SpaceRef

SpaceRef


NASA Spaceline Current Awareness List #750 25 May 2017 (Space Life Science Research Results)

Status Report From: Spaceline
Posted: Friday, May 26, 2017

SPACELINE Current Awareness Lists are distributed via listserv. Please send any correspondence to Robyn Ertwine, SPACELINE Current Awareness Senior Editor,rertwine@nasaprs.com.

 

 

Papers deriving from NASA support:

 

1

Conkin J, Wessel JH, Norcross JR, Bekdash OS, Abercromby AFJ, Koslovsky MD, Gernhardt ML.

Hemoglobin oxygen saturation with mild hypoxia and microgravity.

Aerosp Med Hum Perform. 2017 Jun;88(6):527-34.

http://www.ingentaconnect.com/content/asma/amhp/2017/00000088/00000006/art00004

PI: J.R. Norcross

Note: STS-69 and STS-72 results.

Journal Impact Factor: 0.755

Funding: "This work was made possible through the Human Health and Performance Contract (NNJ15HK11B) between the National Aeronautics and Space Administration and KBRwyle. Funding for this research was provided by the NASA Human Research Program."

 

2

Kast J, Yu Y, Seubert CN, Wotring VE, Derendorf H.

Drugs in space: Pharmacokinetics and pharmacodynamics in astronauts.

Eur J Pharm Sci. 2017 May 19. [Epub ahead of print] Review.

https://www.ncbi.nlm.nih.gov/pubmed/28533143

PIs: C.N. Seubert

Note: Studies conducted on Shuttle missions are mentioned, as well as results from bed rest studies.

Journal Impact Factor: 3.773

Funding: "This work was partly supported by the National Space Biomedical Research Institute NCC 9-58. The research underlying figure 3 was supported by NASA Grant NNJ04HF74G to Christoph N. Seubert."

 

3

Tomimatsu N, Mukherjee B, Harris JL, Boffo FL, Hardebeck M, Potts PR, Khanna KK, Burma S.

DNA damage-induced degradation of EXO1 limits DNA end resection to ensure accurate DNA repair.

J Biol Chem. 2017 May 17. [Epub ahead of print]

https://www.ncbi.nlm.nih.gov/pubmed/28515316

PI: S. Burma

Note: This article may be obtained online without charge.

Journal Impact Factor: 4.258

Funding: "SB is supported by grants from the National Institutes of Health (RO1CA197796, RO1CA149461 and R21CA202403) and the National Aeronautics and Space Administration (NNX16AD78G)."

 

4

Watkins W, Hargens AR, Baird S, Clary EM, Macias BR.

Lower-body negative pressure decreases non-invasively measured intracranial pressure and internal jugular vein cross-sectional area during head-down tilt.

J Appl Physiol (1985). 2017 May 11:jap.00091.2017. [Epub ahead of print]

https://www.ncbi.nlm.nih.gov/pubmed/28495841

PIs: A.R. Hargens, B.R. Macias

Journal Impact Factor: 3.004

Funding: "This study was supported by NSBRI through NCC 9-58 to BRM, NASA grant NNXAJ12G to ARH, NIH grant 5 T35 HL 7491-35 to WW, American Physiological Society Frontiers in Physiology Teacher Professional Development Fellowship to SB, and American Physiological Society Undergraduate Summer Research Fellowship to EC."

 

5

May PC, Kreider W, Maxwell AD, Wang YN, Cunitz BW, Blomgren PM, Johnson C, Park JS, Bailey MR, Lee D, Harper JD, Sorensen MD.

Detection and evaluation of renal injury in burst wave lithotripsy using ultrasound and magnetic resonance imaging.

J Endourol. 2017 May 18. [Epub ahead of print]

https://www.ncbi.nlm.nih.gov/pubmed/28521550

PI: M.R. Bailey

Journal Impact Factor: 2.107

Funding: "We also acknowledge financial support from NIH through NIDDK P01 DK043881, K01 DK104854, R01CA188654; from NSBRI through NASA NCC 958; and from resources through the VA Puget Sound Health Care System, Seattle, Washington."

 

6

Wallace IJ, Demes B, Judex S.

Ontogenetic and genetic influences on bone’s responsiveness to mechanical signals.

In: Building bones: bone formation and development in anthropology. Cambridge Studies in Biological and Evolutionary Anthropology. Cambridge: Cambridge University Press, 2017. p. 205-32.

https://www.cambridge.org/core/books/building-bones/ontogenetic-and-genetic-influences-on-bones-responsiveness-to-mechanical-signals/17D83B4BB63EFED1708BD146B910DB39

PI: S. Judex

Journal Impact Factor: Not applicable to this publication

Funding: PI reports funding under NASA grant NNX12AL25G.

 

7

Anderson AP, Mayer MD, Fellows AM, Cowan DR, Hegel MT, Buckey JC.

Relaxation with immersive natural scenes presented using virtual reality.

