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NASA Spaceline Current Awareness List #842 29 March 2019 (Space Life Science Research Results)

Status Report From: Spaceline
Posted: Friday, March 29, 2019

SPACELINE Current Awareness Lists are distributed via listserv and are available on the NASA Task Book website at https://taskbook.nasaprs.com/Publication/spaceline.cfm. Please send any correspondence to Robyn Ertwine, SPACELINE Current Awareness Senior Editor, SPACELINE@nasaprs.com.

Papers deriving from NASA support:

1

Sutterfield SL, Alexander AM, Hammer SM, Didier KD, Caldwell JT, Barstow TJ, Ade CJ.

Prediction of planetary mission task performance for long-duration spaceflight.

Med Sci Sports Exerc. 2019 Mar 12. [Epub ahead of print]

https://www.ncbi.nlm.nih.gov/pubmed/30882564

PI: T.J. Barstow

Journal Impact Factor: 4.291

Funding: "This study was supported by a National Aeronautics and Space Administration (NASA) research grant awarded to C.J. Ade and T. J. Barstow."

 

2

Goldman SL, Hassan C, Khunte M, Soldatenko A, Jong Y, Afshinnekoo E, Mason CE.

Epigenetic modifications in acute myeloid leukemia: Prognosis, treatment, and heterogeneity.

Front Genet. 2019 Mar 1;10:133.

https://www.ncbi.nlm.nih.gov/pubmed/30881380

PI: C.E. Mason

Note: This article may be obtained online without charge.

Journal Impact Factor: 4.151

Funding: "The study received funding from the Irma T. Hirschl and Monique Weill-Caulier Charitable Trusts, the Bert L and N Kuggie Vallee Foundation, the WorldQuant Foundation, the Pershing Square Sohn Cancer Research Alliance, NASA (NNX14AH50G, NNX17AB26G), the National Institutes of Health (R25EB020393, R01NS076465, R01AI125416, R01ES021006, 1R21AI129851, 1R01MH117406), the Bill and Melinda Gates Foundation (OPP1151054), the Leukemia and Lymphoma Society (LLS) grants (LLS 923816, Mak, LLS-MCL-982, Chen-Kiang)."

 

3

Goldman SL, MacKay M, Afshinnekoo E, Melnick AM, Wu S, Mason CE.

The impact of heterogeneity on single-cell sequencing.

Front Genet. 2019 Mar 1;10:8.

https://www.ncbi.nlm.nih.gov/pubmed/30881372

PI: C.E. Mason

Note: This article may be obtained online without charge.

Journal Impact Factor: 4.151

Funding: "This work was supported by funding from the Irma T. Hirschl and Monique Weill-Caulier Charitable Trusts, Bert L and N Kuggie Vallee Foundation, the WorldQuant Foundation, The Pershing Square Sohn Cancer Research Alliance, NASA (NNX14AH50G and NNX17AB26G), the National Institutes of Health (R25EB020393, R01NS076465, R01AI125416, R01ES021006, 1R21AI129851, and 1R01MH117406), the Bill and Melinda Gates Foundation (OPP1151054)."

 

4

Lawler JM, Garcia-Villatoro EL, Guzzoni V, Hord JM, Botchlett R, Holly D, Lawler MS, Gomes MJ, Ryan P, Rodriguez D, Kuczmarski JM, Fluckey JD, Talcott S.

Effect of combined fish oil & curcumin on murine skeletal muscle morphology and stress response proteins during mechanical unloading.

Nutr Res. 2019 Jan 7. [Article in Press]

http://www.sciencedirect.com/science/article/pii/S0271531718311230

PIs: J.M. Lawler; J.M. Kuczmarski, NSBRI Postdoctoral Fellowship Program

Note: Hindlimb unloading study.

Journal Impact Factor: 2.707

Funding: "Funding for this study was provided by support from the NASA Space Biology program (NNX13AE45G) (JML), National Space Biomedical Research Institute through NCC 9-58 (JML, JMK), NIH (AR054084) (JML), and the Huffines Institute for Sports Medicine (JML), and Coordenação de Aperfeiçoamento de Pessoal de Nível Superior CAPES (VG)."

 

5

Mann V, Grimm D, Corydon TJ, Kruger M, Wehland M, Riwaldt S, Sahana J, Kopp S, Bauer J, Reseland JE, Infanger M, Mari Lian A, Okoro E, Sundaresan A.

Changes in human foetal osteoblasts exposed to the Random Positioning Machine and bone construct tissue engineering.

Int J Mol Sci. 2019 Mar 18;20(6):E1357.

https://www.ncbi.nlm.nih.gov/pubmed/30889841

Note: This article may be obtained online without charge.

