NASA Spaceline Current Awareness List #746 28 April 2017 (Space Life Science Research Results)

Status Report From: Spaceline
Posted: Friday, April 28, 2017

SPACELINE Current Awareness Lists are distributed via listserv. Please send any correspondence to Robyn Ertwine, SPACELINE Current Awareness Senior Editor,



Papers deriving from NASA support:



Alperin N, Bagci AM, Oliu CJ, Lee SH, Lam BL.

Role of cerebrospinal fluid in spaceflight-induced ocular changes and visual impairment in astronauts.

Radiology. 2017 Apr 21:161981. [Epub ahead of print]

PI: N. Alperin

Note: Shuttle, ISS results.

Journal Impact Factor: 6.798

Funding: "Study supported by Johnson Space Center (NNX16AG96G) and Cooperative Agreement to Alperin Noninvasive Diagnostics (NNX14AB51G)."



Singh NK, Blachowicz A, Romsdahl J, Wang C, Torok T, Venkateswaran K.

Draft genome sequences of several fungal strains selected for exposure to microgravity at the International Space Station.

Genome Announc. 2017 Apr 13;5(15):e01602-16.

Note: ISS results. This article may be obtained online without charge.

Journal Impact Factor: Not available for this journal

Funding: "Part of the research described in this publication was carried out at the Jet Propulsion Laboratory (JPL), California Institute of Technology, under a contract with NASA. This research was supported by the JPL Advanced Concept Development fund awarded to K.V. that funded a student fellowship to A.B. Part of the research described in this publication was carried out at Lawrence Berkeley National Laboratory (T.T.) and the University of Southern California (C.W.), which funded a student fellowship to J.R."



Bhattacharya S, Srinivasan K, Abdisalaam S, Su F, Raj P, Dozmorov I, Mishra R, Wakeland EK, Ghose S, Mukherjee S, Asaithamby A.

RAD51 interconnects between DNA replication, DNA repair and immunity.

Nucleic Acids Res. 2017 Feb 21. [Epub ahead of print]

PI: A. Asaithamby, H. Sadek

Note: This article may be obtained online without charge.

Journal Impact Factor: 9.202

Funding: "National Aeronautics and Space Administration [NNX13AD57G and NNX15AE06G]; Cancer Prevention and Research Institute of Texas [RP160520]; National Institute of Health [R01AG053341] to A.A. Funding for open access charge: National Aeronautics and Space Administration."



Simpson RJ, Bigley AB, Agha N, Hanley PJ, Bollard CM.

Mobilizing immune cells with exercise for cancer immunotherapy.

Exerc Sport Sci Rev. 2017 Apr 17. [Epub ahead of print]

PI: R.J. Simpson; A.B. Bigley, NSBRI Postdoctoral Fellowship Program

Journal Impact Factor: 4.451

Funding: "This work was supported by NASA grants NNJ10ZSA003N and NNJ14ZSA001N-FLAGSHIP to R.J. Simpson, NIH grant R21 CA197527-01A1 to R.J. Simpson and A.B. Bigley, NSBRI grant PF04307 to A.B. Bigley, ACSM NASA Foundational Research Grant to N. Agha, and NIH grant P01 CA148600-01A1 to C.M. Bollard."



Diaz-Artiles A, Priesol AJ, Clark TK, Sherwood DP, Oman CM, Young LR, Karmali F.

The impact of oral promethazine on human whole-body motion perceptual thresholds.

J Assoc Res Otolaryngol. 2017 Apr 24. [Epub ahead of print]

PI: L.R. Young

Journal Impact Factor: 3.030

Funding: "This research was supported by the National Space Biomedical Research Institute through NASA NCC 9-58 and by the National Institutes of Health through NIDCD DC013635 (FK)."



Norbury JW, Slaba TC, Sobolevsky N, Reddell B.

Comparing HZETRN, SHIELD, FLUKA and GEANT transport codes.

Life Sci Space Res. 2017 Apr 20. [Article in Press]

PI: J.W. Norbury

Journal Impact Factor: 1.97

Funding: "This work was supported in part by the Human Research Program under the Human Exploration and Operations Mission Directorate of NASA."



Straume T, Slaba TC, Bhattacharya S, Braby LA.

Cosmic-ray interaction data for designing biological experiments in space.

Life Sci Space Res. 2017 Apr 24. [Article in Press]

PI: J.W. Norbury

Journal Impact Factor: 1.97

Funding: "The work was performed under the auspices of the NASA Ames Research Center, the NASA Langley Research Center, and the Texas A&M University. The work was supported in part by the NASA Advanced Exploration Systems (AES) Division to SB and the NASA Human Research Program (HRP) to TCS and TS."



Kruse CPS, Basu P, Luesse DR, Wyatt SE.

Transcriptome and proteome responses in RNAlater preserved tissue of Arabidopsis thaliana

PLoS One. 2017 Apr 19;12(4):e0175943.

PI: S.E. Wyatt

Note: This article may be obtained online without charge.

