NASA Spaceline Current Awareness List #775 24 November 2017 (Space Life Science Research Results)

Status Report From: Spaceline
Posted: Friday, November 24, 2017

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Papers deriving from NASA support:


Thornhill SG, McLean RJC.

Use of whole-cell bioassays for screening quorum signaling, quorum interference, and biofilm dispersion.

Methods Mol Biol. 2018;1673:3-24. Epub 2017 Nov 4.

PI: R.J.C. McLean

Journal Impact Factor: 0.79

Funding: "Work in RJCM’s laboratory is supported by grants from NASA (NNX17AC79G), the Texas State University Research Enhancement Program, and the Biology Department at Texas State University."



Simon JC, Sapozhnikov OA, Kreider W, Breshock M, Williams JC Jr, Bailey MR.

The role of trapped bubbles in kidney stone detection with the color Doppler ultrasound twinkling artifact.

Phys Med Biol. 2017 Nov 13. [Epub ahead of print]

PIs: M.R. Bailey; J.C. Simon/NSBRI Postdoctoral Fellowship Program

Journal Impact Factor: 2.742

Funding: "We would also like to thank our funding sources including the National Space Biomedical Research Institute thought NASA NCC 9-58, the National Institute of Health NIDDK grant DK043881, and the Russian Foundation for Basic Research grant 17-02-00261."



Bouyanfif A, Liyanage S, Hewitt JE, Vanapalli SA, Moustaid-Moussa N, Hequet E, Abidi N.

FTIR imaging detects diet and genotype-dependent chemical composition changes in wild type and mutant C. elegans strains.

Analyst. 2017 Nov 15. [Epub ahead of print]

PI: S. Vanapalli

Journal Impact Factor: 3.885

Funding: "The research was supported in part by NASA Grant # NNX15AL16G (SV), USDA NIFA AFRI #2015-67030-23452 (NMM, SV), the Obesity Research Cluster (NA, NMM), Texas Tech Transdisciplinary Research Academy (NMM, SV), and the Fiber and Biopolymer Research Institute (NA, EH)."



Basner M, Hermosillo E, Nasrini J, McGuire S, Saxena S, Moore TM, Gur RC, Dinges DF.

Repeated administration effects on Psychomotor Vigilance Test (PVT) performance.

Sleep. 2017 Nov 8. [Epub ahead of print] Review.

PI: M. Basner

Journal Impact Factor: 4.923

Funding: "This work was funded by the National Space Biomedical Research Institute (NSBRI) through grant NBPF00012 (NASA NCC 9-58) and by the National Aeronautics and Space Administration (NASA) through grant NNX14AH98G."



Cohen HS, Stitz J, Sangi-Haghpeykar H, Williams SP, Mulavara AP, Peters BT, Bloomberg JJ.

Utility of quick oculomotor tests for screening the vestibular system in the subacute and chronic populations.

Acta Otolaryngol. 2017 Nov 16. [Epub ahead of print]

PIs: J.J. Bloomberg, A.P. Mulavara

Journal Impact Factor: 1.116

Funding: "This work was supported by grants from: the United States National Institutes of Health, National Institute on Deafness and Other Communication Disorders grant 2R01DC009031 (HSC), the National Space Biomedical Research Institute through NASA NCC 9-58 (APM, JJB), and also by a fellowship from the Austria Marshall Plan Foundation (JS)."



Liang Y, Horrey WJ, Howard ME, Lee ML, Anderson C, Shreeve MS, O'Brien CS, Czeisler CA.

Prediction of drowsiness events in night shift workers during morning driving.

Accid Anal Prev. 2017 Nov 7. [Epub ahead of print]

PI: M.L. Lee

Journal Impact Factor: 2.685

Funding: "This study was supported by a grant from the Institute of Breathing and Sleep Research (to M.E.H.); by Liberty Mutual Insurance; National Institutes of Health Award 5T32HL7901-14 (to M.L.L.); National Space Biomedical Research Institute Award PF03002 (to M.L.L.); Department of Homeland Security Federal Emergency Management Agency Assistance to Firefighter Grant EMW-2010-FP-00521 (to C.A.C.); National Heart, Lung and Blood Institute Cooperative Agreement U01- HL111478 (to C.A.C.); National Institute of Occupational Safety and Health Grant R01-OH0103001 (to C.A.C.); National Institute on Aging Grant R01-AG044416 (to C.A.C.); and an endowed professorship provided to Harvard Medical School by Cephalon, Inc. (to C.A.C.)."



Other papers of interest:



Fomina EV, Lysova NY, Kukoba TB, Grishin AP, Kornienko MB.

One-year mission on ISS is a step towards interplanetary missions.

Aerosp Med Hum Perform. 2017 Dec;88(12):1094-9.

Note: ISS results.



Bizzarri M, Masiello MG, Giuliani A, Cucina A.

Gravity constraints drive biological systems toward specific organization patterns: Commitment of cell specification is constrained by physical cues.

Bioessays. 2017 Nov 14. [Epub ahead of print] Review.

Note: The review includes discussion of studies conducted on the ISS and using Random Positioning Machines and 3-D clinostats.



Di Rienzo M, Vaini E, Lombardi P.

An algorithm for the beat-to-beat assessment of cardiac mechanics during sleep on Earth and in microgravity from the seismocardiogram.

Sci Rep. 2017 Nov 15;7(1):15634.      

Note: ISS results. This article may be obtained online without charge.



Anken R, Knie M, Hilbig R.

Inner ear otolith asymmetry in late-larval cichlid fish (Oreochromis mossambicus, Perciformes) showing kinetotic behaviour under diminished gravity.

Sci Rep. 2017 Nov 15;7(1):15630.

Note: TEXUS sounding rocket results. This article may be obtained online without charge.



