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NASA Spaceline Current Awareness List #849 17 May 2019 (Space Life Science Research Results)

Status Report From: Spaceline
Posted: Friday, May 17, 2019

SPACELINE Current Awareness Lists are distributed via listserv and are available on the NASA Task Book website at: https://taskbook.nasaprs.com/Publication/spaceline.cfm. Please send any correspondence to Robyn Ertwine, SPACELINE Current Awareness Senior Editor, SPACELINE@nasaprs.com.

 

 

Papers deriving from NASA support:

 

1

Thosar SS, Berman AM, Herzig MX, McHill AW, Bowles NP, Swanson CM, Clemons NA, Butler MP, Clemons AA, Emens JS, Shea SA.

Circadian rhythm of vascular function in midlife adults.

Arterioscler Thromb Vasc Biol. 2019 Apr 18. [Epub ahead of print]

https://www.ncbi.nlm.nih.gov/pubmed/31070470

PI: S.S. Thosar

Note: This article may be obtained online without charge.

Journal Impact Factor: 6.607

Funding: "This work was supported by the National Institutes of Health grant numbers R01-HL125893, R01-HL142064, HL125893-03S1, R01 HL140577 and K24-HL76446 F32-HL131308, F32DK107146, KL2TR002370, and UL1TR000128; National Space Biomedical Research Institute through NCC 9–58; Medical Research Foundation of Oregon; American Sleep Medicine Foundation; Ford Foundation Fellowship; and the Oregon Institute of Occupational Health Sciences via funds from the Division of Consumer and Business Services of the State of Oregon (ORS 656.630)."

 

2

Ryder JW, Fullmer P, Buxton RE, Crowell JB, Goetchius E, Bekdash O, DeWitt JK, Hwang EY, Feiveson A, English KL, Ploutz-Snyder LL.

A novel approach for establishing fitness standards for occupational task performance.

Eur J Appl Physiol. 2019 May 8. [Epub ahead of print]

https://www.ncbi.nlm.nih.gov/pubmed/31069517

PIs: J.W. Ryder, L.L. Ploutz-Snyder

Journal Impact Factor: 2.401

Funding: "This work was supported by the National Aeronautics and Space Administration Human Research Program NNJ15HK11B." LLP-S reports funding under NASA grant NNX16AO74G.

 

3

Touchstone H, Bryd R, Loisate S, Thompson M, Kim S, Puranam K, Senthilnathan AN, Pu X, Beard R, Rubin J, Alwood J, Oxford JT, Uzer G.

Recovery of stem cell proliferation by low intensity vibration under simulated microgravity requires LINC complex.

npj Microgravity. 2019 May 15;5(1):11.

https://www.nature.com/articles/s41526-019-0072-5

Note: A clinostat was used. This article may be obtained online without charge.

Journal Impact Factor: 2.00

Funding: "This study was supported by NASA EPSCoR NNX15AK35A (G.U.), NASA ISGC NNX15AI04H (G.U.), NIH 5P2CHD086843-03 (G.U.), and P20GM109095 (G.U., J.T.O.). Authors acknowledge further support by the Institutional Development Award (IDeA) Program from the National Institute of General Medical Sciences of the National Institutes of Health under Grants #P20GM103408 and P20GM109095. We also acknowledge support from The Biomolecular Research Center at Boise State with funding from the National Science Foundation, Grants #0619793 and #0923535; the MJ Murdock Charitable Trust; Lori and Duane Steuckle, and the Idaho State Board of Education."

 

4

Penninckx S, Cekanaviciute E, Degorre C, Guiet E, Viger L, Lucas S, Costes SV.

Dose, LET and strain dependence of radiation-induced 53BP1+ foci in 15 mouse strains ex vivo introducing novel DNA damage metrics.

Radiat Res. 2019 May 13. [Epub ahead of print]

https://www.ncbi.nlm.nih.gov/pubmed/31081741

PI: S.V. Costes

Journal Impact Factor: 1.691

Funding: "This work was supported by the National Aeronautics and Space Administration (grant no. NNL15AA08I [NNJ16HP24I] to SVC, principal investigator). S. Penninckx is a PhD fellow funded by the Belgian Fund for Scientific Research (FRS-FNRS, Belgium)."

______________________________________________________

 

 

Other papers of interest:

 

1

Bacci G, Amalfitano S, Levantesi C, Rossetti S, Garrelly L, Canganella F, Bianconi G, Di Pilato V, Rossolini GM, Mengoni A, Fani R, Perrin E.

Microbial community composition of water samples stored inside the International Space Station.

Res Microbiol. 2019 May 7. [Epub ahead of print]

https://www.ncbi.nlm.nih.gov/pubmed/31075387

Note: ISS results.

