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NASA Spaceline Current Awareness List #839 8 March 2019 (Space Life Science Research Results)

Status Report From: Spaceline
Posted: Friday, March 8, 2019

SPACELINE Current Awareness Lists are distributed via listserv and are available on the NASA Task Book website at https://taskbook.nasaprs.com/Publication/spaceline.cfm. Please send any correspondence to Robyn Ertwine, SPACELINE Current Awareness Senior Editor, SPACELINE@nasaprs.com.

 

Papers deriving from NASA support:

 

1

Rooney BV, Crucian BE, Pierson DL, Laudenslager ML, Mehta SK.

Herpes virus reactivation in astronauts during spaceflight and its application on Earth.

Front Microbiol. 2019 Feb 7;10:16. Review.

https://www.ncbi.nlm.nih.gov/pubmed/30792698

PI: D.L. Pierson

Note: Space Shuttle and ISS results. This article may be obtained online without charge.

Journal Impact Factor: 4.019

Funding: "This work was supported by NASA (Grant Nos. 111-30-10-03 and 111-30-10-06) to DP."

 

2

Moore ST, Dilda V, Morris TR, Yungher DA, MacDougall HG, Wood SJ.

Long-duration spaceflight adversely affects post-landing operator proficiency.

Sci Rep. 2019 Feb 25;9(1):2677.

https://www.ncbi.nlm.nih.gov/pubmed/30804413

PI: S.T. Moore

Note: ISS results. This article may be obtained online without charge.

Journal Impact Factor: 4.122

Funding: "This project was funded by NASA grants NNX09AL14G and NNX12AM25G awarded to S.T.M."

 

3

Nakada Y, Nhi Nguyen NU, Xiao F, Savla JJ, Lam NT, Abdisalaam S, Bhattacharya S, Mukherjee S, Asaithamby A, Gillette TG, Hill JA, Sadek HA.

DNA damage response mediates pressure overload-induced cardiomyocyte hypertrophy.

Circulation. 2019 Feb 26;139(9):1237-9.

https://www.ncbi.nlm.nih.gov/pubmed/30802166

PI: H.A. Sadek

Journal Impact Factor: 18.88

Funding: "Dr Sadek is supported by grants from the National Institutes of Health (1R01HL115275 and 5R01H2131778), National Aeronautics and Space Administration (NNX-15AE06G), American Heart Association (16EIA27740034), Cancer Prevention and Research Institute of Texas (RP160520), Hamon Center for Regenerative Science and Medicine, and Fondation Leducq. Dr Asaithamby is supported by a grant from the National Institute of Aging (R01AG053341). Dr Hill is supported by grants from the National Institute of Health (R01120732, R01128215, and R01126012)."

 

4

Berrios DC, Beheshti A, Costes SV.

FAIRness and usability for open-access omics data systems.

AMIA Annu Symp Proc. 2018 Dec 5;2018:232-41.

https://www.ncbi.nlm.nih.gov/pubmed/30815061

Note: GeneLab is available at https://genelab.nasa.gov/. This article may be obtained online without charge.

Journal Impact Factor: Not available for this journal

Funding: No funding cited. The authors are affiliated with NASA Ames Research Center.

 

5

Zhang L, Kim SB, Luitel K, Shay JW.

Cholesterol depletion by TASIN-1 induces apoptotic cell death through the ER Stress/ROS/JNK signaling in colon cancer cells.

Mol Cancer Ther. 2018 May;17(5):943-51.

https://www.ncbi.nlm.nih.gov/pubmed/29467273

PIs: A.J. Fornace/J.W. Shay/NSCOR

Journal Impact Factor: 5.265

Funding: "This work was supported by CPRIT Grants #RP130189 and #RP160180 to J.W. Shay. This work was performed in laboratories constructed with support from NIH grant C06 RR30414, and supported by NNX15AI21G from NASA and the Harold Simmon NCI Designated Comprehensive Cancer Center Support Grant (CA142543)."

 

6

Pujol-Canadell M, Young E, Smilenov L.

Use of a humanized mouse model system in the validation of human radiation biodosimetry standards.

