NASA Spaceline Current Awareness List #828 14 December 2018 (Space Life Science Research Results)

Status Report From: Spaceline
Posted: Friday, December 14, 2018

SPACELINE Current Awareness Lists are distributed via listserv and are available on the NASA Task Book website at Please send any correspondence to Robyn Ertwine, SPACELINE Current Awareness Senior Editor,

Papers deriving from NASA support:



Hoehn D, Pujol-Canadell M, Young EF, Serban G, Shuryak I, Maerki J, Xu Z, Chowdhury M, Luna AM, Vlad G, Smilenov LB.

Effects of high- and low-LET radiation on human hematopoietic system reconstituted in immunodeficient mice.

Radiat Res. 2018 Dec 6. [Epub ahead of print]

PI: L.B. Smilenov

Journal Impact Factor: 2.53

Funding: "This work was supported by the National Aeronautics and Space Administration (; NASA grant no. NNX14AC27G to LS), the Center for High-Throughput Minimally-Invasive Radiation Biodosimetry, National Institute of Allergy and Infectious Diseases (; NIAID grant no. U19 AI067773) and the Radiation Countermeasures Center of Research Excellence, NIAID (; grant no. U19 AI AI67798)....These studies used the resources of the Columbia University Cancer Center Flow Core Facility funded in part by NCI Cancer Center Support Grant no. P30CA013696."



Thosar SS, Rueda JF, Berman AM, Lasarev MR, Herzig MX, Clemons NA, Roberts SA, Bowles NP, Emens JS, Ellison DH, Shea SA.

Separate and interacting effects of the endogenous circadian system and behaviors on plasma aldosterone in humans.

Am J Physiol Regul Integr Comp Physiol. 2018 Dec 6. [Epub ahead of print]

PI: S.S. Thosar, NSBRI Postdoctoral Fellowship Program

Journal Impact Factor: 3.082

Funding: "This work was supported by NIH grants R01 HL125893, R01 HL125893-03S1, R01 HL142064, and R01 HL140577; F32-HL13130; National Space Biomedical Research Institute through NCC 9-58, Ford Foundation Fellowship; Oregon Institute of Occupational Health Sciences at Oregon Health & Science University via funds from the Division of Consumer and Business Services of the State of Oregon (ORS 656.630) and National Institutes of Health Clinical Translational Science Award [UL1TR000128]."



Matula E, Nabity JA.

Failure modes, causes, and effects of algal photobioreactors used to control a spacecraft environment.

Life Sci Space Res. 2018 Dec 5. [Article in Press]

Journal Impact Factor: 1.97

Funding: "This research is supported by a NASA Space Technology Research Fellowship [NNX15AP52H]."



Singh NK, Wood JM, Karouia F, Venkateswaran K.

Correction to: Succession and persistence of microbial communities and antimicrobial resistance genes associated with International Space Station environmental surfaces.

Microbiome. 2018 Dec 4;6(1):214.

PIs: C.E. Mason, K. Venkateswaran

Note: From the authors: "Following publication of the original article, the authors reported a typographic error in scientific notation in the number of reads, the text should read as: "Approximately 7.3 × 108 reads associated with microorganisms were generated after high quality trimming from PMA (21 samples) and non-PMA treated (21 samples) samples. All metagenomics reads were normalized across all samples, which yielded 3.1 × 108 in total, and 7.4 × 106 assigned to each sample, without affecting the taxonomic diversity." The authors regret these errors and the inconvenience caused." The original article was published on 23 Nov 2018 and appeared in SPACELINE Current Awareness List #826, 30 Nov 2018. The corrected article may be obtained online without charge.

