NASA Spaceline Current Awareness List #727 9 December 2016 (Space Life Science Research Results)

Status Report From: Spaceline
Posted: Friday, December 9, 2016

SpaceRef Editor's note: NASA's various life sciences programs have prepared the SPACELINE Current Awareness updates since 1999 covering all aspects of space life science, gravitational biology, space medicine, and human factors. NASA does not maintain a website - nor does it have an archive of this resource online. However, SpaceRef does have a complete archive of SPACELINE updates all the way back to 1999 that can be accessed here: 


SPACELINE Current Awareness Lists are now distributed via listserv. Please send any correspondence to Robyn Ertwine, SPACELINE Current Awareness Senior Editor,


Papers deriving from NASA support:



Abshire CF, Prasai K, Soto I, Shi R, Concha M, Baddoo M, Flemington EK, Ennis DG, Scott RS, Harrison L.

Exposure of Mycobacterium marinum to low-shear modeled microgravity: Effect on growth, the transcriptome and survival under stress.

npj Microgravity. 2016 Dec 1;2:16038.

PI: L. Harrison

Note: A rotary cell culture system was used. This article may be obtained online without charge.

Journal Impact Factor: Not available for this journal.

Funding: "This work was supported by grant number NNX13AM02G (LH) from NASA and funds for the RNA-Seq sample processing were provided by the Feist-Weiller Cancer Center at LSU Health Sciences Center—Shreveport (LH). Bioinformatic analysis was supported by grants R01 AI101046 (EKF) and R01 AI106676 (EKF) from National Institute of Allergy and Infectious Diseases." "Published in cooperation with the Biodesign Institute at Arizona State University, with the support of NASA."



Peake JM, Neubauer O, Walsh NP, Simpson RJ.

Recovery of the immune system after exercise.

J Appl Physiol (1985). 2016 Dec 01:jap.00622.2016. [Epub ahead of print]

PI: R.J. Simpson

Journal Impact Factor: 3.004

Funding: "Jonathan Peake is supported by funding from the Centre of Excellence for Applied Sport Science Research at the Queensland Academy of Sport, Brisbane, Australia." The PI reports that this work is related to his NASA grants.



Templin T, Sharma P, Guida P, Grabham P.

Short-term effects of low-LET radiation on the endothelial barrier: Uncoupling of PECAM-1 and the production of endothelial microparticles.

Radiat Res. 2016 Dec 1. [Epub ahead of print]

PI: P. Grabham

Journal Impact Factor: 3.022

Funding: "This work was supported by NASA, grant nos. NNJ09ZSA001N and NNJ11ZSA001N."



Sweet TB, Hurley SD, Wu MD, Olschowka JA, Williams JP, O'Banion MK.

Neurogenic effects of low-dose whole-body HZE (Fe) ion and gamma irradiation.

Radiat Res. 2016 Dec 01. [Epub ahead of print]

Journal Impact Factor: 3.022

Funding: "Support for this work was provided by DOE-NASA Low Dose Radiation Biology Program (grant nos. DE-FG02-07ER64338 and NIH/NIAID 5U19 AI091036)."



Lee SH, Dudok B, Parihar VK, Jung KM, Zöldi M, Kang YJ, Maroso M, Alexander AL, Nelson GA, Piomelli D, Katona I, Limoli CL, Soltesz I.

Neurophysiology of space travel: Energetic solar particles cause cell type-specific plasticity of neurotransmission.

Brain Struct Funct. 2016 Nov 30. [Epub ahead of print]

PIs: G.A. Nelson/C.L. Limoli/I. Soltesz/NSCOR; C.L. Limoli/V.K. Parihar/G.A. Nelson/I. Soltesz/NSCOR

Note: This article may be obtained online without charge.

Journal Impact Factor: 5.811

Funding: "This work was supported by NASA NSCOR grants NNX10AD59G and NNX15AI22G (to C.L.L. G.N. and I.S.), the College of Medicine, University of Arkansas for Medical Sciences (startup funding to S.-H.L), Core Facilities of the Center for Translational Neuroscience, Award P30GM110702 from the IDeA program at NIGMS and R25NS065741-04S1 to A.A., Momentum Program (LP2013-54/2013) and Wellcome Trust (090946/Z/09/Z) to I.K., and NIH (NS089575) to C.L.L."



Gilat M, Hall JM, Ehgoetz Martens KA, Shine JM, Walton CC, MacDougall HG, Moore ST, Lewis SJ.