Aerosp Med Hum Perform. 2017 Jun;88(6):520-6.

http://www.ingentaconnect.com/content/asma/amhp/2017/00000088/00000006/art00003

PI: J.C. Buckey

Journal Impact Factor: 0.755

Funding: "This effort was supported by the National Space Biomedical Research Institute project NBPF03801 (P.I. Jay Buckey) through NCC 9-58."

 

8

Deming CA, Vasterling JJ.

Workplace social support and behavioral health prior to long-duration spaceflight.

Aerosp Med Hum Perform. 2017 Jun;88(6):565-73. Review.

http://www.ingentaconnect.com/content/asma/amhp/2017/00000088/00000006/art00009

Journal Impact Factor: 0.755

Funding: "This project was funded by the NASA Human Research Program (HRP), Behavioral Health and Performance (BHP) Group."

 

9

Cullinane CR, Rhodes RA, Stirling LA.

Mobility and agility during locomotion in the Mark III space suit.

Aerosp Med Hum Perform. 2017 Jun;88(6):589-96.

http://www.ingentaconnect.com/content/asma/amhp/2017/00000088/00000006/art00013

Journal Impact Factor: 0.755

Funding: "This work was supported by NASA award NNX15AR20G and by the National Space Biomedical Research Institute through NASA NCC 9-58." C.R. Cullinane is part of NSBRI’s Mentored Research Program.

______________________________________________________

 

Other papers of interest:

 

1

Halbandge SD, Vidyasagar PB, Karuppayil SM.

Saccharomyces cerevisiae as a model for space biology.

In: Yeast diversity in human welfare. Singapore: Springer, 2017. p. 29-52.

http://link.springer.com/chapter/10.1007%2F978-981-10-2621-8_2

Note: Discussion includes results from Chinese satellite flights, Apollo 16, FOTON-M3, and Shuttle missions as well as studies conducted using clinostats, Random Positioning Machines, and Rotating Wall Vessels.

 

2

Byloos B, Coninx I, Van Hoey O, Cockell C, Nicholson N, Ilyin V, Van Houdt R, Boon N, Leys N.

The impact of space flight on survival and interaction of Cupriavidus metallidurans CH34 with basalt, a volcanic Moon analog rock. 

Front Microbiol. 2017 Apr 28;8:671.

https://www.ncbi.nlm.nih.gov/pubmed/28503167

Note: FOTON-M4 results. This article may be obtained online without charge.

 

3

Hu HX, Du FY, Fu WW, Jiang SF, Cao J, Xu SH, Wang HP, Chang H, Goswami N, Gao YF.

A dramatic blood plasticity in hibernating and 14-day hindlimb unloading Daurian ground squirrels (Spermophilus dauricus).

J Comp Physiol B. 2017 May 13. [Epub ahead of print]

https://www.ncbi.nlm.nih.gov/pubmed/28501920

Note: Hindlimb unloading study.

 

4

Porta A, Marchi A, Bari V, De Maria B, Esler M, Lambert E, Baumert M.

Assessing the strength of cardiac and sympathetic baroreflex controls via transfer entropy during orthostatic challenge.

Philos Trans A Math Phys Eng Sci. 2017 Jun 28;375(2096): 20160290. Epub 2017 May 17.

https://www.ncbi.nlm.nih.gov/pubmed/28507235                                           

 

5

Murphy FG, Hada EA, Doolette DJ, Howle LE.

Probabilistic pharmacokinetic models of decompression sickness in humans, Part 1: Coupled perfusion-limited compartments.

Comput Biol Med. 2017 May 4;86:55-64. [Epub ahead of print]

https://www.ncbi.nlm.nih.gov/pubmed/28505552

 

6

Shi J, Wang Y, He J, Li P, Jin R, Wang K, Xu X, Hao J, Zhang Y, Liu H, Chen X, Wu H, Ge Q.

Intestinal microbiota contributes to colonic epithelial changes in simulated microgravity mouse model.

FASEB J. 2017 May 11. [Epub ahead of print]

https://www.ncbi.nlm.nih.gov/pubmed/28495755

Note: Hindlimb unloading study.

 

7

Balaban J, Azizi E.

Lowering metabolic rate mitigates muscle atrophy in western fence lizards.

J Exp Biol. 2017 May 15. [Epub ahead of print]

https://www.ncbi.nlm.nih.gov/pubmed/28507191

 

8

Fajardo VA, Mikhaeil JS, Leveille CF, Saint C, LeBlanc PJ.

Cardiolipin content, linoleic acid composition, and tafazzin expression in response to skeletal muscle overload and unload stimuli.

Sci Rep. 2017 May 17;7(1):2060.

https://www.ncbi.nlm.nih.gov/pubmed/28515468

Note: Tenotomy was used. This article may be obtained online without charge.

 

9

Kenny HC, Rudwill F, Breen L, Salanova M, Blottner D, Heise T, Heer M, Blanc S, O'Gorman DJ.