Journal Impact Factor: 3.687

Funding: "This research was funded by NASA grant no. NNX09AV17A, "Development of technologies for elucidation and mitigation of bone loss in microgravity, osteoporosis and inflammatory disease." P.I Alamelu Sundaresan, Mickey Leland study abroad scholarship awarded to Vivek Mann (2015, 2016); This research was also funded by the German Space Agency (DLR, ‘Deutsches Zentrum für Luft- und Raumfahrt’; grant no. DLR/BMWi project 50WB1524 (DG)), Texas Southern University, Houston, Texas, U.S.A and Aarhus University, Aarhus, Denmark."

 

6

Goemaere S, Van Caelenberg T, Beyers W, Binsted K, Vansteenkiste M.

Life on Mars from a self-determination theory perspective: How astronauts’ needs for autonomy, competence and relatedness go hand in hand with crew health and mission success - Results from HI-SEAS IV.

Acta Astronaut. 2019 Mar 22. [Article in Press]

http://www.sciencedirect.com/science/article/pii/S0094576518309871

PI: K. Binsted

Note: The study was conducted as part of the Hawai’i Space Exploration Analog and Simulation (HI-SEAS) IV mission.

Journal Impact Factor: 1.536

Funding: No funding cited. K. Binsted is PI for the HI-SEAS (Hawai'i Space Exploration Analog and Simulation) project.

______________________________________________________

 

 

Other papers of interest:

 

1

Buchheim JI, Matzel S, Rykova M, Vassilieva G, Ponomarev S, Nichiporuk I, Hörl M, Moser D, Biere K, Feuerecker M, Schelling G, Thieme D, Kaufmann I, Thiel M, Choukèr A.

Stress related shift toward inflammaging in cosmonauts after long-duration space flight.

Front Physiol. 2019 Feb 19;10:85.

https://www.ncbi.nlm.nih.gov/pubmed/30873038

Note: ISS results. This article may be obtained online without charge.

 

2

Mao R, Li W, He Z, Bai Z, Xia P, Liang Z, Liu Y.

Physiological, transcriptional, and metabolic alterations in spaceflight-subjected Senna obtusifolia.

Plant Physiol Biochem. 2019 Mar 9;139:33-43.

https://www.ncbi.nlm.nih.gov/pubmed/30878836

Note: Shenzhou-8 results.

 

3

Mattei C, Lim R, Drury H, Nasr B, Li Z, Tadros MA, D'Abaco GM, Stok KS, Nayagam BA, Dottori M.

Generation of vestibular tissue-like organoids from human pluripotent stem cells using the Rotary Cell Culture System.

Front Cell Dev Biol. 2019 Mar 5;7:25.

https://www.ncbi.nlm.nih.gov/pubmed/30891447

Note: A Rotary Cell Culture System (RCCS) was used. This article may be obtained online without charge.

 

4

Yang FN, Xu S, Spaeth A, Galli O, Zhao K, Fang Z, Basner M, Dinges DF, Detre JA, Rao H.

Test-retest reliability of cerebral blood flow for assessing brain function at rest and during a vigilance task.

Neuroimage. 2019 Mar 17;193:157-66.

https://www.ncbi.nlm.nih.gov/pubmed/30894335

 

5

Swain D, Gupta A.

Mechanochemical aspects of skin wound healing in microgravity.

Mech Res Commun. 2019 Mar 23. [Article in Press]

http://www.sciencedirect.com/science/article/pii/S0093641319300941

Note: The authors present "a novel biomechanical-chemical model to understand wound healing in microgravity."

 

6

Mader TH, Gibson CR, Lee AG.

Brain upward shift and spaceflight-associated neuro-ocular syndrome.

JAMA Ophthalmol. 2019 Mar 21. [Epub ahead of print]

https://www.ncbi.nlm.nih.gov/pubmed/30896758

Note: The authors comment on: Shinojima A, Kakeya I, Tada S. Association of space flight with problems of the brain and eyes. JAMA Ophthalmol. 2018 Sep;136(9):1075–1076.https://www.ncbi.nlm.nih.gov/pubmed/29978215, which appeared in SPACELINE Current Awareness List #808, 20 Jul 2018.

 

7

Shinojima A, Kakeya I, Tada S.

Brain upward shift and spaceflight-associated neuro-ocular syndrome-Reply.

JAMA Ophthalmol. 2019 Mar 21. [Epub ahead of print]

https://www.ncbi.nlm.nih.gov/pubmed/30896766

Note: This is a reply to the letter cited above: Mader TH, Gibson CR, Lee AG. Brain upward shift and spaceflight-associated neuro-ocular syndrome. JAMA Ophthalmol. 2019 Mar 21. [Epub ahead of print] https://www.ncbi.nlm.nih.gov/pubmed/30896758.

 

8

Wang S, Li W, Yang X, Huang Y, Sun L-W, Fan Y-B.

