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NASA Spaceline Current Awareness List #761 11 August 2017 (Space Life Science Research Results))

Status Report From: Spaceline
Posted: Friday, August 11, 2017

SPACELINE Current Awareness Lists are distributed via listserv. Please send any correspondence to Robyn Ertwine, SPACELINE Current Awareness Senior Editor,rertwine@nasaprs.com.

 

 

Papers deriving from NASA support:

 

1

Castro-Wallace S, Stahl S, Voorhies A, Lorenzi H, Douglas GL.

Response of Lactobacillus acidophilus ATCC 4356 to low-shear modeled microgravity. 

Acta Astronaut. 2017 Oct;139:463-8. Epub 2017 Jul 25.

http://www.sciencedirect.com/science/article/pii/S0094576517300243

PIs: G.L. Douglas, H. Lorenzi

Note: A Rotating Wall Vessel was used.

Journal Impact Factor: 1.536

Funding: "This work was funded by the National Aeronautics and Space Administration Human Research Program's Space Human Factors and Habitability Element." H. Lorenzi reports funding under NASA grant NNX12AB02G.

 

2

Douglas GL, Voorhies AA.

Evidence based selection of probiotic strains to promote astronaut health or alleviate symptoms of illness on long duration spaceflight missions.

Benef Microbes. 2017 Aug 1. [Epub ahead of print] Review.

https://www.ncbi.nlm.nih.gov/pubmed/28760005

Journal Impact Factor: 2.923

Funding: No funding cited. G.L. Douglas is affiliated with NASA Johnson Space Center.

 

3

Gadomski BC, McGilvray KC, Easley JT, Palmer RH, Jiao J, Li X, Qin YX, Puttlitz CM.

An investigation of shock wave therapy and low-intensity pulsed ultrasound on fracture healing under reduced loading conditions in an ovine model.

J Orthop Res. 2017 Aug 1. [Epub ahead of print]

https://www.ncbi.nlm.nih.gov/pubmed/28762588

PIs: Y.X. Qin, C.M. Puttlitz

Note: Animals underwent hindlimb metatarsal unloading.

Journal Impact Factor: 2.692

Funding: "This work was supported by the National Aeronautics and Space Administration (NNX11AQ81G), and the National Space Biomedical Research Institute through NASA Cooperative Agreement NCC 9-58."

 

4

Metzger CE, Brezicha JE, Elizondo JP, Narayanan AS, Hogan HA, Bloomfield SA.

Differential responses of mechanosensitive osteocyte proteins in forelimbs and hindlimbs in hindlimb unloaded rats.

Bone. 2017 Aug 3. [Epub ahead of print]

https://www.ncbi.nlm.nih.gov/pubmed/28782619

PIs: H.A. Hogan; J.E. Brezicha and A.S. Narayanan, NSBRI Graduate Training Fellowship Program

Note: Hindlimb unloading study.

Journal Impact Factor: 4.14

Funding: "This study was supported by NASA Space Biology #NNX13AM43G. JEB and SAN were supported via the NASA-National Space Biomedical Research Institute Predoctoral Fellowship by NASA Cooperative Agreement NCC 9-58. JPE was supported via the National Science Foundation Award No. HRD-1612776."

 

5

Krause AR, Speacht TL, Zhang Y, Lang CH, Donahue HJ.

Simulated space radiation sensitizes bone but not muscle to the catabolic effects of mechanical unloading.

PLoS One. 2017 Aug 3;12(8):e0182403.

https://www.ncbi.nlm.nih.gov/pubmed/28767703

PI: H.J. Donahue

Note: Hindlimb unloading study. This article may be obtained online without charge.

Journal Impact Factor: 2.806

Funding: "This work was supported by National Space Biomedical Research Institute grant MA02802, and NIH grant R01Ar068132-18."

 

6

Lima F, Swift JM, Greene ES, Allen MR, Cunningham DA, Braby LA, Bloomfield SA.

Exposure to low-dose X-ray radiation alters bone progenitor cells and bone microarchitecture.

Radiat Res. 2017 Aug 3. [Epub ahead of print]

https://www.ncbi.nlm.nih.gov/pubmed/28771086

PIs: S.A. Bloomfield; J.M. Swift, NSBRI Graduate Training Fellowship

Journal Impact Factor: 2.539

Funding: "These studies were funded through NASA Cooperative Agreement NCC 9-58 with the National Space Biomedical Research Institute (SAB). Further support was provided by a National Space Biomedical Research Institute Graduate Training Fellowship (no. NSBRI-RFP-05-02 to JMS). The micro-CT scanner used in this study was purchased by an equipment grant from the National Institutes of Health (grant no. S10-RR023710)."

 

7

Yin Y, Li R, Xu K, Ding S, Li J, Baek G, Ramanand SG, Ding S, Liu Z, Gao Y, Kanchwala MS, Li X, Hutchinson R, Liu X, Woldu SL, Xing C, Desai NB, Feng FY, Burma S, de Bono JS, Dehm SM, Mani RS, Chen BPC, Raj GV. 

