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NASA Spaceline Current Awareness List 739 10 March 2017 (Space Life Science Research Results)

Status Report From: Spaceline
Posted: Friday, March 10, 2017

SPACELINE Current Awareness Lists are distributed via listserv. Please send any correspondence to Robyn Ertwine, SPACELINE Current Awareness Senior Editor, rertwine@nasaprs.com.
 
 
Papers deriving from NASA support:
 
1
Lu T, Zhang Y, Kidane Y, Feiveson A, Stodieck L, Karouia F, Ramesh G, Rohde L, Wu H.
Cellular responses and gene expression profile changes due to bleomycin-induced DNA damage in human fibroblasts in space.
PLoS One. 2017 Mar 1;12(3):e0170358.
https://www.ncbi.nlm.nih.gov/pubmed/28248986
PI: H. Wu
Note: ISS results. This article may be obtained online without charge.
Journal Impact Factor: 3.057
Funding: "This work was supported by the NASA Fundamental Space Biology Program."
 
2
Siamwala JH, Macias BR, Lee PC, Hargens AR.
Gender differences in tibial microvascular flow responses to head down tilt and lower body negative pressure.
Physiol Rep. 2017 Feb;5(4):e13143.
https://www.ncbi.nlm.nih.gov/pubmed/28242824
PIs: B.R. Macias, A.R. Hargens
Note: Head-down tilt study. This article may be obtained online without charge.
Journal Impact Factor: 1.618
Funding: "This study was supported by a Wood Whelan travel fellowship (JHS), National Space Biomedical Research Institute grant NCC 9-58 to BRM and NASA grant NNX13AJ12G to ARH."
 
3
Nestorova GG, Hasenstein K, Nguyen N, DeCoster MA, Crews ND.
Lab-on-a-chip mRNA purification and reverse transcription via a solid-phase gene extraction technique.
Lab Chip. 2017 Feb 24. [Epub ahead of print]
https://www.ncbi.nlm.nih.gov/pubmed/28232986
Journal Impact Factor: 5.586
Funding: "This work was supported by NASA EPSCOR #NNH13ZHA001C and NSF CBET-1151148."
 
4
Marshall-Goebel K, Mulder E, Donoviel D, Strangman G, Suarez JI, Venkatasubba Rao C, Frings-Meuthen P, Limper U, Rittweger J, Bershad EM.
An international collaboration studying the physiological and anatomical cerebral effects of carbon dioxide during head-down tilt bed rest: The SPACECOT study.
J Appl Physiol (1985). 2017 Feb 23:jap.00885.2016. [Epub ahead of print]
https://www.ncbi.nlm.nih.gov/pubmed/28235859
PI: E.M. Bershad
Note: Bed rest study.
Journal Impact Factor: 3.004
Funding: "This study was supported by the National Space Biomedical Research Institute (NSBRI) through NASA NCC 9-58, Baylor College of Medicine Center for Space Medicine and the German Aerospace Center (DLR) Institute of Aerospace Medicine."
 
5
Sridharan DM, Enerio S, Pluth JM.
Lesion complexity drives age related cancer susceptibility in human mammary epithelial cells.
Aging (Albany NY). 2017 Feb 28. [Epub ahead of print]
https://www.ncbi.nlm.nih.gov/pubmed/28245431
PI: J.M. Pluth
Note: This article may be obtained online without charge.
Journal Impact Factor: 3.979
Funding: "NASA grants NNJ13HA96I and NNJ12HD071 awarded to JMP funded this study."
 
6
Davidson BP, Hodovan J, Belcik JT, Moccetti F, Xie A, Ammi AY, Lindner JR.
Rest-stress limb perfusion imaging in humans with contrast ultrasound using intermediate-power imaging and microbubbles resistant to inertial cavitation.
J Am Soc Echocardiogr. 2017 Feb 23. [Epub ahead of print]
https://www.ncbi.nlm.nih.gov/pubmed/28238588
PI: J.R. Lindner
Journal Impact Factor: 4.254
Funding: "Dr. Lindner is supported by grant nos. R01-HL078610, R01-HL111969, and R01-HL120046 from the National Institutes of Health and grant no. 14NSBRI1-0025 from the National Space Biomedical Research Institute (NASA). Dr. Moccetti is supported by a grant from the Swiss National Science Foundation (P2BSP3_158853). The study was funded in part by a grant from GE Healthcare, Amersham, United Kingdom."
 