Radiat Res. 2019 Feb 25. [Epub ahead of print]

https://www.ncbi.nlm.nih.gov/pubmed/30802180

PI: L. Smilenov

Journal Impact Factor: 2.53

Funding: "This work was supported by the Center for High-Throughput Minimally-Invasive Radiation Biodosimetry, National Institute of Allergy and Infectious Diseases (NIAID grant no. U19 AI067773), the Radiation Countermeasures Center of Research Excellence, NIAID (grant no. U19 AI AI67798) and the National Aeronautics and Space Administration (grant no. NNX14AC27G; www.nasa.gov/exploration/humanresearch/) to LS."

 

7

Moreno-Villanueva M, Wu H.

Radiation and microgravity – Associated stress factors and carcinogenesis.

REACH. 2019 Mar;13:100027. Review.

http://www.sciencedirect.com/science/article/pii/S2352309318300105

PI: H. Wu

Note: This article may be obtained online without charge.

Journal Impact Factor: Not available for this journal

Funding: "The authors would like to acknowledge NASA Space Biology Program and the German Research Association (DFG) (Grant # MO 2243-2-1)."

 

8

Bower JL, Laughlin MS, Connaboy C, Simpson RJ, Alfano CA.

Factor structure and validation of the mental health checklist (MHCL) for use in isolated, confined and extreme environments.

Acta Astronaut. 2019 Mar 7. [Article in Press]

https://www.sciencedirect.com/science/article/pii/S0094576518314073

PI: C.A. Alfano

Journal Impact Factor: 1.536

Funding: "This work was supported by the National Aeronautics and Space Administration (NASA; grant number NNX15AC13G) awarded to C. Alfano and R. Simpson."

 

9

Clebone A, Burian BK, Tung A.

Matching design to use: A task analysis comparison of three cognitive aid designs used during simulated crisis management.

Can J Anaesth. 2019 Feb 25. [Epub ahead of print]

https://www.ncbi.nlm.nih.gov/pubmed/30805904

Journal impact Factor: 3.377

Funding: No funding cited. B.K. Burian is affiliated with NASA Ames Research Center.

 

10

St Hilaire MA, Anderson C, Anwar J, Sullivan JP, Cade BE, Flynn-Evans EE, Czeisler CA, Lockley SW.

Brief (<4 hour) sleep episodes are insufficient for restoring performance in first-year resident physicians working overnight extended-duration work shifts.

Sleep. 2019 Feb 22. [Epub ahead of print]

https://www.ncbi.nlm.nih.gov/pubmed/30794317

PI: C.A. Czeisler

Journal Impact Factor: 5.135

Funding: "The present study was supported by a grant from the National Heart, Lung and Blood Institute (4U01 HL111478). The original study was supported by a grant (R01 HS12032) from the Agency for Healthcare Research and Quality (AHRQ), affording data-confidentiality protection by federal statute (Public Health Service Act 42 U.S.C.); a grant from the National Institute of Occupational Safety and Health (R01 OH07567), which provided a Certificate of Confidentiality for data protection; the Department of Medicine, Brigham and Women's Hospital; the Division of Sleep Medicine, Harvard Medical School; Brigham and Women's Hospital; and a General Clinical Research Center grant (M01 RR02635) from the National Center for Research Resources; a traveling fellowship from the Wellcome Trust, United Kingdom (060018/B/99/Z) awarded to Dr Steven W Lockley, PhD; an AHRQ career development award (K08 HS13333) to Dr Christopher P Landrigan, MD, MPH; an AHRQ National Research Service Award (F32 HS14130) awarded to Dr John W Cronin, MD; and a National Heart, Lung, and Blood Institute fellowship in the program of training in Sleep, Circadian, and Respiratory Neurobiology at Brigham and Women's Hospital (T32 HL079010); Dr Charles A Czeisler, PhD, MD, was supported in part by the National Space Biomedical Research Institute, through NASA (NCC 9-58)."

______________________________________________________

 

 

Other papers of interest:

 

1

Cao D, Song J, Ling S, Niu S, Lu L, Cui Z, Li Y, Hao S, Zhong G, Qi Z, Sun W, Yuan X, Li H, Zhao D, Jin X, Liu C, Wu X, Kan G, Cao H, Kang Y, Yu S, Li Y.

