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NASA Spaceline Current Awareness List #866 20 September 2019 (Space Life Science Research Results)

Status Report From: Spaceline
Posted: Friday, September 20, 2019

SPACELINE Current Awareness Lists are distributed via listserv and are available on the NASA Task Book website at https://taskbook.nasaprs.com/Publication/spaceline.cfm. Please send any correspondence to Robyn Ertwine, SPACELINE Current Awareness Senior Editor, SPACELINE@nasaprs.com.

 

Papers deriving from NASA support:

 

1

Liu H, Begik O, Lucas MC, Ramirez JM, Mason CE, Wiener D, Schwartz S, Mattick JS, Smith MA, Novoa EM.

Accurate detection of m6A RNA modifications in native RNA sequences.

Nat Commun. 2019 Sep 9;10(1):4079.

https://www.ncbi.nlm.nih.gov/pubmed/31501426

PI: C.E. Mason

Note: This article may be obtained online without charge.

Journal Impact Factor: 11.878

Funding: "O.B. is supported by an international PhD fellowship (UIPA) from the University of New South Wales. M.C.L. is supported by CRG International PhD Fellowships Programme. E.M.N was supported by a DECRA fellowship from the Australian Research Council (DE170100506) and is currently supported by CRG Severo Ochoa Funding. This work was funded by the Australian Research Council (DP180103571). We acknowledge the support of the Spanish Ministry of Economy, Industry and Competitiveness (MEIC) to the EMBL partnership, Centro de Excelencia Severo Ochoa and CERCA Programme/Generalitat de Catalunya. C.E.M thanks funding from the Bert L and N Kuggie Vallee Foundation, the WorldQuant Foundation, The Pershing Square Sohn Cancer Research Alliance, NASA (NNX14AH50G, NNX17AB26G), the National Institutes of Health (R01ES021006, 1R21AI129851, and 1R01MH117406), the Bill and Melinda Gates Foundation (OPP1151054), the Leukemia and Lymphoma Society grants (LLS 9238-16, LLS-MCL-982)."

 

2

Galeota-Sprung B, Guindon B, Sniegowski P.

The fitness cost of mismatch repair mutators in Saccharomyces cerevisiae: Partitioning the mutational load.

Heredity (Edinb). 2019 Sep 12. [Epub ahead of print]

https://www.ncbi.nlm.nih.gov/pubmed/31515531

Journal Impact Factor: 3.179

Funding: "This research was facilitated by a National Aeronautics and Space Administration grant (NNA15BB04A) to PDS and a National Science Foundation Graduate Research Fellowship to BGS."

 

3

Qin YX, Xia Y, Muir J, Lin W, Rubin CT.

Quantitative ultrasound imaging monitoring progressive disuse osteopenia and mechanical stimulation mitigation in calcaneus region through a 90-day bed rest human study.

J Orthop Translat. 2019 Jul;18:48-58.

https://www.ncbi.nlm.nih.gov/pubmed/31508307

PI: Y.X. Qin

Note: Bed rest study. This article may be obtained online without charge.

Journal Impact Factor: 3.063

Funding: "This work was kindly supported by the National Space Biomedical Research Institute (TD00405 & SMST01603) through NASA Cooperative Agreement NCC 9-58, and NASA."

 

4

Davis CM, Rabin BM.

Space radiation-induced cognitive deficits following head-only, whole body, or body-only exposures.

THREE. 2019 Sep 11. Review.

https://three.jsc.nasa.gov/articles/Cog_Defects_Davis-Rabin.pdf

PIs: C.M. Davis; B.M. Rabin; C.M. Davis/VNSCOR

Note: This article may be obtained online without charge.

Journal Impact Factor: Not applicable to this publication

Funding: "Preparation of this review was supported by NASA grants NNX15AC71G and 80NSSC18K1080 to CMD and NNX16AE06G to BMR."

 

5

Noohi F, Kinnaird C, De Dios Y, Kofman I, Wood SJ, Bloomberg JJ, Mulavara AP, Sienko KH, Polk TA, Seidler RD.

Deactivation of somatosensory and visual cortices during vestibular stimulation is associated with older age and poorer balance.