Journal Impact Factor: 2.829

Funding: From the original paper: "This research was funded by a 2012 Space Biology NNH12ZTT001N grant no. 19–12829-26 under Task Order NNN13D111T award to KV, which also funded post-doctoral fellowship for ACS and NKS. We would also like to thank the Epigenomics Core Facility at Weill Cornell Medicine, the Bert L and N Kuggie Vallee Foundation, the WorldQuant Foundation, NASA (NNX14AH50G, NNX17AB26G), the National Institutes of Health (R01ES021006, 1R21AI129851), the Bill and Melinda Gates Foundation (OPP1151054), and the Alfred P. Sloan Foundation (G-2015-13964)."




Other papers of interest:



Lü D, Sun S, Zhang F, Luo C, Zheng L, Wu Y, Li N, Zhang C, Wang C, Chen Q, Long M.

Microgravity-induced hepatogenic differentiation of rBMSCs on board the SJ-10 satellite.

FASEB J. 2018 Dec 6. [Epub ahead of print]

Note: Chinese satellite SJ-10 results.



Tascher G, Gerbaix M, Maes P, Chazarin B, Ghislin S, Antropova E, Vassilieva G, Ouzren-Zarhloul N, Gauquelin-Koch G, Vico L, Frippiat JP, Bertile F.

Analysis of femurs from mice embarked on board BION-M1 biosatellite reveals a decrease in immune cell development, including B cells, after 1 wk of recovery on Earth.

FASEB J. 2018 Dec 6. [Epub ahead of print]

Note: Bion M-1 results.



Yurkevich OY, Smatadze TE, Levinshikh MA, Zoshchuk SA, Signalova OB, Surzhikov SA, Sychev VN, Amosova AV, Muravenko OV.

Molecular cytogenetics of Pisum sativum L. grown under spaceflight-related stress.

Biomed Res Int. 2018 Dec 6;2018:4549294.

Note: ISS results. This article may be obtained online without charge.



Xu T, Lu C, Feng L, Fan LX, Sun J, Fan B, Wang Q, Wang Y, Liu XM, Wang FZ.

Liquid chromatography-mass spectrometry-based urinary metabolomics study on a rat model of simulated microgravity-induced depression.

J Pharm Biomed Anal. 2019 Feb;165:31-40. Epub 2018 Nov 26.

Note: Hindlimb unloading study.



Maggioni MA, Castiglioni P, Merati G, Brauns K, Gunga HC, Mendt S, Opatz OS, Rundfeldt LC, Steinach M, Werner A, Stahn AC.

High-intensity exercise mitigates cardiovascular deconditioning during long-duration bed rest.

Front Physiol. 2018 Nov 19;9:1553.

Note: Head-down tilt bed rest study. This article may be obtained online without charge.



Caldwell JT, Sutterfield SL, Post HK, Lovoy GM, Banister HR, Hammer SM, Ade CJ.

Vasoconstrictor responsiveness through alterations in relaxation time and metabolic rate during rhythmic handgrip contractions.

Physiol Rep. 2018 Dec;6(23):e13933.



You JS, McNally RM, Jacobs BL, Privett RE, Gundermann DM, Lin KH, Steinert ND, Goodman CA, Hornberger TA.

The role of raptor in the mechanical load-induced regulation of mTOR signaling, protein synthesis, and skeletal muscle hypertrophy.

FASEB J. 2018 Dec 3. [Epub ahead of print]



Duan Y, Beli E, Li Calzi S, Quigley JL, Miller RC, Moldovan L, Feng D, Salazar TE, Hazra S, Al-Sabah J, Chalam KV, Phuong Trinh TL, Meroueh M, Markel TA, Murray MC, Vyas RJ, Boulton ME, Parsons-Wingerter P, Oudit GY, Obukhov AG, Grant MB. 

Loss of angiotensin-converting enzyme 2 exacerbates diabetic retinopathy by promoting bone marrow dysfunction.

Stem Cells. 2018 Sep;36(9):1430-40.



Ge J, Sun D, Teng L, Su B, Niu X, Luo W.

Effects of 25-hydroxyvitamin D on bone microstructure in T2MD rats.

J Musculoskelet Neuronal Interact. 2018 Dec 1;18(4):525-9.



