NASA Spaceline Current Awareness List #762 18 August 2017 (Space Life Science Research Results))

Status Report From: Spaceline
Posted: Friday, August 18, 2017

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Please note: The next issue of SPACELINE Current Awareness (List #763) will be sent on Friday, September 1, 2017.


Papers deriving from NASA support:



Guo CJ, Sun WW, Bruno KS, Oakley BR, Keller NP, Wang CCC.

Spatial regulation of a common precursor from two distinct genes generates metabolite diversity.

Chem Sci. 2015 Oct 1;6(10):5913-21.

PI: C.C.C. Wang

Note: This article may be obtained online without charge.

Journal Impact Factor: 8.668

Funding: "Chun-Jun Guo was supported by the National Science Foundation – Emerging Frontiers in Research and Innovation-MIKS (Grant 1136903). Research conducted in the lab of Clay C. C. Wang is supported by the National Institute of General Medical Sciences GM084077, the National Science Foundation – Emerging Frontiers in Research and Innovation-MIKS (Grant 1136903), the Department of Energy, Bioenergy Technologies office, the Department of Defense Strategic Environmental Research and Development program (SERDP), and the National Aeronautics and Space Administration Space Biology program."



Gao B, Huang C, Kernstine K, Pelekanou V, Kluger Y, Jiang T, Peters-Hall JR, Coquelin M, Girard L, Zhang W, Huffman K, Oliver D, Kinose F, Haura E, Teer JK, Rix U, Le AT, Aisner DL, Varella-Garcia M, Doebele RC, Covington KR, Hampton OA, Doddapaneni HV, Jayaseelan JC, Hu J, Wheeler DA, Shay JW, Rimm DL, Gazdar A, Minna JD.

Non-malignant respiratory epithelial cells preferentially proliferate from resected non-small cell lung cancer specimens cultured under conditionally reprogrammed conditions.

Oncotarget. 2017 Feb 14;8(7):11114-26.

PIs: J.D. Minna/L. Girard/J.W. Shay/A. Gazdar/NSCOR

Note: This article may be obtained online without charge.

Journal Impact Factor: 5.168

Funding: "This study was supported by National Cancer Institute Specialized Program of Research Excellence in Lung Cancer SPORE Grants: P50CA70907 (J.D.M., A.F.G. UT Southwestern) and P50CA058187 (University of Colorado); NCI Designated Comprehensive Cancer Center Support Grants: P30CA142543 (UT Southwestern), P30CA016359 (Yale University), P30CA076292 (H. Lee Moffitt Cancer Center & Research Institute) and P30CA046934 (University of Colorado); T32 CA124334 and the Cystic Fibrosis Foundation Postdoctoral Fellowship (J. P-H.); Cystic Fibrosis Foundation grant SHAY15XX0; funding from Gilead Sciences (D.L.R); the Cancer Prevention and Research Institute of Texas (CPRIT) RP110708 (J.D.M., D.A.W.) and National Cancer Institute UO1 CA176284. This work was performed in part in laboratories constructed with support from National Institutes of Health grant C06 RR30414 (J.P.H. and J.W.S.). The human studies were conducted with approval from the relevant institutional review boards." PI reports funding under NASA grant NNX11AC54G.



Ade CJ, Broxterman RM, Charvat JM, Barstow TJ.

Incidence rate of cardiovascular disease end points in the National Aeronautics and SpaceAdministration Astronaut corps.

J Am Heart Assoc. 2017 Aug 7;6(8):e005564.

PI: T.J. Barstow

Note: The study includes astronauts' health data recorded at NASA Johnson Space Center between 1959 and 2010. This article may be obtained online without charge.

Journal Impact Factor: 4.863

Funding: "This study was supported by the National Aeronautics and Space Administration (NASA) research grant NNJ12ZSA002N awarded to Ade and Barstow."



Oehler AC, Minnier J, Lindner JR.

Increased coronary tortuosity is associated with increased left ventricular longitudinal myocardial shortening.