Androgen receptor variants mediate DNA repair after prostate cancer irradiation.

Cancer Res. 2017 Jul 28. [Epub ahead of print]

https://www.ncbi.nlm.nih.gov/pubmed/28754673

PI: S. Burma

Journal Impact Factor: 9.122

Funding: "This work was supported by the following grants: W81XWH-15-1-0128 (Y. Yin), W81XWH-14-1-0556 (Y. Yin), W81XWH-13-2-0093 (G. V. Raj), and W81XWH-12-1-0288 (G. V. Raj) from the Department of Defense, 1R01CA200787-01(G. V. Raj), R01CA174777 (S. M. Dehm), RO1CA149461, RO1CA197796 and R21CA202403 (S. Burma), R01CA166677 (B. P. Chen), UL1TR001105 (C. Xing), and R00CA160640 (R. S. Mani) from the NIH, NNX16AD78G from the National Aeronautics and Space Administration (S. Burma) and the Mimi and John Cole Prostate Cancer Fund (G. V. Raj)."

 

8                    

Koppelmans V, Bloomberg JJ, De Dios YE, Wood SJ, Reuter-Lorenz PA, Kofman IS, Riascos R, Mulavara AP, Seidler RD.

Brain plasticity and sensorimotor deterioration as a function of 70 days head down tilt bed rest.

PLoS One. 2017 Aug 2;12(8):e0182236.

https://www.ncbi.nlm.nih.gov/pubmed/28767698

PIs: R.D. Seidler; V. Koppelmans, NSBRI Postdoctoral Fellowship Program

Note: Head-down tilt bed rest study. This article may be obtained online without charge.

Journal Impact Factor: 2.806

Funding: "This work is supported by grants from the following institutions: 1) the National Space Biomedical Research Institute (http://nsbri.org/funding/): a. NASA cooperative agreement NCC 9-58 awarded to RDS, b. MA02701 awarded to RDS, c. PF04101 awarded to VK; 2) the National Aeronautics and Space Administration (https://www.nasa.gov/about/research/index.html): a. NASA; NNX11AR02G awarded to RDS, b. NASA Flight Analogs Project; and 3) National Institutes of Health (https://www.nih.gov/), National Center for Advancing Translational Sciences (https://ncats.nih.gov), NASA Flight Analogs Project (1UL1RR029876-01) awarded to AR Brasier."

 

9

Cowings PS, Toscano WB, Reschke MF, Gebreyesus F, Rocha C.

Autogenic-Feedback Training Exercise (AFTE) mitigates the effects of spatial disorientation to simulated Orion spacecraft re-entry: Individual differences. 

Moffett FIeld, CA: NASA Ames Research Center, 2017 May. 75 p. NASA/TM-2017-219511.

https://ntrs.nasa.gov/archive/nasa/casi.ntrs.nasa.gov/20170006194.pdf

PI: P.S. Cowings

Note: This article may be obtained online without charge.

Journal Impact Factor: Not applicable to this publication

Funding: "This project was funded by NASA’s Human Research Program (HRP), Human Health Countermeasures (HHC) Element."

______________________________________________________

 

Other papers of interest:

 

1

Arinell K, Blanc S, Welinder KG, Støen OG, Evans AL, Fröbert O.

Physical inactivity and platelet function in humans and brown bears: A comparative study.

Platelets. 2017 Jul 31. [Epub ahead of print]

https://www.ncbi.nlm.nih.gov/pubmed/28758823

Note: Head-down tilt bed rest study.

 

2

Han CH, Zhang PX, Liu Y, Zheng J, Liu K, Wei D, Qiao T, Peng B, Liu W.

Changes in angiotensin II and angiotensin-converting enzyme of different tissues after prolonged hyperoxia exposure.

Undersea Hyperb Med. 2017 Jan-Feb;44(1):39-44.

https://www.ncbi.nlm.nih.gov/pubmed/28768084

 

3

Smith ZM, Krizay E, Sá RC, Li ET, Scadeng M, Powell FL Jr, Dubowitz DJ.

Evidence from high altitude acclimatization for an integrated cerebrovascular and ventilatory hypercapnic response, but different responses to hypoxia.

J Appl Physiol (1985). 2017 Jul 13:jap.00341.2017. [Epub ahead of print]

https://www.ncbi.nlm.nih.gov/pubmed/28705997

 

4

Min J, Wright WE, Shay JW.

Alternative lengthening of telomeres mediated by mitotic DNA synthesis engages break-induced replication processes.

Mol Cell Biol. 2017 Jul 31. [Epub ahead of print]

https://www.ncbi.nlm.nih.gov/pubmed/28760773

 

5

Kleiman NJ, Stewart FA, Hall EJ.

Modifiers of radiation effects in the eye.

Life Sci Space Res. 2017 Nov;15:43-54. Review. Epub 2017 Jul 18.

http://www.sciencedirect.com/science/article/pii/S2214552417300421

 

6

Chung JM, Ahn JY.

