NASA Spaceline Current Awareness List #740 17 March 2017 (Space Life Science Research Results)

Status Report From: Spaceline
Posted: Friday, March 17, 2017

SPACELINE Current Awareness Lists are distributed via listserv. Please send any correspondence to Robyn Ertwine, SPACELINE Current Awareness Senior Editor,
In case you missed it: Here’s a link to an NPR story about microbiologist and NASA astronaut Kate Rubins and her work during her stint on the International Space Station. The story aired on NPR’s Morning Edition on March 14.
Papers deriving from NASA support:
Sá RC, Zeman KL, Bennett WD, Prisk GK, Darquenne C.
Regional ventilation is the main determinant of alveolar deposition of coarse particles in the supine healthy human lung during tidal breathing.
J Aerosol Med Pulm Drug Deliv. 2017 Mar 9. [Epub ahead of print]
PI: G.K. Prisk
Journal Impact Factor: 3.041
Funding: "This study was funded by the National Space Biomedical Research Institute through NASA NCC 9-58. This work was supported by NIH Grants R01 HL080203, R01 HL081171, and R01 HL104118."
Sibonga JD, Truszkowski P.
Conference proceedings—2010 Bone Summit: Risk for early onset osteoporosis.
Houston, TX: NASA Johnson Space Center, 2016 Dec. 40 p. NASA/TM-2016-219284.
Note: This article may be obtained online without charge.
Journal Impact Factor: Not applicable to this publication
Funding: No funding cited. J.D. Sibonga is affiliated with NASA Johnson Space Center.
Slaba TC, Stoffle NN.
Evaluation of HZETRN on the Martian surface: Sensitivity tests and model results.
Life Sci Space Res. 2017 Mar 9. [Article in Press]
PI: J.W. Norbury
Journal Impact Factor: Not available for this journal
Funding: "This work was supported by the Human Research and Advanced Exploration Systems Programs under the Human Exploration and Operations Mission Directorate of NASA and by NASA contract NNJ15HK11B."
Committee to Review NASA’s Evidence Reports on Human Health Risks; Board on Health Sciences Policy; IOM (Institute of Medicine). Scott-Conner CEH, Masys DR, Liverman CT, Editors.
Review of NASA's evidence reports on human health risks: 2016 letter report.
Washington, DC: National Academies Press, 2017. 76 p.
Note: From the abstract: "This is the fourth in a series of five letter reports that provide an independent review of the more than 30 evidence reports that NASA has compiled on human health risks for long-duration and exploration spaceflights. This letter report reviews eight evidence reports and examines the quality of the evidence, analysis, and overall construction of each report; identifies existing gaps in report content; and provides suggestions for additional sources of expert input." This article may be obtained online without charge.
Journal Impact Factor: Not applicable to this publication
Funding: "This project was supported by Contract NNH13CK19B, Task Order NNH13CK20D, between the National Academy of Sciences and the National Aeronautics and Space Administration."
Note: The open access journal Open Agriculture has published a series of articles on the topic 'Agriculture in Space.' From the Editor’s Note: "This special issue is anchored by papers that put 'agriculture in space' into context through an overview of the history and near future of crop research in space (Wheeler), a look at the current state of crop research on the International Space Station (Massa), and a commentary on the long standing but poorly understood [or at least poorly quantified] psychological benefits and impacts of human-plant associations in spaceflight and analog scenarios (Guy). Combined with a rich and diverse offering of research and design papers this special issue represents a long overdue dedicated venue for crop research in the context of spaceflight." Articles by NASA-affiliated authors appear here; those by non-NASA authors appear at the end of this List.
Massa GD, Dufour NF, Carver JA, Hummerick ME, Wheeler RM, Morrow RC, Smith TM.
VEG-01: Veggie hardware validation testing on the International Space Station.
Open Agriculture. 2017 Feb;2(1):23-41.
Note: This article may be obtained online without charge.
Journal Impact Factor: Not available for this journal
Funding: "Funding for the Veggie hardware technology validation tests was from NASA’s Space Life and Physical Sciences (SLPS) program."
Graham T, Wheeler R.
Mechanical stimulation modifies canopy architecture and improves volume utilization efficiency in bell pepper: Implications for bioregenerative life-support and vertical farming.
Open Agriculture. 2017 Feb;2(1):42.
Note: This citation originally appeared in SPACELINE Current Awareness List #737, 24 Feb 2017. This article may be obtained online without charge.