J Am Soc Echocardiogr. 2017 Aug 3. [Epub ahead of print]

PI: J.R. Lindner

Journal Impact Factor: 6.852

Funding: "Dr. Lindner is supported by grants R01-HL078610 and R01-HL130046 from the National Institutes of Health and grant 14NSBRI1-0025 from the National Space Biomedical Research Institute (NSBRI)."



Chang J, Wang Y, Pathak R, Sridharan V, Jones T, Mao XW, Nelson G, Boerma M, Hauer-Jensen M, Zhou D, Shao L.

Whole body proton irradiation causes acute damage to bone marrow hematopoietic progenitor and stem cells in mice.

Int J Radiat Biol. 2017 Aug 7. [Epub ahead of print]

PIs: M. Boerma/X.W. Mao/G. Nelson/M. Hauer-Jensen/NSBRI Center for Research on Cardiac, Vascular, and Acute Effects of Space Radiation

Note: This article may be obtained online without charge.

Journal Impact Factor: 1.992

Funding: "The study was supported in part by the National Space Biomedical Research Institute through NCC 9-58, Centers of Biomedical Research Excellence [P20, GM109005], Arkansas Research Alliance Scholarship, and Rockefeller Leukemia and Lymphoma Research Endowment."



LaRanger R, Peters-Hall JR, Coquelin M, Alabi BR, Chen C, Wright WE, Shay J.

Reconstituting mouse lungs with conditionally reprogrammed human bronchial epithelial cells.

Tissue Eng Part A. 2017 Jul 20. [Epub ahead of print]

PIs: J.D. Minna/J. Shay/NSCOR

Journal Impact Factor: 3.485

Funding: PI reports funding under NASA grant NNX11AC54G.



Goel N.

Genetic markers of sleep and sleepiness.

Sleep Med Clin. 2017 Sep;12(3):289-99. Review.

PI: N. Goel

Journal Impact Factor: 0.95

Funding: "Office of Naval Research N00014-11-1-0361, National Aeronautics and SpaceAdministration NNX14AN49G."



Kleiman NJ, Stewart FA, Hall EJ.

Modifiers of radiation effects in the eye.

Life Sci Space Res. 2017 Nov;15:43-54. Review. Epub 2017 Jul 18.

PI: E.J. Hall

Journal Impact Factor: 1.97

Funding: No funding cited. The PI  reports funding through NASA grant NNJ05H138G.



Gilroy S, Swanson SJ.

Tip growth.

In: eLS. Chichester, U.K: John Wiley & Sons, Ltd, 2017. p. 1-4.

PI: S. Gilroy

Journal Impact Factor: Not applicable to this publication.

Funding: "Tip growth research in the Gilroy lab is funded by NSF (MCB-1329723, IOS-1557899) and NASA NNX14AT25G."



Laughlin MS, Murray JD, Lee LR, Wear ML, Van Baalen M.

Tracking historical NASA EVA training: Lifetime Surveillance of Astronaut Health (LSAH) development of the EVA Suit Exposure Tracker (EVA SET).

Houston, TX: NASA Johnson Space Center, 2017 Jan. 18 p.

Note: This article may be obtained online without charge.

Journal Impact Factor: Not applicable to this publication

Funding: No funding cited. The authors are affiliated with NASA Johnson Space Center.



Other papers of interest:



Hughson RL, Peterson SD, Yee NJ, Greaves DK.

Cardiac output by pulse contour analysis does not match the increase measured by rebreathing during human spaceflight.

J Appl Physiol (1985). 2017 Aug 10. [Epub ahead of print]

Note: ISS results.



Wu CW, Storey KB.

Regulation of Smad mediated microRNA transcriptional response in ground squirrels during hibernation.

Mol Cell Biochem. 2017 Aug 5. [Epub ahead of print]



Bradley JH, Stein R, Randolph B, Molina E, Arnold JP, Gregg RK.

T cell resistance to activation by dendritic cells requires long-term culture in simulated microgravity.

Life Sci Space Res. 2017 Aug 8. [Article in Press]

Note: A rotary cell culture system was used.



Sahebi R, Aghaei M, Halvaei S, Alizadeh A.

The role of microgravity in cancer: A dual-edge sword.

Multidiscip Cancer Investig. 2017 Jul;1(3):1-5. Review.

