NASA Spaceline Current Awareness List #774 17 November 2017 (Space Life Science Research Results)

Status Report From: Spaceline
Posted: Friday, November 17, 2017

SPACELINE Current Awareness Lists are distributed via listserv. Please send any correspondence to Robyn Ertwine, SPACELINE Current Awareness Senior Editor,

Papers deriving from NASA support:


Childress P, Brinker A, Gong C-MS, Harris JL, Olivos DJ III, Rytlewski JD, Scofield DC, Choi SY, Shirazi-Fard Y, McKinley TO, Chu T-MG, Conley CL, Chakraborty N, Hammamieh R, Kacena MA.

Forces associated with launch into space do not impact bone fracture healing.

Life Sci Space Res. 2017 Nov 11. [Article in Press]

Note: ISS results.

Journal Impact Factor: 1.97

Funding: "This work was supported in part by a grant from the Orthopaedic Trauma Association (MAK, TOM) and the Ralph W. and Grace M. Showalter Research Trust Fund (MAK). In addition, research reported in this publication was supported in part by the following grants: NIH NIAMS R01 AR060863 (MAK) and GA-2015-217 from the Center for the Advancement of Sciences in Space (CASIS, MAK). This work was also supported by the US Army Medical Research and Materiel Command (NC, RH). Additionally, this work supported by the NASA Ames Research Center (CSG, SYC, YS-F)." Work at NASA Ames Research Center was supported by the Rodent Research Project.



Hahn C, Hans M, Hein C, Mancinelli RL, Mucklich F, Wirth R, Rettberg P, Hellweg CE, Moeller R.

Pure and oxidized copper materials as potential antimicrobial surfaces for spaceflight activities.

Astrobiology. 2017 Nov 8. [Epub ahead of print]

Journal Impact Factor: 2.603

Funding: "This work was supported by the Helmholtz Space Life Sciences Research School (SpaceLife) and the German Aerospace Center of the Helmholtz Association (PhD fellowship to Claudia Hahn; VO-KH-300). . . . C.H., P.R., C.E.H., and R.M. were supported by DLR grant DLR-FuE-Projekt ISS LIFE, Programm RF-FuW, Teilprogramm 475. R.M.'s contribution is part of the ESA projects: "Testing antimicrobial metal surfaces under spaceflight conditions—an effective strategy to prevent microbial biofilm formation" [No. ESA-HSO-ESR-ILSRA-2014-054; BIOFILMS (Biofilm Inhibition On Flight equipment and on board the ISS using microbiologically Lethal Metal Surfaces)] and "Antimicrobial materials, surfaces and textiles on-board the Concordia Antarctic Research Station as a test-bed approach for the reduction of the microbial contamination on future human space missions (ANTI-BACS)" [No. ESA-AO-11-Concordia-022]." R. L. Mancinelli is affiliated with NASA Ames Research Center.



Todorova PK, Mukherjee B, Burma S.

MET signaling promotes DNA repair and radiation resistance in glioblastoma stem-like cells.

Ann Transl Med. 2017 Feb;5(3):61.

PI: S. Burma

Note: This is a Comment on: De Bacco F, D'Ambrosio A, Casanova E, et al. MET inhibition overcomes radiation resistance of glioblastoma stem-like cells. EMBO Mol Med 2016;8:550-68. This article may be obtained online without charge.

Journal Impact Factor: Not available for this journal

Funding: "S Burma is supported by grants from the National Institutes of Health (RO1CA149461, RO1CA197796 and R21CA202403) and the National Aeronautics and Space Administration (NNX16AD78G)."



Kiffer F, Carr H, Groves T, Anderson JE, Alexander T, Wang J, Seawright JW, Sridharan V, Carter G, Boerma M, Allen AR.

Effects of 1H + 16O charged particle irradiation on short-term memory and hippocampal physiology in a murine model.

Radiat Res. 2017 Nov 14. [Epub ahead of print]

PI: M. Boerma/NSBRI Center for Research on Cardiac, Vascular, and Acute Effects of Space Radiation

Journal Impact Factor: 2.539

Funding: "This work was supported by the NSBRI (grant no. RE03701, through no. NCC 9-58)."



Purgason A, Zhang Y, Hamilton SR, Gridley DS, Sodipe A, Jejelowo O, Ramesh GT, Moreno-Villanueva M, Wu H.

Apoptosis and expression of apoptosis-related genes in mouse intestinal tissue after whole-body proton exposure.

Mol Cell Biochem. 2017 Nov 2. [Epub ahead of print]

PI: H. Wu

Journal Impact Factor: 2.669

Funding: "This work was supported by the US Department of Energy Low Dose Radiation Program and the NASA Human Research Program. AP was supported in part by the NASA Graduate Student Research Program. MMV was supported by German Research Foundation (DFG)."



