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NASA Spaceline Current Awareness List #822 31 October 2018 (Space Life Science Research Results)

Status Report From:
Posted: Thursday, November 1, 2018

SPACELINE Current Awareness Lists are distributed via listserv and are available on the NASA Task Book website at https://taskbook.nasaprs.com/Publication/spaceline.cfm. Please send any correspondence to Robyn Ertwine, SPACELINE Current Awareness Senior Editor, SPACELINE@nasaprs.com.

Papers deriving from NASA support:

1

Sharma N, Moore L, Chidambaram S, Colangelo NW, de Toledo SM, Azzam EI.

c-Jun N-terminal kinase inhibition induces mitochondrial oxidative stress and decreases survival in human neural stem progenitors.

Dev Neurosci. 2018 Oct 18. [Epub ahead of print]

https://www.ncbi.nlm.nih.gov/pubmed/30336480

PI: E.I. Azzam

Journal Impact Factor: 2.133

Funding: "This work was supported by grant CA049062 from the National Institutes of Health and NNX15AD62G from the National Aeronautics and Space Administration awarded to EIA, and grant DFHS17PPC030 from the New Jersey Commission on Cancer Research awarded to L.M."

 

2

Khera A, Budoff MJ, O'Donnell CJ, Ayers CA, Locke J, de Lemos JA, Massaro JM, McClelland RL, Taylor A, Levine BD.

Astronaut Cardiovascular Health and Risk Modification (Astro-CHARM) coronary calcium atherosclerotic cardiovascular disease risk calculator.

Circulation. 2018 Oct 23;138(17):1819-27.

https://www.ncbi.nlm.nih.gov/pubmed/30354651

PI: A. Khera

Journal Impact Factor: 18.88

Funding: "The Astro-CHARM calculator was developed with support from the National Space Biomedical Research Institute through NCC 9-58. The Dallas Heart Study was funded by the Donald W. Reynolds Foundation (Las Vegas, Nevada) and was partially supported by US Public Health Service General Clinical Research Center grant M01-RR00633 from the National Institutes of Health/National Center for Research Resources-Continuing Review. The Framingham Heart Study was supported by the National Heart, Lung, and Blood Institute’s Framingham Heart Study (contract no. N01‐HC‐25195, HL076784, AG028321, HL070100, HL060040, HL080124, HL071039, HL077447, and HL107385)....The MESA study was supported by contracts HHSN268201500003I, N01-HC-95159, N01-HC-95160, N01-HC-95161, N01-HC-95162, N01-HC-95163, N01-HC-95164, N01-HC-95165, N01-HC-95166, N01-HC-95167, N01-HC-95168 and N01-HC-95169 from the National Heart, Lung, and Blood Institute, and by grants UL1-TR-000040, UL1-TR-001079, and UL1-TR-001420 from National Center for Advancing Translational Science....The PACC study was Supported by the Congressionally directed, Peer Reviewed Medical Research Program, grant ERMS 00239017-00216."

 

3

Malik M, Suboc TM, Tyagi S, Salzman N, Wang J, Ying R, Tanner MJ, Kakarla M, Baker JE, Widlansky ME.

Lactobacillus plantarum 299v supplementation improves vascular endothelial function and reduces inflammatory biomarkers in men with stable coronary artery disease.

Circ Res. 2018 Oct 12;123(9):1091-102.

https://www.ncbi.nlm.nih.gov/pubmed/30355158

PI: J.E. Baker

Note: This article may be obtained online without charge.

Journal Impact Factor: 15.211

Funding: "The project described was supported by the National Center for Advancing Translational Sciences, National Institutes of Health, Award Number UL1TR001436. This work was funded, in part, by a grant from the Clinical Translational Research Initiative of Southeast Wisconsin (UL1TR001436). M.E. Widlansky is supported by HL125409, HL128240, and American Heart Association grant 15SFRN23910002. J.E. Baker is supported by HL054075 and grant NNX15AD69G from the National Aeronautics and Space Administration. N. Salzman is supported by DK088831 and GM122503. M. Malik, T.M. Suboc, and J. Wang received support from T32HL007792. S. Tyagi is supported by T32GM089586."

