NASA Spaceline Current Awareness List #801 1 June 2018 (Space Life Science Research Results)

Status Report From: Spaceline
Posted: Friday, June 1, 2018

SPACELINE Current Awareness Lists are distributed via listserv and are available on the NASA Task Book website at Please send any correspondence to Robyn Ertwine, SPACELINE Current Awareness Senior Editor,

 Papers deriving from NASA support:

The abstract in PubMed or at the publisher's site is linked when available and will open in a new window.

Papers deriving from NASA support:

  1. Urbaniak C, Massa G, Hummerick M, Khodadad C, Schuerger A, Venkateswaran K. Draft genome sequences of two Fusarium oxysporum isolates cultured from infected zinnia hybrida plants grown on the International Space Station. Genome Announc. 2018 May 17;6(20):e00326-18. PIs: K. Venkateswaran; C. Urbaniak, NASA Postdoctoral Program Note: ISS results. This article may be obtained online without charge.

    Journal Impact Factor: 1.18

    Funding: "This research was funded by a 2012 Space Biology NNH12ZTT001N grant number 19-12829-26 under Task Order NNN13D111T award to K.V. Funding for C.U. was supported by the NASA Postdoctoral Program. Funding for the Veggie hardware technology validation tests was from NASA’s Space Life and Physical Sciences Research and Applications (SLPSRA) Space Biology program."
  2. Krukowski K, Feng X, Paladini MS, Chou A, Sacramento K, Grue K, Riparip LK, Jones T, Campbell-Beachler M, Nelson G, Rosi S. Temporary microglia-depletion after cosmic radiation modifies phagocytic activity and prevents cognitive deficits. Sci Rep. 2018 May 18;8(1):7857. PI: J. Raber Note: This article may be obtained online without charge.

    Journal Impact Factor: 4.259

    Funding: "This work was supported by NASA grant NNX13AD60G. KK is supported by an NRSA post-doctoral fellowship from the NIA F32AG054126."
  3. Krukowski K, Jones T, Campbell-Beachler M, Nelson G, Rosi S. Peripheral T cells as a biomarker for oxygen-ion-radiation-induced social impairments. Radiat Res. 2018 May 29. [Epub ahead of print]. PI: J. Raber Journal Impact Factor: 2.539

    Funding: 2.539 Funding: "This research was supported by the National Aeronautic Space Agency (NASA grant no. NNX13AD60G). The San Francisco General Hospital Flow Cytometry Core Facility was supported by the NIH (grant no. P30 AI027763)."
  4. McHill AW, Hull JT, Wang W, Czeisler CA, Klerman EB. Chronic sleep curtailment, even without extended (>16-h) wakefulness, degrades human vigilance performance. Proc Natl Acad Sci U S A. 2018 May 21. [Epub ahead of print]. PIs: E.B. Klerman, D. Schreckenghost Journal Impact Factor: 9.661

    Funding: "Funding: NIH (Grants KL2TR002370, F32DK107146, T32HL007901, K24HL105664, R01HL114088, R01GM105018, R01HL128538, P01AG009975, R21HD086392) and NSBRI (Grants HFP02802, HFP04201, HDP0006)."

Other papers of interest:

