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NASA Spaceline Current Awareness List #843 5 April 2019 (Space Life Science Research Results)

Status Report From: Spaceline
Posted: Friday, April 5, 2019

SPACELINE Current Awareness Lists are distributed via listserv and are available on the NASA Task Book website at https://taskbook.nasaprs.com/Publication/spaceline.cfm. Please send any correspondence to Robyn Ertwine, SPACELINE Current Awareness Senior Editor, SPACELINE@nasaprs.com.


Papers deriving from NASA support:

1

Urbaniak C, van Dam P, Zaborin A, Zaborina O, Gilbert JA, Torok T, Wang CCC, Venkateswaran K.

Genomic characterization and virulence potential of two Fusarium oxysporum isolates cultured from the International Space Station.

mSystems. 2019 Mar 19;4(2):e00345-18.

https://www.ncbi.nlm.nih.gov/pubmed/30944876

PIs: K. Venkateswaran; C. Urbaniak, NASA Postdoctoral Fellowship Program

Note: ISS results. This article may be obtained online without charge.

Journal Impact Factor: 5.75

Funding: "Part of the research described in this publication was carried out at the Jet Propulsion Laboratory, California Institute of Technology, under a contract with NASA. The C. elegans work was supported by the Tissue Engineering and Cell Models Core of the NIDDK Digestive Diseases Research Core Center (DDRCC) P30 DK42086 at the University of Chicago. This research was funded by 2012 Space Biology NNH12ZTT001N grant no. 19-12829-26 under Task Order NNN13D111T awarded to K.V. C.U. was funded by the NASA Postdoctoral program fellowship. Government sponsorship is acknowledged."

 

2

Beisel NS, Noble J, Barbazuk WB, Paul A-L, Ferl RJ.

Spaceflight-induced alternative splicing during seedling development in Arabidopsis thaliana.

npj Microgravity. 2019 Apr 3;5(1):9.

https://www.nature.com/articles/s41526-019-0070-7

PIs: R.J. Ferl, A-L. Paul

Note: ISS results. This article may be obtained online without charge.

Journal Impact Factor: 2.00

Funding: "This work was funded by grants NNX12AN69G to R.J.F. and A.-L.P. from NASA Space Life and Physical Sciences, managed through Kennedy Space Center."

 

3

Kwok AT, Moore JE, Rosas S, Kerr BA, Andrews RN, Nguyen CM, Lee J, Furdui CM, Collins BE, Munley MT, Willey JS.

Knee and hip joint cartilage damage from combined spaceflight hazards of low-dose radiation less than 1 Gy and prolonged hindlimb unloading.

Radiat Res. 2019 Mar 29. [Epub ahead of print]

https://www.ncbi.nlm.nih.gov/pubmed/30925135

PI: J.S. Willey

Note: Hindlimb unloading study.

Journal Impact Factor: 2.53

Funding: "This research was supported by the National Aeronautics and Space Administration (NASA grant no. NNX15AB50G to JSW). Additionally, this work was supported in part by the National Institutes of Health (NIH grant nos. U19 AI67798 and T35 OD010946) and a National Cancer Institute (NCI) Cancer Center Support Grant (P30 CA012197) to the Comprehensive Cancer Center of Wake Forest Baptist Medical Center, as well as the North Carolina Biotechnology Center (no. 2015-IDG-1006). We also acknowledge the support of the Comparative Pathology Laboratory Shared Resources and the Proteomics and Metabolomics Shared Resources, which is partly supported by Comprehensive Cancer Center of Wake Forest Baptist Medical Center (NCI Cancer Center Support Grant No. P30CA012197)."

 

4

Raber J, Yamazaki J, Torres ERS, Kirchoff N, Stagaman K, Sharpton T, Turker MS, Kronenberg A.

Combined effects of three high-energy charged particle beams important for space flight on brain, behavioral and cognitive endpoints in B6D2F1 female and male mice.

Front Physiol. 2019 Mar 12;10:179.

https://www.ncbi.nlm.nih.gov/pubmed/30914962

PI: A. Kronenberg

Note: This article may be obtained online without charge.

Journal Impact Factor: 2.323

Funding: "This work was supported by NASA grant NNJ16HP23I and by NIA T32 AG055378-01A1, and NIEHS T32ES007060-38."

 

5

Graham T, Yorio N, Zhang P, Massa G, Wheeler RM.

Early seedling response of six candidate crop species to increasing levels of blue light.

Life Sci Space Res. 2019 May;21:40-8.  Epub 2019 Apr 3.

https://www.sciencedirect.com/science/article/pii/S2214552418300968

Journal Impact Factor: 1.97

Funding: "This work was supported by the NASA Post-Doctoral Program (Thomas Graham) through NASA’s Space Life and Physical Sciences Research and Applications (SLPSRA), the University of Guelph’s Controlled Environment Systems Research Facility, and a NASA Center Innovation Fund (CIF) grant from Space Technology Mission Directorate (STMD)."

_______________________________________________________

 

 

Other papers of interest:

 

1

Scott JPR, Weber T, Green DA.

