NASA Spaceline Current Awareness List #789 9 March 2018 (Space Life Science Research Results)

Status Report From: Spaceline
Posted: Friday, March 9, 2018

SPACELINE Current Awareness Lists are distributed via listserv and are available on the NASA Task Book website at Please send any correspondence to Robyn Ertwine, SPACELINE Current Awareness Senior Editor,



Papers deriving from NASA support:



Fajardo-Cavazos P, Leehan JD, Nicholson WL.

Alterations in the spectrum of spontaneous rifampicin-resistance mutations in the Bacillus subtilis rpoB gene after cultivation in the human spaceflight environment.

Front Microbiol. 2018 Feb 14;9:192. 

PI: W.T. Nicholson

Note: ISS results. This article may be obtained online without charge.

Journal Impact Factor: 4.076

Funding: "This work was supported by NASA Research Opportunities in Space Biology grants NNX12AN70G and NNX14AT38G to WN and PF-C."



Spielmann G, Laughlin MS, Kunz H, Crucian BE, Quiriarte HD, Mehta SK, Pierson DL, Simpson RJ.

Latent viral reactivation is associated with changes in plasma antimicrobial protein concentrations during long-duration spaceflight.

Acta Astronaut. 2018 Mar 2. [Article in Press]

PIs: B.E. Crucian, R.J. Simpson

Note: ISS results.

Journal Impact Factor: 1.536

Funding: "Funding to BC, DP and SM relative to the "Integrated Immune" flight study was provided by the NASA Human Research Program, Human Health and Countermeasures Element, and funding to RS relative to the “Salivary Markers” flight study was provided by NASA grants NNJ10ZSA003N, NNJ14ZSA001N-FLAGSHIP and NNJ14ZSA001N-MIXEDTOPICS."



Alperin N, Bagci AM.

Spaceflight-induced visual impairment and globe deformations in astronauts are linked to orbital cerebrospinal fluid volume increase.

Acta Neurochir Suppl. 2018;126:215-9.

PI: N. Alperin

Note: ISS results.

Journal Impact Factor: 1.17

Funding: "This work has been funded by NASA grants NNX14AB51G through a Cooperative Agreement to Alperin Noninvasive Diagnostics, Inc."



Siamwala JH, Moossazadeh DG, Macaulay TR, Becker RL, Hargens RH, Hargens AR.

Aging decreases hand volume expansion with water immersion.

Front Physiol. 2018 Feb 14;9:72.

PI: A.R. Hargens

Note: This article may be obtained online without charge.

Journal Impact Factor: 2.323

Funding: "This study was supported by a Wood Whelan travel fellowship (JS) and NASA grant NNX13AJ12G (AH)."



Yuan P, Koppelmans V, Reuter-Lorenz P, De Dios Y, Gadd N, Riascos R, Kofman I, Bloomberg J, Mulavara A, Seidler RD.

Change of cortical foot activation following 70 days of head down bed rest.

J Neurophysiol. 2018 Feb 28. [Epub ahead of print]

PI: R.D. Seidler

Note: Bed rest study.

Journal Impact Factor: 2.396

Funding: PI reports funding under NASA NNX11AR02G and NSBRI NCC 9-58-SA02802.



Dentinger A, MacDonald M, Ebert D, Garcia K, Sargsyan A.

Volumetric ophthalmic ultrasound for inflight monitoring of visual impairment and intracranial pressure.

Acta Neurochir Suppl. 2018;126:97-101.

PI: A. Dentinger

Note: Head-down tilt study.

Journal Impact Factor: 1.17

Funding: "This work was supported by a grant from the National Space Biomedical Research Institute (NSBRI) through NASA NCC 9-58."



Pennline JA, Mulugeta L.

Mapping bone mineral density obtained by quantitative computed tomography to bone volume fraction.

Cleveland, OH: NASA Glenn Research Center, 2017 Jun. 19 p. NASA/TM—2017-219490.  

Note: This article may be obtained online without charge.

Journal Impact Factor: Not applicable to this publication

Funding: No funding cited. J.A. Pennline is affiliated with NASA Glenn Research Center.



Turner RT, Martin SA, Iwaniec UT.

Metabolic coupling between bone marrow adipose tissue and hematopoiesis.

Curr Osteoporos Rep. 2018 Feb 28. [Epub ahead of print]

PI: R.T. Turner

Journal Impact Factor: 3.721

Funding: "Grants from the National Institutes of Health (AR060913 and AR066811) and the National Aeronautics and Space Administration (NNX12AL24) supported this work."



Ishak S, Bubka A, Bonato F.

Visual occlusion decreases motion sickness in a flight simulator.

