NASA Spaceline Current Awareness List #777 8 December 2017 (Space Life Science Research Results)

Status Report From: Spaceline
Posted: Friday, December 8, 2017

SPACELINE Current Awareness Lists are distributed via listserv. Please send any correspondence to Robyn Ertwine, SPACELINE Current Awareness Senior Editor,

Papers deriving from NASA support:


Ward C, Rettig TA, Hlavacek S, Bye BA, Pecaut MJ, Chapes SK.

Effects of spaceflight on the immunoglobulin repertoire of unimmunized C57BL/6 mice.

Life Sci Space Res. 2017 Dec 2. [Article in Press]

PIs: S.K. Chapes, M.J. Pecaut

Note: ISS results.

Journal Impact Factor: 1.97

Funding: The PIs report: "Our work is supported by NASA grants NNX13AN34G and NNX15AB45G, NIH grant GM103418."



Dutta SM, Hadley MM, Peterman S, Jewell JS, Duncan VD, Britten RA.

Quantitative proteomic analysis of the hippocampus of rats with GCR-induced spatial memory impairment.

Radiat Res. 2017 Dec 5. [Epub ahead of print]

PI: R.A. Britten

Journal Impact Factor: 2.539

Funding: "This work was funded by NASA (grant nos. NNX11AC56G and NNX14AE73G)."



Rudobeck E, Bellone JA, Szücs A, Bonnick K, Mehrotra-Carter S, Badaut J, Nelson GA, Hartman RE, Vlkolinsky R.

Low-dose proton radiation effects in a transgenic mouse model of Alzheimer's disease - Implications for space travel.

PLoS One. 2017 Nov 29;12(11):e0186168.

PIs: R. Vlkolinsky; C. Limoli/G.A. Nelson/R. Vlkolinsky/NSCOR

Note: This article may be obtained online without charge.

Journal Impact Factor: 2.806

Funding: "This work was funded by National Astronautics and Space Administration (NASA) grant NNX11AE41G (R. Vlkolinsky), and in part by grant NNX15AI22G (G. A. Nelson). A. Szücs was partially supported by the National Research, Development and Innovation Office of Hungary under grant KTIA_NAP_13-2014-0018."



Mulvihill JJE, Raykin J, Snider EJ, Schildmeyer LA, Zaman I, Platt MO, Kelly DJ, Ethier CR.

Development of a platform for studying 3D astrocyte mechanobiology: Compression of astrocytes in collagen gels.

Ann Biomed Eng. 2017 Nov 27. [Epub ahead of print]

PI: J. Raykin, NSBRI Postdoctoral Fellowship Program

Journal Impact Factor: 3.221

Funding: "This work was supported by the Georgia Research Alliance, the Irish Research Council through the ELEVATE: Irish Research Council International Career Development Fellowship—co-funded by Marie Curie Actions, the National Space Biomedical Research Institute through NCC 9-58, and the National Science Foundation Graduate Research Fellowship under Grant No. DGE-1148903."



Koppelmans V, Bloomberg JJ, Mulavara AP, Seidler RD.

Erratum: Brain structural plasticity with spaceflight.

npj Microgravity. 2017 Nov 27;3(1):30.

PI: R.D. Seidler

Note: "In this Article, data within Supplementary Figure 1 inadvertently included information that breached subject confidentiality. This information has been removed from Supplementary Figure 1 in the online versions of the paper." The original citation appeared in SPACELINE Current Awareness List #729, 23 Dec 2015. This article may be obtained online without charge.

Journal Impact Factor: Not available for this journal

Funding: From the original entry: "This work was supported by a grant from the National Aeronautics and Space Administration (NASA; NNX11AR02G)."



Other papers of interest:



Gloor GB, Macklaim JM, Pawlowsky-Glahn V, Egozcue JJ.

Microbiome datasets are compositional: And this is not optional.

Front Microbiol. 2017 Nov 15;8:2224. Review.

Note: This article may be obtained online without charge.



Gupta V, Sorrell VL.

Sometimes you have to tilt your head and strain to take a picture of the truth.

J Am Soc Echocardiogr. 2017 Dec;30(12):1189-92.

Note: This is an Editorial Comment on the article: Negishi K, Borowski AG, Popovic ZB, Greenberg NL, Martin DS, Bungo MW, Levine BD, Thomas JD. Effect of gravitational gradients on cardiac filling and performance. J Am Soc Echocardiogr. 2017 Dec;30(12):1180-1188. Epub 2017 Oct 19. The study was NASA-funded and the citation appeared in SPACELINE Current Awareness List #771, 27 Oct 2017.



Zhang H, Yan H, Ying J, Du L, Zhang C, Yang Y, Wang H, Wang H.

Resveratrol ameliorates ionizing irradiation-induced long-term immunosuppression in mice.

Int J Radiat Biol. 2017 Nov 29. [Epub ahead of print]



Aihara M, Hirose N, Katsuta W, Saito F, Maruyama H, Hagiwara H.

A new model of skeletal muscle atrophy induced by immobilization using a hook-and-loop fastener in mice.

J Phys Ther Sci. 2017 Oct;29(10):1779-83.