7
Hu M, Lam H, Yeh R, Teeratananon M, Qin YX.
Comparison of morphological changes of muscle fibers in response to dynamic electrical muscle contraction and dynamic hydraulic stimulation in a rat hindlimb disuse model.
Physiol Res. 2017 Feb 28. [Epub ahead of print]
https://www.ncbi.nlm.nih.gov/pubmed/28248540
PI: Y.X. Qin
Note: Hindlimb unloading study. This article may be obtained online without charge.
Journal Impact Factor: 1.618
Funding: "The authors are thankful for the kind support from National Institute of Health (R01 AR52379 and AR61821, YXQ), US Army Medical Research and Materiel Command, and National Space Biomedical Research Institute through NASA Cooperative Agreement NCC 9-58 (YXQ)."
 
8
Berdahl J.
The eye in space.
US Ophthalmic Rev. 2016;9(2):76-7.
http://www.touchophthalmology.com/articles/eye-space
PI: J. Berdahl
Note: This article may be obtained online without charge.
Journal Impact Factor: Not available for this journal
Funding: "This work supported by the National Space Biomedical Research Institute through NASA NCC 9-58."
 
9
Landon LB, Rokholt C, Slack KJ, Pecena Y.
Selecting astronauts for long-duration exploration missions: Considerations for team performance and functioning.
REACH. 2017 Mar 6. [Article in Press]
http://www.sciencedirect.com/science/article/pii/S2352309316300281
Journal Impact Factor: Not available for this journal
Funding: "This research did not receive any specific grant from funding agencies in the public, commercial, or not-for-profit sectors." L.B. Landon and K.J. Slack are affiliated with NASA Johnson Space Center.
 
Related work by Landon, et al.:
 
10
Landon LB, Rokholt C, Slack KJ, Pecena Y.
Selecting astronauts for long-duration exploration missions: A retrospective review and considerations for team performance and functioning.
Houston, TX: NASA Johnson Space Center, 2016 Dec. 68 p. NASA/TM-2016-219283.
https://ston.jsc.nasa.gov/collections/TRS/listfiles.cgi?DOC=TM-2016-219283
Note: This article may be obtained online without charge.
Journal Impact Factor: Not applicable to this publication
Funding: No funding cited. L.B. Landon and K.J. Slack are affiliated with NASA Johnson Space Center.
______________________________________________________
 
Other papers of interest:
 
1
Thiel CS, de Zélicourt D, Tauber S, Adrian A, Franz M, Simmet DM, Schoppmann K, Hauschild S, Krammer S, Christen M, Bradacs G, Paulsen K, Wolf SA, Braun M, Hatton J, Kurtcuoglu V, Franke S, Tanner S, Cristoforetti S, Sick B, Hock B, Ullrich O.
Rapid adaptation to microgravity in mammalian macrophage cells.
Sci Rep. 2017;7(1):43.
https://www.ncbi.nlm.nih.gov/pubmed/28242876
Note: ISS results. This article may be obtained online without charge.
 
2
Sotnezova EV, Markina EA, Andreeva ER, Buravkova LB.
Myeloid precursors in the bone marrow of mice after a 30-day space mission on a Bion-M1 biosatellite.
Bull Exp Biol Med. 2017 Feb;162(4):496-500.
https://www.ncbi.nlm.nih.gov/pubmed/28243916
Note: Bion-M1 results. "Translated from Byulleten 'Eksperimental'noi Biologii i Meditsiny, Vol. 162, No. 10, pp. 495-499, October, 2016. Original article submitted January 22, 2016."
 
3
Thiel CS, Lauber BA, Polzer J, Ullrich O.
Time course of cellular and molecular regulation in the immune system in altered gravity: Progressive damage or adaptation?
REACH. 2017 Mar 7. [Article in Press] Review.
http://www.sciencedirect.com/science/article/pii/S2352309317300019
Note: The review includes results from both spaceflight and ground-based microgravity simulation studies.
 
4
Smith JR, Alexander AM, Hammer SM, Didier KD, Kurti SP, Broxterman RM, Barstow TJ, Harms CA.
Cardiovascular consequences of the inspiratory muscle metaboreflex: Effects of age and sex.
Am J Physiol Heart Circ Physiol. 2017 Feb 24:ajpheart.00818.2016. [Epub ahead of print]
https://www.ncbi.nlm.nih.gov/pubmed/28235792
 
5
Li J, Chen J, Li X, Qian Y.
Vaccination efficacy with marrow mesenchymal stem cell against cancer was enhanced under simulated microgravity.
Biochem Biophys Res Commun. 2017 Feb 24. [Epub ahead of print]
https://www.ncbi.nlm.nih.gov/pubmed/28238782
Note: A clinostat was used.
 