 

4

Metzger CE, Narayanan SA, Zawieja DC, Bloomfield SA. 

A moderately elevated soy protein diet mitigates inflammatory changes in gut and in bone turnover during chronic TNBS-induced inflammatory bowel disease.

Appl Physiol Nutr Metab. 2018 Oct 23. [Epub ahead of print]

https://www.ncbi.nlm.nih.gov/pubmed/30352170

Journal Impact Factor: 2.518

Funding: "This work was supported by the Transforming Lives Seed Grant through the College of Education and Human Development (Texas A&M University; awarded to SAB), National Institutes of Health U01HL123420 (Texas A&M University; awarded to DCZ). Additional funds were provided by the Sydney and J.L. Huffines Institute for Sports Medicine and Human Performance (awarded to CEM). SAN was supported in part via the NSBRI Space Life Sciences Fellowship (NCC 9-58)."

 

5

Deymier AC, Schwartz AG, Cai Z, Daulton TL, Pasteris JD, Genin GM, Thomopoulos S.

The multiscale structural and mechanical effects of mouse supraspinatus muscle unloading on the mature enthesis.

Acta Biomater. 2018 Oct 17. [Epub ahead of print]

https://www.ncbi.nlm.nih.gov/pubmed/30342287

PI: A.C. Deymier, NSBRI First Award Fellowship

Note: Shoulders of adult mice were paralyzed using botulinum A injections.

Journal Impact Factor: 6.383

Funding: "This project was funded by National Institute of Health (NIH) R01 EB016422 and R01 AR057836. Dr. Deymier was funded in part by the National Space Biomedical Research Institute (NSBRI) NSBRI-RFA-13-01 Postdoctoral First Fellow Award. Dr. Schwartz was funded by NIH T32 AR060719. The TEM studies were partially supported by the Institute of Materials Science & Engineering at Washington University."

 

6

Pendleton MM, Sadoughi S, Li A, O'Connell GD, Alwood JS, Keaveny TM.

High-precision method for cyclic loading of small-animal vertebrae to assess bone quality.

Bone Rep. 2018 Oct 27. [Article in Press]

http://www.sciencedirect.com/science/article/pii/S2352187218300536

PI: J.S. Alwood

Note: This article may be obtained online without charge.

Journal Impact Factor: Not available for this journal

Funding: "This research was supported by a NASA Science and Technology Research Fellowship (NSTRF) NNX14AM56H to MMP, and guidance from NSTRF research collaborator, Dr. Jean D. Sibonga. Additional experimental resources were provided through NASA Space Biology PECASE to JSA. Computational resources were made available through the National Science Foundation via XSEDE, Grant TG-MCA00N019 to TMK. We also thank Shannon Emerzian and Ryan Scott for help with specimen preparation."

 

7

Guan F, Geng C, Ma D, Bronk L, Kerr M, Li Y, Gates D, Kroger B, Sahoo N, Titt U, Grosshans D, Mohan R.

RBE model-based biological dose optimization for proton radiobiology studies.

Int J Part Ther. 2018 Summer;5(1):160-71.

https://www.ncbi.nlm.nih.gov/pubmed/30338268

Note: This article may be obtained online without charge.

Journal Impact Factor: Not available for this journal

Funding: "This work was supported by the National Cancer Institute (Grant No. U19 CA021239) and by an Institutional Research Seed Grant from The University of Texas MD Anderson Cancer Center." D. Gates is affiliated with NASA Johnson Space Center.

 

8

Iancu OD, Boutros SW, Olsen RHJ, Davis MJ, Stewart B, Eiwaz M, Marzulla T, Belknap J, Fallgren CM, Edmondson EF, Weil MM, Raber J.

