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NASA Spaceline Current Awareness List #743 7 April 2017 (Space Life Science Research Results)

Status Report From: Spaceline
Posted: Friday, April 7, 2017

SPACELINE Current Awareness Lists are distributed via listserv. Please send any correspondence to Robyn Ertwine, SPACELINE Current Awareness Senior Editor, rertwine@nasaprs.com.
 
In case you missed it: The Associated Press recently did a story on the development of a potato that is capable of growing on Mars. The project is a collaborative effort between scientists at the International Potato Center (CIP) in Lima, Peru and NASA Ames Research Center. The team has successfully grown a potato plant in a Mars simulator. The variety is resistant to low temperatures and a high-carbon dioxide atmosphere. The AP story can be found at:
http://network.ap.org/dynamic/stories/L/LT_PERU_SPUDS_ON_MARS?SITE=AP&SECTION=HOME&TEMPLATE=DEFAULT&CTIME=2017-03-30-01-30-27
 
"The Potato on Mars team is a cross-disciplinary cohort of CIP and NASA scientists representing the fields of agriculture, plant breeding, astrobiology, medicine, and physics. Together they are exploring how to grow potatoes on Mars while simultaneously benefiting Farmers of Earth" – from the CIP website at: http://potatoes.space/mars/
 
Papers deriving from NASA support:
 
1
Strangman GE, Zhang Q, Marshall-Goebel K, Mulder E, Stevens B, Clark JB, Bershad EM.
Increased cerebral blood volume pulsatility during head-down tilt with elevated carbon dioxide: The SPACECOT Study.
J Appl Physiol (1985). 2017 Mar 30:jap.00947.2016. [Epub ahead of print]
https://www.ncbi.nlm.nih.gov/pubmed/28360122
PI: E.M. Bershad
Note: Head-down tilt bed rest study. This article may be obtained online without charge.
Journal Impact Factor: 3.004
Funding: "This work was supported by the National Space Biomedical Research Institute through NASA NCC 9-58."
 
2
Ritchie LE, Taddeo SS, Weeks BR, Carroll RJ, Dykes L, Rooney LW, Turner ND.
Impact of novel sorghum bran diets on DSS-induced colitis.
Nutrients. 2017 Mar 27;9(4).
https://www.ncbi.nlm.nih.gov/pubmed/28346392
Note: This article may be obtained online without charge.
Journal Impact Factor: 3.759
Funding: "Research support from the United Sorghum Checkoff Program (R0031A-09 and HVM006-12) and the NIH/National Institute of Diabetes and Digestive and Kidney Diseases Grant P30 DK34987. The work was also supported through a fellowship to Lauren Ritchie from the National Space Biomedical Research Institute through NCC 9-58 (EO01001) and Whole Systems Genomics at Texas A&M University."
 
3
Chang J, Feng W, Wang Y, Allen AR, Turner J, Stewart B, Raber J, Hauer-Jensen M, Zhou D, Shao L.
28Si total body irradiation injures bone marrow hematopoietic stem cells via induction of cellular apoptosis.
Life Sci Space Res. 2017 Apr 5. [Article in Press]
http://www.sciencedirect.com/science/article/pii/S2214552417300202
PI: J. Raber
Journal Impact Factor: Not available for this journal
Funding: "The study was supported in part by NASA grant NNJ12ZSA001N (JR), Center of Biomedical Research Excellence (P20, GM109005, MHJ, DZ), an Arkansas Research Alliance Scholarship (DZ), and the Rockefeller Leukemia and Lymphoma Research Endowment (DZ)."
 
4
Morris CJ, Purvis TE, Mistretta J, Hu K, Scheer FA.
Circadian misalignment increases C-reactive protein and blood pressure in chronic shift workers.
J Biol Rhythms. 2017 Mar 1. [Epub ahead of print]
https://www.ncbi.nlm.nih.gov/pubmed/28347188
PI: C.J. Morris
Journal Impact Factor: 2.824
Funding: "This study was supported by NHLBI Grant R01 HL094806 to F.A.J.L.S. C.J.M. was supported by the NSBRI through NASA Grant NCC 9-58, NHLBI Grant R01 HL094806, NIDDK Grant R01 DK099512, and NHLBI Grant R01 HL118601. F.A.J.L.S. was supported by NHLBI Grant R01 HL094806, NIDDK Grant R01 DK099512, and NHLBI Grant R01 HL118601. K.H was supported by NHLBI R00 HL102241, NIA R01AG048108-01A1 and NIA P01AG009975. The project described was supported by Clinical Translational Science Award UL1RR025758 to Harvard University and Brigham and Women’s Hospital from the National Center for Research Resources."
 
