SpaceRef

SpaceRef


NASA Spaceline Current Awareness List #730 6 January 2017 (Space Life Science Research Results)

Status Report From: Spaceline
Posted: Friday, January 6, 2017



SpaceRef Editor's note: NASA's various life sciences programs have prepared the SPACELINE Current Awareness updates since 1999 covering all aspects of space life science, gravitational biology, space medicine, and human factors. NASA does not maintain a website - nor does it have an archive of this resource online. However, SpaceRef does have a complete archive of SPACELINE updates all the way back to 1999 that can be accessed here: http://www.spaceref.com/news/mission.html?mid=188&pag

SPACELINE Current Awareness Lists are now distributed via listserv. Please send any correspondence to Robyn Ertwine, SPACELINE Current Awareness Senior Editor, rertwine@nasaprs.com.
 
 
Papers deriving from NASA support:
 
1
Martin DS, Lee SM, Matz TP, Westby CM, Scott JM, Stenger MB, Platts SH.
Internal jugular pressure increases during parabolic flight.
Physiol Rep. 2016 Dec;4(24).
https://www.ncbi.nlm.nih.gov/pubmed/28039409
Note: Parabolic flight results
Journal Impact Factor: Not available for this journal
Funding: "Funding for this study was provided by the NASA Human Research Program."
 
2
Lu T, Zhang Y, Wong M, Feiveson A, Gaza R, Stoffle N, Wang H, Wilson B, Rohde L, Stodieck L, Karouia F, Wu H.
Detection of DNA damage by space radiation in human fibroblasts flown on the International Space Station.
Life Sci Space Res. 2016 Dec 24. [Article in Press]
http://www.sciencedirect.com/science/article/pii/S221455241630089X
Note: ISS results.
Journal Impact Factor: Not available for this publication
Funding: "This work was supported by the NASA Fundamental Space Biology Program and the NASA Human Research Program."
 
3
Diaz Artiles A, Heldt T, Young LR.
Effects of artificial gravity on the cardiovascular system: Computational approach.
Acta Astronaut. 2016 Sep-Oct;126:395-410.
http://www.sciencedirect.com/science/article/pii/S009457651530299X
PI: L.R. Young
Journal Impact Factor: 1.095
Funding: "This project was supported by the MIT/Skolkovo Development Project (Seed Grant 6925991), and the National Space Biomedical Research Institute through NASA NCC 9-58. In addition, the Fulbright Commission has provided additional support."
 
4
Slaba TC, Bahadori AA, Reddell BD, Singleterry RC, Clowdsley MS, Blattnig SR.
Optimal shielding thickness for galactic cosmic ray environments.
Life Sci Space Res. 2017 Feb;12:1-15. Epub 2016 Dec 27.
http://www.sciencedirect.com/science/article/pii/S2214552416300992
Journal Impact Factor: Not available for this journal
Funding: "This work was supported by the Advanced Radiation Protection Project under the Game Changing Division of the Space Technology Mission Directorate of NASA."
 
5
Dennis LE, Spaeth AM, Goel N.
Phenotypic stability of energy balance responses to experimental total sleep deprivation and sleep restriction in healthy adults.
Nutrients. 2016 Dec 19;8(12).
https://www.ncbi.nlm.nih.gov/pubmed/27999367
PI: N. Goel
Note: This article may be obtained online without charge.
Journal Impact Factor: 30759
Funding: "This research was supported by the Department of the Navy, Office of Naval Research Award No. N00014-11-1-0361 (N.G.); National Aeronautics and Space Administration NNX14AN49G (N.G.); Clinical and Translational Research Center (CTRC) grant UL1TR000003; and NIH grant F31 AG044102 (A.M.S.)."
 
6
Barratt M.
Space physiology and medicine.
In: Ernsting's aviation and space medicine. 5 ed. Boca Raton, FL: CRC Press, 2016. p. 323-54.
https://www.crcpress.com/Ernstings-Aviation-and-Space-Medicine-5E/Gradwell-Rainford/p/book/9781444179941 [URL for the book]
Journal Impact Factor: Not applicable to this publication
Funding: No funding cited. M. Barratt is affiliated with NASA Johnson Space Center
______________________________________________________
 
Other papers of interest:
 
1
Mora M, Perras A, Alekhova TA, Wink L, Krause R, Aleksandrova A, Novozhilova T, Moissl-Eichinger C.
Resilient microorganisms in dust samples of the International Space Station—Survival of the adaptation specialists.
Microbiome. 2016 Dec 20;4(1):65.
https://www.ncbi.nlm.nih.gov/pubmed/27998314
Note: ISS results. This article may be obtained online without charge.
 
2
Chatani M, Morimoto H, Takeyama K, Mantoku A, Tanigawa N, Kubota K, Suzuki H, Uchida S, Tanigaki F, Shirakawa M, Gusev O, Sychev V, Takano Y, Itoh T, Kudo A.
Acute transcriptional up-regulation specific to osteoblasts/osteoclasts in medaka fish immediately after exposure to microgravity.
Sci Rep. 2016 Dec 22;6:39545.
https://www.ncbi.nlm.nih.gov/pubmed/28004797
Note: ISS results. This article may be obtained online without charge.
 