Ushakov IB, Voronkov YI, Bukhtiyarov IrV, Tikhonova GI, Gorchakova TY, Bryleva MS.

A cohort mortality study among Soviet and Russian cosmonauts, 1961-2014.

Aerosp Med Hum Perform. 2017 Dec;88(12):1060-5.

Note: The study spans the Soviet/Russian manned space programs.



Campbell MR.

Dr. Sherman Vinograd and his contributions to the Skylab Medical Program.

Aerosp Med Hum Perform. 2017 Dec;88(12):1140-1.

Note: During Dr. Vinograd's tenure as NASA's Chief of Medical Science and Technology and Director of Biomedical Research (1961-1979), he established the In-flight Medical Experiments Program used from Mercury through Skylab programs, and established joint projects for the study of space medicine with the Department of Defense and the Air Force. He was the founding member of the Manned Orbiting Laboratory Biomedical Experiment Working Group, which established eight critical medical issues for further study. The recommendations of this group formed the basis for Skylab biomedical experiments.



Cerri M.

Consciousness in hibernation and synthetic torpor.

J Integr Neurosci. 2017 Nov 7. [Epub ahead of print]



Michaletti A, Gioia M, Tarantino U, Zolla L.

Effects of microgravity on osteoblast mitochondria: A proteomic and metabolomics profile.

Sci Rep. 2017 Nov 13;7(1):15376.

Note: A Random Positioning Machine was used. This article may be obtained online without charge.



Morabito C, Guarnieri S, Catizone A, Schiraldi C, Ricci G, Mariggio MA.

Transient increases in intracellular calcium and reactive oxygen species levels in TCam-2 cells exposed to microgravity.

Sci Rep. 2017 Nov 15;7(1):15648.

Note: A Random Positioning Machine was used. This article may be obtained online without charge.



Gaffney CJ, Fomina E, Babich D, Kitov V, Uskov K, Green DA.

The effect of long-term confinement and the efficacy of exercise countermeasures on muscle strength during a simulated mission to Mars: Data from the Mars500 study.

Sports Med Open. 2017 Nov 13;3(1):40.

Note: Mars500 study results.



Kang KS, Lastfogel J, Ackerman LL, Jea A, Robling AG, Tholpady SS.

Loss of mechanosensitive sclerostin may accelerate cranial bone growth and regeneration.

J Neurosurg. 2017 Nov 10. [Epub ahead of print]



Wu D, Zheng C, Wu J, Huang R, Chen X, Zhang T, Zhang L.

Molecular biological effects of weightlessness and hypergravity on intervertebral disc degeneration.

Aerosp Med Hum Perform. 2017 Dec;88(12):1123-8.

Note: Hindlimb unloading and centrifugation were used.



Adrian G, Ceberg C, Carneiro A, Ekblad L.

Rescue effect inherited in colony formation assays affects radiation response.

Radiat Res. 2017 Nov 14. [Epub ahead of print]



Steinman J, Epperly M, Hou W, Willis J, Wang H, Fisher R, Liu B, Bahar I, McCaw T, Kagan V, Bayir H, Yu J, Wipf P, Li S, Huq MS, Greenberger JS.

Improved total-body irradiation survival by delivery of two radiation mitigators that target distinct cell death pathways.

Radiat Res. 2017 Nov 15. [Epub ahead of print]



Kim YH, Kwon T, Song D, Kim YJ.

Full-body animation of human locomotion in reduced gravity using physics-based control.

IEEE Comput Graph Appl. 2017 Nov-Dec;37(6):28-39.

Note: From the Introduction: "In this article, we propose a physics-based approach to simulate a full-body animation of human locomotion in a reduced-gravity environment, such as on the Moon or Mars. As input, our method takes motion-captured human motions gathered under the Earth’s gravitational condition (1 g), including walking, running, and turning, and builds an inverted pendulum on a cart (IPC) control model, which is analyzed and combined with the center-of-mass (COM) trajectories of the motion-captured characters. Then, for a given gravity condition, such as 1/3 g for Mars or 1/6 g for the Moon, we map the control model to the altered gravity and plan footsteps that match the pendulum’s reduced-gravity dynamics."



Dart TS, Gallo M, Beer J, Fischer J, Morgan TR, Pilmanis A.

Hyperoxia and hypoxic hypoxia effects on simple and choice reaction times.

Aerosp Med Hum Perform. 2017 Dec;88(12):1073-80.



Takács E, Czigler I, Pató LG, Balázs L.

Dissociated components of executive control in acute hypobaric hypoxia.

Aerosp Med Hum Perform. 2017 Dec;88(12):1081-7.



Kim JS, Kwon YS, Bae DW, Kwak YS, Kwack YB.

Proteomic analysis of Coprinopsis cinerea under conditions of horizontal and perpendicular gravity.

Mycobiology. 2017 Sep;45(3):226-31.

Note: Fungi were grown in either a horizontal or perpendicular orientation.



Dai K, Yu Q, Zhang Z, Wang Y, Wang X.

Non-methane hydrocarbons in a controlled ecological life support system.

Chemosphere. 2018 Feb;193:207-12. Epub 2017 Nov 7.



Ko SM, Ji YG.

How we can measure the non-driving-task engagement in automated driving: Comparing flow experience and workload.

Appl Ergon. 2018 Feb;67:237-45. Epub 2017 Oct 23.

Note: The NASA Task Load Index was used.



Lee SC, Cha MC, Hwangbo H, Mo S, Ji YG.

Smartphone form factors: Effects of width and bottom bezel on touch performance, workload, and physical demand.

Appl Ergon. 2018 Feb;67:142-50. Epub 2017 Nov 7.

Note: The NASA Task Load Index was used.

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