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NASA Spaceline Current Awareness List #783 26 January 2018 (Space Life Science Research Results)

Status Report From: Spaceline
Posted: Friday, January 26, 2018

SPACELINE Current Awareness Lists are distributed via listserv and are available on the NASA Task Book website at https://taskbook.nasaprs.com/Publication/spaceline.cfm. Please send any correspondence to Robyn Ertwine, SPACELINE Current Awareness Senior Editor, SPACELINE@nasaprs.com.

Papers deriving from NASA support:

1

Urbaniak C, Sielaff AC, Frey KG, Allen JE, Singh N, Jaing C, Wheeler K, Venkateswaran K.

Detection of antimicrobial resistance genes associated with the International Space Station environmental surfaces.

Sci Rep. 2018 Jan 16;8(1):814.

https://www.ncbi.nlm.nih.gov/pubmed/29339831

PIs: K. Venkateswaran, C. Jaing

Note: ISS results. GeneLab: "The raw metagenomics sequences can be downloaded from the following GeneLab website (https://genelab-data.ndc.nasa.gov/genelab/accession/GLDS-66/)." This article may be obtained online without charge.

Journal Impact Factor: 4.259

Funding: "This research was funded by a 2012 Space Biology NNH12ZTT001N grant no. 19-12829-26 under Task Order NNN13D111T award to KV which also funded post-doctoral fellowship for ACS, NS, and NASA Space Biology program sponsored NPP post-doc for CU. This work was performed under the auspices of the U.S. Department of Energy by Lawrence Livermore National Laboratory under Contract DE-AC52-07NA27344. In addition, the research carried out at Lawrence Livermore National Laboratory was funded by a 2014 Space Biology NNH14ZTT002N grant no. NNX15AJ29G award to CJ which also funded JEA."

 

2

Patel N, Pass A, Mason S, Gibson CR, Otto C.

Optical coherence tomography analysis of the optic nerve head and surrounding structures in long-duration International Space Station Astronauts.

JAMA Ophthalmol. 2018 Jan 11. [Epub ahead of print]

https://www.ncbi.nlm.nih.gov/pubmed/29327060

Note: ISS results. See the following citation for Invited Commentary: Lee AG, Mader TH, Gibson CR, Tarver W. Ocular coherence tomographic analysis of the optic nerve head and surrounding structures in Space Flight-Associated Neuro-ocular Syndrome. JAMA Ophthalmol. 2018 Jan 11. https://www.ncbi.nlm.nih.gov/pubmed/29327046.

Journal Impact Factor: 5.625

Funding: "This study was supported by a KBRwyle subcontract. Drs Patel and Pass were supported by the University of Houston College of Optometry core facilities grant NIH P30 EY007551 from the National Institutes of Health."

 

3

Lee AG, Mader TH, Gibson CR, Tarver W.

Ocular coherence tomographic analysis of the optic nerve head and surrounding structures in Space Flight-Associated Neuro-ocular Syndrome.

JAMA Ophthalmol. 2018 Jan 11. [Epub ahead of print]

https://www.ncbi.nlm.nih.gov/pubmed/29327046

Note: This is an Invited Commentary on the previous citation: Patel N, Pass A, Mason S, Gibson CR, Otto C. Optical coherence tomography analysis of the optic nerve head and surrounding structures in long-duration International Space Station astronauts. JAMA Ophthalmol. 2018 Jan 11. https://www.ncbi.nlm.nih.gov/pubmed/29327060.

Journal Impact Factor: 5.625

Funding: No funding cited. "Drs Lee, Mader, Gibson, and Tarver report serving as employees or consultants for National Aeronautics and Space Administration (NASA)."

 

4

Radford NB, DeFina LF, Leonard D, Barlow CE, Willis BL, Gibbons LW, Gilchrist SC, Khera A, Levine BD.

Cardiorespiratory fitness, coronary artery calcium and cardiovascular disease events in a cohort of generally healthy, middle aged men: Results from the Cooper Center Longitudinal Study.

Circulation. 2018 Jan 17. [Epub ahead of print]

https://www.ncbi.nlm.nih.gov/pubmed/29343464

PI: B.D. Levine

Journal Impact Factor: 19.309

Funding: "This study was supported by the National Space Biomedical Research Institute through NASA NCC 9-58."

