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NASA Spaceline Current Awareness List #875 22 November 2019 (Space Life Science Research Results)

Status Report From: Spaceline
Posted: Friday, November 22, 2019

SPACELINE Current Awareness Lists are distributed via listserv and are available on the NASA Task Book website at https://taskbook.nasaprs.com/Publication/spaceline.cfm. Please send any correspondence to Robyn Ertwine, SPACELINE Current Awareness Senior Editor, SPACELINE@nasaprs.com.

 

 

Papers deriving from NASA support:

 

1

Young KS, Rajulu S.

Changes in seated height in microgravity.

Appl Ergon. 2020 Feb;83:102995. Epub 2019 Nov 15.

https://www.ncbi.nlm.nih.gov/pubmed/31739138

Note: ISS and Space Shuttle results.

Journal Impact Factor: 2.610

Funding: "This work was supported by the National Aeronautics and Space Administration (NASA) Johnson Space Center and partially funded by Human Health and Performance Contract, NNJ15HK11B."

 

2

Wnorowski A, Sharma A, Chen H, Wu H, Shao NY, Sayed N, Liu C, Countryman S, Stodieck LS, Rubins KH, Wu SM, Lee PHU, Wu JC.

Effects of spaceflight on human induced pluripotent stem cell-derived cardiomyocyte structure and function.

Stem Cell Reports. 2019 Oct 29. [Epub ahead of print]

https://www.ncbi.nlm.nih.gov/pubmed/31708475

Note: ISS results. This article may be obtained online without charge.

Journal Impact Factor: 5.499

Funding: "We gratefully acknowledge support from Department of Defense National Defense Science and Engineering Graduate Fellowship (A.W.), American Heart Association (AHA) Predoctoral Fellowship 13PRE15770000, National Science Foundation (NSF) Graduate Research Fellowship Program DGE-114747, NIH T32 HL116273 (A.S.), NIH K99 HL133473, AHA postdoctoral fellowship (16POST31150011) (H.W.), NIH K01 HL135455 (N.S.), NIH Director’s Pioneer Award (DP1 LM012179-02), NHLBI Progenitor Cell Biology Consortium (U01 HL099776), AHA Grant-in-Aid (14GRNT18630016) (S.M.W.), Burroughs Wellcome Foundation Innovation in Regulatory Science 1015009, AHA 17MERIT33610009, Center for the Advancement of Science in Space (CASIS) GA-2014-129, NIH R01 HL141371, and NIH UG3 TR002588 (J.C.W.). We also acknowledge the Stanford Neuroscience Microscopy Service (NIH NS069375)." K.H. Rubins is affiliated with NASA Johnson Space Center.

 

3

Deymier AC, Schwartz AG, Lim C, Wingender B, Kotiya A, Shen H, Silva MJ, Thomopoulos S.

Multiscale effects of spaceflight on murine tendon and bone.

Bone. 2020 Feb;131:115152. Epub 2019 Nov 12.

https://www.ncbi.nlm.nih.gov/pubmed/31730829

PIs: S. Thomopoulos; A.C. Deymier, NSBRI Postdoctoral Fellowship Program

Note: ISS results.

Journal Impact Factor: 4.360

Funding: "This project was funded by the National Aeronautics and Space Administration (NASA, NNX09AP05G to ST), the National Space Biomedical Research Institute (NSBRI, NSBRI-RFA-13-01 to ACD), and the National Institutes of Health (NIH R01-AR055580 to ST; NIH R01 AR047867 to MJS). The TEM studies were partially supported by the Institute of Materials Science & Engineering at Washington University."

 

4

Marshall-Goebel K, Laurie SS, Alferova IV, Arbeille P, Aunon-Chancellor SM, Ebert DJ, Lee SMC, Macias BR, Martin DS, Pattarini JM, Ploutz-Snyder R, Ribeiro LC, Tarver WJ, Dulchavsky SA, Hargens AR, Stenger MB. 