5
Beaton KH, Schubert M, Shelhamer M.
Assessment of vestibulo-ocular function without measuring eye movements.
J Neurosci Methods. 2017 May 1;283:1-6. Epub 2017 Mar 20.
https://www.ncbi.nlm.nih.gov/pubmed/28336357
PIs: M. Schubert, M. Shelhamer
Journal Impact Factor: 2.053
Funding: "This work was supported by the NASA Human Research Program through grant NNX10AO19G."
 
6
Tighe S, Afshinnekoo E, Rock TM, McGrath K, Alexander N, McIntyre A, Ahsanuddin S, Bezdan D, Green SJ, Joye S, Stewart Johnson S, Baldwin DA, Bivens N, Ajami N, Carmical JR, Herriott IC, Colwell R, Donia M, Foox J, Greenfield N, Hunter T, Hoffman J, Hyman J, Jorgensen E, Krawczyk D, Lee J, Levy S, Garcia-Reyero N, Settles M, Thomas K, Gómez F, Schriml L, Kyrpides N, Zaikova E, Penterman J, Mason CE.
Genomic methods and microbiological technologies for profiling novel and extreme environments for the Extreme Microbiome Project (XMP).
J Biomol Tech. 2017 Mar 10. [Epub ahead of print]
https://www.ncbi.nlm.nih.gov/pubmed/28337070
PI: C.E. Mason
Note: This article may be obtained online without charge.
Journal Impact Factor: Not available for this journal
Funding: "The authors thank the Epigenomics Core of Weill Cornell Medicine, funding from Starr Cancer Consortium grants (I7-A765, I9-A9-071), Irma T. Hirschl and Monique Weill-Caulier Charitable Trusts, Bert L. and N. Kuggie Vallee Foundation, WorldQuant Foundation, Pershing Square Sohn Cancer Research Alliance, NASA (NNX14AH50G, 15-15Omni2-0063), U.S. National Institutes of Health (R25EB020393, R01NS076465, R01AI125416, R01ES021006), Bill and Melinda Gates Foundation (OPP1151054), and Alfred P. Sloan Foundation (G-2015-13964).The authors thank Europlanet 2020 RI from the European Union’s Horizon 2020 research and innovation programme, under grant agreement No 654208 funded Danakil work, for the Ethiopian Hot Springs."
 
7
Mason CE, Afshinnekoo E, Tighe S, Wu S, Levy S.
International standards for genomes, transcriptomes, and metagenomes.
J Biomol Tech. 2017 Mar 17. [Epub ahead of print]
https://www.ncbi.nlm.nih.gov/pubmed/28337071
PI: C.E. Mason
Note: This article may be obtained online without charge.
Journal Impact Factor: Not available for this journal
Funding: "The authors also thank the following for funding: Starr Cancer Consortium (Grants I7-A765, I9-A9-071), Irma T. Hirschl and Monique Weill-Caulier Charitable Trusts, Bert L. and N. Kuggie Vallee Foundation, WorldQuant Foundation, Pershing Square Sohn Cancer Research Alliance, NASA (NNX14AH50G, 15-15Omni2-0063), and Bill and Melinda Gates Foundation (OPP1151054)."
 
8
Afshinnekoo E, Chou C, Alexander N, Ahsanuddin S, Schuetz AN, Mason CE.
Precision metagenomics: Rapid metagenomic analyses for infectious disease diagnostics and public health surveillance.
J Biomol Tech. 2017 Mar 21. [Epub ahead of print]
https://www.ncbi.nlm.nih.gov/pubmed/28337072
PI: C.E. Mason
Note: This article may be obtained online without charge.
Journal Impact Factor: Not available for this publication
Funding: "The authors also thank the following for funding: Starr Cancer Consortium (Grants I7-A765, I9-A9-071), Irma T. Hirschl and Monique Weill-Caulier Charitable Trusts, Bert L. and N. Kuggie Vallee Foundation, WorldQuant Foundation, Pershing Square Sohn Cancer Research Alliance, NASA (NNX14AH50G, 15-15Omni2-0063), U.S. National Institutes of Health (R25EB020393, R01NS076465, R01AI125416, R01ES021006), Bill and Melinda Gates Foundation (OPP1151054), and Alfred P. Sloan Foundation (G-2015-13964)."
 