Journal Impact Factor: 3.057

Funding: "This research was partially funded by NASA (#NNX13AM48G to SEW and DRL) with supplemental funding provided by NASA GeneLab."



Karouia F, Peyvan K, Pohorille A.

Toward biotechnology in space: High-throughput instruments for in situ biological research beyond Earth.

Biotechnol Adv. 2017 Apr 19. [Epub ahead of print] Review.

Note: >From the Introduction: "This review is focused on high-throughput instruments of "omics" that hold potential to advance qualitatively research in space biology."

Journal Impact Factor: 9.848

Funding: "This work was supported by the National Aeronautics and Space Administration (NASA) Astrobiology Science and Technology Instrument Development, the NASA Astrobiology Program and the Office of Chief Technologist NASA Ames Research Center." F. Karouia and A. Pohorille are affiliated with NASA Ames Research Center.



Other papers of interest:



Tauber S, Lauber BA, Paulsen K, Layer LE, Lehmann M, Hauschild S, Shepherd NR, Polzer J, Segerer J, Thiel CS, Ullrich O.

Cytoskeletal stability and metabolic alterations in primary human macrophages in long-term microgravity.

PLoS One. 2017 Apr 18;12(4):e0175599.

Note: ISS results. This article may be obtained online without charge.



Hauslage J, Cevik V, Hemmersbach R.

Pyrocystis noctiluca represents an excellent bioassay for shear forces induced in ground-based microgravity simulators (clinostat and random positioning machine). 

npj Microgravity. 2017 Apr 24;3(1):12.

Note: A clinostat and Random Positioning Machine were used. This article may be obtained online without charge.



Kashirina D, Pastushkova L, Custaud MA, Dobrokhotov I, Brzhozovsky A, Navasiolava N, Nosovsky A, Kononikhin A, Nikolaev E, Larina I.

Effect of 21-day head down bed rest on urine proteins related to endothelium: Correlations with changes in carbohydrate metabolism.

Acta Astronaut. 2017 Aug;137:122-7. Epub 2017 Apr 19.

Note: Bed rest study.



Marmonti E, Busquets S, Toledo M, Ricci M, Beltrà M, Gudiño V, Oliva F, López-Pedrosa JM, Manzano M, Rueda R, López-Soriano FJ, Argilés JM.

A rat immobilization model based on cage volume reduction: A physiological model for bed rest?

Front Physiol. 2017 Mar 29;8:184.

Note: Reduced volume cages were used. This article may be obtained online without charge.



Rudimov EG, Knjazev EN, Khaustova NA, Grigorieva OV, Buravkova LB.

Transcriptomic changes in human umbilical cord blood endothelial cells under simulated microgravity.

Dokl Biochem Biophys. 2017 Jan;472(1):1-4.

Note: A Random Positioning Machine was used.



Pollock NW, Buteau D.

Updates in decompression illness.

Emerg Med Clin North Am. 2017 May;35(2):301-19.



Tymko MM, Boulet LM, Donnelly J.

Intracranial pressure in outer space: Preparing for the mission to Mars.

J Physiol. 2017 Apr 13. [Epub ahead of print]

Note: This is a Journal Club article highlighting the article: Lawley JS, Petersen LG, Howden EJ, Sarma S, Cornwell WK, Zhang R, Whitworth LA, Williams MA, Levine BD. Effect of gravity and microgravity on intracranial pressure. J Physiol. 2017 Mar 15;595(6):2115-27. The original article was cited in Current Awareness List #733, 27 Jan 2017.



Karsenty G, Mera P.

Molecular bases of the crosstalk between bone and muscle.

Bone. 2017 Apr 17. [Epub ahead of print] Review.



Curthoys IS, MacDougall HG, Vidal PP, de Waele C.

Sustained and transient vestibular systems: A physiological basis for interpreting vestibular function.

Front Neurol. 2017 Mar 30;8:117.

Note: This article may be obtained online without charge.



Smith N, Sandal GM, Leon GR, Kjærgaard A.

Examining personal values in extreme environment contexts: Revisiting the question of generalizability.

Acta Astronaut. 2017 Aug;137:138-44. Epub 2017 Apr 8.

Note: Participants in the study included mountaineers, special forces military personnel, Antarctic over-winterers, and Mars500 Project participants.



Li J, Ye Q, Ding L, Liao Q.

Modeling and dynamic simulation of astronaut's upper limb motions considering counter torques generated by the space suit.

Comput Methods Biomech Biomed Engin. 2017 Apr 19:1-12.



Sakata S, Grove PM, Hill A, Watson MO, Stevenson ARL.

Impact of simulated three-dimensional perception on precision of depth judgements, technical performance and perceived workload in laparoscopy.

Br J Surg. 2017 Apr 20. [Epub ahead of print]

Note: The NASA Task Load Index was used. This article may be obtained online without charge.



Tsao L, Chang J, Ma L.

Fatigue of Chinese railway employees and its influential factors: Structural equation modelling.

Appl Ergon. 2017 Jul;62:131-41. Epub 2017 Mar 11.

Note: The NASA Task Load Index was used.


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