Hematopoietic stem cells and lineage cells undergo dynamic alterations under microgravity and recovery conditions.

FASEB J. 2019 Feb 27. [Epub ahead of print]

https://www.ncbi.nlm.nih.gov/pubmed/30811956

Note: Shenzhou results; hindlimb unloading study.

 

2

Atiakshin DA, Alexeeva NT, Klochkova SV, Nikityuk DB.

[Extracellular matrix collagen fiber structures of the gastrointestinal connective tissues in mice after a 30 day orbital flight].

Vopr Pitan. 2019;88(1):26-40. Russian.

https://www.ncbi.nlm.nih.gov/pubmed/30811131

Note: BION-M1 results.

 

3

Kohn FPM, Hauslage J.

The gravity dependence of pharmacodynamics: The integration of lidocaine into membranes in microgravity.

npj Microgravity. 2019 Mar 6;5(1):5.

https://www.nature.com/articles/s41526-019-0064-5

Note: Mapheus 6 sounding rocket results. This article may be obtained online without charge.

 

4

Gehrke S, Rice S, Stefanoni D, Wilkerson RB, Nemkov T, Reisz JA, Hansen KC, Lucas A, Cabrales P, Drew K, D'Alessandro A.

Red blood cell metabolic responses to torpor and arousal in the hibernator Arctic ground squirrel.

J Proteome Res. 2019 Feb 28. [Epub ahead of print]

https://www.ncbi.nlm.nih.gov/pubmed/30793910

 

5

Horowitz JM, Horwitz BA.

Extreme neuroplasticity of hippocampal CA1 pyramidal neurons in hibernating mammalian species.

Front Neuroanat. 2019 Feb 13;13:9. Review.

https://www.ncbi.nlm.nih.gov/pubmed/30814935

Note: This article may be obtained online without charge.

 

6

Brungs S, Hauslage J, Hemmersbach R.

Validation of random positioning versus clinorotation using a macrophage model system.

Microgravity Sci Technol. 2019 Mar 2. [Article in Press]

https://link.springer.com/article/10.1007%2Fs12217-019-9687-0

Note: A clinostat and a random positioning machine were used. This article may be obtained online without charge.

 

7

Cazzaniga A, Locatelli L, Castiglioni S, Maier JAM.

The dynamic adaptation of primary human endothelial cells to simulated microgravity.

FASEB J. 2019 Feb 28. [Epub ahead of print]

https://www.ncbi.nlm.nih.gov/pubmed/30817172

Note: A rotating wall vessel was used.

 

8

Lanzerstorfer A, Hackl M, Schlömer M, Rest B, Deutsch-Grasl E, Lanzerstorfer C.

The influence of air-dispersed essential oils from lemon (Citrus limon) and silver fir (Abies alba) on airborne bacteria and fungi in hospital rooms.

J Environ Sci Health A Tox Hazard Subst Environ Eng. 2019 Feb 22. [Epub ahead of print]

https://www.ncbi.nlm.nih.gov/pubmed/30795725

Note: This article may be obtained online without charge at https://www.tandfonline.com/doi/full/10.1080/10934529.2018.1546498.

 

9

Zhang Y, Zhang LT, Li ZD, Xin CX, Li XQ, Wang X, Deng YL.

Microbiomes of China's Space Station during assembly, integration, and test operations.

Microb Ecol. 2019 Feb 26. [Epub ahead of print]

https://www.ncbi.nlm.nih.gov/pubmed/30809693

 

10

Mukherjee S, Abdisalaam S, Bhattacharya S, Srinivasan K, Sinha D, Asaithamby A.

Mechanistic link between DNA damage sensing, repairing and signaling factors and immune signaling.

Adv Protein Chem Struct Biol. 2019;115:297-324.

https://www.ncbi.nlm.nih.gov/pubmed/30798935

 

11

Alessandro C, Sarabadani Tafreshi A, Riener R.

Cardiovascular responses to leg muscle loading during head-down tilt at rest and after dynamic exercises.

Sci Rep. 2019 Feb 26;9(1):2804.

https://www.ncbi.nlm.nih.gov/pubmed/30808948

Note: Head-down tilt study. This article may be obtained online without charge.