9
Ahsanuddin S, Afshinnekoo E, Gandara J, Hakyemezoğlu M, Bezdan D, Minot S, Greenfield N, Mason CE.
Assessment of REPLI-g multiple displacement whole genome amplification (WGA) techniques for metagenomic applications.
J Biomol Tech. 2017 Mar 21. [Epub ahead of print]
https://www.ncbi.nlm.nih.gov/pubmed/28344519
PI: C.E. Mason
Note: This article may be obtained online without charge.
Journal Impact Factor: Not available for this journal
Funding: "The authors also thank the Epigenomics Core Facility at Weill Cornell Medicine, as well as the Starr Cancer Consortium (Grants I7-A765, I9-A9-071), and funding from the Irma T. Hirschl and Monique Weill-Caulier Charitable Trusts, Bert L. and N. Kuggie Vallee Foundation, WorldQuant Foundation, Pershing Square Sohn Cancer Research Alliance, NASA (NNX14AH50G, 15-15Omni2-0063), U.S. National Institutes of Health (R25EB020393, R01NS076465, R01AI125416, R01ES021006), Bill and Melinda Gates Foundation (OPP1151054), and Alfred P. Sloan Foundation (G-2015-13964)."
______________________________________________________
 
Other papers of interest:
 
1
Gazerani P.
Space headaches.
Future Neurol. 2017 Mar 30. [Epub ahead of print]
http://www.futuremedicine.com/doi/10.2217/fnl-2017-0002
Note: Specific spaceflights are not identified; results of head-down tilt bed rest studies are discussed.
 
2
Xue L, Li Y, Chen J.
Duration of simulated microgravity affects the differentiation of mesenchymal stem cells.
Mol Med Rep. 2017 Mar 22. [Epub ahead of print]
https://www.ncbi.nlm.nih.gov/pubmed/28339035
Note:  Clinorotation was used. This article may be obtained online without charge.
 
3
Cheng YP, Zhang HJ, Su YT, Meng XX, Xie XP, Chang YM, Bao JX.
Acid sphingomyelinase/ceramide regulates carotid intima-media thickness in simulated weightless rats.
Pflugers Arch. 2017 Mar 29. [Epub ahead of print]
https://www.ncbi.nlm.nih.gov/pubmed/28357491
Note: Hindlimb unloading study.
 
4
Ax M, Sanchez-Crespo A, Lindahl SG, Mure M, Petersson J.
The influence of gravity on regional lung blood flow in humans - SPECT in the upright and head-down posture.
J Appl Physiol (1985). 2017 Mar 23. [Epub ahead of print]
https://www.ncbi.nlm.nih.gov/pubmed/28336539
Note: Head-down tilt study.
 
5
Verma AK, Garg A, Xu D, Bruner M, Fazel-Rezai R, Blaber AP, Tavakolian K.
Skeletal muscle pump drives control of cardiovascular and postural systems.
Sci Rep. 2017 Mar 27;7:45301.
https://www.ncbi.nlm.nih.gov/pubmed/28345674
Note: This article may be obtained online without charge.
 
6
Turroni S, Rampelli S, Biagi E, Consolandi C, Severgnini M, Peano C, Quercia S, Soverini M, Carbonero FG, Bianconi G, Rettberg P, Canganella F, Brigidi P, Candela M.
Temporal dynamics of the gut microbiota in people sharing a confined environment, a 520-day ground-based space simulation, MARS500.
Microbiome. 2017 Mar 24;5(1):39.
https://www.ncbi.nlm.nih.gov/pubmed/28340597
Note: Data are from the Mars500 Project. This article may be obtained online without charge.
 