PLoS One. 2019 Sep 13;14(9):e0221954.

https://www.ncbi.nlm.nih.gov/pubmed/31513630

PI: R.D. Seidler

Note: This article may be obtained online without charge.

Journal Impact Factor: 11.048

Funding: "This study was supported by grants from National Space Biomedical Research Institute (NASA NCC 9-58), National Aeronautics and Space Administration (NNX11AR02G), and National Institutes of Health (1S10OD012240-01A1)."

 

6

Strangman GE, Sawyer A, Fabre KM, Urquieta E, Hury J, Wu J, Peterman A, Hoffman J, Donoviel D.

Deep space applications for point-of-care technologies.

Curr Opin Biomed Eng. 2019 Sep 16. [Article in Press]

http://www.sciencedirect.com/science/article/pii/S2468451119300340

Journal Impact Factor: Not available for this journal

Funding: "This paper was supported by the Translational Research Institute through NASA Cooperative Agreement NNX16AO69A."

 

7

Halamek LP, Cady RAH, Sterling MR.

Using briefing, simulation and debriefing to improve human and system performance.

Semin Perinatol. 2019 Aug 10. [Epub ahead of print]

https://www.ncbi.nlm.nih.gov/pubmed/31500845

Journal Impact Factor: 2.883

Funding: No funding cited. M.R. Sterling is affiliated with NASA Johnson Space Center.

_______________________________________________________

 

 

Other papers of interest:

 

1

Feng NY, Junkins MS, Merriman DK, Bagriantsev SN, Gracheva EO.

Osmolyte depletion and thirst suppression allow hibernators to survive for months without water.

Curr Biol. 2019 Aug 7. [Epub ahead of print]

https://www.ncbi.nlm.nih.gov/pubmed/31495581

Note: This article may be obtained online without charge.

 

2

Vasyanina KA, Klyueva LA, Klochkova SV.

Structural parameters of mesenteric lymph nodes in mice exposed to factors of modeled aerial environment of space vehicles.

Bull Exp Biol Med. 2019 Sep 9. [Epub ahead of print]

https://www.ncbi.nlm.nih.gov/pubmed/31502124

Note: The authors studied the effects of inhalation exposure to a mixture containing acetone, acetaldehyde, and ethanol in concentrations typical of closed environment in space vehicles on the structure of mesenteric lymph nodes in F1 male mice.

 

3

Wilbur SM, Barnes BM, Kitaysky AS, Williams CT.

Tissue-specific telomere dynamics in hibernating arctic ground squirrels (Urocitellus parryii).

J Exp Biol. 2019 Sep 12. [Epub ahead of print]

https://www.ncbi.nlm.nih.gov/pubmed/31515236

 

4

Dey D.

Space microbiology: Modern research and advantages for human colonization on Mars.

Int J for Res Appl Sci Biotechnol. 2019 Jul;6(4):4-10.

https://doi.org/10.31033/ijrasb.6.4.2

Note: This article may be obtained online without charge.

 

5

Barbic F, Heusser K, Minonzio M, Shiffer D, Cairo B, Tank J, Jordan J, Diedrich A, Gauger P, Zamuner RA, Porta A, Furlan R.

Effects of prolonged head-down bed rest on cardiac and vascular baroreceptor modulation and orthostatic tolerance in healthy individuals.

Front Physiol. 2019 Aug 23;10:1061.

https://www.ncbi.nlm.nih.gov/pubmed/31507438

Note: Head-down tilt bed rest study. This article may be obtained online without charge.

 

6

Elias Neto J, Ferreira A, Futuro G, Santos LCD, Heringer Filho N, Gomes F, Mill JG.

Influences on the functional behavior of great arteries during orthostasis.

Arq Bras Cardiol. 2019 Sep 9. [Epub ahead of print]

https://www.ncbi.nlm.nih.gov/pubmed/31508691

Note: Tilt-table study. This article may be obtained online without charge.

 

7

Kermorgant M, Nasr N, Custaud MA, Navasiolava N, Arbeille P, Guinet P, Labrunée M, Besnier F, Arvanitis DN, Czosnyka M, Senard JM, Pavy-Le Traon A.

