SpaceRef

SpaceRef


NASA Spaceline Current Awareness List #729 23 December 2016 (Space Life Science Research Results)

Status Report From: Senate Committee on Commerce, Science, and Transportation,
Posted: Friday, December 23, 2016

SpaceRef Editor's note: NASA's various life sciences programs have prepared the SPACELINE Current Awareness updates since 1999 covering all aspects of space life science, gravitational biology, space medicine, and human factors. NASA does not maintain a website - nor does it have an archive of this resource online. However, SpaceRef does have a complete archive of SPACELINE updates all the way back to 1999 that can be accessed here: http://www.spaceref.com/news/mission.html?mid=188&pag 

 SPACELINE Current Awareness Lists are now distributed via listserv. Please send any correspondence to Robyn Ertwine, SPACELINE Current Awareness Senior Editor, rertwine@nasaprs.com.

 

Please note: The next issue of SPACELINE Current Awareness (List #730) will be sent on Friday, January 6, 2017.

 

Papers deriving from NASA support:

 

1

Indo HP, Majima HJ, Terada M, Suenaga S, Tomita K, Yamada S, Higashibata A, Ishioka N, Kanekura T, Nonaka I, Hawkins CL, Davies MJ, Clair DK, Mukai C.

Changes in mitochondrial homeostasis and redox status in astronauts following long stays in space.

Sci Rep. 2016 Dec 16;6:39015.

https://www.ncbi.nlm.nih.gov/pubmed/27982062

Note: ISS results. This article may be obtained online without charge.

Journal Impact Factor:  0.755

Funding: "This study was supported in part by the JAXA-ISS Space Medicine Program Grant from the Japan Aerospace Exploration Agency." M. Terada is affiliated with NASA Ames Research Center

 

2

Afshinnekoo E, Mason CE.

Epigenetic therapy in a new era of medicine: Creating and integrating molecular profiles of patients.

Ann Transl Med. 2016 Nov;4(21):436.

https://www.ncbi.nlm.nih.gov/pubmed/27942527

PI: C.E. Mason

Note: This is a Commentary on the article: Hasanali ZS, Saroya BS, Stuart A, Shimko S, Evans J, Vinod Shah M, Sharma K, Leshchenko VV, Parekh S, Loughran TP Jr, Epner EM. Epigenetic therapy overcomes treatment resistance in T cell prolymphocytic leukemia. Sci Transl Med. 2015 Jun 24;7(293):293ra102. https://www.ncbi.nlm.nih.gov/pubmed/26109102. This article may be obtained online without charge.

Journal Impact Factor: Not available for this journal

Funding: "The authors would like to thank the Epigenomics Core Facility at Weill Cornell Medicine, as well as the Starr Cancer Consortium grants (I7-A765, I9-A9-071) and funding from the Irma T. Hirschl and Monique Weill-Caulier Charitable Trusts, Bert L and N Kuggie Vallee Foundation, the WorldQuant Foundation, The Pershing Square Sohn Cancer Research Alliance, NASA (NNX14AH50G, 15-15Omni2-0063), the National Institutes of Health (R25EB020393, R01NS076465, R01AI125416, R01ES021006), the Bill and Melinda Gates Foundation (OPP1151054), and the Alfred P. Sloan Foundation (G-2015-13964)."

 

3

Oestreich AK, Kamp WM, McCray MG, Carleton SM, Karasseva N, Lenz KL, Jeong Y, Daghlas SA, Yao X, Wang Y, Pfeiffer FM, Ellersieck MR, Schulz LC, Phillips CL.

Decreasing maternal myostatin programs adult offspring bone strength in a mouse model of osteogenesis imperfecta.

Proc Natl Acad Sci U S A. 2016 Nov 22;113(47):13522-7.

https://www.ncbi.nlm.nih.gov/pubmed/27821779

PI: S.M. Carleton, NSBRI Postdoctoral Fellowship Program

Journal Impact Factor: 9.674

Funding: "This work was supported in part by National Institutes of Health Grant AR055907 (to S.M.C., Y.J., X.Y., Y.W., C.L.P.); National Space and Biomedical Research Institute Postdoctoral Fellowship NCC 9-58 (to S.M.C.); Leda J. Sears Trust Foundation Grant (S.M.C., A.K.O., C.L.P.); University of Missouri Life Sciences Fellowship (A.K.O.); Missouri Mission Enhancement (L.C.S.); and University of Missouri Interdisciplinary Intercampus Research Program (C.L.P., Y.W., A.K.O., L.C.S.)."

 

4

Poulose SM, Rabin BM, Bielinski DF, Kelly ME, Miller MG, Thanthaeng N, Shukitt-Hale B.