  1. Zheng HQ. Flowering in space. Microgravity Sci Technol. 2018 May 31. [Article in Press] Note: Chinese satellite SJ-8 and SJ-10 and Chinese space lab TG-2 results.
  2. Bettis T, Kim BJ, Hamrick MW. Impact of muscle atrophy on bone metabolism and bone strength: Implications for muscle-bone crosstalk with aging and disuse. Osteoporos Int. 2018 May 18. [Epub ahead of print] Review. Note: The review examines results from ISS studies as well as bed rest, hindlimb unloading, and botulinum toxin studies.
  3. Sahana J, Nassef MZ, Wehland M, Kopp S, Krüger M, Corydon TJ, Infanger M, Bauer J, Grimm D. Decreased E-cadherin in MCF7 human breast cancer cells forming multicellular spheroids exposed to simulated microgravity. Proteomics. 2018 May 21. [Epub ahead of print] Note: A random positioning machine was used.
  4. Horie K, Kudo T, Yoshinaga R, Akiyama N, Sasanuma H, Kobayashi TJ, Shimbo M, Jeon H, Miyao T, Miyauchi M, Shirakawa M, Shiba D, Yoshida N, Muratani M, Takahashi S, Akiyama T. Long-term hindlimb unloading causes a preferential reduction of medullary thymic epithelial cells expressing autoimmune regulator (Aire). Biochem Biophys Res Commun. 2018 Jun 27;501(3):745-50. Note: Hindlimb unloading study.
  5. Otsuka T, Imura T, Nakagawa K, Shrestha L, Takahashi S, Kawahara Y, Sueda T, Kurisu K, Yuge L. Simulated microgravity culture enhances the neuroprotective effects of human cranial bone-derived mesenchymal stem cells in traumatic brain injury. Stem Cells Dev. 2018 May 23. [Epub ahead of print] Note: A 3D clinostat was used.
  6. Backx EMP, Horstman AMH, Marzuca-Nassr GN, van Kranenburg J, Smeets JS, Fuchs CJ, Janssen AAW, de Groot L, Snijders T, Verdijk LB, van Loon LJC. Leucine supplementation does not attenuate skeletal muscle loss during leg immobilization in healthy, young men. Nutrients. 2018 May 17;10(5):E635. Note: Full leg casts were used. This article may be obtained online without charge.
  7. Ferrara PJ, Verkerke ARP, Brault JJ, Funai K. Hypothermia decreases O2 cost for ex vivo contraction in mouse skeletal muscle. Med Sci Sports Exerc. 2018 May 22. [Epub ahead of print]
  8. Kawamoto E, Tamakoshi K, Ra SG, Masuda H, Kawanaka K. Immobilization rapidly induces thioredoxin-interacting protein (TXNIP) gene expression together with insulin resistance in rat skeletal muscle. J Appl Physiol (1985). 2018 May 24. [Epub ahead of print] Note: Hindlimb immobilization study.
  9. Penna F, Ballarò R, Beltrá M, De Lucia S, Costelli P. Modulating metabolism to improve cancer-induced muscle wasting. Oxid Med Cell Longev. 2018 Jan 29;2018:7153610. Review. Note: This article may be obtained online without charge.
  10. Shum AMY, Poljak A, Bentley NL, Turner N, Tan TC, Polly P. Proteomic profiling of skeletal and cardiac muscle in cancer cachexia: Alterations in sarcomeric and mitochondrial protein expression. Oncotarget. 2018 Apr 24;9(31):22001-22. Note: This article may be obtained online without charge.
  11. Franz-Odendaal TA, Edsall S. Long-term effects of simulated microgravity and vibration exposure on skeletal development in zebrafish. Stem Cells Dev. 2018 May 23. [Epub ahead of print] Note: A rotating wall vessel was used.
  12. Higueras M, González JE, Di Giorgio M, Barquinero J. A note on Poisson goodness-of-fit tests for ionizing radiation induced chromosomal aberration samples. Int J Radiat Biol. 2018 May 18. [Epub ahead of print]
  13. Hinrikus H, Bachmann M, Lass J. Understanding physical mechanism of low-level microwave radiation effect. Int J Radiat Biol. 2018 May 18. [Epub ahead of print] Review.
  14. Jermusek F Jr, Benedict C, Dreischmeier E, Brand M, Uder M, Jeffery JJ, Ranallo FN, Fahl WE. Significant suppression of CT radiation-induced DNA damage in normal human cells by the PrC-210 radioprotector Radiat Res. 2018 May 21. [Epub ahead of print]
  15. Pannkuk EL, Laiakis EC, Fornace AJ Jr, Fatanmi OO, Singh VK. A metabolomic serum signature from nonhuman primates treated with a radiation countermeasure, gamma-tocotrienol, and exposed to ionizing radiation. Health Phys. 2018 Jul;115(1):3-11. Epub 2018 May 23.
  16. Szarka M, Szilasi S, Donczo B, Sarkozy D, Rajta I, Guttman A. The effect of simulated space radiation on the N-glycosylation of human immunoglobulin G1. Electrophoresis. 2018 May 18. [Epub ahead of print]
  17. Takeuchi N, Mori T, Suzukamo Y, Izumi SI. Modulation of excitability in the temporoparietal junction relieves virtual reality sickness. Cyberpsychol Behav Soc Netw. 2018 May 24. [Epub ahead of print
  18. Vidafar P, Gooley JJ, Burns AC, Rajaratnam SMW, Rueger M, Van Reen E, Czeisler CA, Lockley SW, Cain SW. Increased vulnerability to attentional failure during acute sleep deprivation in women depends on menstrual phase. Sleep. 2018 May 22. [Epub ahead of print]
  19. Reynolds RJ, Day SM. The effect of competing risks on astronaut and cosmonaut mortality. Life Sci Space Res. 2018 May 23. [Article in Press]
  20. Guerringue Y, Thomine S, Frachisse JM. Sensing and transducing forces in plants with MSL10 and DEK1 mechanosensors. FEBS Lett. 2018 May 21. [Epub ahead of print]. Note: This article may be obtained online without charge.
  21. Meinen E, Dueck T, Kempkes F, Stanghellini C. Growing fresh food on future space missions: Environmental conditions and crop managementE. Sci Hortic (Amsterdam). 2018 May 17;235:270-8. Note: This article may be obtained online without charge.
  22. Morozov YA, Trifonov SV, Ushakova SA, Anishchenko OV, Tikhomirov AA. Feasibility of incorporating all products of human waste processing into material cycling in the BTLSS. Life Sci Space Res. 2018 Aug;18:29-34. Epub 2018 May 23.

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