Introduction to the Frontiers Research Topic: Optimization of exercise countermeasures for human space flight - Lessons from terrestrial physiology and operational considerations.

Front Physiol. 2019 Mar 7;10:173.

https://www.ncbi.nlm.nih.gov/pubmed/30899226

Note: Exercise methods used during the Apollo, Skylab, Space Shuttle, and ISS missions are discussed. From the Introduction: "The aim of this Perspective, which serves as a preface to the Frontiers Research Topic Optimization of Exercise Countermeasures (CM) for Human Space Flight – Lessons from Terrestrial Physiology and Operational Considerations, is threefold: to briefly review the use and apparent efficacy of exercise in space, to consider the impact of the transition from ISS to exploration mission vehicles and habitats, and identify potential areas where terrestrial exercise physiology knowledge might contribute to the optimization of future spaceflight CM exercise." This article may be obtained online without charge.

 

2

Zhang B, Bai P, Zhao X, Yu Y, Zhang X, Li D, Liu C.

Increased growth rate and amikacin resistance of Salmonella enteritidis after one-month spaceflight on China's Shenzhou-11 spacecraft.

Microbiologyopen. 2019 Mar 25. [Epub ahead of print]

https://www.ncbi.nlm.nih.gov/pubmed/30912318

Note: Shenzhou-11 results. This article may be obtained online without charge.

 

3

Krüger M, Kopp S, Wehland M, Bauer J, Baatout S, Moreels M, Egli M, Corydon TJ, Infanger M, Grimm D.

Growing blood vessels in space: Preparation studies of the SPHEROIDS project using related ground-based studies.

Acta Astronaut. 2019 Jun 1;159:267-72. Epub 2019 Mar 28.

http://www.sciencedirect.com/science/article/pii/S0094576518320605

Note: ISS results. A random positioning machine was used.

 

4

Dobynde MI, Effenberger F, Kartashov DA, Shprits YY, Shurshakov VA.

Ray-tracing simulation of the radiation dose distribution on the surface of the spherical phantom of the MATROSHKA-R experiment onboard the ISS.

Life Sci Space Res. 2019 Apr 3. [Article in Press]

http://www.sciencedirect.com/science/article/pii/S2214552418300804

Note: ISS results.

 

5

Gan L, Chao Y, Su H, Ren Y, Yin S, Han L.

Altered promoter and G-box binding factor for 1-deoxy-d-xylulose-5-phosphate synthase gene grown from Poa pratensis seeds after spaceflight.

Int J Mol Sci. 2019 Mar 21;20(6):E1398.

https://www.ncbi.nlm.nih.gov/pubmed/30901811

Note: Seeds were flown on a recoverable Chinese satellite. This article may be obtained online without charge.

 

6

Stok WJ, Karemaker JM, Berecki-Gisolf J, Immink RV, van Lieshout JJ.

Slow sinusoidal tilt movements demonstrate the contribution to orthostatic tolerance of cerebrospinal fluid movement to and from the spinal dural space.

Physiol Rep. 2019 Feb;7(4):e14001.

https://www.ncbi.nlm.nih.gov/pubmed/30810293

Note: ISS results. From the Discussion: "This study was undertaken on the assumption that dynamic (passive) changes of body posture might shed more light on the individual capacity to autoregulate cerebral blood flow. The results of these studies were to help predict orthostatic intolerance after challenges like (short-lasting) space flight." Study participants included five cosmonauts who later spent time on the ISS and were retested upon return to Earth and the seven astronauts who were lost in the Columbia Space Shuttle accident. A related editorial has been published and is cited below: Petersen LG, Ogoh S. Gravity, intracranial pressure, and cerebral autoregulation. Physiol Rep. 2019 Mar 26;7(6):e14039. https://www.ncbi.nlm.nih.gov/pubmed/30912269. Both articles may be obtained online without charge.

 

7

Petersen LG, Ogoh S.

Gravity, intracranial pressure, and cerebral autoregulation.

Physiol Rep. 2019 Mar 26;7(6):e14039.

https://www.ncbi.nlm.nih.gov/pubmed/30912269

Note: This editorial discusses the article: Stok WJ, Karemaker JM, Berecki-Gisolf J, Immink RV, van Lieshout JJ. Slow sinusoidal tilt movements demonstrate the contribution to orthostatic tolerance of cerebrospinal fluid movement to and from the spinal dural space. Physiol Rep. 2019 Feb;7(4):e14001.https://www.ncbi.nlm.nih.gov/pubmed/30810293, cited above. Both articles may be obtained online without charge.

 

8

Convertino VA, Schlotman TE, Stacey W, Hinojosa-Laborde C.

Capacity to compensate for central hypovolemia and effects of menstrual cycle phases.

Aerosp Med Hum Perform. 2019 Apr 1;90(4):378-83.

https://www.ncbi.nlm.nih.gov/pubmed/30922425

Note: Lower body negative pressure was used.

 

9

Koons NJ, Suresh MR, Schlotman TE, Convertino VA.

Interrelationship between sex, age, blood volume, and V̇O2max.