Neurochemical differences in learning and memory paradigms among rats supplemented with anthocyanin-rich blueberry diets and exposed to acute doses of 56Fe particles.

Life Sci Space Res. 2016 Dec 15. [Article in Press]

http://www.sciencedirect.com/science/article/pii/S2214552416300864

PI: B.M. Rabin

Journal Impact Factor: Not available for this journal

Funding: "This research was supported in part by USDA Intramural and N.A.S.A. Grants NNX13AB73G."

 

5

Hanu AR, Barberiz J, Bonneville D, Byun SH, Chen L, Ciambella C, Dao E, Deshpande V, Garnett R, Hunter SD, Jhirad A, Johnston EM, Kordic M, Kurnell M, Lopera L, McFadden M, Melnichuk A, Nguyen J, Otto A, Scott R, Wagner DL, Wiendels M.

NEUDOSE: A CubeSat mission for dosimetry of charged particles and neutrons in low-Earth orbit.

Radiat Res. 2016 Dec 21. [Epub ahead of print]

https://www.ncbi.nlm.nih.gov/pubmed/28001909

Journal Impact Factor: 3.022

Funding: "ARH was supported by an appointment to the NASA Postdoctoral Program at Goddard Space Flight Center (administered by Oak Ridge Associated Universities through a contract with NASA)." A.R. Hanu and S.D. Hunter are affiliated with NASA Goddard Space Flight Center.

 

6

Koppelmans V, Bloomberg JJ, Mulavara AP, Seidler RD.

Brain structural plasticity with spaceflight.

npj Microgravity. 2016 Nov 2;2(1):2.

http://www.nature.com/articles/s41526-016-0001-9

PI: R.D. Seidler

Note: This article may be obtained online without charge.

Journal Impact Factor: Not available for this journal

Funding: "This work was supported by a grant from the National Aeronautics and Space Administration (NASA; NNX11AR02G)."

 

7

Yun S, Reynolds RP, Masiulis I, Eisch AJ.

Re-evaluating the link between neuropsychiatric disorders and dysregulated adult neurogenesis.

Nat Med. 2016 Nov;22(11):1239-47.

https://www.ncbi.nlm.nih.gov/pubmed/27783068

PI: A.J. Eisch

Journal Impact Factor: 30.357

Funding: "This work was supported by grants to A.J.E. from the US National Institutes of Health (DA023701, DA023555, MH107945) and the US National Aeronautics and Space Administration (NNX15AE09G). S.Y. was funded by a postdoctoral institutional training grant (NIMH T32-MH076690, Basic Science Training Program in the Neurobiology of Mental Illness, PI, C. Tamminga)."

 

Note: A new edition of Space Physiology and Medicine has been published. The editors and many of the chapter authors are or have been affiliated with NASA Headquarters or NASA Johnson Space Center. The book and individual chapters are listed below.

 

8

Nicogossian AE, Williams RS, Huntoon CL, Doarn CR, Polk JD, Schneider VS. (Editors)

Space physiology and medicine: From evidence to practice. 4th ed.

New York: Springer; 2016. 509 p.

http://link.springer.com/book/10.1007/978-1-4939-6652-3

Note: From the Introduction: The 4th edition of Space Physiology and Medicine "is intended for teachers, students, and practitioners interested and engaged in this rapidly evolving discipline. The knowledge gained over the past five decades is reflected in this textbook. A common outline provides the reader with a ready cross-referencing between different chapters. . . This fourth edition builds on the foundation of the previous three editions, adding new information on relevant legislation, medical policy, and ethics. A syllabus and a set of teaching materials are made available for academic purposes. The standard chapter outline contains Case Studies, which add an important element for the reader to connect the evidence to clinical practice. The information contained in the chapters reflects the evidence in a point of time, which is subject to potential change based on new information obtained from research and observations conducted on the International Space Station (ISS). The Self-Study Questions and Key Points summarize the knowledge underpinning space medicine standards of practice and the remaining uncertainties to be addressed. Supplemental information from biomedical research based on human surrogate subjects and biological specimens are also included as appropriate."

 

9

Nicogossian AE, Doarn CR, Hu Y.

Evolution of human capabilities and space medicine.

In: Space physiology and medicine: From evidence to practice. New York: Springer, 2016. p. 3-57.

http://link.springer.com/chapter/10.1007%2F978-1-4939-6652-3_1

 

10

Nicogossian AE.

The environment of space exploration.

In: Space physiology and medicine: From evidence to practice. New York: Springer, 2016. p. 59-94.

http://link.springer.com/chapter/10.1007%2F978-1-4939-6652-3_2

 

11

Nicogossian AE, Williams RS, Huntoon CL, Doarn CR.

Living and working in space: An overview of physiological adaptation, performance, and health risks.