 

2

Van Ombergen A, Jillings S, Jeurissen B, Tomilovskaya E, Rumshiskaya A, Litvinova L, Nosikova I, Pechenkova E, Rukavishnikov I, Manko O, Danylichev S, Rühl RM, Kozlovskaya IB, Sunaert S, Parizel PM, Sinitsyn V, Laureys S, Sijbers J, Zu Eulenburg P, Wuyts FL.

Brain ventricular volume changes induced by long-duration spaceflight.

Proc Natl Acad Sci U S A. 2019 May 6. [Epub ahead of print]

https://www.ncbi.nlm.nih.gov/pubmed/31061119

Note: ISS results. This article may be obtained online without charge.

 

3

Mathers KE, Staples JF.

Differential post-translational modification of mitochondrial enzymes corresponds with metabolic suppression during hibernation.

Am J Physiol Regul Integr Comp Physiol. 2019 May 8. [Epub ahead of print]

https://www.ncbi.nlm.nih.gov/pubmed/31067076

 

4

Woodcock EM, Girvan P, Eckert J, Lopez-Duarte I, Kubankova M, van Loon J, Brooks NJ, Kuimova MK.

Measuring intracellular viscosity in conditions of hypergravity.

Biophys J. 2019 Apr 8. [Epub ahead of print]

https://www.ncbi.nlm.nih.gov/pubmed/31053255

Note: Centrifugation was used.

 

5

Zhang X, Chu X, Chen L, Fu J, Wang S, Song J, Kan G, Jiang W, He G, Chen X, Li W.

Simulated weightlessness procedure, head-down bed rest impairs adult neurogenesis in the hippocampus of rhesus macaque.

Mol Brain. 2019 May 9;12(1):46.

https://www.ncbi.nlm.nih.gov/pubmed/31072406

Note: Head-down tilt bed rest study. This article may be obtained online without charge.

 

6

Wostyn P, Mader TH, Gibson CR, Killer HE.

The escape of retrobulbar cerebrospinal fluid in the astronaut's eye: Mission impossible?

Eye (Lond). 2019 May 7. [Epub ahead of print] Review.

https://www.ncbi.nlm.nih.gov/pubmed/31065103

 

7

Bouvière J, Trignol A, Hoang DH, Del Carmine P, Goriot ME, Ben Larbi S, Barritault D, Banzet S, Chazaud B.

Heparan sulfate mimetics accelerate post-injury skeletal muscle regeneration.

Tissue Eng Part A. 2019 May 7. [Epub ahead of print]

https://www.ncbi.nlm.nih.gov/pubmed/31062647

 

8

Besschetnova T, Brooks DJ, Hu D, Nagano K, Nustad J, Ominsky M, Mitlak B, Hattersley G, Bouxsein ML, Baron R, Lanske B.

Abaloparatide improves cortical geometry and trabecular microarchitecture and increases vertebral and femoral neck strength in a rat model of male osteoporosis.

Bone. 2019 Apr 30;124:148-57.

https://www.ncbi.nlm.nih.gov/pubmed/31051317

 

9

Bullock WA, Pavalko FM, Robling AG.

Osteocytes and mechanical loading: The Wnt connection.

Orthod Craniofac Res. 2019 May;22(Suppl 1):175-9.

https://www.ncbi.nlm.nih.gov/pubmed/31074153

 

10

Chandler H, Brooks DJ, Hattersley G, Bouxsein ML, Lanske B.

Abaloparatide increases bone mineral density and bone strength in ovariectomized rabbits with glucocorticoid-induced osteopenia.

Osteoporos Int. 2019 May 3. [Epub ahead of print]

https://www.ncbi.nlm.nih.gov/pubmed/31053927

Note: This article may be obtained online without charge.

 

11

Moridera K, Uchida S, Tanaka S, Menuki K, Utsunomiya H, Yamaoka K, Sonomoto K, Tanaka Y, Sakai A.

Skeletal unloading reduces cluster of differentiation (CD) 38 expression in the bone marrow and osteoblasts of mice.

J Orthop Sci. 2019 May 6. [Epub ahead of print]

https://www.ncbi.nlm.nih.gov/pubmed/31072650

Note: Hindlimb unloading study. This article may be obtained online without charge.

 

12

Pannkuk EL, Laiakis EC, Singh VK, Fornace AJ.

Author Correction: Lipidomic signatures of nonhuman primates with radiation-induced hematopoietic syndrome.

Sci Rep. 2019 May 3;9(1):6878.

https://www.ncbi.nlm.nih.gov/pubmed/31053740

Note: This corrigendum corrects an error in the abstract of the original article. The corrected text is: "The current study addresses temporal changes in the serum lipidome from 4 h to 28 d in nonhuman primates (NHPs) with radiation-induced hematopoietic syndrome (6.5 Gy exposure, LD50/60)." The original article was: Pannkuk EL, Laiakis EC, Singh VK, Fornace AJ. Lipidomic signatures of nonhuman primates with radiation-induced hematopoietic syndrome. Sci Rep. 2017 Aug 29;7(1):9777. https://www.ncbi.nlm.nih.gov/pubmed/28852188. It appeared in SPACELINE Current Awareness List #766, 22 Sep 2017. Both articles may be obtained online without charge.