 

5

McGinnis GJ, Raber J.

CNS side effects of immune checkpoint inhibitors: Preclinical models, genetics and multimodality therapy.

Immunotherapy. 2017 Sep;9(11):929-41.

https://www.ncbi.nlm.nih.gov/pubmed/29338610

PIs: J. Raber; M. Weil/J. Raber/NSCOR

Note: This article may be obtained online without charge.

Journal Impact Factor: 2.716

Funding: "GJ McGinnis is supported by an HHMI Medical Research Fellowship, the Collins Medical Trust, an RSNA Research Medical Student Grant (RMS1416) and the development account of J Raber. The tumor models and radiation treatment in authors’ preclinical tumor models were supported by NCI R01 CA182311 and an instrument grant from the MJ Murdock Charitable Trust and the Providence Research Foundation. For radiation studies, J Raber is supported by NASA NNJ12ZSA001N and NNX15AK13G."

 

6

Li X, Baek G, Ramanand SG, Sharp A, Gao Y, Yuan W, Welti J, Rodrigues DN, Dolling D, Figueiredo I, Sumanasuriya S, Crespo M, Aslam A, Li R, Yin Y, Mukherjee B, Kanchwala M, Hughes AM, Halsey WS, Chiang CM, Xing C, Raj GV, Burma S, de Bono J, Mani RS.

BRD4 promotes DNA repair and mediates the formation of TMPRSS2-ERG gene rearrangements in prostate cancer.

Cell Rep. 2018 Jan 16;22(3):796-808.

https://www.ncbi.nlm.nih.gov/pubmed/29346775

PI: S. Burma

Journal Impact Factor: 8.282

Funding: "The authors acknowledge the assistance of the UT Southwestern Live Cell Imaging Facility, a Shared Resource of the Harold C. Simmons Cancer Center, is supported in part by an NCI Cancer Center Support Grant (1P30 CA142543-01). NIH Pathway to Independence (PI) Award (R00CA160640) to R.S.M. and startup funds from UT Southwestern supported research reported in this publication. R.S.M. also acknowledges funding from the ACS-IRG New Investigator Award in Cancer Research (IRG-02-196), and from the Prostate Cancer Research Program (PCRP) – Impact Award – US Department of Defense (W81XWH-17-1-0675). J.d.B. (W81XWH-17-1-0676) and G.V.R. (W81XWH-17-1-0674) acknowledges funding from the Prostate Cancer Research Program (PCRP) – Impact Award – US Department of Defense. The authors acknowledge funding from Prostate Cancer UK, the Prostate Cancer Foundation, Movember, Stand Up To Cancer, the US Department of Defense, Cancer Research UK, the UK Department of Health to the ICR/Royal Marsden ECMC, the Academy of Medical Sciences, and NHS funding to the NIHR Biomedical Research Centre at the Royal Marsden and The Institute of Cancer Research. A.S. is supported by a Medical Research Council fellowship. S.B. is supported by grants from the NIH (RO1CA149461, RO1CA197796, and R21CA202403) and the National Aeronautics and Space Administration (NNX16AD78G). C.-M.C. is supported by grants from the NIH (CA103867), CPRIT (RP140367), and the Welch Foundation (I-1805). C.X. was partially supported by NIH grant UL1TR001105."

 

7

Serrador JM, Deegan BM, Geraghty MC, Wood SJ.

Enhancing vestibular function in the elderly with imperceptible electrical stimulation.

Sci Rep. 2018 Jan 10;8(1):336.

https://www.ncbi.nlm.nih.gov/pubmed/29321511

PI: J.M. Serrador

Note: This article may be obtained online without charge.

Journal Impact Factor: 4.259

Funding: "This work was supported by NASA (grant NNJ04HI13G), the Science Foundation Ireland Walton Visiting Fellow Award."

______________________________________________________

 

 

Other papers of interest:

 

1

Baio J, Martinez AF, Bailey LL, Hasaniya N, Pecaut M, Kearns-Jonker M.

Spaceflight activates protein kinase C alpha signaling and modifies the developmental stage of human neonatal cardiovascular progenitor cells.