Note: From the Introduction: "The aim of the present review is to focus on the consequences of exposing the cancer cells to reduced gravity." Methods of microgravity simulation are not identified. This article may be obtained online without charge.



Qing L, Ariyadewa DK, Yi H, Wang Y, Zhou Q, Xu W.

Skin lesions in swine with decompression sickness: Clinical appearance and pathogenesis.

Front Physiol. 2017 Jul 25;8:540.

Note: This article may be obtained online without charge.



Dankel SJ, Mattocks KT, Jessee MB, Buckner SL, Mouser JG, Loenneke JP.

Do metabolites that are produced during resistance exercise enhance muscle hypertrophy?

Eur J Appl Physiol. 2017 Aug 3. [Epub ahead of print] Review.



McKenna CF, Fry CS.

Altered satellite cell dynamics accompany skeletal muscle atrophy during chronic illness, disuse, and aging.

Curr Opin Clin Nutr Metab Care. 2017 Aug 8. [Epub ahead of print] Review.

Note: Hindlimb unloading, bed rest, and immobilization studies are discussed.



Nakamura K, Ohsawa I, Masuzawa R, Konno R, Watanabe A, Kawano F.

Running training experience attenuates disuse atrophy in fast-twitch skeletal muscles of rats.

J Appl Physiol (1985). 2017 Aug 3. [Epub ahead of print]

Note: Hindlimb unloading study.



Treffel L, Massabuau N, Zuj K, Custaud MA, Gauquelin-Koch G, Blanc S, Gharib C, Millet C.

Pain and vertebral dysfunction in dry immersion: A model of microgravity simulation different from bed rest studies.

Pain Res Manag. 2017;2017:9602131.

Note: Dry immersion study. This article may be obtained online without charge.



Yang J, Yang Z, Li W, Xue Y, Xu H, Li J, Shang P.

Glucocorticoid: A potential role in microgravity-induced bone loss.

Acta Astronaut. 2017 Aug 9. [Article in Press]

Note: The authors review results from spaceflight and ground-based studies in humans and animals.



Vuolo M, Baiocco G, Barbieri S, Bocchini L, Giraudo M, Gheysens T, Lobascio C, Ottolenghi A.

Exploring innovative radiation shielding approaches in space: A material and design study for a wearable radiation protection spacesuit.

Life Sci Space Res. 2017 Nov;15:69-78. Epub 2017 Aug 9.



Russo M, Cesqui B, La Scaleia B, Ceccarelli F, Maselli A, Moscatelli A, Zago M, Lacquaniti F, d'Avella A.

Intercepting virtual balls approaching under different gravity conditions: Evidence for spatial prediction.

J Neurophysiol. 2017 Aug 2. [Epub ahead of print]



Mazloumi Gavgani A, Hodgson DM, Nalivaiko E.

Effects of visual flow direction on signs and symptoms of cybersickness.

PLoS One. 2017 Aug 4;12(8):e0182790.

Note: This article may be obtained online without charge.



Gravano S, Zago M, Lacquaniti F.

Mental imagery of gravitational motion.

Cortex. 2017 Aug 9. [Article in Press]

Note: From the Introduction: "Here we tested whether the internal model of gravity is accessed when target motion is imagined rather than real."



Gontier C.

How to prevent mind-wandering during an EVA? Presentation of a mind-wandering detection method using ECG technology in a Mars-analog environment.

Acta Astronaut. 2017 Aug 10. [Article in Press]

Note: Results are from the Mars analog mission, MDRS 164, at the Mars Desert Research Station in 2016.



Wang Y, Zhou Y, Rao LL, Zheng R, Liang ZY, Chen XP, Tan C, Tian ZQ, Wang CH, Bai YQ, Chen SG, Li S.

Effect of 45-day −6° head-down bed rest on cooperation and aggression.

Appl Cogn Psychol. 2017 Aug 11. [Article in Press]

Note: Bed rest study.



Soto-Burgos J, Bassham DC.

SnRK1 activates autophagy via the TOR signaling pathway in Arabidopsis thaliana

PLoS One. 2017 Aug 4;12(8):e0182591.

Note: This article may be obtained online without charge.

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