6
Rydze R, Schutt A, Gibbons W, Nodler J.
Gravity and embryo development.
Curr Obstet Gynecol Rep. 2017 Mar 3:1-4. [Article in Press] Review.
http://link.springer.com/article/10.1007/s13669-017-0193-3
Note: >From the abstract: "This article examines the devices used to simulate microgravity on Earth. It also explores the evidence behind microgravity’s effects on immunomodulation, cell signaling pathways, and gene activation, as well as the impact of these changes on embryo development."
 
7
Hirayama Y, Nakanishi R, Maeshige N, Fujino H.
Preventive effects of nucleoprotein supplementation combined with intermittent loading on capillary regression induced by hindlimb unloading in rat soleus muscle.
Physiol Rep. 2017 Feb;5(4).
https://www.ncbi.nlm.nih.gov/pubmed/28242821
 Note: Hindlimb unloading study. This article may be obtained online without charge.
 
8
Kishimoto H, Uchida T, Kitahata K, Nikawa T.
[Plasticity of skeletal muscle against unloading stress.]
Clin Calcium. 2017;27(3):351-6. Japanese.
https://www.ncbi.nlm.nih.gov/pubmed/28232649
 
9
Buehlmeier J, Frings-Meuthen P, Mohorko N, Lau P, Mazzucco S, Ferretti JL, Biolo G, Pisot R, Simunic B, Rittweger J.
Markers of bone metabolism during 14 days of bed rest in young and older men.
J Musculoskelet Neuronal Interact. 2017 Mar 1;17(1):399-408.
https://www.ncbi.nlm.nih.gov/pubmed/28250244
Note: Bed rest study.
 
10
Minematsu A, Hanaoka T, Takeshita D, Takada Y, Okuda S, Imagita H, Sakata S.
Long-term wheel-running can prevent deterioration of bone properties in diabetes mellitus model rats.
J Musculoskelet Neuronal Interact. 2017 Mar 1;17(1):433-43.
https://www.ncbi.nlm.nih.gov/pubmed/28250247
 
11
Boice JD Jr.
Space: The final frontier—Research relevant to Mars.
Health Phys. 2017 Apr;112(4):392-7.
https://www.ncbi.nlm.nih.gov/pubmed/28234699
Note: Gradual exposure to radiation during long-duration spaceflight is discussed.
 
12
Meier MM, Matthiä D.
Assessment of the skin dose for aircrew.
J Radiol Prot. 2017 Jun;37(2):321-8. Epub 2017 Mar 2.
https://www.ncbi.nlm.nih.gov/pubmed/28253197
 
13
Toschi N, Kim J, Sclocco R, Duggento A, Barbieri R, Kuo B, Napadow V.
Motion sickness increases functional connectivity between visual motion and nausea-associated brain regions.
Auton Neurosci. 2017 Jan;202:108-13.
https://www.ncbi.nlm.nih.gov/pubmed/28245927
 
14
Grandl W.
Human life in the solar system.
REACH. 2017 Mar 7. [Article in Press]
http://www.sciencedirect.com/science/article/pii/S2352309317300020
Note: >From the abstract: "The goal of this paper is to provide an overview of ideas and proposals for space stations and space colonies since the last hundred years, starting with the Russian space pioneer Tsiolkovsky and focusing on some recent projects of the author."
 
15
Jordan A, Chandler J, MacCready JS, Huang J, Osteryoung KW, Ducat DC.
Engineering cyanobacterial cell morphology for enhanced recovery and processing of biomass.
Appl Environ Microbiol. 2017 Feb 24. [Epub ahead of print]
https://www.ncbi.nlm.nih.gov/pubmed/28235875
 
16
Cavallaro U.
Women spacefarers: Sixty different paths to space.
Chaum, Switzerland: Springer International, 2017. 403 p.
http://www.springer.com/us/book/9783319340470?wt_mc=ThirdParty.SpringerLink.3.EPR653.About_eBook#aboutBook
Note: From promotional materials about the book: "This book tells the fascinating stories of the valiant women who broke down barriers to join the space program. Beginning with the orbital flight of USSR cosmonaut Valentina Tereshkova in 1963, they became players in the greatest adventure of our time. The author contextualizes their accomplishments in light of the political and cultural climate, from the Cold War in the background to the changing status of women in society at large during the Seventies. The book includes the biographies of, and in some cases interviews with, the sixty women who flew in space in the first half century of space history. It reports their achievements and some little known details. The result is a gallery of pioneering women who reached for the stars: women who, with exceptional skill, hard work, and dedication, reached impressive careers as accomplished pilots, researchers, and engineers; many are now in high level managerial positions both at NASA or in public and private organizations, and all left a legacy of strength."

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