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NASA Spaceline Current Awareness List #784 2 February 2018 (Space Life Science Research Results)

Status Report From: Spaceline
Posted: Friday, February 2, 2018

SPACELINE Current Awareness Lists are distributed via listserv and are available on the NASA Task Book website at https://taskbook.nasaprs.com/Publication/spaceline.cfm. Please send any correspondence to Robyn Ertwine, SPACELINE Current Awareness Senior Editor, SPACELINE@nasaprs.com.

Papers deriving from NASA support:

1

Chakraborty N, Cheema AK, Gautam A, Donohue D, Hoke A, Conley C, Jett M, Hammamieh R.

Gene-metabolite profile integration to understand the cause of spaceflight induced immunodeficiency.

npj Microgravity. 2018 Jan 29;4(1):4.

https://www.nature.com/articles/s41526-017-0038-4

Note: STS-135 results. This article may be obtained online without charge.

Journal Impact Factor: Not available for this journal

Funding: "We are thankful to MRMC for the financial support." C. Conley is affiliated with NASA Johnson Space Center.

 

2

Cromer WE, Zawieja SD, Doersch KM, Stagg H, Hunter F, Tharakan B, Childs E, Zawieja DC.

Burn injury-associated MHCII(+) immune cell accumulation around lymphatic vessels of the mesentery and increased lymphatic endothelial permeability are blocked by doxycycline treatment.

Lymphat Res Biol. 2018 Jan 23. [Epub ahead of print]

https://www.ncbi.nlm.nih.gov/pubmed/29359999

PIs: D.C. Zawieja; W.E. Cromer, NSBRI Postdoctoral Fellowship Program

Journal Impact Factor: 1.551

Funding: "NIH DK099221, HL096552, R01 HL094269, CA136466, The Scott and White Research Foundation, The Texas A&M Health Science Center, The Center for Cell Death and Differentiation, and by the National Space Biomedical Research Institute through NASA NCC 9-58." D.C. Zawieja reports funding under NASA grant NNX15AG54G for protocols used in this study.

 

3

Asselin-Labat ML, Rampersad R, Xu X, Ritchie ME, Michalski J, Huang L, Onaitis MW.

High-LET radiation increases tumor progression in a K-Ras-driven model of lung adenocarcinoma.

Radiat Res. 2017 Nov;188(5):562-70.

https://www.ncbi.nlm.nih.gov/pubmed/28952911

PIs: D.G. Kirsch/M.W. Onaitis/NSCOR

Journal Impact Factor: 2.539

Funding: "This work was funded by the National Aeronautics and Space Administration (NASA grant no. NSCOR NNX11AC60G)."

 

4

Clark TK, Yi Y, Galvan-Garza R, Bermudez Rey MC, Merfeld DM.

When uncertain, does human self-motion decision-making fully utilize complete information?

J Neurophysiol. 2017 Dec 20. [Epub ahead of print]

https://www.ncbi.nlm.nih.gov/pubmed/29357467

PI: T.K. Clark, NSBRI Postdoctoral Fellowship Program

Journal Impact Factor: 2.396

Funding: "This work was supported by the National Space Biomedical Research Institute (NSBRI) through NASA Grant NCC9-58 (T.K. Clark), via National Institute of Deafness and Other Communications Disorders Grants R01DC04158 and R01DC014924 (Y. Yi & D. M. Merfeld), and a NASA Space Technology Research Fellowship, Grant #NNX13AM68H (R.C. Galvan-Garza)."

 

5

Hilleary R, Gilroy S.

Systemic signaling in response to wounding and pathogens.

Curr Opin Plant Biol. 2018 Jan 16;43:57-62. Review.

https://www.ncbi.nlm.nih.gov/pubmed/29351871

PI: S. Gilroy

Note: This review is part of a themed issue on Physiology and Metabolism. The issue Table of Contents is available at: https://www.sciencedirect.com/journal/current-opinion-in-plant-biology/vol/43/suppl/C.