Perception. 2018 Jan 1. [Epub ahead of print]

Note: This article may be obtained online without charge.

Journal Impact Factor: 1.087

Funding: "This research was supported in part by National Aeronautics and Space Administration grant NNX06AG65G and National Science Foundation grant BCS-0447785."



Thosar SS, Herzig MX, Roberts SA, Berman AM, Clemons NA, McHill AW, Bowles NP, Morimoto M, Butler MP, Emens JS, Shea SA.

Lowest perceived exertion in the late morning due to effects of the endogenous circadian system.

Br J Sports Med. 2018 Feb 23. [Epub ahead of print]

PI: S.S. Thosar, NSBRI Postdoctoral Fellowship Program

Journal Impact Factor: 6.724

Funding: "Financial support: R01-HL125893 (SAS), F32-HL131308, National Space Biomedical Research Institute through NCC 9-58 and Medical Research Foundation of Oregon (SST), F32DK107146 (AWM), American Sleep Medicine Foundation (MPB), Ford Foundation (NPB) and Oregon Institute of Occupational Health Sciences and CTSA grant (UL1TR000128)."




Other papers of interest:



Lang JM, Coil DA, Neches RY, Brown WE, Cavalier D, Severance M, Hampton-Marcell JT, Gilbert JA, Eisen JA.

A microbial survey of the International Space Station (ISS).

PeerJ. 2017 Dec 5;5:e4029.

Note: ISS results. Corrections have been made to this article and the specifics are available at This article may be obtained online without charge.



Tan X, Xu A, Zhao T, Zhao Q, Zhang J, Fan C, Deng Y, Freywald A, Genth H, Xiang J.

Simulated microgravity inhibits cell focal adhesions leading to reduced melanoma cell proliferation and metastasis via FAK/RhoA-regulated mTORC1 and AMPK pathways.

Sci Rep. 2018 Feb 28;8(1):3769.

Note: A clinostat was used. This article may be obtained online without charge.



Dulawa J, Kokot M.

Water immersion model in nephrology: From hydrotherapy to weightlessness.

G Ital Nefrol. 2018 Feb;35(Suppl 70):143-5.

Note: The impact of the space program on the use of water immersion as as investigative tool is discussed. This article may be obtained online without charge.



Beblo-Vranesevic K, Bohmeier M, Perras AK, Schwendner P, Rabbow E, Moissl-Eichinger C, Cockell CS, Vannier P, Marteinsson VT, Monaghan EP, Ehrenfreund P, Garcia-Descalzo L, Gómez F, Malki M, Amils R, Gaboyer F, Westall F, Cabezas P, Walter N, Rettberg P.

Lack of correlation of desiccation and radiation tolerance in microorganisms from diverse extreme environments tested under anoxic conditions.

FEMS Microbiol Lett. 2018 Feb 21. [Epub ahead of print]

Note: This article may be obtained online without charge.



Barassi G, Bellomo RG, Porreca A, Giannuzzo G, Irace G, Trivisano L, Saggini R.

Rehabilitation of neuromotor disabilities in aquatic microgravity environment.

Adv Exp Med Biol. 2018 Feb 28. [Epub ahead of print]

Note: Water immersion was tested in the rehabilitation of neuromotor and neurological disorders.



Chang H, Jiang S, Ma X, Peng X, Zhang J, Wang Z, Xu S, Wang H, Gao Y.

Proteomic analysis reveals the distinct energy and protein metabolism characteristics involved in myofiber type conversion and resistance of atrophy in the extensor digitorum longus muscle of hibernating Daurian ground squirrels.

Comp Biochem Physiol Part D Genomics Proteomics. 2018 Jun;26:20-31. Epub 2018 Feb 13.



Ferrando B, Gomez-Cabrera MC, Salvador-Pascual A, Puchades C, Derbre F, Gratas-Delamarche A, Laparre L, Olaso-Gonzalez G, Cerda M, Viosca E, Alabajos A, Sebastiá V, Alberich-Bayarri A, Garcia-Castro F, Viña J.

Allopurinol partially prevents disuse muscle atrophy in mice and humans.

Sci Rep. 2018 Feb 23;8(1):3549.

Note: Hindlimb unloading study. This article may be obtained online without charge.



Hvid LG, Aagaard P, Ørtenblad N, Kjaer M, Suetta C.

Plasticity in central neural drive with short-term disuse and recovery - effects on muscle strength and influence of aging.

Exp Gerontol. 2018 Feb 21. [Epub ahead of print]



Pigna E, Renzini A, Greco E, Simonazzi E, Fulle S, Mancinelli R, Moresi V, Adamo S.

