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NASA Spaceline Current Awareness List #776 1 December 2017 (Space Life Science Research Results)

Status Report From: Spaceline
Posted: Friday, December 1, 2017

SPACELINE Current Awareness Lists are distributed via listserv. Please send any correspondence to Robyn Ertwine, SPACELINE Current Awareness Senior Editor, rertwine@nasaprs.com.

Papers deriving from NASA support:

1

Stahn AC, Werner A, Opatz O, Maggioni MA, Steinach M, von Ahlefeld VW, Moore A, Crucian BE, Smith SM, Zwart SR, Schlabs T, Mendt S, Trippel T, Koralewski E, Koch J, Choukèr A, Reitz G, Shang P, Röcker L, Kirsch KA, Gunga HC.

Increased core body temperature in astronauts during long-duration space missions.

Sci Rep. 2017 Nov 23;7(1):16180.

https://www.ncbi.nlm.nih.gov/pubmed/29170507

Note: ISS results. This article may be obtained online without charge.

Journal Impact Factor: 4.259

Funding: "This investigation was supported by the ELIPS 3 and 4 programs of ESA and DLR grants 50WB0724 and 50WB1030." B.E. Crucian, S.M. Smith, and S.R. Zwart are affiliated with NASA Johnson Space Center.

 

2

Aseyev N, Vinarskaya AK, Roshchin M, Korshunova TA, Malyshev AY, Zuzina AB, Ierusalimsky VN, Lemak MS, Zakharov IS, Novikov IA, Kolosov P, Chesnokova E, Volkova S, Kasianov A, Uroshlev L, Popova Y, Boyle RD, Balaban PM.

Adaptive changes in the vestibular system of land snail to a 30-day spaceflight and readaptation on return to Earth.

Front Cell Neurosci. 2017 Nov 1;11:348.

https://www.ncbi.nlm.nih.gov/pubmed/29163058

PI: R.D. Boyle

Note: Bion M-1 results. This article may be obtained online without charge.

Journal Impact Factor: 4.555

Funding: "This study was supported by RFBR grant No 12-04-01166-a, and by RSF grant 14-25-00072 (transcriptome analysis). . . .RB supported in part by NASA grant (11_Omni_2_0002) and from NASA Human Research and Space Biology Programs. YP supported by NASA Postdoctoral Program administered by the Oak Ridge Associated Universities."

 

3

DasSarma P, DasSarma S.

Survival of microbes in Earth's stratosphere.

Curr Opin Microbiol. 2017 Nov 17;43:24-30.

https://www.ncbi.nlm.nih.gov/pubmed/29156444

Journal Impact Factor: 6.635

Funding: "Research in the authors’ laboratory is supported by National Aeronautics and Space Administration grant NNX15AM07G."

 

4

Balasubramanian S, Tepelus T, Stenger MB, Lee SMC, Laurie SS, Liu JHK, Feiveson AH, Sadda SR, Huang AS, Macias BR.

Thigh cuffs as a countermeasure for ocular changes in simulated weightlessness.

Ophthalmology. 2017 Nov 16. [Epub ahead of print]

https://www.ncbi.nlm.nih.gov/pubmed/29153458

PI: B.R. Macias

Note: Postures used were sitting, supine, 15° head-down tilt, and 15° head-down tilt with thigh cuffs.

Journal Impact Factor: 8.204

Funding: "Supported by the National Space Biomedical Research Institute (NSBRI; Houston, TX) through National Aeronautics and Space Administration (NASA) Cooperative Agreement no. NCC 9-58 (B.R.M., A.S.H.), and an unrestricted grant from Research to Prevent Blindness to UCLA (New York, NY)."

 

5

Zhang LF, Hargens AR.

Spaceflight-induced intracranial hypertension and visual impairment: Pathophysiology and countermeasures.

Physiol Rev. 2018 Jan 1;98(1):59-87. Review. Epub 2017 Nov 24.

https://www.ncbi.nlm.nih.gov/pubmed/29167331

PI: A.R. Hargens

Journal Impact Factor: 27.312

Funding: "This work was supported by the National Natural Science Foundation of China (to L.-F. Zhang) and NASA Grants NNX13AJ12G, NNX13AM89G, and NNX14AP25G (to A. R. Hargens)."