Villasana LE, Akinyeke T, Weber S, Raber J.

Paradoxical effects of 137Cs irradiation on pharmacological stimulation of reactive oxygen species in hippocampal slices from apoE2 and apoE4 mice.

Oncotarget. 2017 Sep 1;8(44):76587-605.

PI: J. Raber

Note: This article may be obtained online without charge.

Journal Impact Factor: 5.168

Funding: "This work was supported by NIA grant T32 NS007466-05, NIMH grant MH77647, NASA Grants NNJ05HE63G, NNJ12ZSA001N, NNX10AD59G, NNJ12ZSA001N, Alzheimer’s Association Grant IIRG-05-14021 and an APA Dissertation Award."



Alfano CA, Bower J, Cowie J, Lau S, Simpson RJ.

Long-duration space exploration and emotional health: Recommendations for conceptualizing and evaluating risk.

Acta Astronaut. 2017 Nov 10. [Article in Press] Review.

PI: C. Alfano

Note: Results from Shuttle/Mir, ISS, and the Mars500 Project are discussed.

Journal Impact Factor: 1.536

Funding: "This paper was supported by a research grant from the National Aeronautics and Space Administration (NASA; # NNX15AC13G) awarded to C. Alfano and R. Simpson."



Dennis LE, Wohl RJ, Selame LA, Goel N.

Healthy adults display long-term trait-like neurobehavioral resilience and vulnerability to sleep loss.

Sci Rep. 2017 Nov 2;7(1):14889.

PIs: N. Goel, D.F. Dinges

Note: This article may be obtained online without charge.

Journal Impact Factor: 4.259

Funding: "All aspects of this work were primarily supported by the Department of the Navy, Office of Naval Research (Award No. N00014-11-1-0361). Partial support was also provided by National Aeronautics and Space Administration (NASA) NNX14AN49G, Clinical and Translational Research Center grant UL1TR000003, NIH grants R01 NR004281 and R01 HL102119, National Space Biomedical Research Institute Award through NASA NCC 9-58, and the Air Force Office of Scientific Research Award No. FA9550-05-1-0293."



Other papers of interest:



Boguraev AS, Christensen HC, Bonneau AR, Pezza JA, Nichols NM, Giraldez AJ, Gray MM, Wagner BM, Aken JT, Foley KD, Copeland DS, Kraves S, Alvarez Saavedra E.

Successful amplification of DNA aboard the International Space Station.

npj Microgravity. 2017 Nov 16;3(1):26.

Note: ISS results. This article may be obtained online without charge.



Alperin N, Bagci AM, Lee SH.

Spaceflight-induced changes in white matter hyperintensity burden in astronauts.

Neurology. 2017 Oct 27. [Epub ahead of print]

Note: ISS and STS results.



Clément G.

Perception of time in microgravity and hypergravity during parabolic flight.

Neuroreport. 2017 Nov 6. [Epub ahead of print]

Note: Parabolic flight results.



Macaluso T, Bourdin C, Buloup F, Mille ML, Sainton P, Sarlegna FR, Vercher JL, Bringoux L.

Sensorimotor reorganizations of arm kinematics and postural strategy for functional whole-body reaching movements in microgravity.

Front Physiol. 2017 Oct 20;8:821.

Note: Parabolic flight study. This article may be obtained online without charge.



Shen Y, Guo S, Zhao P, Wang L, Wang X, Li J, Bian Q.

Research on lettuce growth technology onboard Chinese Tiangong II Spacelab.

Acta Astronaut. 2017 Nov 8. [Article in Press]

Note: Chinese satellite results.



Weiss WM, Mulet-Sierra A, Kunze M, Jomha NM, Adesida AB.

Coculture of meniscus cells and mesenchymal stem cells in simulated microgravity.

npj Microgravity. 2017 Nov 10;3(1):28.

Note: A rotary cell culture system was used. This article may be obtained online without charge.



Verma AK, Xu D, Garg A, Cote AT, Goswami N, Blaber AP, Tavakolian K.

Non-linear heart rate and blood pressure interaction in response to lower-body negative pressure.

Front Physiol. 2017 Oct 24;8:767.

Note: This article may be obtained online without charge.



Lindén C, Qvarlander S, Jóhannesson G, Johansson E, Östlund F, Malm J, Eklund A.

Normal-tension glaucoma has normal intracranial pressure: A prospective study of intracranial pressure and intraocular pressure in different body positions.

