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NASA Spaceline Current Awareness List #786 16 February 2018 (Space Life Science Research Results)

Status Report From: Spaceline
Posted: Friday, February 16, 2018

SPACELINE Current Awareness Lists are distributed via listserv and are available on the NASA Task Book website at https://taskbook.nasaprs.com/Publication/spaceline.cfm. Please send any correspondence to Robyn Ertwine, SPACELINE Current Awareness Senior Editor, SPACELINE@nasaprs.com.

Papers deriving from NASA support:

1

Colmenares SU, Swenson JM, Langley SA, Kennedy C, Costes SV, Karpen GH.

Drosophila histone demethylase KDM4A has enzymatic and non-enzymatic roles in controlling heterochromatin integrity.

Dev Cell. 2017 Jul 24;42(2):156-69.e5.

https://www.ncbi.nlm.nih.gov/pubmed/28743002

PI: S.V. Costes

Journal Impact Factor: 9.174

Funding: "This work was supported by the Ruth Kirchstein NIH Postdoctoral Fellowship (1F32GM086111) and Laboratory Directed Research and Development Program (LB13037) to S.U.C. and NIH R01 grants R01 GM086613 and GM117420 to G.H.K." The PI reports NASA support under grant NNJ16HP24I.

 

2

Cortese F, Klokov D, Osipov A, Stefaniak J, Moskalev A, Schastnaya J, Cantor C, Aliper A, Mamoshina P, Ushakov I, Sapetsky A, Vanheaelen Q, Alchinova I, Karganov M, Kovalchuk O, Wilkins RC, Shtemberg A, Moreels M, Baatout S, Izumchenko E, de Magalhães JP, Artemov AV, Costes SV, Beheshti A, Mao XW, Pecaut MJ, Kaminskiy D, Ozerov IV, Scheibye-Knudsen M, Zhavoronkov A.

Vive la radiorésistance!: Converging research in radiobiology and biogerontology to enhance human radioresistance for deep space exploration and colonization.

Oncotarget. 2018 Feb 9. [Epub ahead of print]

http://www.oncotarget.com/index.php?journal=oncotarget&page=article&op=view&path[]=24461&path[]=76813

PI: S.V. Costes

Note: From the abstract: "Herein, we lay the foundations of a roadmap toward enhancing human radioresistance for the purposes of deep space colonization and exploration. We outline future research directions toward the goal of enhancing human radioresistance, including upregulation of endogenous repair and radioprotective mechanisms, possible leeways into gene therapy in order to enhance radioresistance via the translation of exogenous and engineered DNA repair and radioprotective mechanisms, the substitution of organic molecules with fortified isoforms, and methods of slowing metabolic activity while preserving cognitive function." This article may be obtained online without charge.

Journal Impact Factor: 5.168

Funding: "The studies were partially supported by the Russian Foundation for Basic Research grant #17-29-01002 ofi_m." The PI reports NASA support under grant NNJ16HP24I.

 

3

Jandial R, Hoshide R, Waters JD, Limoli CL.

Space-brain: The negative effects of space exposure on the central nervous system.

Surg Neurol Int. 2018 Jan 16;9:9.

https://www.ncbi.nlm.nih.gov/pubmed/29416906

PI: C.L. Limoli/NSCOR

Note: This article may be obtained online without charge.

Journal Impact Factor: 1.41

Funding: "This work was supported by NASA Grant NNX15AI22G (CLL)."

 

Note: The following three articles comment on Roberts DR, Albrecht MH, Collins HR, Asemani D, Chatterjee AR, Spampinato MV, Zhu X, Chimowitz MI, Antonucci MU. Effects of spaceflight on astronaut brain structure as indicated on MRI. N Engl J Med. 2017 Nov 2;377(18):1746-53. https://www.ncbi.nlm.nih.gov/pubmed/29091569. The original article was cited in Current Awareness List #773, Nov 9, 2017. The paper reported ISS and STS results. This article may be obtained online without charge.

 

4

Wilson MH, Hargens AR, Imray CH.

Effects of spaceflight on astronaut brain structure.

N Engl J Med. 2018 Feb 8;378(6):581.

https://www.ncbi.nlm.nih.gov/pubmed/29419272

Note: This article may be obtained online without charge.

 

5

Hinkelbein J, Komorowski M, Grau S.

Effects of spaceflight on astronaut brain structure.

N Engl J Med. 2018 Feb 8;378(6):582.

https://www.ncbi.nlm.nih.gov/pubmed/29419273

Note: This article may be obtained online without charge.

 

6

Roberts DR, Antonucci MU.

Effects of spaceflight on astronaut brain structure. [Author reply]

N Engl J Med. 2018 Feb 8;378(6):581-3.

https://www.ncbi.nlm.nih.gov/pubmed/29414278

PI: D.R. Roberts

Note: This article may be obtained online without charge.

Journal Impact Factor: 72.406

Funding: The original paper was "Supported by a grant (NNX13AJ92G) from the National Aeronautics and Space Administration (NASA)."

