SpaceRef

SpaceRef


NASA Spaceline Current Awareness List #782 19 January 2018 (Space Life Science Research Results)

Status Report From: Spaceline
Posted: Friday, January 19, 2018

SPACELINE Current Awareness Lists are distributed via listserv. Please send any correspondence to Robyn Ertwine, SPACELINE Current Awareness Senior Editor, rertwine@nasaprs.com.

Papers deriving from NASA support:

1

Griko Y, Regan MD.

Synthetic torpor: A method for safely and practically transporting experimental animals aboard spaceflight missions to deep space.

Life Sci Space Res. 2018 Jan 12. [Article in Press]

https://www.sciencedirect.com/science/article/pii/S221455241730130X

Journal Impact Factor: 1.97

Funding: "Supported in part by the NASA Human Research Program (HRP), San Jose State University Bridges Program, and NASA contract to the Carnegie Mellon University Silicon Valley #NNX08 –AB13A."

 

2

Carlson C, Singh NK, Bibra M, Sani RK, Venkateswaran K.

Pervasiveness of UVC254-resistant Geobacillus strains in extreme environments.

Appl Microbiol Biotechnol. 2018 Jan 5. [Epub ahead of print]

https://www.ncbi.nlm.nih.gov/pubmed/29305694

Journal Impact Factor: 3.42

Funding: "This study was funded by Dr. Rajesh Sani’s research funds (grant no. NNX16AQ98A) and the NASA South Dakota Space Grant Consortium (grant no. NNX15AJ13H)."

 

3

Rettig TA, Ward C, Bye BA, Pecaut MJ, Chapes SK.

Characterization of the naive murine antibody repertoire using unamplified high-throughput sequencing.

PLoS One. 2018 Jan 10;13(1):e0190982.

https://www.ncbi.nlm.nih.gov/pubmed/29320559

PIs: M.J. Pecaut, S.K. Chapes

Note: GeneLab: The data has been uploaded through NASA's GeneLab and is available under accession number GLDS-141 at https://genelab-data.ndc.nasa.gov/genelab/. This article may be obtained online without charge.

Journal Impact Factor: 2.806

Funding: "This work was supported by NNX13AN34G and NNX15AB45G from National Aeronautics and Space Administration (https://www.nasa.gov/) (SKC and MJP); GM103418 from the National Institute of Health (https://www.nih.gov/) (SKC); College of Veterinary Medicine at Kansas State University (http://www.vet.k-state.edu/); and Kansas State University Johnson Cancer - Research Center (http://cancer.k-state.edu/)."

 

4

Johansen BD, Blue RS, Castleberry TL, Antonsen EL, Vanderploeg JM.

Point-of-care ultrasound for pulmonary concerns in remote spaceflight triage environments.

Aerosp Med Hum Perform. 2018 Feb;89(2):122-9. Review.

http://www.ingentaconnect.com/content/asma/amhp/2018/00000089/00000002/art00009

PI: J.M. Vanderploeg

Journal Impact Factor: 0.933

Funding: "The authors acknowledge the support of the University of Texas Medical Branch and the Center for Space Medicine at Baylor College of Medicine. This work was further supported in part by a grant from the FAA Center of Excellence for Commercial Space Transportation. The authors acknowledge the additional support from the National Space Biomedical Research Institute (NSBRI) through NASA NCC 9-58."

 

5

Kuczmarski JM, Hord JM, Lee Y, Guzzoni V, Rodriguez D, Lawler MS, Garcia-Villatoro EL, Holly D, Ryan P, Falcon K, Garcia M, Janini Gomes M, Fluckey JD, Lawler JM.

Effect of EUK-134 on Akt-mTOR signaling in the rat soleus during 7 days of mechanical unloading.

Exp Physiol. 2018 Jan 8. [Epub ahead of print]

https://www.ncbi.nlm.nih.gov/pubmed/29315934

PIs: J.M. Lawler; J.M. Kuczmarski, NSBRI Postdoctoral Fellowship Program

Note: Hindlimb unloading study.

Journal Impact Factor: 2.912

Funding: "Support for this study was provided by funding from the NASA Space Biology program (NNX13AE45G) (JML), National Space Biomedical Research Institute through NCC 9-58 (JML, JMK), NIH (AR054084) (JML), and the Huffines Institute for Sports Medicine (JML)."

 

6

Mange A, Cao Y, Zhang S, Hienz RD, Davis CM.

Whole-body oxygen (16O) ion-exposure-induced impairments in social odor recognition memory in rats are dose and time dependent.

Radiat Res. 2018 Jan 13. [Epub ahead of print]

https://www.ncbi.nlm.nih.gov/pubmed/29332539

PIs: C.M. Davis, R.D. Hienz

Journal Impact Factor: 2.539

Funding: "This research was supported by NASA grant no. NNX15AC71G and a NASA cooperative agreement, no. NCC 9-58, with the National Space Biomedical Research Institute supported through NASA nos. NCC 9-58-PF02602 and NCC 9-58-NBPF02802."