Space radiation alters genotype-phenotype correlations in fear learning and memory tests.

Front Genet. 2018 Oct 9;9:404.

https://www.ncbi.nlm.nih.gov/pubmed/30356920

PI: M.M. Weil

Note: This article may be obtained online without charge.

Journal Impact Factor: Not available for this journal

Funding: "This work was supported by NASA NNX12AB54G."

 

9

Boyle R, Popova Y, Varelas J.

Influence of magnitude and duration of altered gravity and readaptation to 1 g on the structure and function of the utricle in toadfish, Opsanus tau.

Front Physiol. 2018 Oct 22;9:1469.

https://www.frontiersin.org/article/10.3389/fphys.2018.01469

PI: R. Boyle

Note: This article may be obtained online without charge.

Journal Impact Factor: 4.134

Funding: "We gratefully acknowledge funding through grants by NIH/NIDCD Grant P01 DC01837 (RB) and NASA Grant 03-OBPR-04 (RB), and also support from NASA Human Research (HRP) and Space Biology (SB) Programs (RB) and NASA Postdoctoral Program administered by Oak Ridge Associated Universities (YP)."

 

10

Goel R, Rosenberg MJ, Cohen HS, Bloomberg JJ, Mulavara AP.

Calibrating balance perturbation using electrical stimulation of the vestibular system.

J Neurosci Methods. 2019 Jan 1;311:193-9. Epub 2018 Oct 16.

https://www.ncbi.nlm.nih.gov/pubmed/30339880

PI: A.P. Mulavara

Note: This article may be obtained online without charge.

Journal Impact Factor: 2.668

Funding: "This study was partly supported by grants from the National Space Biomedical Research Institute through NASA NCC 9-58, SA 03801 (APM) and National Institutes of Health grant RO1-DC009031 (HSC)."

 

11

Mickens MA, Torralba M, Robinson SA, Spencer LE, Romeyn MW, Massa GD, Wheeler RM.

Growth of red pak choi under red and blue, supplemented white, and artificial sunlight provided by LEDs.

Sci Hortic (Amsterdam). 2019 Feb;245:200-9. Epub 2018 Oct 22.

http://www.sciencedirect.com/science/article/pii/S030442381830726X

PIs: G. Massa; M.A. Mickens, NASA Postdoctoral Fellowship

Journal Impact Factor: 1.76

Funding: "This work was supported by funding through the Space Life and Physical Sciences Research & Applications Division of NASA's Human Exploration and Operations Mission Directorate which funded the NASA Postdoctoral Fellowship of M. Mickens."

______________________________________________________

 

Other papers of interest:

 

1

Van Ombergen A, Jillings S, Jeurissen B, Tomilovskaya E, Rühl RM, Rumshiskaya A, Nosikova I, Litvinova L, Annen J, Pechenkova EV, Kozlovskaya IB, Sunaert S, Parizel PM, Sinitsyn V, Laureys S, Sijbers J, Zu Eulenburg P, Wuyts FL. 

Brain tissue-volume changes in cosmonauts.

N Engl J Med. 2018 Oct 25;379(17):1678-80.

https://www.ncbi.nlm.nih.gov/pubmed/30354959

Note: ISS results. This article may be obtained online without charge.

 

2

Genchi GG, Degl'Innocenti A, Salgarella AR, Pezzini I, Marino A, Menciassi A, Piccirillo S, Balsamo M, Ciofani G.

Modulation of gene expression in rat muscle cells following treatment with nanoceria in different gravity regimes.

Nanomedicine (Lond). 2018 Oct 18. [Epub ahead of print]

https://www.ncbi.nlm.nih.gov/pubmed/30334476

Note: ISS results.

 

3

Bimpong-Buta NY, Jirak P, Wernly B, Lichtenauer M, Knost T, Abusamrah T, Kelm M, Jung C.