Musculoskeletal alterations of hindlimb during simulated microgravity and reloading in rats: Compared by gender.

Microgravity Sci Technol. 2019 Mar 25. [Article in Press]

https://link.springer.com/article/10.1007%2Fs12217-019-9695-0

Note: Hindlimb unloading study.

 

9

Laiakis EC, Canadell MP, Grilj V, Harken AD, Garty GY, Astarita G, Brenner DJ, Smilenov L, Fornace AJ Jr.

Serum lipidomic analysis from mixed neutron/X-ray radiation fields reveals a hyperlipidemic and pro-inflammatory phenotype.

Sci Rep. 2019 Mar 14;9(1):4539.

https://www.ncbi.nlm.nih.gov/pubmed/30872747

Note: This article may be obtained online without charge.

 

10

Lei R, Yan L, Deng Y, Xu J, Zhao T, Awan MUF, Li Q, Zhou G, Wang X, Ma H.

HMGB1 mediated autophagy protects glioblastoma cells from carbon-ion beam irradiation injury.

Acta Astronaut. 2019 Mar 19. [Article in Press]

http://www.sciencedirect.com/science/article/pii/S009457651831097X

 

11

Unthank JL, Ortiz M, Trivedi H, Pelus LM, Sampson CH, Sellamuthu R, Fisher A, Chua HL, Plett A, Orschell CM, Cohen EP, Miller SJ.

Cardiac and renal delayed expression of acute radiation exposure: Organ differences in vasculopathy, inflammation, senescence and oxidative balance.

Radiat Res. 2019 Mar 22. [Epub ahead of print]

https://www.ncbi.nlm.nih.gov/pubmed/30901530

 

12

Blackwell T, Kriesel DR, Vittinghoff E, O'Brien CS, Sullivan JP, Viyaran NC, Rahman SA, Lockley SW, Barger LK, Halbower AC, Poynter SE, Wright KP Jr, Yu PL, Zee PC, Landrigan CP, Czeisler CA, Stone KL. 

Design and recruitment of the randomized order safety trial evaluating resident-physician schedules (ROSTERS) study.

Contemp Clin Trials. 2019 Mar 15. [Epub ahead of print]

https://www.ncbi.nlm.nih.gov/pubmed/30885799

 

13

Ganesan S, Magee M, Stone JE, Mulhall MD, Collins A, Howard ME, Lockley SW, Rajaratnam SMW, Sletten TL.

The impact of shift work on sleep, alertness and performance in healthcare workers.

Sci Rep. 2019 Mar 15;9(1):4635.

https://www.ncbi.nlm.nih.gov/pubmed/30874565

Note: This article may be obtained online without charge.

 

14

Grant LK, Ftouni S, Nijagal B, De Souza DP, Tull D, McConville MJ, Rajaratnam SMW, Lockley SW, Anderson C.

Circadian and wake-dependent changes in human plasma polar metabolites during prolonged wakefulness: A preliminary analysis.

Sci Rep. 2019 Mar 14;9(1):4428.

https://www.ncbi.nlm.nih.gov/pubmed/30872634

Note: This article may be obtained online without charge.

 

15

Mulhall MD, Sletten TL, Magee M, Stone JE, Ganesan S, Collins A, Anderson C, Lockley SW, Howard ME, Rajaratnam SMW.

Sleepiness and driving events in shift workers: The impact of circadian and homeostatic factors.

Sleep. 2019 Mar 18. [Epub ahead of print]

https://www.ncbi.nlm.nih.gov/pubmed/30882154

 

16

Kolev OI.

Self-motion versus environmental-motion perception following rotational vestibular stimulation and factors modifying them.

Front Neurol. 2019 Feb 27;10:162.

https://www.ncbi.nlm.nih.gov/pubmed/30873110

Note: This article may be obtained online without charge.

 

17

Walter HJ, Li R, Munafo J, Curry C, Peterson N, Stoffregen TA.

Unstable coupling of body sway with imposed motion precedes visually induced motion sickness.

Hum Mov Sci. 2019 Apr;64:389-97.

https://www.ncbi.nlm.nih.gov/pubmed/30876760

 

18

Balint TS, Lee CH.

Pillow talk—Curating delight for astronauts.

Acta Astronaut. 2019 Mar 20. [Article in Press]

http://www.sciencedirect.com/science/article/pii/S0094576518320289

Note: From the Introduction: "In this paper...we explore the topic of interactions between a crew member and his/her personal space on a space mission, with a focus on wellbeing."

 

19

Grigoriev GY, Lagutin AS, Nabiev SS, Zuev BK, Filonenko VA, Legin AV, Kirsanov DO.

Water quality monitoring during interplanetary space flights.

