NASA Spaceline Current Awareness List #815 14 September 2018 (Space Life Science Research Results)

Status Report From: Spaceline
Posted: Saturday, September 15, 2018

SPACELINE Current Awareness Lists are distributed via listserv and are available on the NASA Task Book website at Please send any correspondence to Robyn Ertwine, SPACELINE Current Awareness Senior Editor,

Papers deriving from NASA support:



Smith SM, Zwart SR.

Spaceflight-related ocular changes: The potential role of genetics, and the potential of B vitamins as a countermeasure.

Curr Opin Clin Nutr Metab Care. 2018 Aug 29. [Epub ahead of print] Review.

PI: S.M. Smith

Note: ISS study results are discussed.

Journal Impact Factor: 4.534

Funding: "This work was supported by the Human Health Countermeasures Element of the Human Research Program at the NASA Johnson Space Center."



Graff RM, Kunz HE, Agha NH, Baker FL, Laughlin M, Bigley AB, Markofski MM, LaVoy EC, Katsanis E, Bond RA, Bollard CM, Simpson RJ.

β2-adrenergic receptor signaling mediates the preferential mobilization of differentiated subsets of CD8+ T-cells, NK-cells and non-classical monocytes in response to acute exercise in humans.

Brain Behav Immun. 2018 Aug 30. [Epub ahead of print]

PI: R.J. Simpson

Journal Impact Factor: 6.306

Funding: "This work was supported by NASA Grants NNX12AB48G, NNX16AB29G and NNX16AG02G to R.J. Simpson, NIH Grant R21 CA197527-01A1 to R.J. Simpson and A.B. Bigley, NIH grant R01AI110007 to R.A. Bond and NIH grant P01 CA148600-01A1 to C.M. Bollard."



Barrila J, Crabbé A, Yang J, Franco K, Nydam SD, Forsyth RJ, Davis RR, Gangaraju S, Ott CM, Coyne CB, Bissell MJ, Nickerson CA.

Modeling host-pathogen interactions in the context of the microenvironment: 3-D cell culture comes of age.

Infect Immun. 2018 Sep 4. [Epub ahead of print]

PI: C.A. Nickerson

Note: This article may be obtained online without charge.

Journal Impact Factor: 3.256

Funding: "Funded by NASA grants NNX13AM01G and NNX15AL06G (C.A.N., J.B., C.M.O.), and NIH R01-AI081759 (C.B.C, C.A.N.)."



Schepelmann A, Werner CR, Pennline JA, Lewandowski BE, Mulugeta L.

Overview and evaluation of a computational bone physiology modeling toolchain and its application to testing of exercise countermeasures.

Cleveland, OH: NASA Glenn Research Center, 2018 Aug. 40 p. NASA/TM-2018-219938. 

PI: J.A. Pennline

Note: From the abstract: "The toolchain is evaluated against data collected from subjects in a 70-day bed rest study and is found to provide insight into the amount of exercise stimulus needed to minimize bone loss, quantitatively predicting post-study volumetric BMD of control subjects who did not perform exercise, and qualitatively predicting the effects of exercise." This article may be obtained online without charge.

Journal Impact Factor: Not applicable to this publication

Funding: No funding cited. PI reports funding under the "Digital Astronaut: Bone Remodeling Model" project.



Vincent GR, Gruber J, Newman MC, Clark TK.

Analysis of artificial gravity paradigms using a mathematical model of spatial orientation.

Acta Astronaut. 2018 Sep 12. [Article in Press]

Note: A linear sled was used. For more information about Turbolift, go to

Journal Impact Factor: 2.227

Funding: "This work was supported through the NASA Innovation and Advanced Concepts project "Turbolift"."




Other papers of interest:



Yang J, Zhang G, Dong D, Shang P.

Effects of iron overload and oxidative damage on the musculoskeletal system in the space environment: Data from spaceflights and ground-based simulation models.

Int J Mol Sci. 2018 Sep 3;19(9):E2608. Review.

Note: Specific spaceflights are not identified. Ground-based simulation models are bed rest and hindlimb unloading studies. This article may be obtained online without charge.