Note: A hook-and-loop Velcro fastener was used for hindlimb immobilization. This article may be obtained online without charge.



Felsenthal N, Zelzer E.

Mechanical regulation of musculoskeletal system development.

Development. 2017 Dec 1;144(23):4271-83. Review.

Note: This article may be obtained online without charge.



Hartley A, Gregson CL, Hannam K, Deere KC, Clark EM, Tobias JH.

Sarcopenia is negatively related to high gravitational impacts achieved from day-to-day physical activity.

J Gerontol A Biol Sci Med Sci. 2017 Nov 22. [Epub ahead of print]

Note: From the Abstract: "We aimed to determine if sarcopenia, and specific components of muscle size, function and physical performance, are associated with high impacts achieved during habitual PA, as these are related to bone strength in community-dwelling older women." This article may be obtained online without charge.



Kozakowska M, Pietraszek-Gremplewicz K, Ciesla M, Seczynska M, Bronisz-Budzynska I, Podkalicka P, Bukowska-Strakova K, Loboda A, Jozkowicz A, Dulak J.

Lack of heme oxygenase-1 induces inflammatory reaction and proliferation of muscle satellite cells after cardiotoxin-induced skeletal muscle injury.

Am J Pathol. 2017 Nov 20. [Epub ahead of print]



Lieber RL, Roberts TJ, Blemker SS, Lee SSM, Herzog W.

Skeletal muscle mechanics, energetics and plasticity.

J Neuroeng Rehabil. 2017 Oct 23;14(1):108.

Note: This article may be obtained online without charge.



Verney J, Martin V, Ratel S, Chavanelle V, Bargetto M, Etienne M, Chaplais E, Le Ruyet P, Bonhomme C, Combaret L, Guillet C, Boisseau N, Sirvent P, Dardevet D.

Soluble milk proteins improve muscle mass recovery after immobilization-induced muscle atrophy in old rats but do not improve muscle functional property restoration.

J Nutr Health Aging. 2017 Dec;21(10):1133-41.

Note: Hindlimb unloading study.



Pastrama MI, Scheiner S, Pivonka P, Hellmich C.

A mathematical multiscale model of bone remodeling, accounting for pore space-specific mechanosensation.

Bone. 2017 Nov 20. [Epub ahead of print]



Tsukamoto M, Sakai A.

[Immobilization and bone remodeling disorder].

Clin Calcium. 2017;27(12):1723-30. Japanese.



Klochkova SV, Kvaratskheliya AG, Alekseeva NT, Nikityuk DB.

Regeneration potential of lymphoid tissue of small intestine in mice after exposure to low-intensity radiation.

Bull Exp Biol Med. 2017 Dec;164(2):214-7.



Palmisano S, Arcioni B, Stapley PJ.

Predicting vection and visually induced motion sickness based on spontaneous postural activity.

Exp Brain Res. 2017 Nov 27. [Epub ahead of print]



Bohlmann UM, Bürger MJF.

Anthropomorphism in the search for extra-terrestrial intelligence – The limits of cognition?

Acta Astronaut. 2018 Feb;143:163-8. Epub 2017 Nov 24.

Note: From the Abstract: "This paper aims at pinpointing [anthropomorphism] in a number of classical reactions to basic questions related to the search for extra-terrestrial intelligence. Many of these reactions are based on human motives such as curiosity and fear, rationalised by experience and historical analogy and modelled in the Science Fiction Culture by literature and movies."



De Sá Teixeira NA, Kerzel D, Hecht H, Lacquaniti F.

A novel dissociation between representational momentum and representational gravity through response modality.

Psychol Res. 2017 Nov 23. [Epub ahead of print]

Note: From the Introduction: "In the present study, we investigate whether knowledge about the effects of gravity is exclusively intrinsic to the perceiver’s motor system or whether it is a cognitive factor influencing spatial judgements."



Dieterich M, Brandt T.

Global orientation in space and the lateralization of brain functions.

Curr Opin Neurol. 2017 Nov 20. [Epub ahead of print] Review.



Lee TS, Lee Y-S, Lee J, Chang BC.

Analysis of the intellectual structure of human space exploration research using a bibliometric approach: Focus on human related factors.

Acta Astronautica. 2018 Feb;143:169-82. Epub 2017 Nov 26.



Yah N, Alghamdi SS, Migdadi HM, Farooq M.

Morphological and chromosomal abnormalities in gamma radiation-induced mutagenized faba bean genotypes.

Int J Radiat Biol. 2017 Nov 29:1-32.



Smith CD, Cooper AD, Merullo DJ, Cohen BS, Heaton KJ, Claro PJ, Smith T.

Sleep restriction and cognitive load affect performance on a simulated marksmanship task.

J Sleep Res. 2017 Nov 24. [Epub ahead of print]

Note: The NASA Task Load Index was used.



Tabanfar R, Chan HHL, Lin V, Le T, Irish JC.

Development and face validation of a Virtual Reality Epley Maneuver System (VREMS) for home Epley treatment of benign paroxysmal positional vertigo: A randomized, controlled trial.

Am J Otolaryngol. 2017 Nov 14. [Epub ahead of print]

Note: The NASA Task Load Index was used.


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