Journal Impact Factor: 7.357

Funding: "The work in the authors' laboratory is supported by grants from the National Science Foundation (MCB1329723 and IOS1557899), The National Aeronautics and Space Administration (NNX17AD52G and NNX14AT25G) and the Graduate School of the University of Wisconsin-Madison. RH was supported by NSF GRF and the Graduate School of the University of Wisconsin-Madison."

 

6

McCarroll ML, Ahmed RA, Schwartz A, Gothard MD, Atkinson SS, Hughes P, Brito JC, Assad L, Myers J, George RL.

Medical judgement analogue studies with applications to spaceflight crew medical officer.

BMJ Simul Technol Enhanc Learn. 2017 Oct;3(4):163-8.

https://www.ncbi.nlm.nih.gov/pubmed/29354280

Note: This article may be obtained online without charge.

Journal Impact Factor: 3.32

Funding: "Summa Health System received financial support for this study. The funding was provided entirely by a subcontract with Zin Technologies, Inc." J. Myers is affiliated with NASA Glenn Research Center.

 

7

Smith SM, Zwart SR.

Genetics, vitamins and astronaut eyes.

Retina Specialist. 2017 Nov:33-5.

http://www.retina-specialist.com/article/genetics-vitamins-and-astronaut-eyes

PI: S.M. Smith

Note: ISS results. While the article is not peer-reviewed, it provides an interesting look at some aspects of ophthalmic pathophysiology. This article may be obtained online without charge.

Journal Impact Factor: Not available for this journal

Funding: "The Human Health Countermeasures Element of NASA’s Human Research Program and the Nutritional Biochemistry Laboratory Team have also supported the research."

______________________________________________________

 

Other papers of interest:

 

1

Bevelacqua JJ, Mortazavi SMJ.

Commentary: Human pathophysiological adaptations to the space environment.

Front Physiol. 2018 Jan 8;8:1116.

https://www.ncbi.nlm.nih.gov/pubmed/29358922

Note: This is a commentary on the article "Human pathophysiological adaptations to the space environment" by Demontis GC, Germani MM, Caiani EG, Barravecchi I, Passino C, Angeloi D. Front. Physiol. 2017 Jan 8;8:547. The original citation appeared in SPACELINE Current Awareness List #763, 1 Sep 2017. https://www.ncbi.nlm.nih.gov/pubmed/28824446. This article may be obtained online without charge.

 

2

MacCannell ADV, Jackson EC, Mathers KE, Staples JF.

An improved method for detecting torpor entrance and arousal in a mammalian hibernator using heart rate data.

J Exp Biol. 2018 Jan 18. [Epub ahead of print]

https://www.ncbi.nlm.nih.gov/pubmed/29361606

 

3

Graham DM, Andersen T, Sharek L, Uzer G, Rothenberg K, Hoffman BD, Rubin J, Balland M, Bear JE, Burridge K.

Enucleated cells reveal differential roles of the nucleus in cell migration, polarity, and mechanotransduction.

J Cell Biol. 2018 Jan 19. [Epub ahead of print]

https://www.ncbi.nlm.nih.gov/pubmed/29351995

 

4

Jain D, Puno MR, Meydan C, Lailler N, Mason CE, Lima CD, Anderson KV, Keeney S.

ketu mutant mice uncover an essential meiotic function for the ancient RNA helicase YTHDC2.

Elife. 2018 Jan 23;7:e30919.

https://www.ncbi.nlm.nih.gov/pubmed/29360036

Note: This article may be obtained online without charge.

 

5

Hammer SM, Alexander AM, Didier KD, Smith JR, Caldwell JT, Sutterfield SL, Ade CJ, Barstow TJ.

The noninvasive simultaneous measurement of tissue oxygenation and microvascular hemodynamics during incremental handgrip exercise.

J Appl Physiol (1985). 2017 Dec 14. [Epub ahead of print]

https://www.ncbi.nlm.nih.gov/pubmed/29357515

 

6

Corbiere T, Weinheimer-Haus EM, Judex S, Koh T.

Low-Intensity vibration improves muscle healing in a mouse model of laceration injury.

J Funct Morphol Kinesiol. 2018;3(1):1.

http://www.mdpi.com/2411-5142/3/1/1

Note: This article may be obtained online without charge.