______________________________________________________

 

 

Other papers of interest:

 

1

Dittrich A, Grimm D, Sahana J, Bauer J, Krüger M, Infanger M, Magnusson NE.

Key proteins involved in spheroid formation and angiogenesis in endothelial cells after long-term exposure to simulated microgravity.

Cell Physiol Biochem. 2018 Jan 24;45(2):429-45.

https://www.ncbi.nlm.nih.gov/pubmed/29402845

Note: A Random Positioning Machine was used. This article may be obtained online without charge.

 

2

Hinkelbein J, Russomano T, Hinkelbein F, Komorowski M.

Cardiac arrest during space missions: Specificities and challenges.

Trends Anaesth Crit Care. 2018 Feb 7. [Article in Press]

http://www.trendsanaesthesiacriticalcare.com/article/S2210-8440(17)30196-X/fulltext

Note: From the abstract:  "Here, we discuss the case of a cardiac arrest occurring during spaceflight, and present challenges around the recognition, immediate management including delivering cardio-pulmonary resuscitation and secondary measures such as organ support or evacuation."

 

3

Jiang S, Zhao XC, Jiao B, Yue ZJ, Yu ZB.

Simulated microgravity hampers Notch signaling in the fight against myocardial ischemia-reperfusion injury.

Mol Med Rep. 2018 Jan 25. [Epub ahead of print]

https://www.ncbi.nlm.nih.gov/pubmed/29393447

Note: Hindlimb unloading study. This article may be obtained online without charge.

 

4

Li CF, Sun JX, Gao Y, Shi F, Pan YK, Wang YC, Sun XQ.

Clinorotation-induced autophagy via HDM2-p53-mTOR pathway enhances cell migration in vascular endothelial cells.

Cell Death Dis. 2018 Feb 2;9(2):147.

https://www.ncbi.nlm.nih.gov/pubmed/29396411 

Note: A 2D-clinostat was used. This article may be obtained online without charge.

 

5

Wang H, Hu Z, Shi F, Dong J, Dang L, Wang Y, Sun Z, Zhou H, Zhang S, Cao X, Zhang G.

Osteoblast-targeted delivery of miR-33-5p attenuates osteopenia development induced by mechanical unloading in mice.

Cell Death Dis. 2018 Feb 7;9(2):170.

https://www.ncbi.nlm.nih.gov/pubmed/29415986

Note: Hindlimb unloading was used. This article may be obtained online without charge.

 

6

Chen L, Tang H, Du Y, Dai Z, Wang T, Wu L, Zhou L, Bian P.

Induction of reproductive cell death in Caenorhabditis elegans across entire linear-energy-transfer range of carbon-ion irradiation.

DNA Repair (Amst). 2018 Feb 1;63:39-46.

https://www.ncbi.nlm.nih.gov/pubmed/29414052

 

7

Gulay KCM, Tanaka IB 3rd, Komura J, Tanaka S.

Effects of continuous gamma-ray exposure in utero in B6C3F1 mice on gestation day 18 and at 10 weeks of age.

Radiat Res. 2018 Feb 13. [Epub ahead of print]

https://www.ncbi.nlm.nih.gov/pubmed/29437533

 

8

Yu N, Wang S, Song X, Gao L, Li W, Yu H, Zhou C, Wang Z, Li F, Jiang Q.

Low-dose radiation promotes dendritic cell migration and IL-12 production via the ATM/NF-kappaB pathway.

Radiat Res. 2018 Feb 8. [Epub ahead of print]

https://www.ncbi.nlm.nih.gov/pubmed/29420126

 

9

Tamás LT, Lundberg YW, Büki B.

Vergence increases the gain of the human angular vestibulo-ocular reflex during peripheral hyposensitivity elicited by cold thermal irrigation.

J Vestib Res. 2018;27(5-6):265-70.

https://www.ncbi.nlm.nih.gov/pubmed/29400687

 

10

Neupane AK, Gururaj K, Sinha SK.

Higher asymmetry ratio and refixation saccades in individuals with motion sickness.

J Am Acad Audiol. 2018 Feb;29(2):175-86.

https://www.ncbi.nlm.nih.gov/pubmed/29401064

 

11

Kimura T, Haga K, Shimizu-Mitao Y, Takebayashi Y, Kasahara H, Hayashi KI, Kakimoto T, Sakai T.

Asymmetric auxin distribution is not required to establish root phototropism in Arabidopsis.

Plant Cell Physiol. 2018 Feb 1. [Epub ahead of print]

https://www.ncbi.nlm.nih.gov/pubmed/29401292

 

12

Krishnamurthy RS, Hatton J.

Space science and technologies to advance health-related sustainable development goals.

Bull World Health Organ. 2018 Jan 1;96(1):3-3A.

https://www.ncbi.nlm.nih.gov/pubmed/29403092

Note: The Editorial calls on nations to strengthen health and space policy to encourage collaboration in the use of space science and technology to advance public health. This article may be obtained online without charge.

 

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