Effects of resistance exercise and nutritional supplementation on dynamic cerebral autoregulation in head-down bed rest.

Front Physiol. 2019 Aug 27;10:1114.

https://www.ncbi.nlm.nih.gov/pubmed/31507460

Note: Head-down tilt bed rest study. This article may be obtained online without charge.

 

8

Aoki Y, Ozawa T, Numata O, Takemasa T.

High-molecular-weight polyphenol-rich fraction of black tea does not prevent atrophy by unloading, but promotes soleus muscle mass recovery from atrophy in mice.

Nutrients. 2019 Sep 6;11(9):E2131.

https://www.ncbi.nlm.nih.gov/pubmed/31500089

Note: Hindlimb unloading study. This article may be obtained online without charge.

 

9

Belova SP, Vilchinskaya NA, Mochalova EP, Mirzoev TM, Nemirovskaya TL, Shenkman BS.

Elevated p70S6K phosphorylation in rat soleus muscle during the early stage of unloading: Causes and consequences.

Arch Biochem Biophys. 2019 Sep 10. [Epub ahead of print]

https://www.ncbi.nlm.nih.gov/pubmed/31518555

Note: Hindlimb unloading study.

 

10

Fuchs CJ, Hermans WJH, Holwerda AM, Smeets JSJ, Senden JM, van Kranenburg J, Gijsen AP, Wodzig W, Schierbeek H, Verdijk LB, van Loon LJC.

Branched-chain amino acid and branched-chain ketoacid ingestion increases muscle protein synthesis rates in vivo in older adults: A double-blind, randomized trial.

Am J Clin Nutr. 2019 Jun 28. [Epub ahead of print]

https://www.ncbi.nlm.nih.gov/pubmed/31250889

Note: See #11 below for Commentary.

 

11

Paddon-Jones D, Layman DK.

Branched-chain ketoacid ingestion: An alternative to efficiently increase skeletal muscle protein synthesis.

Am J Clin Nutr. 2019 Aug 26. [Epub ahead of print]

https://www.ncbi.nlm.nih.gov/pubmed/31504096

Note: The authors comment on #10 above: Fuchs CJ, Hermans WJH, Holwerda AM, Smeets JSJ, Senden JM, van Kranenburg J, Gijsen AP, Wodzig WKHW, Schierbeek H, Verdijk LB, van Loon LJC. Branched-chain amino acid and branched-chain ketoacid ingestion increases muscle protein synthesis rates in vivo in older adults: A double-blind, randomized trial. Am J Clin Nutr. 2019 Jun 28. [Epub ahead of print] https://www.ncbi.nlm.nih.gov/pubmed/31250889.

 

12

Leermakers PA, Kneppers AEM, Schols A, Kelders M, de Theije CC, Verdijk LB, van Loon LJC, Langen RCJ, Gosker HR.

Skeletal muscle unloading results in increased mitophagy and decreased mitochondrial biogenesis regulation.

Muscle Nerve. 2019 Sep 8. [Epub ahead of print]

https://www.ncbi.nlm.nih.gov/pubmed/31495926

Note: Hindlimb unloading was used for mice and leg immobilization was used in the human study.

 

13

Petry ÉR, de Freitas Dresch D, Carvalho C, Medeiros PC, Rosa TG, de Oliveira CM, Martins LAM, Schemitt E, Bona S, Guma FCR, Marroni NP, Wannmacher CMD.

Oral glutamine supplementation attenuate inflammation and oxidative stress-mediated skeletal muscle protein content degradation in immobilized rats: Role of 70 kDa heat shock protein.

Free Radic Biol Med. 2019 Sep 7. [Epub ahead of print]

https://www.ncbi.nlm.nih.gov/pubmed/31505269

Note: Hindlimb unloading study.

 

14

Yang DF, Shen YL, Wu CW, Huang YS, Lee PY, Huang XE, Huang WC, Tung YT.

Sleep deprivation reduces the recovery of muscle injury induced by high-intensity exercise in a mouse model.