3
Casellato C, Pedrocchi A, Ferrigno G.
Whole-body movements in long-term weightlessness: Hierarchies of the controlled variables are gravity-dependent.
J Mot Behav. 2016 Dec 27:1-12. [Epub ahead of print]
https://www.ncbi.nlm.nih.gov/pubmed/28027021
Note: ISS results.
 
4
Tanaka K, Nishimura N, Kawai Y.
Adaptation to microgravity, deconditioning, and countermeasures.
J Physiol Sci. 2016 Dec 20. [Epub ahead of print] Review.
https://www.ncbi.nlm.nih.gov/pubmed/28000175
Note: A number of flight studies are mentioned.
 
5
Shao D, Yao L, Riaz MS, Zhu J, Shi J, Jin M, Huang Q, Yang H.
Simulated microgravity affects some biological characteristics of Lactobacillus acidophilus.
Appl Microbiol Biotechnol. 2016 Dec 24. [Epub ahead of print]
https://www.ncbi.nlm.nih.gov/pubmed/28013406
Note: A 2-D rotating wall vessel was used.
 
6
D'Alessandro A, Nemkov T, Bogren LK, Martin SL, Hansen KC.
Comfortably numb and back: Plasma metabolomics reveals biochemical adaptations in the hibernating 13-lined ground squirrel.
J Proteome Res. 2016 Dec 29. [Epub ahead of print]
https://www.ncbi.nlm.nih.gov/pubmed/27991798
 
7
Yoon G, Kim HS.
Gastric acid response to acute exposure to hypergravity.
Oncotarget. 2016 Dec 15. [Epub ahead of print]
https://www.ncbi.nlm.nih.gov/pubmed/27992379
Note: A small animal centrifuge was used.
 
8
Boushel R.
Linking skeletal muscle blood flow and metabolism to the limits of human performance.
Appl Physiol Nutr Metab. 2016 Sep 14:1-5. [Epub ahead of print]
https://www.ncbi.nlm.nih.gov/pubmed/28006435
 
9
Murata M, Nonaka H, Komatsu S, Goto M, Morozumi M, Yamada S, Lin IC, Yamashita S, Tachibana H.
Delphinidin prevents muscle atrophy and upregulates miR-23a expression.
J Agric Food Chem. 2016 Dec 29. [Epub ahead of print]
https://www.ncbi.nlm.nih.gov/pubmed/28000445
 
10
Sainton P, Nicol C, Cabri J, Barthèlemy-Montfort J, Chavet P.
Kinetics and muscle activity patterns during unweighting and reloading transition phases in running.
PLoS One. 2016 Dec 19;11(12):e0168545.
https://www.ncbi.nlm.nih.gov/pubmed/27992539
Note: Lower body negative pressure was used. This article may be obtained online without charge.
 
11
Winnard A, Nasser M, Debuse D, Stokes M, Evetts S, Wilkinson M, Hides J, Caplan N.
Systematic Review of countermeasures to minimise physiological changes and risk of injury to the lumbopelvic area following long-term microgravity.
Musculoskelet Sci Pract. 2016 Dec 19. [Article in Press] Review.
http://www.sciencedirect.com/science/article/pii/S2468781216300078
Note: Bed rest studies are reviewed.
 
12
Alam I, Reilly AM, Alkhouli M, Gerard-O'Riley RL, Kasipathi C, Oakes DK, Wright WB, Acton D, McQueen AK, Patel B, Lim KE, Robling AG, Econs MJ.
Bone mass and strength are significantly improved in mice overexpressing human WNT16 in osteocytes.
Calcif Tissue Int. 2016 Dec 24. [Epub ahead of print]
https://www.ncbi.nlm.nih.gov/pubmed/28013361
 
13
Birkhold AI, Razi H, Duda GN, Checa S, Willie BM.
Tomography-based quantification of regional differences in cortical bone surface remodeling and mechano-response.
Calcif Tissue Int. 2016 Dec 20. [Epub ahead of print]
https://www.ncbi.nlm.nih.gov/pubmed/27999894
 
14
Darnell M, Young S, Gu L, Shah N, Lippens E, Weaver J, Duda G, Mooney D.
Substrate stress-relaxation regulates scaffold remodeling and bone formation in vivo.
Adv Healthc Mater. 2016 Dec 20. [Epub ahead of print]
https://www.ncbi.nlm.nih.gov/pubmed/27995768
 
15
Li J, Yang S, Li X, Liu D, Wang Z, Guo J, Tan N, Gao Z, Zhao X, Zhang J, Gou F, Yokota H, Zhang P.
Role of endoplasmic reticulum stress in disuse osteoporosis.
Bone. 2016 Dec 16;97:2-14.
https://www.ncbi.nlm.nih.gov/pubmed/27989543
Note: Hindlimb unloading study.
 