Blood parameter analysis after short term exposure to weightlessness in parabolic flight.

Clin Hemorheol Microcirc. 2018 Oct 17. [Epub ahead of print]

https://www.ncbi.nlm.nih.gov/pubmed/30347611

Note: Parabolic flight results.

 

4

Balestra C, Machado ML, Theunissen S, Balestra A, Cialoni D, Clot C, Besnard S, Kammacher L, Delzenne J, Germonpré P, Lafère P.

Critical flicker fusion frequency: A marker of cerebral arousal during modified gravitational conditions related to parabolic flights.

Front Physiol. 2018 Oct 2;9:1403.

https://www.ncbi.nlm.nih.gov/pubmed/30333762

Note: Parabolic flight results. This article may be obtained online without charge.

 

5

Enwonwu KG, Ibeh C, Modebe I, Owoaje E, Zoakah AI, Ifeadike C, Ezeama N, Acuike E.

Factors associated with orthostatic hypotension in the elderly in Anambra State.

J Med Biomed Appl Sci. 2018;6(10):173-80.

http://jmbas.in/index.php/jmbas/article/view/163

Note: The paper contains a mini-review of factors associated with orthostatic hypotension. This section includes a discussion of spaceflight and head-down tilt bed rest studies. This article may be obtained online without charge.

 

6

Nemoto S, Ohnuki S, Abe F, Ohya Y.

Simulated microgravity triggers characteristic morphology and stress response in Saccharomyces cerevisiae.

Yeast. 2018 Oct 22. [Epub ahead of print]

https://www.ncbi.nlm.nih.gov/pubmed/30350382

Note: A rotary cell culture system was used.

 

7

Washio T, Vranish JR, Kaur J, Young BE, Katayama K, Fadel PJ, Ogoh S.

Acute reduction in posterior cerebral blood flow following isometric handgrip exercise is augmented by lower body negative pressure.

Physiol Rep. 2018 Oct;6(20):e13886.

https://www.ncbi.nlm.nih.gov/pubmed/30338667

Note: Lower body negative pressure was used.

 

8

Shimkus KL, Jefferson LS, Gordon BS, Kimball SR.

Repressors of mTORC1 act to blunt the anabolic response to feeding in the soleus muscle of a cast-immobilized mouse hindlimb.

Physiol Rep. 2018 Oct;6(20):e13891.

https://www.ncbi.nlm.nih.gov/pubmed/30338657

Note: Hindlimb unloading study; cast immobilization was used. This article may be obtained online without charge.

 

9

Zhang Z-K, Li J, Guan D, Liang C, Zhuo Z, Liu J, Lu A, Zhang G, Zhang B-T.

Long noncoding RNA lncMUMA reverses established skeletal muscle atrophy following mechanical unloading.

Mol Ther. 2018 Oct 25. [Article in Press]

https://www.cell.com/molecular-therapy-family/molecular-therapy/fulltext/S1525-0016(18)30455-6

Note: Hindlimb unloading study. This article may be obtained online without charge.

 

10

Huang Y, Luan H, Sun L, Wang S, Fan Y.

Increased blood flow by unilateral intermittent compression on hindlimbs may prevent bone loss.

Microgravity Sci Technol. 2018 October 25. [Article in Press]

https://link.springer.com/article/10.1007/s12217-018-9661-2

Note: Hindlimb unloading study.

 

11

Li WY, Li XY, Tian YH, Chen XR, Zhou J, Zhu BY, Xi HR, Gao YH, Xian CJ, Chen KM.

Pulsed electromagnetic fields prevented the decrease of bone formation in hindlimb-suspended rats by activating sAC/cAMP/PKA/CREB signaling pathway.

Bioelectromagnetics. 2018 Oct 23. [Epub ahead of print]

https://www.ncbi.nlm.nih.gov/pubmed/30350869

Note: Hindlimb unloading study.

