y, Zhang L, Tong X, Zhang M, Zhao Y, Guo J, Lei L, Chen X, Tickner J, Xu J, Zou J.

Mechanical stress regulates bone metabolism through microRNAs.

J Cell Physiol. 2016 Nov 15. [Epub ahead of print]



McGuire SA, Boone GRE, Sherman PM, Tate DF, Wood JD, Patel B, Eskandar G, Wijtenburg SA, Rowland LM, Clarke GD, Grogan PM, Sladky JH, Kochunov PV.

White matter integrity in high-altitude pilots exposed to hypobaria.

Aerosp Med Hum Perform. 2016 Dec;87(12):983-8.



Dawson L.

The politics and perils of space exploration: Who will compete, who will dominate?

Chaum, Switzerland: Springer International Publishing, 2017.

Note: Chapters include: The New Space Race; The Commercial Space Race; Mars; Why Not Go Back to the Moon?; The Science and Dangers of Outer Space; Politics and the Space Race; The Post-Apollo and Space Shuttle Era; Politics, the ISS, and Private Enterprise; Technological Risks and Accidents; and New Technology and Deep Space. The chapter, The Science and Dangers of Outer Space, examines the space environment, danger of spaceflight, microgravity issues such as muscle atrophy and bone loss, radiation, cardiovascular effects of radiation and space missions, changes to the human mind in space, and space debris.


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