HDAC4 preserves skeletal muscle structure following long-term denervation by mediating distinct cellular responses.

Skelet Muscle. 2018 Feb 24;8(1):6. 

Note: This article may be obtained online without charge.



Brent MB, Brüel A, Thomsen JS.

PTH (1-34) and growth hormone in prevention of disuse osteopenia and sarcopenia in rats.

Bone. 2018 May;110:244-53. Epub 2018 Feb 20.  

Note: Hindlimb immobilization was accomplished via botulinum toxin A.



Tajima T, Menuki K, Okuma KF, Tsukamoto M, Fukuda H, Okada Y, Kosugi K, Yamanaka Y, Uchida S, Sakai A.

Cortical bone loss due to skeletal unloading in aldehyde dehydrogenase 2 gene knockout mice is associated with decreased PTH receptor expression in osteocytes.

Bone. 2018 May;110:254-66. Epub 2018 Feb 23.

Note: Hindlimb unloading study.



Bleedorn JA, Hornberger TA, Goodman CA, Hao Z, Sample SJ, Amene E, Markel MD, Behan M, Muir P.

Temporal mechanically-induced signaling events in bone and dorsal root ganglion neurons after in vivo bone loading.

PLoS One. 2018 Feb 27;13(2):e0192760.

Note: This article may be obtained online without charge.



Li X, Zha X, Wang Y, Jia R, Hu B, Zhao B.

Toxic effects and foundation of proton radiation on the early-life stage of zebrafish development.

Chemosphere. 2018 Jun;200:302-12. Epub 2018 Feb 23.



Salamon N, Grimm JM, Horack JM, Newton EK.

Application of virtual reality for crew mental health in extended-duration space missions.

Acta Astronaut. 2018 Mar 2. [Article in Press]



Stavrou NAM, Debevec T, Eiken O, Mekjavic IB.

Hypoxia exacerbates negative emotional state during inactivity: The effect of 21 days hypoxic bed rest and confinement.

Front Physiol. 2018 Feb 8;9:26.

Note: Bed rest study. This article may be obtained online without charge.



Suedfeld P, Johnson PJ, Gushin V, Brcic J.

Motivational profiles of retired cosmonauts.

Acta Astronaut. 2018 Mar 2. [Article in Press]

Note: Autobiographical interviews with 20 retired long-duration male cosmonauts were scored for references to three core motives: the needs for Achievement, Power, and Affiliation.



Kim HK, Park J, Choi Y, Choe M.

Virtual reality sickness questionnaire (VRSQ): Motion sickness measurement index in a virtual reality environment.

Appl Ergon. 2018 May;69:66-73. Epub 2018 Jan 16.



Kim SH, Kim JS.

Effects of head position on perception of gravity in vestibular neuritis and lateral medullary infarction.

Front Neurol. 2018 Feb 12;9:60.

Note: This article may be obtained online without charge.



Haga K, Frank L, Kimura T, Schwechheimer C, Sakai T.

Roles of AGCVIII kinases in the hypocotyl phototropism of Arabidopsis seedlings.

Plant Cell Physiol. 2018 Feb 26. [Epub ahead of print]



Liu G, Dong C, Fu Y, Wang M, Shao L, Yu J, Liu H.

Is elevated CO2 in space really harmful to growth and development? A case study of Chufa (Cyperus esculentus L.) in Lunar Palace-1.

Acta Astronaut. 2018 Mar 3. [Article in Press]

Note: The study was conducted in China’s Lunar Palace 1, a bioregenerative life support system.



Wang C, Fu D.

Virus-induced gene silencing of the eggplant chalcone synthase gene during fruit ripening modifies epidermal cells and gravitropism.

J Agric Food Chem. 2018 Mar 1. [Epub ahead of print]



Mankins JC, Mankins WM, Walter H.

Biological challenges of true space settlement.

Acta Astronaut. 2018 Mar 5. [Article in Press]



Hulfish E, Diaz MCG, Feick M, Messina C, Stryjewski G.

The impact of a displayed checklist on simulated pediatric trauma resuscitations.

Pediatr Emerg Care. 2018 Feb 28. [Epub ahead of print]

Note: The NASA Task Load Index was used.



Orlandi L, Brooks B.

Measuring mental workload and physiological reactions in marine pilots: Building bridges towards redlines of performance.

Appl Ergon. 2018 May;69:74-92. Epub 2018 Jan 17.

Note: The NASA Task Load Index was used.



Turchin A, Denkenberger D.

Surviving global risks through the preservation of humanity's data on the Moon.

Acta Astronaut. 2018 Mar 2. [Article in Press]

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