Bed rest and resistive vibration exercise unveil novel links between skeletal muscle mitochondrial function and insulin resistance.

Diabetologia. 2017 May 12. [Epub ahead of print]

https://www.ncbi.nlm.nih.gov/pubmed/28500394

 

10

Lomax M, Massey HC, House JR.

Inspiratory muscle training effects on cycling during acute hypoxic exposure.

Aerosp Med Hum Perform. 2017 Jun;88(6):544-9.

http://www.ingentaconnect.com/content/asma/amhp/2017/00000088/00000006/art00006

 

11

Nakagawa K, Tamaki H, Hayao K, Yotani K, Ogita F, Yamamoto N, Onishi H.

Electrical stimulation of denervated rat skeletal muscle retards capillary and muscle loss in early stages of disuse atrophy.

Biomed Res Int. 2017;2017:5695217. Epub 2017 Apr 13.

https://www.ncbi.nlm.nih.gov/pubmed/28497057        

Note: This article may be obtained online without charge.

 

12

Yang CW, Li CI, Li TC, Liu CS, Lin CH, Lin WY, Lin CC.

The joint association of insulin sensitivity and physical activity on the skeletal muscle mass and performance in community-dwelling older adults.

Exp Gerontol. 2017 May 10. [Epub ahead of print]

https://www.ncbi.nlm.nih.gov/pubmed/28502778

 

13

Cresswell EN, Nguyen TM, Horsfield MW, Alepuz AJ, Metzger TA, Niebur GL, Hernandez CJ.

Mechanically induced bone formation is not sensitive to local osteocyte density in rat vertebral cancellous bone.

J Orthop Res. 2017 May 17. [Epub ahead of print]

https://www.ncbi.nlm.nih.gov/pubmed/28513889

 

14

Shi W, Xie Y, He J, Zhou J, Gao Y, Wei W, Ding N, Ma H, Xian CJ, Chen K, Wang J.

Microgravity induces inhibition of osteoblastic differentiation and mineralization through abrogating primary cilia.

Sci Rep. 2017 May 12;7(1):1866.

https://www.ncbi.nlm.nih.gov/pubmed/28500304

Note: A Random Positioning Machine was used. This article may be obtained online without charge.

 

15

Wippert PM, Rector M, Kuhn G, Wuertz-Kozak K.

Stress and alterations in bones: An interdisciplinary perspective.

Front Endocrinol (Lausanne). 2017 May 1;8:96.

https://www.ncbi.nlm.nih.gov/pubmed/28507534

Note: This article may be obtained online without charge.

 

16

Jörges B, López-Moliner J.

Gravity as a strong prior: Implications for perception and action.

Front Hum Neurosci. 2017 Apr 28;11:203.         

https://www.ncbi.nlm.nih.gov/pubmed/28503140

Note: From the Introduction: "The present article reviews evidence brought forward in the literature on whether and to what extent humans can adapt to non-earth gravities." The discussion includes general results from various spaceflights and parabolic flight. This article may be obtained online without charge.

 

17

Guo CCT, Chen DJZ, Wei IY, So RHY, Cheung RTF.

Correlations between individual susceptibility to visually induced motion sickness and decaying time constant of after-nystagmus.

Appl Ergon. 2017 Sep;63:1-8. Epub 2017 Apr 1.

https://www.ncbi.nlm.nih.gov/pubmed/28502398

 

18

Corneliussen JG, Leon GR, Kjærgaard A, Fink BA, Venables NC.

Individual traits, personal values, and conflict resolution in an isolated, confined, extreme environment.

Aerosp Med Hum Perform. 2017 Jun;88(6):535-43.

http://www.ingentaconnect.com/content/asma/amhp/2017/00000088/00000006/art00005

Note: The Spaceflight Cognitive Assessment Tool for Windows (WinSCAT) was used.

 

19

Hall L.

Early human factors studies for spaceflight at the Aeromedical Field Laboratory at Holloman Air Force Base.

Aerosp Med Hum Perform. 2017 Jun;88(6):608-9.

http://www.ingentaconnect.com/content/asma/amhp/2017/00000088/00000006/art00020

Note: Historical article.

 

20

Schwartz JSJ.

Myth-free space advocacy Part I—The myth of innate exploratory and migratory urges.

Acta Astronaut. 2017 Aug;137:450-60.

http://www.sciencedirect.com/science/article/pii/S009457651631222X

Note: From the abstract: "This paper discusses the "myth" that we have an innate drive to explore or to migrate into space."

 

21

Launius R.

Space science: First three round the Moon.

Nature. 2017 May 17;545(7654):285-6.

https://www.ncbi.nlm.nih.gov/pubmed/28516923

Note: This is a commentary on the book Apollo 8: The Thrilling Story of the First Mission to the Moon by Jeffrey Kluger (New York: Henry Holt, 2017). This article may be obtained online without charge.

// end //

More status reports and news releases or top stories.

Please follow SpaceRef on Twitter and Like us on Facebook.

NanoRacks