Tamakoshi K, Nishii Y, Minematsu A.

Upward running is more beneficial than level surface or downslope running in reverting tibia bone degeneration in ovariectomized rats.

J Musculoskelet Neuronal Interact. 2018 Dec 1;18(4):493-500.



Abdelrazzak AB, El-Missiry MA, Ahmed MT, Elnady BF.

Effect of low-dose X-rays on the liver of whole-body irradiated rats.

Int J Radiat Biol. 2018 Dec 3. [Epub ahead of print]



Chen B, Zhang P, Sun F, Li B, Chen Y, Pei S, Zhang Z, Manzoor R, Deng Y, Sun C, Sui L, Kong F, Ma H.

The mechanism of bystander effect induced by different irradiation in human neuroblastoma cells.

Acta Astronaut. 2018 Nov 9. [Article in Press]



Golden AP, Cohen SS, Chen H, Ellis ED, Boice JD Jr.

Evaluation of statistical modeling approaches for epidemiologic studies of low dose radiation health effects.

Int J Radiat Biol. 2018 Nov 30. [Epub ahead of print]



Sureshkumar MA, Delma CR, Manickam K, Mohan S, Habib SL, Natarajan M.

Heterozygous Tsc2 (Tsc2+/-) mouse model to study induced renal cancer in response to ionizing radiation at low doses.

Carcinogenesis. 2018 Dec 2. [Epub ahead of print]



Takai D, Abe A, Komura JI.

Chronic exposure to gamma irradiation at low dose-rates accelerates blood pressure decline associated with aging in female B6C3F1 mice.

Int J Radiat Biol. 2018 Dec 4. [Epub ahead of print]



Reynolds RJ, Day SM.

Mortality of US astronauts: Comparisons with professional athletes.

Occup Environ Med. 2018 Dec 4. [Epub ahead of print]

Note: From the abstract: "Studies of mortality among US astronauts are complicated by the healthy worker effect, which predicts lower mortality for astronauts than the general population based solely on the ability to become and remain an astronaut. We attempt to evaluate astronaut mortality risk while accounting for the healthy worker effect."



Kordium EL, Chapman DK.

Plants and microgravity: Patterns of microgravity effects at the cellular and molecular levels.

Tsitol Genet. 2017 Mar-Apr;51(2):47-58. English and Russian.

Note: The specific spaceflights and methods of microgravity simulation are not provided in the English-language abstract.  This article was published in English in Cytol Genet 2017;51(2):108-16 with first author listed as E.L. Kordyum. It is available at the publisher's website:



Maksaev G, Shoots JM, Ohri S, Haswell ES.

Nonpolar residues in the presumptive pore-lining helix of mechanosensitive channel MSL10 influence channel behavior and establish a nonconducting function.

Plant Direct. 2018 Jun;2(6):e00059.

Note: This article may be obtained online without charge.



Tang J, Bassham DC.

Autophagy in crop plants: What's new beyond Arabidopsis?

Open Biol. 2018 Dec 5;8(12):180162. Review.

Note: This article may be obtained online without charge.



Sharma G, Rai RN.

Reliability modeling and analysis of environmental control and life support systems of space stations: A literature survey.

Acta Astronaut. 2018 Dec 7. [Article in Press] Review.



Taub FB.

Why did carbon become the pseudo-limiting factor in aquatic closed ecological systems?

Life Sci Space Res. 2018 Dec 5. [Article in Press]



Chi CF, Cheng CC, Shih YC, Sun IS, Chang TC.

Learning rates and subjective mental workload in five truck driving tasks.

Ergonomics. 2018 Dec 1. [Epub ahead of print]

Note: The NASA Task Load Index was used.



Marjanovic NS, Teiten C, Pallamin N, L'Her E.

Evaluation of emotional excitation during standardized endotracheal intubation in simulated conditions.

Ann Intensive Care. 2018 Dec 4;8(1):117.

Note: The NASA Task Load Index was used. This article may be obtained online without charge.


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