Ophthalmology. 2017 Oct 30. [Epub ahead of print]

Note: Head-down tilt study. This article may be obtained online without charge.



vanLieshout TL, Stouth DW, Tajik T, Ljubicic V.

Exercise-induced protein arginine methyltransferase expression in skeletal muscle.

Med Sci Sports Exerc. 2017 Nov 6. [Epub ahead of print]



Bullock WA, Robling AG.

WNT-mediated modulation of bone metabolism: Implications for WNT targeting to treat extraskeletal disorders.

Toxicol Pathol. 2017 Nov 5. [Epub ahead of print] Review.



Qian W, Gong L, Cui X, Zhang Z, Bajpai A, Liu C, Castillo A, Teo JCM, Chen W.

Nanotopographic regulation of human mesenchymal stem cell osteogenesis.

ACS Appl Mater Interfaces. 2017 Nov 8. [Epub ahead of print]



Rozental TD, Johannesdottir F, Kempland KC, Bouxsein ML.

Characterization of trabecular bone microstructure in premenopausal women with distal radius fractures.

Osteoporos Int. 2017 Nov 3. [Epub ahead of print]



Rozental TD, Walley KC, Demissie S, Caksa S, Martinez-Betancourt A, Parker AM, Tsai JN, Yu EW, Bouxsein ML.

Bone material strength index as measured by impact microindentation in postmenopausal women with distal radius and hip fractures.

J Bone Miner Res. 2017 Nov 8. [Epub ahead of print]



Xue Y, Baker AL, Nader S, Orlander P, Sanchez AJ, Kellam J, Rianon NJ, Ambrose CG.

Lumbar spine trabecular bone score (TBS) reflects diminished bone quality in patients with diabetes mellitus and oral glucocorticoid therapy.

J Clin Densitom. 2017 Nov 1. [Epub ahead of print]



Zheng T, Kang JH, Sim JS, Kim JW, Koh JT, Shin CS, Lim H, Yim M.

The farnesoid X receptor negatively regulates osteoclastogenesis in bone remodeling and pathological bone loss.

Oncotarget. 2017 Aug 28;8(44):76558-73.

Note: This article may be obtained online without charge.



Jones B.

Proton radiobiology and its clinical implications.

Ecancermedicalscience. 2017 Oct 26;11:777. Review. 04614

Note: This article may be obtained online without charge.



Li D, Chen R, Wang YW, Fornace AJ Jr, Li HH.

Prior irradiation results in elevated programmed cell death protein 1 (PD-1) in T cells.

Int J Radiat Biol. 2017 Nov 7. [Epub ahead of print]



Hamilton TJ, Morrill A, Lucas K, Gallup J, Harris M, Healey M, Pitman T, Schalomon M, Digweed S, Tresguerres M.

Establishing zebrafish as a model to study the anxiolytic effects of scopolamine.

Sci Rep. 2017 Nov 8;7(1):15081.

Note: This article may be obtained online without charge.



Muntaseer Mahfuz M, Schubert MC, Todd CJ, Figtree WVC, Khan SI, Migliaccio AA.

The effect of visual contrast on human vestibulo-ocular reflex adaptation.

J Assoc Res Otolaryngol. 2017 Nov 6. [Epub ahead of print]



Stewart CE, Kanicki AC, Altschuler RA, King WM.

Vestibular short latency evoked potential (VsEP) is abolished by low frequency noise exposure in rats.

J Neurophysiol. 2017 Nov 8. [Epub ahead of print]



Wuehr M, Boerner JC, Pradhan C, Decker J, Jahn K, Brandt T, Schniepp R.

Stochastic resonance in the human vestibular system - Noise-induced facilitation of vestibulospinal reflexes.

Brain Stimul. 2017 Oct 31. [Epub ahead of print]



Velichko VV, Tikhomirov AA, Ushakova SA.

Estimating CO2 gas exchange in mixed age vegetable plant communities grown on soil-like substrates for life support systems.

Life Sci Space Res. 2017 Nov 11. [Article in Press] 



Qin YX, Fu Y, Chen H, Sun Y.

Microgravity effect on endophytic bacteria communities of Triticum aestivum.

Acta Astronaut. 2017 Nov 10. [Article in Press]

Note: A random positioning machine was used.



Nakajima S, Shiraga K, Suzuki T, Kondo N, Ogawa Y.

Chlorophyll, carotenoid and anthocyanin accumulation in mung bean seedling under clinorotation.

Microgravity Sci Technol. 2017 Nov 10. [Article in Press]

Note: A slow-rotating clinostat was used.



Harmer SL, Brooks CJ.

Growth-mediated plant movements: Hidden in plain sight.

Curr Opin Plant Biol. 2017 Nov 3;41:89-94. Review.

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