Relationship between clinical and radiologic findings of spinal cord injury in decompression sickness.

Undersea Hyperb Med. 2017 Jan-Feb;44(1):57-62.

https://www.ncbi.nlm.nih.gov/pubmed/28768086

 

7

Aguiar AF, Vechetti-Júnior IJ, Souza RW, Piedade WP, Pacagnelli FL, Leopoldo AS, Casonatto J, Dal-Pai-Silva M.

Nitric oxide synthase inhibition impairs muscle regrowth following immobilization.

Nitric Oxide. 2017 Jul 28. [Epub ahead of print]

https://www.ncbi.nlm.nih.gov/pubmed/28757440

Note: Casting was used for immobilization.

 

8

Belavý DL, Ohshima H, Rittweger J, Felsenberg D.

High-intensity flywheel exercise and recovery of atrophy after 90 days bed-rest.

BMJ Open Sport Exerc Med. 2017 Jul 24;3(1):e000196.

https://www.ncbi.nlm.nih.gov/pubmed/28761699

Note: Head-down tilt bed rest study. This article may be obtained online without charge.

 

9

Deschenes MR, Adan MA, Kapral MC, Kressin KA, Leathrum CM, Seo A, Li S, Schaffrey EC.

Neuromuscular adaptability of male and female rats to muscle unloading.

J Neurosci Res. 2017 Jul 31. [Epub ahead of print]

https://www.ncbi.nlm.nih.gov/pubmed/28759131

Note: Hindlimb unloading study.

 

10

Ashique AM, Hart LS, Thomas CDL, Clement JG, Pivonka P, Carter Y, Mousseau DD, Cooper DML.

Lacunar-canalicular network in femoral cortical bone is reduced in aged women and is predominantly due to a loss of canalicular porosity.

Bone Rep. 2017 Dec;7:9-16. Epub 2017 Jun 28.

https://www.ncbi.nlm.nih.gov/pubmed/28752112

Note: This article may be obtained online without charge.

 

11

Cardozo CP, Graham ZA.

Muscle-bone interactions: Movement in the field of mechano-humoral coupling of muscle and bone.

Ann N Y Acad Sci. 2017 Aug 1. [Epub ahead of print]

https://www.ncbi.nlm.nih.gov/pubmed/28763828

 

12

Chen Z, Zhang Y, Liang C, Chen L, Zhang G, Qian A.

Mechanosensitive miRNAs and bone formation.

Int J Mol Sci. 2017 Aug 2;18(8):E1684. Review.

https://www.ncbi.nlm.nih.gov/pubmed/28767056

Note: This article may be obtained online without charge.

 

13

Yu K, Sellman DP, Bahraini A, Hagan ML, Elsherbini A, Vanpelt KT, Marshall PL, Hamrick MW, McNeil A, McNeil PL, McGee-Lawrence ME.

Mechanical loading disrupts osteocyte plasma membranes which initiates mechanosensation events in bone.

J Orthop Res. 2017 Jul 29. [Epub ahead of print]

https://www.ncbi.nlm.nih.gov/pubmed/28755471

 

14

Hübner PP, Khan SI, Lasker DM, Migliaccio AA.

Core body temperature effects on the mouse vestibulo-ocular reflex.

J Assoc Res Otolaryngol. 2017 Jul 28. [Epub ahead of print]

https://www.ncbi.nlm.nih.gov/pubmed/28755310

 

15

Singh M, Gupta A, Laxmi A.

Striking the right chord: Signaling enigma during root gravitropism.

Front Plant Sci. 2017 2017 Jul 27;8:1304.

http://journal.frontiersin.org/article/10.3389/fpls.2017.01304

Note: This article may be obtained online without charge.

 

16

Taniguchi M, Furutani M, Nishimura T, Nakamura M, Fushita T, Iijima K, Baba K, Tanaka H, Toyota M, Tasaka M, Morita MT.

The Arabidopsis LAZY1 family plays a key role in gravity signaling within statocytes and in branch angle control of roots and shoots.

Plant Cell. 2017 Aug 1. [Epub ahead of print]

https://www.ncbi.nlm.nih.gov/pubmed/28765510

 

17

Narasimha S, Agnisarman S, Chalil Madathil K, Gramopadhye A, McElligott JT.

Designing home-based telemedicine systems for the geriatric population: An empirical study.

Telemed J E Health. 2017 Jul 31. [Epub ahead of print]

https://www.ncbi.nlm.nih.gov/pubmed/28759323

Note: The NASA Task Load Index was used.

 

18

Shuggi IM, Oh H, Shewokis PA, Gentili RJ.

Mental workload and motor performance dynamics during practice of reaching movements under various levels of task difficulty.

Neuroscience. 2017 Jul 27. [Epub ahead of print]

https://www.ncbi.nlm.nih.gov/pubmed/28757242

Note: The NASA Task Load Index was used.

// end //

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