 

7

Antonsen EL, Mulcahy RA, Rubin D, Blue RS, Canga MA, Shah R.

Prototype development of a tradespace analysis tool for spaceflight medical resources.

Aerosp Med Hum Perform. 2018 Feb;89(2):108-14.

http://www.ingentaconnect.com/content/asma/amhp/2018/00000089/00000002/art00007

Journal Impact Factor: 0.933

Funding: No funding cited. E.L. Antonsen, M.A. Canga, and R. Shah are affiliated with NASA Johnson Space Center.

 

8

Olafson KN, Nguyen TQ, Vekilov PG, Rimer JD.

Deconstructing quinoline-class antimalarials to identify fundamental physicochemical properties of beta-hematin crystal growth inhibitors.

Chemistry. 2017 Oct 4;23(55):13638-47.

https://www.ncbi.nlm.nih.gov/pubmed/28833627

PI: P.G. Vekilov

Journal Impact Factor: 5.317

Funding: "This work was supported by NIH (Grant 1R21AI126215-01), The Welch Foundation (Grant E-1794), and NASA (NNX14AD68G and NNX14AE79G)."

 

9

Olafson KN, Rimer JD, Vekilov PG.

Early onset of kinetic roughening due to a finite step width in hematin crystallization.

Phys Rev Lett. 2017 Nov 10;119(19):198101.

https://www.ncbi.nlm.nih.gov/pubmed/29219496

PI: P.G. Vekilov

Journal Impact Factor: 8.462

Funding: "This work was supported by National Institutes of Health (NIH) (Grant No. 1R21AI126215-01), National Science Foundation (NSF) (DMR-1710354), National Aeronautics and Space Administration (NASA) (NNX14AD68G and NNX14AE79G), and The Welch Foundation (Grant No. E-1794)."

 

10

Safari MS, Byington MC, Conrad JC, Vekilov PG.

Polymorphism of lysozyme condensates.

J Phys Chem B. 2017 Oct 5;121(39):9091-101.

https://www.ncbi.nlm.nih.gov/pubmed/28881129

PI: P.G. Vekilov

Journal Impact Factor: 3.177

Funding: "This work was supported by grants from NASA (NNX14AD68G and NNX14AE79G), NSF (MCB-1518204, DMR-1710354, and DMR-1131155), and the Welch Foundation (E-1869)."

______________________________________________________

 

Other papers of interest:

 

1

Krause L, Braun M, Hauslage J, Hemmersbach R.

Analysis of statoliths displacement in Chara rhizoids for validating the microgravity-simulation quality of clinorotation modes.

Microgravity Sci Technol. 2018 Jan 13. [Article in Press]

https://link.springer.com/article/10.1007%2Fs12217-017-9580-7

Note: MAXUS sounding rocket results. A Random Positioning Machine was used for ground-based experiments.

 

2

Masiello MG, Verna R, Cucina A, Bizzarri M.

Physical constraints in cell fate specification. A case in point: Microgravity and phenotypes differentiation.

Prog Biophys Mol Biol. 2018 Jan 4. [Epub ahead of print]

https://www.ncbi.nlm.nih.gov/pubmed/29307754

Note: Specific spaceflights and microgravity simulation methods are not identified.

 

3

Al-horani RA, Wingo JE, Ng J, Bishop P, Richardson M.

Precooling and warm-up effects on time trial cycling during heat stress.

Aerosp Med Hum Perform. 2018 Feb;89(2):87-93.

http://www.ingentaconnect.com/content/asma/amhp/2018/00000089/00000002/art00004

 

4

Dey S, Choudhury S.

Physiological significance of gravity receptors on larval cephalic cuticle in the silk moth, Antheraea proylei Jolly.

Microsc Res Tech. 2018 Jan 8. [Epub ahead of print]

https://www.ncbi.nlm.nih.gov/pubmed/29316029

 

5

Faherty SL, Villanueva-Cañas JL, Blanco MB, Albà MM, Yoder AD.

Transcriptomics in the wild: Hibernation physiology in free-ranging dwarf lemurs.

Mol Ecol. 2018 Jan 10. [Epub ahead of print]

https://www.ncbi.nlm.nih.gov/pubmed/29319912

Note: This article may be obtained online without charge.

 

6

Radugina E, Grigoryan E.

Heat shock response and shape regulation during newt tail regeneration.

J Therm Biol. 2018 Jan;71:171-9.

https://www.ncbi.nlm.nih.gov/pubmed/29301687

Note: Results are compared to prior studies that used centrifugation during regeneration. This article may be obtained online without charge.

 

7

Szivak TK, Lee EC, Saenz C, Flanagan SD, Focht BC, Volek JS, Maresh CM, Kraemer WJ.

Adrenal stress and physical performance during military survival training.