7
Wang T, Chen H, Lv K, Ji G, Zhang Y, Wang Y, Li Y, Qu L.
iTRAQ-based proteomics analysis of hippocampus in spatial memory deficiency rats induced by simulated microgravity.
J Proteomics. 2017 Mar 21. [Epub ahead of print]
https://www.ncbi.nlm.nih.gov/pubmed/28341594
Note: Hindlimb unloading study.
 
8
Baehr LM, West DW, Marshall AG, Marcotte GR, Baar K, Bodine SC.
Muscle-specific and age-related changes in protein synthesis and protein degradation in response to hindlimb unloading in rats.
J Appl Physiol (1985). 2017 Mar 23:jap.00703.2016. [Epub ahead of print]
https://www.ncbi.nlm.nih.gov/pubmed/28336537
Note: Hindlimb unloading study.
 
9
Dziki JL, Giglio RM, Sicari BM, Wang DS, Gandhi RM, Londono R, Dearth CL, Badylak SF.
The effect of mechanical loading upon extracellular matrix bioscaffold-mediated skeletal muscle remodeling.
Tissue Eng Part A. 2017 Mar 27. [Epub ahead of print]
https://www.ncbi.nlm.nih.gov/pubmed/28345417
Note: Hindlimb unloading study.
 
10
King EC, Patel V, Anand M, Zhao X, Crump SM, Hu Z, Weisleder N, Abbott GW.
Targeted deletion of Kcne3 impairs skeletal muscle function in mice.
FASEB J. 2017 Mar 29. [Epub ahead of print]
https://www.ncbi.nlm.nih.gov/pubmed/28356343
Note: Hindlimb unloading study.
 
11
Alp M, Cucinotta FA.
Track structure model of microscopic energy deposition by protons and heavy ions in segments of neuronal cell dendrites represented by cylinders or spheres.
Life Sci Space Res. 2017 Apr 2. [Article in Press]
http://www.sciencedirect.com/science/article/pii/S2214552416301006
 
12
Dauer LT, Ainsbury EA, Dynlacht J, Hoel D, Klein BE, Mayer D, Prescott CR, Thornton RH, Vano E, Woloschak GE, Flannery CM, Goldstein LE, Hamada N, Tran PK, Grissom MP, Blakely EA.
Guidance on radiation dose limits for the lens of the eye: Overview of the recommendations in NCRP Commentary No. 26.
Int J Radiat Biol. 2017 Apr 3:1-9. [Epub ahead of print]
https://www.ncbi.nlm.nih.gov/pubmed/28346025
 
13
Matthiä D, Berger T.
The radiation environment on the surface of Mars – Numerical calculations of the galactic component with GEANT4/PLANETOCOSMICS.
Life Sci Space Res. 2017 Apr 1. [Article in Press]
http://www.sciencedirect.com/science/article/pii/S2214552417300081
 
14
Pannkuk EL, Laiakis EC, Authier S, Wong K, Fornace AJ Jr.
Gas chromatography/mass spectrometry metabolomics of urine and serum from nonhuman primates exposed to ionizing radiation: Impacts on the tricarboxylic acid cycle and protein metabolism.
J Proteome Res. 2017 Apr 04. [Epub ahead of print]
https://www.ncbi.nlm.nih.gov/pubmed/28351153
 
15
Skeldon AC, Phillips AJ, Dijk DJ.
The effects of self-selected light-dark cycles and social constraints on human sleep and circadian timing: A modeling approach.
Sci Rep. 2017 Mar 27;7:45158.
https://www.ncbi.nlm.nih.gov/pubmed/28345624
Note: This article may be obtained online without charge.
 
16
Hsu YW, Jauh GY.
VPS36-mediated plasma membrane protein turnover is critical for Arabidopsis root gravitropism.
Plant Signal Behav. 2017 Mar 24. [Epub ahead of print]
https://www.ncbi.nlm.nih.gov/pubmed/28340324
 
17
Tabanfar R, Qiu J, Chan H, Aflatouni N, Weersink R, Hasan W, Irish JC.
Real-time continuous image-guided surgery: Preclinical investigation in glossectomy.
Laryngoscope. 2017 Mar 27. [Epub ahead of print]
https://www.ncbi.nlm.nih.gov/pubmed/28349585
Note: The NASA Task Load Index was used.

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