Stem Cells Dev. 2018 Jan 10. [Epub ahead of print]

https://www.ncbi.nlm.nih.gov/pubmed/29320953

Note: ISS results. Funding for this experiment was provided by the Center for Advancement of Science in Space (Grant no. GA-2014-130 to MKJ).

 

2

Xu D, Gao Y, Guo L, Lin C, Sun Y.

Effect of dys-1 mutation on gene expression profile in space-flown C. elegans.

Muscle Nerve. 2018 Jan 18. [Epub ahead of print]

https://www.ncbi.nlm.nih.gov/pubmed/29346705

Note: Shenzhou-8 results.

 

3

Fischer J, Laforsch C.

The influence of gravity and light on locomotion and orientation of Heterocypris incongruens and Notodromas monacha (Crustacea, Ostracoda).

npj Microgravity. 2018 Jan 18;4(1):3.

https://www.ncbi.nlm.nih.gov/pubmed/29367947  

Note: Parabolic flight and TEXUS results. Clinorotation was used for ground-based experiments. This article may be obtained online without charge.

 

4

Li W, Wang D, Wang D.

Regulation of the response of Caenorhabditis elegans to simulated microgravity by p38 mitogen-activated protein kinase signaling.

Sci Rep. 2018 Jan 16;8(1):857.

https://www.ncbi.nlm.nih.gov/pubmed/29339777

Note: The Synthecon Rotary System™ was used. This article may be obtained online without charge.

 

5

Mayorova TD, Smith CL, Hammar K, Winters CA, Pivovarova NB, Aronova MA, Leapman RD, Reese TS.

Cells containing aragonite crystals mediate responses to gravity in Trichoplax adhaerens (Placozoa), an animal lacking neurons and synapses.

PLoS One. 2018 Jan 17;13(1):e0190905.

https://www.ncbi.nlm.nih.gov/pubmed/29342202

Note: A change in gravity was accomplished by tilting lab cover slips with attached animals to 90°. This article may be obtained online without charge.

 

6

Hatzistergos KE, Jiang Z, Valasaki K, Takeuchi LM, Balkan W, Atluri P, Saur D, Seidler B, Tsinoremas N, DiFede D, Hare JM.

Simulated microgravity impairs cardiac autonomic neurogenesis from neural crest cells.

Stem Cells Dev. 2018 Jan 16. [Epub ahead of print]

https://www.ncbi.nlm.nih.gov/pubmed/29336212

Note: A rotary cell suspension systems was used. Partially funded by "Award #GA2014131 from the Center for the Advancement of Science in Space (CASIS) to J.M.H."

 

7

Kopp S, Sahana J, Islam T, Petersen AG, Bauer J, Corydon TJ, Schulz H, Saar K, Huebner N, Slumstrup L, Riwaldt S, Wehland M, Infanger M, Luetzenberg R, Grimm D.

The role of NFκB in spheroid formation of human breast cancer cells cultured on the Random Positioning Machine.

Sci Rep. 2018 Jan 17;8(1):921.

https://www.ncbi.nlm.nih.gov/pubmed/29343717

Note: A Random Positioning Machine was used. This article may be obtained online without charge.

 

8

He L, Chen Z, Wang S, Wu M, Setlow P, Li YQ.

Germination, outgrowth and vegetative growth kinetics of dry heat-treated individual spores of Bacillus species.

Appl Environ Microbiol. 2018 Jan 12. [Epub ahead of print]

https://www.ncbi.nlm.nih.gov/pubmed/29330188

 

9

Chang SF, Lin PC, Yang RS, Yang RJ.

The preliminary effect of whole-body vibration intervention on improving the skeletal muscle mass index, physical fitness, and quality of life among older people with sarcopenia.

BMC Geriatr. 2018 Jan 17;18(1):17.

https://www.ncbi.nlm.nih.gov/pubmed/29343219

Note: This article may be obtained online without charge.

 

10

Kawao N, Moritake A, Tatsumi K, Kaji H.

Roles of irisin in the linkage from muscle to bone during mechanical unloading in mice.

Calcif Tissue Int. 2018 Jan 13. [Epub ahead of print]

https://www.ncbi.nlm.nih.gov/pubmed/29332162

Note: Hindlimb unloading was used.

 

11

Hara ES, Okada M, Nagaoka N, Hattori T, Iida LM, Kuboki T, Nakano T, Matsumoto T.