 

6

Shanmugarajan S, Zhang Y, Moreno-Villanueva M, Clanton R, Rohde LH, Ramesh GT, Sibonga JD, Wu H.

Combined effects of simulated microgravity and radiation exposure on osteoclast cell fusion.

Int J Mol Sci. 2017 Nov 18;18(11):E2443.

https://www.ncbi.nlm.nih.gov/pubmed/29156538

PI: H. Wu

Note: A rotating wall vessel was used. This article may be obtained online without charge.

Journal Impact Factor: 3.226

Funding: "This work was supported in part by the NASA Human Research Program and the University of Houston Institute for Space Systems Operations (ISSO) Program."

 

7

Zhang J, Shim G, de Toledo SM, Azzam EI.

The translationally controlled tumor protein and the cellular response to ionizing radiation-induced DNA damage.

Results Probl Cell Differ. 2017;64:227-53.

https://www.ncbi.nlm.nih.gov/pubmed/29149412

PI: E.I. Azzam

Journal Impact Factor: 2.12

Funding: "This work was supported by grant CA049062 from the National Institutes of Health, grant NNX15AD62G from the National Aeronautics and Space Administration, and the Program for Changjiang Scholars and Innovative Research Team, University of Ministry of Education, China."

 

8

Karmali F, Bermúdez Rey MC, Clark TK, Wang W, Merfeld DM.

Multivariate analyses of balance test performance, vestibular thresholds, and age.

Front Neurol. 2017 Nov 8;8:578.

https://www.ncbi.nlm.nih.gov/pubmed/29167656

PI: T.K. Clark, NSBRI Postdoctoral Fellowship Program

Note: This article may be obtained online without charge.

Journal Impact Factor: 3.184

Funding: "This research was supported by NIH/NIDCD R01-DC01458, R01-DC014924 and R03-DC013635." PI reports funding under NSBRI NCC 9-58-PF03502.

 

9

Clément G.

International roadmap for artificial gravity research.

npj Microgravity. 2017 Nov 24;3(1):29. Review.

https://www.nature.com/articles/s41526-017-0034-8

Note: This article may be obtained online without charge.

Journal Impact Factor: Not available for this journal

Funding: No funding cited. C. Clément is affiliated with NASA Johnson Space Center.

______________________________________________________

 

Other papers of interest:

 

1

Lacquaniti F, Ivanenko YP, Sylos-Labini F, La Scaleia V, La Scaleia B, Willems PA, Zago M.

Human locomotion in hypogravity: From basic research to clinical applications.

Front Physiol. 2017 Nov 7;8:893. Review.

https://www.ncbi.nlm.nih.gov/pubmed/29163225

Note: Apollo and parabolic flight results. Discussion of simulators focuses on body weight support systems, lower body positive pressure, passive gravity balancing systems, and exoskeletons. This article may be obtained online without charge.

 

2

Costa-Almeida R, Granja PL, Gomes ME.

Gravity, tissue engineering, and the missing link.

Trends Biotechnol. 2017 Nov 16. [Epub ahead of print]

https://www.ncbi.nlm.nih.gov/pubmed/29153346

Note: Discussion focuses on spaceflight, rotation, and centrifugation.

 

3

Barnes KR, Janecke JN.

Physiological and biomechanical responses of highly trained distance runners to lower-body positive pressure treadmill running.

Sports Med Open. 2017 Nov 21;3(1):41.

https://www.ncbi.nlm.nih.gov/pubmed/29159682  

 

4

Mayo B, Miles C, Sims S, Driller M.

The effect of resistance training in a hypoxic chamber on physical performance in elite rugby athletes.

High Alt Med Biol. 2017 Nov 21. [Epub ahead of print]

https://www.ncbi.nlm.nih.gov/pubmed/29161094

 

5

Williams CT, Buck CL, Sheriff MJ, Richter MM, Krause JS, Barnes BM.

Sex-dependent phenological plasticity in an Arctic hibernator.