Aerosp Med Hum Perform. 2018 Feb;89(2):99-107.

http://www.ingentaconnect.com/content/asma/amhp/2018/00000089/00000002/art00006

 

8

Xie X, Liu D, Lei D, Liu Y, Wang Q, Wen Z, Qiu J, Jia D, Gregersen H, Wang G.

Effects of simulated microgravity on vascular development in zebrafish.

Mol Cell Biomech. 2017;14(3):171-86.

http://www.techscience.com/doi/10.3970/mcb.2017.014.171.html

Note: An MG-IIA bioreactor was used. This article may be obtained online without charge.

 

9

Kim D, Kim YH, Kwon S.

Enhanced nasal drug delivery efficiency by increasing mechanical loading using hypergravity.

Sci Rep. 2018 Jan 9;8(1):168.

https://www.ncbi.nlm.nih.gov/pubmed/29317727

Note: Centrifugation was used.

 

10

Li EW, McKee-Muir OC, Gilbert PM.

Cellular biomechanics in skeletal muscle regeneration.

Curr Top Dev Biol. 2018;126:125-76. Review.

https://www.ncbi.nlm.nih.gov/pubmed/29304997

 

11

Bauer DC, Black DM, Bouxsein ML, Lui LY, Cauley JA, de Papp AE, Grauer A, Khosla S, McCulloch CE, Eastell R.

Treatment-related changes in bone turnover and fracture risk reduction in clinical trials of anti-resorptive drugs: A meta-regression.

J Bone Miner Res. 2018 Jan 10. [Epub ahead of print]

https://www.ncbi.nlm.nih.gov/pubmed/29318649

 

12

Fitzgerald J.

Cartilage breakdown in microgravity—a problem for long-term spaceflight?

npj Regen Med. 2017 Apr 11;2:10.

https://www.ncbi.nlm.nih.gov/pubmed/29302346

Note: The Editorial discusses recent research about the mechanisms of joint tissue damage in microgravity and repair after return to Earth. This article may be obtained online without charge.

 

13

Liu C, Carrera R, Flamini V, Kenny L, Cabahug-Zuckerman P, George BM, Hunter D, Liu B, Singh G, Leucht P, Mann KA, Helms JA, Castillo AB.

Effects of mechanical loading on cortical defect repair using a novel mechanobiological model of bone healing.

Bone. 2018 Mar;108:145-55.

https://www.ncbi.nlm.nih.gov/pubmed/29305998

 

14

St Hilaire MA, Rahman SA, Gooley JJ, Witt-Enderby PA, Lockley SW.

Relationship between melatonin and bone resorption rhythms in premenopausal women.

J Bone Miner Metab. 2018 Jan 9. [Epub ahead of print]

https://www.ncbi.nlm.nih.gov/pubmed/29318392

 

15

Barthel J, Sarigul-Klijn N.

Radiation production and absorption in human spacecraft shielding systems under high charge and energy Galactic Cosmic Rays: Material medium, shielding depth, and byproduct aspects.

Acta Astronaut. 2018 Mar;144:254-62.

http://www.sciencedirect.com/science/article/pii/S0094576517311724

 

16

Hagiwara Y, Niimi A, Isono M, Yamauchi M, Yasuhara T, Limsirichaikul S, Oike T, Sato H, Held KD, Nakano T, Shibata A.

3D-structured illumination microscopy reveals clustered DNA double-strand break formation in widespread γH2AX foci after high LET heavy-ion particle radiation.

Oncotarget. 2017 Nov 25;8(65):109370-81.

https://www.ncbi.nlm.nih.gov/pubmed/29312614

Note: This article may be obtained online without charge.

 

17

Heselich A, Frieß JL, Ritter S, Benz NP, Layer PG, Thielemann C.

High LET radiation shows no major cellular and functional effects on primary cardiomyocytes in vitro.

Life Sci Space Res. 2018 Jan 11. [Article in Press]

https://www.sciencedirect.com/science/article/pii/S2214552417301025

 

18

Kartashov DA, Shurshakov V.

Analysis of space radiation exposure levels at different shielding configurations by ray-tracing dose estimation method.

Acta Astronaut. 2018 Jan 10. [Article in Press]

https://www.sciencedirect.com/science/article/pii/S0094576517303983

 

19

Previc FH.

Intravestibular balance and motion sickness.

Aerosp Med Hum Perform. 2018 Feb;89(2):130-40.

http://www.ingentaconnect.com/content/asma/amhp/2018/00000089/00000002/art00010

 

20

Liu D, Xie B, Dong C, Liu G, Hu D, Qin YX, Li H, Liu H.

Effect of fertilizer prepared from human feces and straw on germination, growth and development of wheat.

Acta Astronaut. 2018 Jan 10. [Article in Press]

https://www.sciencedirect.com/science/article/pii/S0094576517311001

// end //

More status reports and news releases or top stories.

Please follow SpaceRef on Twitter and Like us on Facebook.

SpaceRef Newsletter