Aerosp Med Hum Perform. 2019 Apr 1;90(4):362-8.

https://www.ncbi.nlm.nih.gov/pubmed/30922423

 

10

Rice GM, Snider D, Drollinger S, Greil C, Bogni F, Phillips J, Raj A, Marco K, Linnville S.

Gender differences in dry-EEG manifestations during acute and insidious normobaric hypoxia.

Aerosp Med Hum Perform. 2019 Apr 1;90(4):369-77.

https://www.ncbi.nlm.nih.gov/pubmed/30922424

 

11

Mortazavi SMJ.

Acquired antibiotic resistance in Escherichia coli exposed to simulated microgravity: Possible role of other space stressors and adaptive responses.

MBio. 2019 Mar 26;10(2):e00165-19.

https://www.ncbi.nlm.nih.gov/pubmed/30914503

Note: The author comments on: Tirumalai MR, Karouia F, Tran Q, Stepanov VG, Bruce RJ, Ott CM, Pierson DL, Fox GE. Evaluation of acquired antibiotic resistance in Escherichia coli exposed to long-term low-shear modeled microgravity and background antibiotic exposure. MBio. 2019 Jan 15;10(1):e02637-18.https://www.ncbi.nlm.nih.gov/pubmed/30647159, in which a rotary cell culture system was used. The original article was cited in SPACELINE Current Awareness List #833 on 25 Jan 2019. Both articles may be obtained online without charge.

 

12

Tirumalai MR, Fox GE.

Reply to Mortazavi, "Acquired antibiotic resistance in Escherichia coli exposed to simulated microgravity: Possible role of other space stressors and adaptive responses."

MBio. 2019 Mar 26;10(2):e00391-19.

https://www.ncbi.nlm.nih.gov/pubmed/30914512

Note: This is a reply to the letter cited above: Mortazavi SMJ. Acquired antibiotic resistance in Escherichia coli exposed to simulated microgravity: Possible role of other space stressors and adaptive responses. MBio. 2019 Mar 26;10(2). https://www.ncbi.nlm.nih.gov/pubmed/30914503. Both articles may be obtained online without charge.

 

13

Shenkman BS, Kozlovskaya IB.

Cellular responses of human postural muscle to dry immersion.

Front Physiol. 2019 Mar 11;10:187.

https://www.ncbi.nlm.nih.gov/pubmed/30914964

Note: Dry immersion was used. This article may be obtained online without charge.

 

14

Wang P, Zhang H, Li Z, Liu X, Jin Y, Lei M, Jiao Z, Bi Y, Guo W.

Low-dose radiation promotes the proliferation and migration of AGE-treated endothelial progenitor cells derived from bone marrow via activating SDF-1/CXCR4/ERK signaling pathway.

Radiat Res. 2019 Mar 29. [Epub ahead of print]

https://www.ncbi.nlm.nih.gov/pubmed/30925138

 

15

Gonfalone AA.

Hypothetical role of gravity in rapid eye movements during sleep.

Med Hypotheses. 2019 Jun 1;127:63-5. Epub 2019 Mar 28.

http://www.sciencedirect.com/science/article/pii/S0306987719301227

Note: This article may be obtained online without charge.

 

16

Chauvet H, Moulia B, Legue V, Forterre Y, Pouliquen O.

Revealing the hierarchy of processes and time-scales that control the tropic response of shoots to gravi-stimulations.

J Exp Bot. 2019 Mar 27;70(6):1955-67.

https://www.ncbi.nlm.nih.gov/pubmed/30916341

Note: A rotating table was used.  This article may be obtained online without charge.

 

17

Wang P, Nolan TM, Yin Y, Bassham DC.

Identification of transcription factors that regulate ATG8 expression and autophagy in Arabidopsis.

Autophagy. 2019 Mar 25. [Epub ahead of print]

https://www.ncbi.nlm.nih.gov/pubmed/30909785

 

18

Kovalev VS, Manukovsky NS, Tikhomirov AA.

Computing-feasibility study of NASA nutrition requirements as applied to a bioregenerative life support system.

Acta Astronaut. 2019 Apr 2. [Article in Press]

http://www.sciencedirect.com/science/article/pii/S0094576518306696

 

19

Bazazan A, Dianat I, Bahrampour S, Talebian A, Zandi H, Sharafkhaneh A, Maleki-Ghahfarokhi A.

Association of musculoskeletal disorders and workload with work schedule and job satisfaction among emergency nurses.

Int Emerg Nurs. 2019 Mar 19. [Epub ahead of print]

https://www.ncbi.nlm.nih.gov/pubmed/30902617

Note: The NASA Task Load Index was used.

 

20

Sun J, Cheng S, Ma J, Xiong K, Su M, Hu W.

Assessment of the static upright balance index and brain blood oxygen levels as parameters to evaluate pilot workload.

PLoS One. 2019 Mar 28;14(3):e0214277.

https://www.ncbi.nlm.nih.gov/pubmed/30921375

Note: The NASA Task Load Index was used. This article may be obtained online without charge.

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