Life Sci. 2019 Oct 15;235:116835. Epub 2019 Sep 4.

https://www.ncbi.nlm.nih.gov/pubmed/31493480

Note: Hindlimb unloading study.

 

15

Curtis KJ, Oberman AG, Niebur GL.

Effects of mechanobiological signaling in bone marrow on skeletal health.

Ann N Y Acad Sci. 2019 Sep 11. [Epub ahead of print] Review.

https://www.ncbi.nlm.nih.gov/pubmed/31508828

 

16

Main RP, Shefelbine SJ, Meakin LB, Silva MJ, van der Meulen MCH, Willie BM.

The murine axial compression tibial loading model to study bone mechanobiology: Implementing the model and reporting results.

J Orthop Res. 2019 Sep 11. [Epub ahead of print] Review.

https://www.ncbi.nlm.nih.gov/pubmed/31508836

Note: Various unloading models are discussed.

 

17

Shuaib A, Motan D, Bhattacharya P, McNabb A, Skerry TM, Lacroix D.

Heterogeneity in the mechanical properties of integrins determines mechanotransduction dynamics in bone osteoblasts.

Sci Rep. 2019 Sep 11;9(1):13113.

https://www.ncbi.nlm.nih.gov/pubmed/31511609

Note: This article may be obtained online without charge.

 

18

Dobynde MI, Shprits YY.

Radiation environment created with GCRs inside a spacecraft.

Life Sci Space Res. 2019 Sep 12. [Article in Press]

https://www.sciencedirect.com/science/article/abs/pii/S2214552419300677

 

19

Erofeeva LM.

Structural and functional parameters of the thymus in mice exposed to γ-irradiation after restraint stress.

Bull Exp Biol Med. 2019 Sep 9. [Epub ahead of print]

https://www.ncbi.nlm.nih.gov/pubmed/31502139

 

20

Hasse FC, Koerber SA, Prigge ES, Liermann J, von Knebel Doeberitz M, Debus J, Sterzing F.

Overcoming radioresistance in WiDr cells with heavy ion irradiation and radiosensitization by 2-deoxyglucose with photon irradiation.

Clin Transl Radiat Oncol. 2019 Nov;19:52-8. Epub 2019 Aug 20.

https://www.ncbi.nlm.nih.gov/pubmed/31517070

Note: This article may be obtained online without charge.

 

21

Kudryashev VA, Kim DS.

Determination of the total effective dose of external and internal exposure by different ionizing radiation sources.

Radiat Prot Dosimetry. 2019 Sep 11. [Epub ahead of print]

https://www.ncbi.nlm.nih.gov/pubmed/31506690

 

22

Nagayama K, Fukuei T.

Cyclic stretch-induced mechanical stress to the cell nucleus inhibits ultraviolet radiation-induced DNA damage.

Biomech Model Mechanobiol. 2019 Sep 10. [Epub ahead of print]

https://www.ncbi.nlm.nih.gov/pubmed/31506862

 

23

Jinzaki M, Yamada Y, Nagura T, Nakahara T, Yokoyama Y, Narita K, Ogihara N, Yamada M.

Development of upright computed tomography with area detector for whole-body scans: Phantom study, efficacy on workflow, effect of gravity on human body, and potential clinical impact.

Invest Radiol. 2019 Sep 9. [Epub ahead of print]

https://www.ncbi.nlm.nih.gov/pubmed/31503082

 

24

Khairat S, Coleman C, Ottmar P, Bice T, Koppel R, Carson SS.

Physicians' gender and their use of electronic health records: Findings from a mixed-methods usability study.

J Am Med Inform Assoc. 2019 Aug 28. [Epub ahead of print]

https://www.ncbi.nlm.nih.gov/pubmed/31504578

Note: The NASA Task Load Index was used.

 

25

Kokoroko E, Sanda MA.

Effect of workload on job stress of Ghanaian OPD nurses: The role of coworker support.

Saf Health Work. 2019 Sep;10(3):341-6.

https://www.ncbi.nlm.nih.gov/pubmed/31497331

Note: The NASA Task Load Index was used. This article may be obtained online without charge.

// end //

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