 

12

Conceiҫão MS, Ugrinowitsch C.

Exercise with blood flow restriction: An effective alternative for the non-pharmaceutical treatment for muscle wasting.

J Cachexia Sarcopenia Muscle. 2019 Feb 27. [Epub ahead of print]

https://www.ncbi.nlm.nih.gov/pubmed/30816026

Note: This article may be obtained online without charge.

 

13

Kwon H, Guasch M, Nagy JA, Rutkove SB, Sanchez B.

New electrical impedance methods for the in situ measurement of the complex permittivity of anisotropic skeletal muscle using multipolar needles.

Sci Rep. 2019 Feb 28;9(1):3145.

https://www.ncbi.nlm.nih.gov/pubmed/30816169

Note: This article may be obtained online without charge.

 

14

Oikawa SY, Callahan DM, McGlory C, Toth MJ, Phillips SM.

Maintenance of skeletal muscle function following reduced daily physical activity in healthy older adults: A pilot trial.

Appl Physiol Nutr Metab. 2019 Feb 22. [Epub ahead of print]

https://www.ncbi.nlm.nih.gov/pubmed/30794431

 

15

Otsuka Y, Egawa K, Kanzaki N, Izumo T, Rogi T, Shibata H.

Quercetin glycosides prevent dexamethasone-induced muscle atrophy in mice.

Biochem Biophys Rep. 2019 Jul;18:100618. Epub 2019 Feb 11.

https://www.ncbi.nlm.nih.gov/pubmed/30805562

Note: This article may be obtained online without charge.

 

16

Pagnotti GM, Styner M, Uzer G, Patel VS, Wright LE, Ness KK, Guise TA, Rubin J, Rubin CT.

Combating osteoporosis and obesity with exercise: Leveraging cell mechanosensitivity.

Nat Rev Endocrinol. 2019 Feb 27. [Epub ahead of print] Review.

https://www.ncbi.nlm.nih.gov/pubmed/30814687

 

17

El-Jaby S, Lewis BJ, Tomi L.

On the decision making criteria for cis-lunar reference mission scenarios.

Life Sci Space Res. 2019 Feb 28. [Article in Press]

http://www.sciencedirect.com/science/article/pii/S2214552418300981

Note: From the Introduction: "The objective of this paper is to highlight the subtle effect of shield thickness, SPE [solar particle events] parametric model, dose metric, and transport code on the decision-making criteria."

 

18

Menger R, Wolf M, Thakur JD, Nanda A, Martino A.

Astronaut Michael Collins, Apollo 8, and the anterior cervical fusion that changed the history of human spaceflight.

J Neurosurg Spine. 2019 Feb 22. [Epub ahead of print]

https://www.ncbi.nlm.nih.gov/pubmed/30797203

Note: The article provides details about anterior cervical fusion surgery on Michael Collins and its effects on astronaut selection for Apollo mission crews.

 

19

Baral A.

Lazy rice in space: Gravity regulates helical movement in plants.

Physiol Plant. 2019 Mar;165(3):448-50.

https://www.ncbi.nlm.nih.gov/pubmed/30788843

Note: The author comments on: Kobayashi A, Kim HJ, Tomita Y, Miyazawa Y, Fujii N, Yano S, Yamazaki C, Kamada M, Kasahara H, Miyabayashi S, Shimazu T, Fusejima Y, Takahashi H. Circumnutational movement in rice coleoptiles involves the gravitropic response: Analysis of an agravitropic mutant and space-grown seedlings. Physiol Plant. 2019 Mar;165(3):464-475.https://www.ncbi.nlm.nih.gov/pubmed/30159898, which appeared in SPACELINE Current Awareness List #814, 7 Sep 2018. The article by Baral may be obtained online without charge.

 

20

Kim NY, House R, Yun MH, Nam CS.

Neural correlates of workload transition in multitasking: An ACT-R model of hysteresis effect.

Front Hum Neurosci. 2019 Jan 24;12:535.

https://www.ncbi.nlm.nih.gov/pubmed/30804767

Note: The NASA Task Load Index was used. This article may be obtained online without charge.

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