Journal Impact Factor: Not available for this journal
Funding: "Oak Ridge Associated Universities (ORAU) NASA Post-Doctoral Research Fellowship Program for financial support of Thomas Graham." The PI reports funding under the Dwarf Fruit Production Study.
Wheeler RM.
Agriculture for space: People and places paving the way.
Open Agriculture. 2017 Feb;2(1):14-32. Review.
Note: This article may be obtained online without charge.
Journal Impact Factor:  Not available for this journal
Funding: No funding cited. R.M. Wheeler is affiliated with NASA Kennedy Space Center.
Other papers of interest:
Tsybko AS, Ilchibaeva TV, Popova NK.
The effect of space flight on genes expression in the brain of experimental animals.
Russ J Genet: Appl Res. 2017 Jan;7(1):100-8. Review.
Note: Bion-M1 results.
Makarov IA, Voronkov YI, Aslanjan MG.
Ophthalmic changes associated with long-term exposure to microgravity.
Human Physiology. 2017 Jan;43(1):105-13. Review.
Note: ISS and Shuttle results.
Tepfer D, Leach S.
Survival and DNA damage in plant seeds exposed for 558 and 682 days outside the International Space Station.
Astrobiology. 2017 Mar 6. [Epub ahead of print]
Note: ISS results. This article may be obtained online without charge.
Van Ombergen A, Demertzi A, Tomilovskaya E, Jeurissen B, Sijbers J, Kozlovskaya IB, Parizel PM, Van de Heyning PH, Sunaert S, Laureys S, Wuyts FL.
The effect of spaceflight and microgravity on the human brain.
J Neurol. 2017 Mar 07. [Epub ahead of print]
Note: Specific spaceflights are not identified. Analogs discussed include dry immersion, bed rest, and parabolic flight. This article may be obtained online without charge.
Bauer J, Kopp S, Schlagberger EM, Grosse J, Sahana J, Riwaldt S, Wehland M, Luetzenberg R, Infanger M, Grimm D.
Proteome analysis of human follicular thyroid cancer cells exposed to the random positioning machine.
Int J Mol Sci. 2017 Mar 3;18(3).
Note: A Random Positioning Machine was used. This article may be obtained online without charge.
Tessier SN, Luu BE, Smith JC, Storey KB.
The role of global histone post-translational modifications during mammalian hibernation.
Cryobiology. 2017 Feb 28. [Epub ahead of print]
Fernandez-Gonzalo R, Baatout S, Moreels M.
Impact of particle irradiation on the immune system: From the clinic to Mars.
Front Immunol. 2017 Feb 22;8:177. Review.
Note: This article may be obtained online without charge.
Arentson-Lantz EJ, Saeed IH, Frassetto LA, Masharani U, Harnish RJ, Seo Y, VanBrocklin HF, Hawkins RA, Mari-Aparici C, Pampaloni MH, Slater J, Paddon-Jones D, Lang TF.
11C-L-methyl methionine dynamic PET/CT of skeletal muscle: Response to protein supplementation compared to L-[ring 13C6] phenylalanine infusion with serial muscle biopsy.
Ann Nucl Med. 2017 Mar 4. [Epub ahead of print]
Note: This article may be obtained online without charge.
Lee S, Leone TC, Rogosa L, Rumsey J, Ayala J, Coen PM, Fitts RH, Vega RB, Kelly DP.
Skeletal muscle PGC-1β signaling is sufficient to drive an endurance exercise phenotype and to counteract components of detraining in mice.
Am J Physiol Endocrinol Metab. 2017 Mar 7:ajpendo.00380.2016. [Epub ahead of print]
Petrov AM, Kravtsova VV, Matchkov VV, Vasiliev AN, Zefirov AL, Chibalin AV, Heiny JA, Krivoi, II.
Membrane lipid rafts disturbance in the response of rat skeletal muscle to short-term disuse.
Am J Physiol Cell Physiol. 2017 Mar 8:ajpcell.00365.2016. [Epub ahead of print]
Note: Hindlimb unloading study.
Hradsky O, Soucek O, Maratova K, Matyskova J, Copova I, Zarubova K, Bronsky J, Sumnik Z.
Supplementation with 2000 IU of cholecalciferol is associated with improvement of trabecular bone mineral density and muscle power in pediatric patients with IBD.
Inflamm Bowel Dis. 2017 Apr;23(4):514-23. Epub 2017 Mar 6.