 

7

Yakabe M, Ogawa S, Ota H, Iijima K, Eto M, Ouchi Y, Akishita M.

Inhibition of interleukin-6 decreases atrogene expression and ameliorates tail suspension-induced skeletal muscle atrophy.

PLoS One. 2018 Jan 19;13(1):e0191318.

https://www.ncbi.nlm.nih.gov/pubmed/29351340

Note: Hindlimb unloading study. This article may be obtained online without charge.

 

8

Zhang SF, Zhang Y, Li B, Chen N.

Physical inactivity induces the atrophy of skeletal muscle of rats through activating AMPK/FoxO3 signal pathway.

Eur Rev Med Pharmacol Sci. 2018 Jan;22(1):199-209.

https://www.ncbi.nlm.nih.gov/pubmed/29364488

Note: Hindlimb unloading study.

 

9

Sharma D, Larriera AI, Palacio-Mancheno PE, Gatti V, Fritton JC, Bromage TG, Cardoso L, Doty SB, Fritton SP.

The effects of estrogen deficiency on cortical bone microporosity and mineralization.

Bone. 2018 Jan 20;110:1-10.

https://www.ncbi.nlm.nih.gov/pubmed/29357314

 

10

Chishti AA, Baumstark-Khan C, Koch K, Kolanus W, Feles S, Konda B, Azhar A, Spitta LF, Henschenmacher B, Diegeler S, Schmitz C, Hellweg CE.

Linear energy transfer modulates radiation-induced NF-kappa B activation and expression of its downstream target genes.

Radiat Res. 2018 Jan 25. [Epub ahead of print]

https://www.ncbi.nlm.nih.gov/pubmed/29369006

 

11

Hubert G, Aubry S.

Atmospheric cosmic-ray variation and ambient dose equivalent assessments considering ground level enhancement thanks to coupled anisotropic solar cosmic ray and extensive air shower modeling.

Radiat Res. 2017 Nov;188(5):517-31.

https://www.ncbi.nlm.nih.gov/pubmed/28841391

 

12

Port M, Majewski M, Herodin F, Valente M, Drouet M, Forcheron F, Tichy A, Sirak I, Zavrelova A, Malkova A, Becker BV, Veit DA, Waldeck S, Badie C, O'Brien G, Christiansen H, Wichmann J, Eder M, Beutel G, Vachelova J, Doucha-Senf S, Abend M.

Validating baboon ex vivo and in vivo radiation-related gene expression with corresponding human data.

Radiat Res. 2018 Jan 26. [Epub ahead of print]

https://www.ncbi.nlm.nih.gov/pubmed/29373091

 

13

Williams J, Yang N, Wood A, Zindy E, Meng QJ, Streuli CH.

Epithelial and stromal circadian clocks are inversely regulated by their mechano-matrix environment.

J Cell Sci. 2018 Jan 19. [Epub ahead of print]

https://www.ncbi.nlm.nih.gov/pubmed/29361531

Note: This article may be obtained online without charge.

 

14

Kwon JY, Bercovici HL, Cunningham K, Varnum MEW.

How will we react to the discovery of extraterrestrial life?

Front Psychol. 2018 Jan 10;8:2308.

https://www.ncbi.nlm.nih.gov/pubmed/29367849

Note: From the abstract: "We report the results of three empirical studies assessing psychological reactions to the discovery of extraterrestrial life using the Linguistic Inquiry and Word Count (LIWC) text analysis software." This article may be obtained online without charge.

 

15

Nelson M.

Pushing Our Limits: Insights from Biosphere 2.

Tucson: University of Arizona Press, 2018. 328 p.

https://uapress.arizona.edu/book/pushing-our-limits

Note: From the publisher’s website: "Pushing Our Limits is a fresh examination of Biosphere 2, the world’s first man-made mini-world, twenty-five years after its first closure experiment. Author Mark Nelson, one of the eight crew members locked in the enclosure during the 1991–1993 experiment, offers a compelling insider’s view of the dramatic story behind Biosphere 2."

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