Franchi MV, Raiteri BJ, Longo S, Sinha S, Narici MV, Csapo R.

Muscle architecture assessment: Strengths, shortcomings and new frontiers of in vivo imaging techniques.

Ultrasound Med Biol. 2018 Sep 2. [Epub ahead of print] Review.



Petrova IO, Tyganov SA, Mirzoev TM, Tsaturyan AK, Kozlovskaya IB, Shenkman BS.

Early decline in rat soleus passive tension with hindlimb unloading: Inactivation of cross-bridges or activation of calpains?

Dokl Biochem Biophys. 2018 Jul;481(1):205-7.

Note: Hindlimb unloading study.



Thorrez L, DiSano K, Shansky J, Vandenburgh H.

Engineering of human skeletal muscle with an autologous deposited extracellular matrix.

Front Physiol. 2018 Aug 20;9:1076.

Note: This article may be obtained online without charge.



Hoffstaetter LJ, Mastrotto M, Merriman DK, Dib-Hajj SD, Waxman SG, Bagriantsev SN, Gracheva EO.

Somatosensory neurons enter a state of altered excitability during hibernation.

Curr Biol. 2018 Aug 22. [Epub ahead of print]

Note: This article may be obtained online without charge.



Bai J, Bao M, Zhang T, Jiang Y.

A virtual reality approach identifies flexible inhibition of motion aftereffects induced by head rotation.

Behav Res Methods. 2018 Sep 5. [Epub ahead of print]



Heutink J, Broekman M, Brookhuis KA, Melis-Dankers B, Cordes C.

The effects of habituation and adding a rest-frame on experienced simulator sickness in an advanced mobility scooter simulator.

Ergonomics. 2018 Sep 6. [Epub ahead of print]



Nouri S, Karmali F.

Variability in the vestibulo-ocular reflex and vestibular perception.

Neuroscience. 2018 Sep 4. [Epub ahead of print]



Becker W, Kassubek J, Maurer C, Mergner T.

Targeting head movements in humans: Compensation for disturbance from simultaneous body rotations.

Hum Mov Sci. 2018 Sep 3;61:197-218.



Eron JN, Ogorodnikov D, Horn AKE, Yakushin SB.

Adaptation of spatio-temporal convergent properties in central vestibular neurons in monkeys.

Physiol Rep. 2018 Sep;6(17):e13750.

Note: This article may be obtained online without charge.



McMahon WR, Ftouni S, Drummond SPA, Maruff P, Lockley SW, Rajaratnam SMW, Anderson C.

The wake maintenance zone shows task dependent changes in cognitive function following one night without sleep.

Sleep. 2018 Aug 29. [Epub ahead of print]



Grippo AJ, Scotti ML, Wardwell J, McNeal N, Bates SL, Chandler DL, Ihm E, Jadia N.

Cardiac and behavioral effects of social isolation and experimental manipulation of autonomic balance.

Auton Neurosci. 2018 Nov;214:1-8. Epub 2018 Aug 14.

Note: Hindlimb unloading study.



Bevelacqua JJ, Mortazavi SMJ.

Comments on "Irradiation effects of MeV protons on dry and hydrated Brassica rapa seeds."

Life Sci Space Res. 2018 Sep 11. [Article in Press]

Note: The authors comment on the article: Deoli NT, Hasenstein KH. Irradiation effects of MeV protons on dry and hydrated Brassica rapa seeds. Life Sci Space Res. 2018 Aug 21. [Article in Press], which appeared in SPACELINE Current Awareness List #812 on 24 Aug 2018.



Prenafeta-Boldú FX, Roca N, Villatoro C, Vera L, de Hoog GS.

Prospective application of melanized fungi for the biofiltration of indoor air in closed bioregenerative systems.

J Hazard Mater. 2019 Jan;361:1-9. Epub 2018 Aug 19.

Note: This article may be obtained online without charge.



Deshpande GG, Sanford JE, Tripathi S.

Comparison of flow resistance characteristics and placement of two endotracheal tubes.

Respir Care. 2018 Sep;63(9):1118-24.

Note: The NASA Task Load Index was used.


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