Staircase climbing is not solely a visual compensation strategy to alleviate freezing of gait in Parkinson's disease.

J Neurol. 2016 Nov 29. [Epub ahead of print]

PI: S.T. Moore

Journal Impact Factor: 3.408

Funding: "M Gilat is supported by a University of Sydney International Scholarship. JM Hall is supported by a Western Sydney University Postgraduate Research Award. KA Ehgoetz Martens is supported by Parkinson Canada. JM Shine is supported by a National Health and Medical Research Council CJ Martin Fellowship. CC Walton is supported by an Australian Postgraduate Award at the University of Sydney. HG MacDougall is supported by a grant from the Garnett Passe and Rodney Williams Memorial Foundation. ST Moore is supported by NASA grant NNX12AM25G. SJG Lewis is supported by an NHMRC-ARC Dementia Fellowship."



Choi S, Ray HE, Lai SH, Alwood JS, Globus RK.

Preservation of multiple mammalian tissues to maximize science return from ground based and spaceflight experiments.

PLoS One. 2016 Dec 1;11(12):e0167391.

Note: This article may be obtained online without charge.

Journal Impact Factor: 3.057

Funding: "The funder, NASA, a U.S. Government agency, (Space Biology Program) provided support in the form of salaries for authors (RKG, SC, SL, JSA and HER), but did not have any additional role in the study design, data collection and analysis, and decisions in preparation of the manuscript. Funds for the supplies and materials needed to conduct the research were provided by NASA (ISS Research Integration Office). Funds for the laboratory space were provided by multiple NASA programs. These funding sources were supplied as directed funds to advance knowledge about the methods needed to conduct research on the ISS, and were not competed (as a grant would be). For authors that are not government employees (SC, SL, and HER), funding was provided as-needed salary support by implementation through the appropriate government services contractor companies under contract number NNA14AB82C." The authors are affiliated with NASA Ames Research Center.



Other papers of interest:



Strádi A, Pálfalvi JK, Szabó J, Pázmándi T, Ivanova OA, Shurshakov VA.

Cosmic radiation measurements on the Foton-M4 satellite by passive detectors.

Acta Astronaut. 2017 Feb;131:110-2.

Note: Foton-M4 results.



Lee SG, Wu HM, Lee CG, Oh CS, Chung SW, Kim SG.

Binge alcohol intake after hypergravity stress sustainably decreases AMPK and transcription factors necessary for hepatocyte survival.

Alcohol Clin Exp Res. 2016 Nov 30. [Epub ahead of print]

Note: A centrifuge was used.



Iles TL, Laske TG, Garshelis DL, Iaizzo PA.

Blood clotting behavior is innately modulated in Ursus americanus during early and late denning relative to summer months.

J Exp Biol. 2016 Nov 24. [Epub ahead of print]



Caldwell JT, Wardlow GC, Branch PA, Ramos M, Black CD, Ade CJ.

Effect of exercise-induced muscle damage on vascular function and skeletal muscle microvascular deoxygenation.

Physiol Rep. 2016 Nov;4(22). [Article in Press]

Note: This article may be obtained online without charge.



Fry CS, Nayeem SZ, Dillon EL, Sarkar PS, Tumurbaatar B, Urban RJ, Wright TJ, Sheffield-Moore M, Tilton RG, Choudhary S.

Glucocorticoids increase skeletal muscle NF-κB inducing kinase (NIK): Links to muscle atrophy.

Physiol Rep. 2016 Nov;4(21).

Note: This article may be obtained online without charge.



Li TS, Shi H, Wang L, Yan C.

Effect of bone marrow mesenchymal stem cells on satellite cell proliferation and apoptosis in immobilization-induced muscle atrophy in rats.

Med Sci Monit. 2016 Nov 29;22:4651-60.

Note: Immobilization was accomplished via plaster cast. This article may be obtained online without charge.



Rindom E, Vissing K.

Mechanosensitive molecular networks involved in transducing resistance exercise-signals into muscle protein accretion.

Front Physiol. 2016 Nov 17;7:547. Review.

Note: This article may be obtained online without charge.



Fratini A, Bonci T, Bull AM.

Whole body vibration treatments in postmenopausal women can improve bone mineral density: Results of a stimulus focussed meta-analysis.

PLoS One. 2016 Dec 1;11(12):e0166774. Review.

Note: This article may be obtained online without charge.



Ritter Z, Belavy D, Baumann WW, Felsenberg D.