Am Nat. 2017 Dec;190(6):854-9.

https://www.ncbi.nlm.nih.gov/pubmed/29166160

 

6

Goswami N, Blaber AP, Hinghofer-Szalkay H, Montani JP.

Orthostatic intolerance in older persons: Etiology and countermeasures.

Front Physiol. 2017 Nov 9;8:803.

https://www.ncbi.nlm.nih.gov/pubmed/29163185

Note: This article may be obtained online without charge.

 

7

Wang S, Yin Z, Zhao B, Qi Y, Liu J, Rahimi SA, Lee LY, Li S.

Microgravity simulation activates Cdc42 via Rap1GDS1 to promote vascular branch morphogenesis during vasculogenesis.

Stem Cell Res. 2017 Dec;25:157-65.

https://www.ncbi.nlm.nih.gov/pubmed/29145128

Note: A 2-D clinostat was used. This article may be obtained online without charge.

 

8

Murphy FG, Hada EA, Doolette DJ, Howle LE.

Probabilistic pharmacokinetic models of decompression sickness in humans: Part 2, Coupled perfusion-diffusion models.

Comput Biol Med. 2018 Jan;92:90-7. Epub 2017 Nov 15.

https://www.ncbi.nlm.nih.gov/pubmed/29161578

 

9

Guitart M, Lloreta J, Mañas-Garcia L, Barreiro E.

Muscle regeneration potential and satellite cell activation profile during recovery following hindlimb immobilization in mice.

J Cell Physiol. 2017 Nov 18. [Epub ahead of print]

https://www.ncbi.nlm.nih.gov/pubmed/29150943

Note: Hindlimb unloading study.

 

10

Hu X, Charles JP, Akay T, Hutchinson JR, Blemker SS.

Are mice good models for human neuromuscular disease? Comparing muscle excursions in walking between mice and humans.

Skelet Muscle. 2017 Nov 16;7(1):26.

https://www.ncbi.nlm.nih.gov/pubmed/29145886

Note: This article may be obtained online without charge.

 

11

Curtis KJ, Coughlin TR, Mason DE, Boerckel JD, Niebur GL.

Bone marrow mechanotransduction in porcine explants alters kinase activation and enhances trabecular bone formation in the absence of osteocyte signaling.

Bone. 2018 Feb;107:78-87. Epub 2017 Nov 14.

https://www.ncbi.nlm.nih.gov/pubmed/29154967

 

12

Khrimian L, Obri A, Karsenty G.

Modulation of cognition and anxiety-like behavior by bone remodeling.

Mol Metab. 2017 Dec;6(12):1610-5.

https://www.ncbi.nlm.nih.gov/pubmed/29157601

Note: This article may be obtained online without charge.

 

13

Pelin T, Aramesh T, Constantin D, Mirjam N, Mihir S, Siamak S, Roland S, Michael S, Devakar E.

Early mechanical stimulation only permits timely bone healing in sheep.

J Orthop Res. 2017 Nov 21. [Epub ahead of print]

https://www.ncbi.nlm.nih.gov/pubmed/29159911

 

14

Schofield PN, Kondratowicz M.

Evolving paradigms for the biological response to low dose ionising radiation; the role of epigenetics.

Int J Radiat Biol. 2017 Nov 20. [Epub ahead of print]

https://www.ncbi.nlm.nih.gov/pubmed/29157078

 

15

Mullick AA, Turpin NA, Hsu SC, Subramanian SK, Feldman AG, Levin MF.

Referent control of the orientation of posture and movement in the gravitational field.

Exp Brain Res. 2017 Nov 21. [Epub ahead of print]

https://www.ncbi.nlm.nih.gov/pubmed/29164285

 

16

Hodkinson PD, Anderton RA, Posselt BN, Fong KJ.

An overview of space medicine.

Br J Anaesth. 2017 Dec 1;119(Suppl 1):i143-i53. Review.

https://www.ncbi.nlm.nih.gov/pubmed/29161391

Note: From the abstract: "This review introduces the field of space medicine and describes the different types of spaceflight, environmental challenges, associated medical and physiological effects, and operational medical considerations. It will describe the varied roles of the space medicine doctor, including the conduct of surgery and anaesthesia, and concludes with a vision of the future for space medicine in the UK."

 

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