In: Space physiology and medicine: From evidence to practice. New York: Springer, 2016. p. 95-134.

http://link.springer.com/chapter/10.1007%2F978-1-4939-6652-3_3

 

12

James JT.

Toxicology.

In: Space physiology and medicine: From evidence to practice. New York: Springer, 2016. p. 137-53.

http://link.springer.com/chapter/10.1007%2F978-1-4939-6652-3_4

 

13

Oubre CM, Pierson DL, Ott CM.

Microbiology.

In: Space physiology and medicine: From evidence to practice. New York: Springer, 2016. p. 155-67.

http://link.springer.com/chapter/10.1007%2F978-1-4939-6652-3_5

 

14

Allen CS, Danielson RW, Allen JR.

Acoustics and audition.

In: Space physiology and medicine: From evidence to practice. New York: Springer, 2016. p. 169-96.

http://link.springer.com/chapter/10.1007%2F978-1-4939-6652-3_6

 

15

Bacal K, Romano J.

Radiation health and protection.

In: Space physiology and medicine: From evidence to practice. New York: Springer, 2016. p. 197-224.

http://link.springer.com/chapter/10.1007%2F978-1-4939-6652-3_7

 

16

Schneider VS, Charles JB, Conkin J, Prisk GK.

Cardiopulmonary system: Aeromedical considerations.

In: Space physiology and medicine: From evidence to practice. New York: Springer, 2016. p. 227-44.

http://link.springer.com/chapter/10.1007%2F978-1-4939-6652-3_8

 

17

Reschke MF, Clément G, Thorson SL, Harm DL, Mader TH, Dudley AM, Wood SJ, Bloomberg JJ, Mulavara AP, Gibson CR, Williams DR.

Neurology.

In: Space physiology and medicine: From evidence to practice. New York: Springer, 2016. p. 245-82.

http://link.springer.com/chapter/10.1007%2F978-1-4939-6652-3_9

 

18

Smith SM, Whitson PA, Zwart SR, Huntoon CL.

Regulatory physiology.

In: Space physiology and medicine: From evidence to practice. New York: Springer, 2016. p. 283-305.

http://link.springer.com/chapter/10.1007%2F978-1-4939-6652-3_10

 

19

Lane HW, Smith SM, Kloeris VL.

Metabolism and nutrition.

In: Space physiology and medicine: From evidence to practice. New York: Springer, 2016. p. 307-21.

http://link.springer.com/chapter/10.1007%2F978-1-4939-6652-3_11

 

20

Putcha L, Taylor PW, Daniels VR, Pool SL.

Clinical pharmacology and therapeutics.

In: Space physiology and medicine: From evidence to practice. New York: Springer, 2016. p. 323-46.

http://link.springer.com/chapter/10.1007%2F978-1-4939-6652-3_12

 

21

Schneider VS, Ploutz-Snyder L, LeBlanc AD, Sibonga J.

Musculoskeletal adaptation to space flight.

In: Space physiology and medicine: From evidence to practice. New York: Springer, 2016. p. 347-65.

http://link.springer.com/chapter/10.1007%2F978-1-4939-6652-3_13

 

22

Sipes WE, Polk JD, Beven G, Shepanek M.

Behavioral health and performance.

In: Space physiology and medicine: From evidence to practice. New York: Springer, 2016. p. 367-89.

http://link.springer.com/chapter/10.1007%2F978-1-4939-6652-3_14

 

23

Doarn CR, Williams RS, Schneider VS, Polk JD.

Principles of crew health monitoring and care.

In: Space physiology and medicine: From evidence to practice. New York: Springer, 2016. p. 393-421.

http://link.springer.com/chapter/10.1007%2F978-1-4939-6652-3_15 

 

 

24

Doarn CR, Williams RS, Nicogossian AE, Polk JD.

International dimension of space medicine.

In: Space physiology and medicine: From evidence to practice. New York: Springer, 2016. p. 423-37.

http://link.springer.com/chapter/10.1007%2F978-1-4939-6652-3_16

 

25

Nicogossian AE, Williams DR, Williams RS, Schneider VS.

Simulations and analogs (Test-beds).

In: Space physiology and medicine: From evidence to practice. New York: Springer, 2016. p. 441-61.

http://link.springer.com/chapter/10.1007%2F978-1-4939-6652-3_17

 

26

Doarn CR, Williams RS, Nicogossian AE, Polk JD.

Training in space medicine.

In: Space physiology and medicine: From evidence to practice. New York: Springer, 2016. p. 463-77.

http://link.springer.com/chapter/10.1007%2F978-1-4939-6652-3_18

 

27

Doarn CR, Nicogossian AE, Schneider VS, Williams RS.