Acta Astronaut. 2019 Mar 26. [Article in Press]

http://www.sciencedirect.com/science/article/pii/S0094576518319933

 

20

Canarini A, Kaiser C, Merchant A, Richter A, Wanek W.

Root exudation of primary metabolites: Mechanisms and their roles in plant responses to environmental stimuli.

Front Plant Sci. 2019 Feb 21;10:157. Review.

https://www.ncbi.nlm.nih.gov/pubmed/30881364

Note: This article may be obtained online without charge.

 

 

Please note: The following articles were published in the Russian aerospace journal Aviakosmicheskaia i Ekologicheskaia Meditsina in 2016 and 2017; they were republished in English in the December 2018 issue of Human Physiology.

 

21

Kozlovskaya IB.

Gravity and the tonic postural motor system.

Hum Physiol. 2018 Dec 1;44(7):725-39. Review.

https://link.springer.com/article/10.1134/S036211971807006X

Note: Originally published in Russian in Aviakosmicheskaya i Ekologicheskaya Meditsina, 2017;51(3):5-21.

 

22

Ilyin EA.

Physiological status of polar explorers and its improvement with drugs in conditions of one-year isolation at the Vostok Station in the Antarctic.

Hum Physiol. 2018 Dec 1;44(7):740-7.

https://link.springer.com/article/10.1134/S0362119718070046

Note: Originally published in Russian in Aviakosmicheskaya i Ekologicheskaya Meditsina, 2017;51(4):5-14.

 

23

Kuznetsova PG, Gushchin VI, Natura ES.

The association between psychological stability and successful interpersonal interaction in isolation: Theoretical and methodical aspects.

Hum Physiol. 2018 Dec 1;44(7):748-52.

https://link.springer.com/article/10.1134/S0362119718070071

Note: Originally published in Russian in Aviakosmicheskaya i Ekologicheskaya Meditsina, 2017;51(4):28-33.

 

24

Naumov IA, Kornilova LN, Glukhikh DO, Pavlova AS, Khabarova EV, Ekimovsky GA, Vasin AV.

Effect of repeated space flights on ocular tracking.

Hum Physiol. 2018 Dec 1;44(7):765-74.

https://link.springer.com/article/10.1134/S0362119718070095 

Note: ISS results. Originally published in Russian in Aviakosmicheskaya i Ekologicheskaya Meditsina, 2016;50(1):17-27. The Russian version appeared in SPACELINE Current Awareness List #706, 8 July 2016.

 

25

Kotovskaya AR.

Human tolerance of g-loads in space missions and artificial gravity.

Hum Physiol. 2018 Dec 1;44(7):779-93.

https://link.springer.com/article/10.1134/S0362119718070058

Note: Soyuz, Mir, and ISS results are discussed. Originally published in Russian in Aviakosmicheskaya i Ekologicheskaya Meditsina, 2017;51(5):5-21.

 

26

Suvorov AV, Pamova AP, Fedorovich AA.

Specifics of microcirculation under the conditions of "dry" immersion.

Hum Physiol. 2018 Dec 1;44(7):794-8.

https://link.springer.com/article/10.1134/S0362119718070162

Note: Dry immersion was used. Originally published in Russian in Aviakosmicheskaya i Ekologicheskaya Meditsina, 2017;51(6):32-7.

 

27

Ponomarev SA, Muranova AV, Kalinin SA, Antropova EN, Rykova MP, Koloteva MI, Orlov OI.

Cell immunity indices in crew members of the Moon-2015 Project.

Hum Physiol. 2018 Dec 1;44(7):799-805.

https://link.springer.com/article/10.1134/S0362119718070125

Note: Results are from the Moon-2015 Project, which simulated an 8-day lunar mission with an all-female crew. Originally published in Russian in Aviakosmicheskaya i Ekologicheskaya Meditsina, 2017;51(2):13-9.

 

28

Makarov IA, Voronkov YI.

Effects of physical loads in supine position on intraocular pressure.

Hum Physiol. 2018 Dec 1;44(7):806-9.

https://link.springer.com/article/10.1134/S0362119718070083

Note: Originally published in Russian in Aviakosmicheskaya i Ekologicheskaya Meditsina, 2017;51(2):47-51.

 

29

Novikov VE, Oganov VS, Kabitskaya OE, Murashko LM, Naidina VP, Chernikhova EA.

Mineral bone density and body composition of participants in experiment Mars-500.

Hum Physiol. 2018 Dec 1;44(7):815-8.

https://link.springer.com/article/10.1134/S0362119718070101

Note: Results are from the Mars-500 Project. Originally published in Russian in Aviakosmicheskaya i Ekologicheskaya Meditsina, 2016;50(1):35-8. The Russian version appeared in SPACELINE Current Awareness List #706, 8 July 2016.

 

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