Chondrocyte burst promotes space for mineral expansion.

Integr Biol (Camb). 2018 Jan 22;10(1):57-66.

https://www.ncbi.nlm.nih.gov/pubmed/29334399

Note: Hindlimb immobilization was used.

 

12

Allen B, Acharya MM, Lu C, Giedzinski E, Chmielewski N, Quach D, Hefferan M, Johe KK, Limoli CL.

Remediation of radiation-induced cognitive dysfunction through oral administration of the neuroprotective compound NSI-189.

Radiat Res. 2018 Jan 19. [Epub ahead of print]

https://www.ncbi.nlm.nih.gov/pubmed/29351056

 

13

Alp M, Cucinotta FA.

Biophysics model of heavy-ion degradation of neuron morphology in mouse hippocampal granular cell layer neurons.

Radiat Res. 2018 Jan 18. [Epub ahead of print]

https://www.ncbi.nlm.nih.gov/pubmed/29346028

 

14

Rudqvist N, Laiakis EC, Ghandhi SA, Kumar S, Knotts JD, Chowdhury M, Fornace AJ Jr, Amundson SA.

Global gene expression response in mouse models of DNA repair deficiency after gamma irradiation.

Radiat Res. 2018 Jan 19. [Epub ahead of print]

https://www.ncbi.nlm.nih.gov/pubmed/29351057

 

15

Laurens J, Angelaki DE.

The brain compass: A perspective on how self-motion updates the head direction cell attractor.

Neuron. 2018 Jan 17;97(2):275-89.

https://www.ncbi.nlm.nih.gov/pubmed/29346751

 

16

Wei Y, Zheng J, So RHY.

Allocating less attention to central vision during vection is correlated with less motion sickness.

Ergonomics. 2018 Jan 11. [Epub ahead of print]

https://www.ncbi.nlm.nih.gov/pubmed/29325490

 

17

Lock J, Bearman C.

Normalization of deviation: Quotation error in human factors.

Hum Factors. 2018 Jan 1. [Epub ahead of print]

https://www.ncbi.nlm.nih.gov/pubmed/29328781

Note: From Methods: "A study was conducted examining quotation accuracy of 187 extracts from 118 published articles that cited a control article (Vaughan’s 1996 book: The Challenger Launch Decision: Risky Technology, Culture, and Deviance at NASA)."

 

18

Basner M, Dinges DF.

Sleep duration in the United States 2003-2016: First signs of success in the fight against sleep deficiency?

Sleep. 2018 Jan 8. [Epub ahead of print]

https://www.ncbi.nlm.nih.gov/pubmed/29325164

 

19

Barger LK, Runyon MS, Renn ML, Moore CG, Weiss PM, Condle JP, Flickinger KL, Divecha AA, Coppler PJ, Sequeira DJ, Lang ES, Higgins JS, Patterson PD.

Effect of fatigue training on safety, fatigue, and sleep in emergency medical services personnel and other shift workers: A systematic review and meta-analysis.

Prehosp Emerg Care. 2018 Jan 11. [Epub ahead of print]

https://www.ncbi.nlm.nih.gov/pubmed/29324059

Note: This article may be obtained online without charge.

 

20

Martin-Gill C, Barger LK, Moore CG, Higgins JS, Teasley EM, Weiss PM, Condle JP, Flickinger KL, Coppler PJ, Sequeira DJ, Divecha AA, Matthews ME, Lang ES, Patterson PD.

Effects of napping during shift work on sleepiness and performance in emergency medical services personnel and similar shift workers: A systematic review and meta-analysis.

Prehosp Emerg Care. 2018 Jan 11. [Epub ahead of print]

https://www.ncbi.nlm.nih.gov/pubmed/29324083

Note: This article may be obtained online without charge.

 

21

Myers JB, Wages RK, Rowe D, Nollette C, Touchstone M, Sinclair J, Mund EL, Eberly JM, Montes JD, Sherlock RJ, Barger LK, Drummond SPA, Gurubhagavatula I.

What an evidence-based guideline for fatigue risk management means for us: Statements from stakeholders.

Prehosp Emerg Care. 2018 Jan 11. [Epub ahead of print]

https://www.ncbi.nlm.nih.gov/pubmed/29324078

Note: This article may be obtained online without charge.

// end //

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