Commercial space tourism and space as a biomedical laboratory.

In: Space physiology and medicine: From evidence to practice. New York: Springer, 2016. p. 481-8.

http://link.springer.com/chapter/10.1007%2F978-1-4939-6652-3_19

______________________________________________________

 

Other papers of interest:

 

1

Golding JF, Paillard AC, Normand H, Besnard S, Denise P.

Prevalence, predictors, and prevention of motion sickness in zero-G parabolic flights.

Aerosp Med Hum Perform. 2017 Jan;88(1):3-9.

http://www.ingentaconnect.com/content/asma/amhp/2017/00000088/00000001/art00004

Note: Parabolic flight results.

 

2

Hasegawa T, Oe H, Taki M, Sakaguchi H, Hirano S, Wada Y.

End-tidal CO2 relates to seasickness susceptibility: A study in Antarctic voyages.

Auris Nasus Larynx. 2016 Dec 13. [Epub ahead of print]

https://www.ncbi.nlm.nih.gov/pubmed/27986366

 

3

Marshall-Goebel K, Mulder E, Bershad E, Laing C, Eklund A, Malm J, Stern C, Rittweger J.

Intracranial and intraocular pressure during various degrees of head-down tilt.

Aerosp Med Hum Perform. 2017 Jan;88(1):10-6.

http://www.ingentaconnect.com/content/asma/amhp/2017/00000088/00000001/art00005

Note: Head-down tilt study with lower body negative pressure.

 

4

Irimia JM, Guerrero M, Rodriguez-Miguelez P, Cadefau JA, Tesch PA, Cusso RRC, Fernandez-Gonzalo R.

Metabolic adaptations in skeletal muscle after 84 days bed rest with and without concurrent flywheel resistance exercise.

J Appl Physiol (1985). 2016 Dec 8:jap.00521.2016. [Epub ahead of print]

https://www.ncbi.nlm.nih.gov/pubmed/27932674

Note: Bed rest study.

 

5

Okushima D, Poole DC, Barstow TJ, Rossiter HB, Kondo N, Bowen TS, Amano T, Koga S.

Greater V̇O2peak is correlated with greater skeletal muscle deoxygenation amplitude and hemoglobin concentration within individual muscles during ramp-incremental cycle exercise.

Physiol Rep. 2016 Dec;4(23).

https://www.ncbi.nlm.nih.gov/pubmed/27986837

Note: This article may be obtained online without charge.

 

6

Theilen NT, Kunkel GH, Tyagi SC.

The role of exercise and TFAM in preventing skeletal muscle atrophy.

J Cell Physiol. 2016 Dec 14. [Epub ahead of print] Review

https://www.ncbi.nlm.nih.gov/pubmed/27966783

Note: Hindlimb unloading studies are included in the review.

 

7

Vegger JB, Brüel A, Dahlgaard AF, Thomsen JS.

Alterations in gene expression precede sarcopenia and osteopenia in botulinum toxin immobilized mice.

J Musculoskelet Neuronal Interact. 2016 Dec 14;16(4):355-68.

https://www.ncbi.nlm.nih.gov/pubmed/27973388

Note: Immobilization was accomplished via botulinum toxin.

 

8

Maycas M, Esbrit P, Gortázar AR.

Molecular mechanisms in bone mechanotransduction.

Histol Histopathol. 2016 Dec 16:11858. Review. [Epub ahead of print]

https://www.ncbi.nlm.nih.gov/pubmed/27981526

Note: This article may be obtained online without charge.

 

9

Mavromichalaki H, Preka-Papadema P, Theodoropoulou A, Paouris E, Apostolou T.

A study of the possible relation of the cardiac arrhythmias occurrence to the polarity reversal of the solar magnetic field.

Adv Space Res. 2017 Jan;59(1):366-78.

http://www.sciencedirect.com/science/article/pii/S027311771630477X 

 

10

Ilbasmis S, Yildiz S.

Respiratory and pulse changes due to vestibular stimulations in a motion-based simulator.

Aerosp Med Hum Perform. 2017 Jan;88(1):48-51.

http://www.ingentaconnect.com/content/asma/amhp/2017/00000088/00000001/art00011

 

11

Hickey E, Pham-Hung E, Nosikova Y, Halvorsen F, Gritti M, Schwartz S, Caldarone CA, Van Arsdell G.

NASA model of "threat and error" in pediatric cardiac surgery: Patterns of error chains.

Ann Thorac Surg. 2016 Dec 9. [Epub ahead of print]

https://www.ncbi.nlm.nih.gov/pubmed/27955899

Note: The NASA threat-and-error model was used.

 

// end //

More status reports and news releases or top stories.

Please follow SpaceRef on Twitter and Like us on Facebook.

NanoRacks