In vivo bone remodeling rates determination and compressive stiffness variations before, during 60 days bed rest and two years follow up: A micro-FE-analysis from HR-PQCT measurements of the Berlin Bed Rest Study-2.

Acta Astronaut. 2016 Dec 5. [Article in Press]

Note: Bed rest study.



Wittkowske C, Reilly GC, Lacroix D, Perrault CM.

In vitro bone cell models: Impact of fluid shear stress on bone formation.

Front Bioeng Biotechnol. 2016 Nov 15;4:87. Review.

Note: This article may be obtained online without charge.



Hamada N.

Ionizing radiation sensitivity of the ocular lens and its dose rate dependence.

Int J Radiat Biol. 2016 Nov 30:1-32. [Epub ahead of print]



Koops L.

Cosmic radiation exposure of future hypersonic flight missions.

Radiat Prot Dosimetry. 2016 Nov 24. [Epub ahead of print]



Paithankar JG, Deeksha K, Patil RK.

Gamma radiation tolerance in different life stages of the fruit fly Drosophila melanogaster.

Int J Radiat Biol. 2016 Nov 28:1-27. [Epub ahead of print]



Forbes PA, Luu BL, Van der Loos HF, Croft EA, Inglis JT, Blouin JS.

Transformation of vestibular signals for the control of standing in humans.

J Neurosci. 2016 Nov 9;36(45):11510-20.



Hogendoorn H, Verstraten FA, MacDougall H, Alais D.

Vestibular signals of self-motion modulate global motion perception.

Vision Res. 2016 Nov 25;130:22-30. [Epub ahead of print]

Note: A rotating chair was used.



Lawson BD, Rupert AH, McGrath BJ.

The neurovestibular challenges of astronauts and balance patients: Some past countermeasures and two alternative approaches to elicitation, assessment and mitigation.

Front Syst Neurosci. 2016 Nov 22;10(96).

Note: This article may be obtained online without charge.



Maxwell R, von Kirschbaum C, Jerin C, Lehnen N, Krause E, Gürkov R.

Effect of spatial orientation of the horizontal semicircular canal on the vestibulo-ocular reflex.

Otol Neurotol. 2016 Nov 24. [Epub ahead of print]



Takahashi M, Umetsu K, Oono Y, Higaki T, Blancaflor EB, Rahman A.

SMALL ACIDIC PROTEIN 1 (SMAP1) and SCFTIR1 ubiquitin proteasome pathway act in concert to induce 2,4-dichlorophenoxyacetic acid-mediated alteration of actin in Arabidopsis roots.

Plant J. 2016 Nov 25. [Epub ahead of print]



Takemura K, Kamachi H, Kume A, Fujita T, Karahara I, Hanba YT.

A hypergravity environment increases chloroplast size, photosynthesis, and plant growth in the moss Physcomitrella patens.

J Plant Res. 2016 Nov 28. [Epub ahead of print]

Note: A centrifuge was used.



Avercheva OV, Berkovich YA, Konovalova IO, Radchenko SG, Lapach SN, Bassarskaya EM, Kochetova GV, Zhigalova TV, Yakovleva OS, Tarakanov IG.

Optimizing LED lighting for space plant growth unit: Joint effects of photon flux density, red to white ratios and intermittent light pulses.

Life Sci Space Res. 2016 Dec 6. [Article in Press]



Fu Y, Li L, Xie B, Dong C, Wang M, Jia B, Shao L, Dong Y, Deng S, Liu H, Liu G, Liu B, Hu D, Liu H.

How to establish a bioregenerative life support system for long-term crewed missions to the Moon or Mars.

Astrobiology. 2016 Dec 2. [Epub ahead of print]

Note: Results are from a Lunar Palace 1 BLSS 105-day study.



Attias J, Philip ATC, Waldie J, Simon NE, David AG.

The Gravity-Loading Countermeasure Skinsuit (GLCS) and its effect upon aerobic exercise performance.

Acta Astronaut. 2016 Dec 6.



Aubert AE, Larina I, Momken I, Blanc S, White O, Prisk GK, Linnarsson D.

Towards human exploration of space: The THESEUS review series on cardiovascular, respiratory, and renal research priorities.

npj Microgravity. 2016 Dec 1;2:16031.

Note: This article may be obtained online without charge.



// end //

More status reports and news releases or top stories.

Please follow SpaceRef on Twitter and Like us on Facebook.