 

13

Buckey JC.

Use of gases to treat cochlear conditions.

Front Cell Neurosci. 2019 Apr 24;13:155.

https://www.ncbi.nlm.nih.gov/pubmed/31068792

Note: This article may be obtained online without charge.

 

14

Koppen M, Ter Horst AC, Medendorp WP.

Weighted visual and vestibular cues for spatial updating during passive self-motion.

Multisens Res. 2019 Jan 1. [Epub ahead of print]

https://www.ncbi.nlm.nih.gov/pubmed/31059483

 

15

Sprecher KE, Ritchie HK, Burke TM, Depner CM, Smits AN, Dorrestein PC, Fleshner M, Knight R, Lowry CA, Turek FW, Vitaterna MH, Wright KP Jr.

Trait-like vulnerability of higher-order cognition and ability to maintain wakefulness during combined sleep restriction and circadian misalignment.

Sleep. 2019 May 9. [Epub ahead of print]

https://www.ncbi.nlm.nih.gov/pubmed/31070769

 

16

Xie H, Engle NL, Venketachalam S, Yoo CG, Barros J, Lecoultre M, Howard N, Li G, Sun L, Srivastava AC, Pattathil S, Pu Y, Hahn MG, Ragauskas AJ, Nelson RS, Dixon RA, Tschaplinski TJ, Blancaflor EB, Tang Y. 

Combining loss of function of FOLYLPOLYGLUTAMATE SYNTHETASE1 and CAFFEOYL-COA 3-O-METHYLTRANSFERASE1 for lignin reduction and improved saccharification efficiency inArabidopsis thaliana.

Biotechnol Biofuels. 2019 May 3;12:108.

https://www.ncbi.nlm.nih.gov/pubmed/31073332

Note: This article may be obtained online without charge.

 

17

Goodman MB, Sengupta P.

How Caenorhabditis elegans senses mechanical stress, temperature, and other physical stimuli.

Genetics. 2019 May;212(1):25-51.

https://www.ncbi.nlm.nih.gov/pubmed/31053616

Note: This article may be obtained online without charge.

 

18

Panesar SS, Fernandez-Miranda JC, Kliot M, Ashkan K.

In Reply: Neurosurgery and manned spaceflight.

Neurosurgery. 2019 May 6. [Epub ahead of print]

https://www.ncbi.nlm.nih.gov/pubmed/31058971

Note: The authors comment on: Agrawal A, Pacheco-Hernandez A, Moscote-Salazar LR. Letter: Neurosurgery and manned spaceflight. Neurosurgery. 2019 Apr 8. [Epub ahead of print]https://www.ncbi.nlm.nih.gov/pubmed/30957146, which appeared in SPACELINE Current Awareness List #845, 19 Apr 2019. The original article is: Panesar SS, Fernandez-Miranda JC, Kliot M, Ashkan K. Neurosurgery and manned spaceflight. Neurosurgery. 2018 Nov 8. [Epub ahead of print] Review. https://www.ncbi.nlm.nih.gov/pubmed/30407580. It appeared in SPACELINE Current Awareness List #824, 16 Nov 2018. The Letter and Reply may be obtained online without charge.

 

19

Zuccarelli L, Galasso L, Turner R, Coffey EJB, Bessone L, Strapazzon G.

Human physiology during exposure to the cave environment: A systematic review with implications for aerospace medicine.

Front Physiol. 2019 Apr 24;10:442. Review.

https://www.ncbi.nlm.nih.gov/pubmed/31068833

Note: From the abstract: "The aim of our review was to conduct a systematic bibliographic research review of the effects of short and prolonged exposure to a cave environment on human physiology, with a view to extend the results to implications for human planetary exploration missions." This article may be obtained online without charge.

 

20

Mixter S, Mathiassen SE, Hallman D.

Alternations between physical and cognitive tasks in repetitive work - Effect of cognitive task difficulty on fatigue development in women.

Ergonomics. 2019 May 4. [Epub ahead of print]

https://www.ncbi.nlm.nih.gov/pubmed/31056015

Note: This article may be obtained online without charge.

 

21

Condino S, Carbone M, Piazza R, Ferrari M, Ferrari V.

Perceptual limits of optical see-through visors for augmented reality guidance of manual tasks.

IEEE Trans Biomed Eng. 2019 May 6. [Epub ahead of print]

https://www.ncbi.nlm.nih.gov/pubmed/31059421

Note: The NASA Task Load Index was used.

...

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