16
Li W-T, Huang Y-F, Sun L-W, Luan H-Q, Zhu B-Z, Fan Y-B.
Would interstitial fluid flow be responsible for skeletal maintenance in tail-suspended rats?
Microgravity Sci Technol. 2016 Dec 29:1-8.
http://link.springer.com/article/10.1007%2Fs12217-016-9530-9
Note: Hindlimb unloading study.
 
17
Treffel L, Mkhitaryan K, Gellee S, Gauquelin-Koch G, Gharib C, Blanc S, Millet C.
Intervertebral disc swelling demonstrated by 3D and water content magnetic resonance analyses after a 3-day dry immersion simulating microgravity.
Front Physiol. 2016 Dec 5;7:605.
https://www.ncbi.nlm.nih.gov/pubmed/27994557
Note: Dry immersion was used. This article may be obtained online without charge.
 
18
Wang T, Chen H, Lv K, Ji G, Liang F, Zhang Y, Wang Y, Liu X, Cao H, Kan G, Xiong J, Li Y, Qu L.
Activation of HIF-1alpha and its downstream targets in rat hippocampus after long-term simulated microgravity exposure.
Biochem Biophys Res Commun. 2016 Dec 14. [Epub ahead of print]
https://www.ncbi.nlm.nih.gov/pubmed/27988334
Note: Hindlimb unloading study.
 
19
Hussain S, Dutta A, Sarkar A, Singh A, Gupta ML, Biswas S.
Proteomic analysis of irradiated lung tissue of mice using gel-based proteomic approach.
Int J Radiat Biol. 2016 Dec 21:1-8. [Epub ahead of print]
https://www.ncbi.nlm.nih.gov/pubmed/28000521
 
20
Kim S, Choe JH, Lee GJ, Kim YS, Kim SY, Lee HM, Jin HS, Kim TS, Kim JM, Cho MJ, Shin EC, Jo EK, Kim JS.
Ionizing radiation induces innate immune responses in macrophages by generation of mitochondrial reactive oxygen species.
Radiat Res. 2016 Dec 21. [Epub ahead of print]
https://www.ncbi.nlm.nih.gov/pubmed/28001907
 
21
Luo L, Nishi K, Urata Y, Yan C, Hasan AS, Goto S, Kudo T, Li ZL, Li TS.
Ionizing radiation impairs endogenous regeneration of infarcted heart: An in vivo 18F-FDG PET/CT and 99mTc-tetrofosmin SPECT/CT study in mice.
Radiat Res. 2016 Dec 6. [Epub ahead of print]
https://www.ncbi.nlm.nih.gov/pubmed/27922334
 
22
McKay CD, Standage M.
Astronaut adherence to exercise-based reconditioning: Psychological considerations and future directions.
Musculoskelet Sci Pract. 2016 Dec 19. [Article in Press]
http://www.sciencedirect.com/science/article/pii/S2468781216300091
 
23
Guseman JM, Webb K, Srinivasan C, Dardick C.
DRO1 influences root system architecture in Arabidopsis and Prunus species.
Plant J. 2016 Dec 28. [Epub ahead of print]
https://www.ncbi.nlm.nih.gov/pubmed/28029738
 
24
Kamachi H, Tamaoki D, Karahara I.
Plasma membrane-anchored chloroplasts are necessary for the gravisensing system of Ceratopteris richardii prothalli.
J Plant Res. 2016 Dec 17. [Epub ahead of print]
https://www.ncbi.nlm.nih.gov/pubmed/27988818
 
25
Kim SM, Kim H, Yang D, Park J, Park R, Namkoong S, Lee JI, Choi I, Kim H-S, Kim H, Park J.
An experimental and theoretical approach to optimize a three-dimensional clinostat for life science experiments.
Microgravity Sci Technol. 2016 Dec 27:1-10.
http://link.springer.com/article/10.1007%2Fs12217-016-9529-2
Note: A 3-D clinostat was used.
 
26
Li Y, He L, Pan S, Zhang L, Zhang W, Yi H, Niu Y.
Three-dimensional simulated microgravity culture improves the proliferation and odontogenic differentiation of dental pulp stem cell in PLGA scaffolds implanted in mice.
Mol Med Rep. 2016 Dec 14. [Epub ahead of print]
https://www.ncbi.nlm.nih.gov/pubmed/28000851
Note: A rotary cell culture system was used.
 
27
Xu T, Shi W, Huang J, Song Y, Zhang F, Xu LP, Zhang X, Wang S.
Superwettable microchips as a platform toward microgravity biosensing.
ACS Nano. 2016 Dec 22. [Epub ahead of print]
https://www.ncbi.nlm.nih.gov/pubmed/27992718
Note: From the Abstract: "Here we introduce superhydrophilic microwells onto superhydrophobic substrates that are capable of capturing and transferring microdroplets, demonstrating a proof-of-concept study of a biosensing platform toward microgravity application." The system was developed for use aboard the International Space Station.
 

// end //

More status reports and news releases or top stories.

Please follow SpaceRef on Twitter and Like us on Facebook.