Ling S, Zhong G, Sun W, Liang F, Wu F, Li H, Li Y, Zhao D, Song J, Jin X, Wu X, Song H, Li Q, Li Y, Chen S, Xiong J, Li Y.
Circulating microRNAs correlated with bone loss induced by 45 days of bed rest.
Front Physiol. 2017 Feb 14;8:69.
Note: Bed rest study. This article may be obtained online without charge.
Shi GX, Zheng XF, Zhu C, Li B, Wang YR, Jiang SD, Jiang LS.
Evidence of the role of R-spondin 1 and its receptor Lgr4 in the transmission of mechanical stimuli to biological signals for bone formation.
Int J Mol Sci. 2017 Mar 7;18(3).
Note: This article may be obtained online without charge.
Uchida R, Nakata K, Kawano F, Yonetani Y, Ogasawara I, Nakai N, Mae T, Matsuo T, Tachibana Y, Yokoi H, Yoshikawa H.
Vibration acceleration promotes bone formation in rodent models.
PLoS One. 2017 Mar 6;12(3):e0172614.
Note: This article may be obtained online without charge.
Golla S, Golla JP, Krausz KW, Manna SK, Simillion C, Beyoğlu D, Idle JR, Gonzalez FJ.
Metabolomic analysis of mice exposed to gamma radiation reveals a systemic understanding of total-body exposure.
Radiat Res. 2017 Mar 9. [Epub ahead of print]
Talibov M, Salmelin R, Lehtinen-Jacks S, Auvinen A.
Estimation of occupational cosmic radiation exposure among airline personnel: Agreement between a job-exposure matrix, aggregate, and individual dose estimates.
Am J Ind Med. 2017 Apr;60(4):386-93. Epub 2017 Mar 6.
Yentrapalli R, Merl-Pham J, Azimzadeh O, Mutschelknaus L, Peters C, Hauck SM, Atkinson MJ, Tapio S, Moertl S.
Quantitative changes in the protein and miRNA cargo of plasma exosome-like vesicles after exposure to ionizing radiation.
Int J Radiat Biol. 2017 Mar 7:1-12. [Epub ahead of print]
Otero-Millan J, Zee DS, Schubert MC, Roberts DC, Ward BK.
Three-dimensional eye movement recordings during magnetic vestibular stimulation.
J Neurol. 2017 Mar 7. [Epub ahead of print]
Zhou W, Wang J, Pan L, Qi R, Liu P, Liu J, Cai Y.
Sex and age differences in motion sickness in rats: The correlation with blood hormone responses and neuronal activation in the vestibular and autonomic nuclei.
Front Aging Neurosci. 2017 Feb 15;9:29.
Note: This article may be obtained online without charge.
Deng C, Wang T, Wu J, Xu W, Li H, Liu M, Wu L, Lu J, Bian P.
Effect of modeled microgravity on radiation-induced adaptive response of root growth in Arabidopsis thaliana.
Mutat Res. 2017 Feb;796:20-8.
Note: A 2-D rotation clinostat was used.
Polinski E, Schueler O, Krause L, Wimmer MA, Hemmersbach R, Goldbach HE.
2-D clinorotation alters the uptake of some nutrients in Arabidopsis thaliana.
J Plant Physiol. 2017 May;212:54-7. Epub 2017 Feb 17.
Note: A Random Positioning Machine was used.
Roychoudhry S, Kieffer M, Del Bianco M, Liao CY, Weijers D, Kepinski S.
The developmental and environmental regulation of gravitropic setpoint angle in Arabidopsis and bean.
Sci Rep. 2017 Mar 03;7:42664.
Note: This article may be obtained online without charge.
Note: The remaining articles from the Open Agriculture topical issue 'Agriculture in Space' are listed below.
White Paper: The space agriculture endeavour.
Open Agriculture. 2016 Sep;1(1):70-3.
Note: This article may be obtained online without charge.
Mauerer M, Schubert D, Zabel P, Bamsey M, Kohlberg E, Mengedoht D.
Initial survey on fresh fruit and vegetable preferences of Neumayer Station crew members: Input to crop selection and psychological benefits of space-based plant production systems.
Open Agriculture. 2016 Dec;1(1):179-88.
Note: This article may be obtained online without charge.
Odeh R, Guy CL.
Gardening for therapeutic people-plant interactions during long-duration space missions.
Open Agriculture. 2017 Feb;2(1):1-13. Review.
Note: This article may be obtained online without charge.

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