 

12

Metzger CE, Swift SN, Baek K, De Souza MJ, Bloomfield SA.

Fat and lean mass predict bone mass during energy restriction in sedentary and exercising rodents.

Front Physiol. 2018 Sep 25;9:1346.

https://www.ncbi.nlm.nih.gov/pubmed/30356821

Note: This article may be obtained online without charge.

 

13

Barnard SGR, Moquet J, Lloyd S, Ellender M, Ainsbury EA, Quinlan RA.

Dotting the eyes: Mouse strain dependency of the lens epithelium to low dose radiation-induced DNA damage.

Int J Radiat Biol. 2018 Oct 25. [Epub ahead of print]

https://www.ncbi.nlm.nih.gov/pubmed/30359158

 

14

Garrett J, Sampson CH, Plett PA, Crisler R, Parker J, Venezia R, Chua HL, Hickman DL, Booth C, MacVittie T, Orschell CM, Dynlacht JR.

Characterization and etiology of swollen muzzles in irradiated mice.

Radiat Res. 2018 Oct 19. [Epub ahead of print]

https://www.ncbi.nlm.nih.gov/pubmed/30339056

 

15

Vijayalaxmi, Prihoda TJ.

Comprehensive review of quality of publications and meta-analysis of genetic damage in mammalian cells exposed to non-ionizing radiofrequency fields.

Radiat Res. 2018 Oct 19. [Epub ahead of print] Review.

https://www.ncbi.nlm.nih.gov/pubmed/30339042

 

16

Cook HE 4th, Hassebrock JA, Smart LJ Jr.

Responding to other people's posture: Visually induced motion sickness from naturally generated optic flow.

Front Psychol. 2018 Oct 8;9:1901.

https://www.ncbi.nlm.nih.gov/pubmed/30349501

Note: This article may be obtained online without charge.

 

17

Hagan ML, Bahraini A, Pierce JL, Bass SM, Yu K, Elsayed R, Elsalanty M, Johnson MH, McNeil A, McNeil PL, McGee-Lawrence ME.

Inhibition of osteocyte membrane repair activity via dietary vitamin E deprivation impairs osteocyte survival.

Calcif Tissue Int. 2018 Oct 24. [Epub ahead of print]

https://www.ncbi.nlm.nih.gov/pubmed/30357446

 

18

Miao ZQ, Zhao PX, Mao J, Yu L, Yuan Y, Tang H, Liu ZB, Xiang C.

Arabidopsis HB52 mediates the crosstalk between ethylene and auxin by transcriptionally modulating PIN2, WAG1, and WAG2 during primary root elongation.

Plant Cell. 2018 Oct 17. [Epub ahead of print]

https://www.ncbi.nlm.nih.gov/pubmed/30333147

 

19

Bagheri Hosseinabadi M, Khanjani N, Etemadinezhad S, Samaei SE, Raadabadi M, Mostafaee M.

The associations of workload, individual and organizational factors on nurses' occupational injuries.

J Clin Nurs. 2018 Oct 24. [Epub ahead of print]

https://www.ncbi.nlm.nih.gov/pubmed/30357967

Note: The NASA Task Load Index was used.

 

20

Hackett M, Proctor M.

The effect of autostereoscopic holograms on anatomical knowledge: A randomised trial.

Med Educ. 2018 Nov;52(11):1147-55.

https://www.ncbi.nlm.nih.gov/pubmed/30345673

Note: The NASA Task Load Index was used.

 

21

Shanmugham M, Strawderman L, Babski-Reeves K, Bian L.

Alarm-related workload in default and modified alarm settings and the relationship between alarm workload, alarm response rate, and care provider experience: Quantification and comparison study.

JMIR Hum Factors. 2018 Oct 23;5(4):e11704.

https://www.ncbi.nlm.nih.gov/pubmed/30355550

Note: The NASA Task Load Index was used. This article may be obtained online without charge.

// end //

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