Assessment of jugular venous blood flow stasis and thrombosis during spaceflight.

JAMA Netw Open. 2019 Nov 1;2(11):e1915011.

https://www.ncbi.nlm.nih.gov/pubmed/31722025

PIs: M.B. Stenger, A.R. Hargens, S.A. Dulchavsky

Note: ISS results. Lower body negative pressure was used in ground-based experiments. This article may be obtained online without charge.

Journal Impact Factor: Not available for this journal

Funding: "This work was supported by the National Aeronautics and Space Administration under the Human Research Program (grant NNJ11ZSA002NA)."

 

5

Vandenbrink JP, Herranz R, Poehlman WL, Alex Feltus F, Villacampa A, Ciska M, Javier Medina F, Kiss JZ.

RNA-seq analyses of Arabidopsis thaliana seedlings after exposure to blue-light phototropic stimuli in microgravity.

Am J Bot. 2019 Nov 10. [Epub ahead of print]

https://www.ncbi.nlm.nih.gov/pubmed/31709515

PI: J.Z. Kiss

Note: ISS results.

Journal Impact Factor: 2.841

Funding: "Funding was provided by grants NNX12AO65G and 80NSSC17K0546 from NASA (PI = J. Z. Kiss)."

 

6

Scott JM, Dolan LB, Norton L, Charles JB, Jones LW.

Multisystem toxicity in cancer: Lessons from NASA's Countermeasures Program.

Cell. 2019 Nov 14;179(5):1003-9.

https://www.ncbi.nlm.nih.gov/pubmed/31730844

Note: This article may be obtained online without charge.

Journal Impact Factor: 36.216

Funding: "L.W.J. is supported by research grants from the National Cancer Institute. L.W.J. and J.M.S. are supported by AKTIV Against Cancer and the KavliTrust. J.M.S., L.W.J., and L.N. are supported by the Memorial Sloan Kettering Cancer Center Support Grant/Core Grant (P30 CA008748)." J.B. Charles is affiliated with NASA Johnson Space Center.

 

7

Britten RA, Duncan VD, Fesshaye AS, Wellman LL, Fallgren CM, Sanford LD.

Sleep fragmentation exacerbates executive function impairments induced by protracted low dose rate neutron exposure.

Int J Radiat Biol. 2019 Nov 14. [Epub ahead of print]

https://www.ncbi.nlm.nih.gov/pubmed/31724895         

PIs: R.A. Britten; C. Limoli/R.A. Britten/NSCOR

Journal Impact Factor: 2.266

Funding: "This work was funded by NASA grant support NNX15AI22G and NNX16AC40G."

 

8

Slaba TC, Singleterry RC.

Correct modeling results are needed to inform mission planning and shield design.

Life Sci Space Res. 2019 Nov 16. [Article in Press]

http://www.sciencedirect.com/science/article/pii/S2214552419301385

Note: The authors comment on: El-Jaby S, Lewis BJ, Tomi L. On the decision making criteria for cis-lunar reference mission scenarios. Life Sci Space Res. 2019 May;21: 25-39, https://www.ncbi.nlm.nih.gov/pubmed/31101153, which appeared in SPACELINE Current Awareness List #839, 8 Mar 2019. A response to this comment can be found at #13 in the Other paper of interest section of this List.

Journal Impact Factor: 2.066

Funding: "This work was supported by the Advanced Exploration Systems (AES) under the Human Exploration and Operations Mission Directorate of NASA."

 

9

Landon LB, Douglas GL, Downs ME, Greene MR, Whitmire AM, Zwart SR, Roma PG.

The behavioral biology of teams: Multidisciplinary contributions to social dynamics in isolated, confined, and extreme environments.

Front Psychol. 2019 Nov 21;10:2571. Review.

https://www.frontiersin.org/article/10.3389/fpsyg.2019.02571

PI: P. Roma

Note: This article may be obtained online without charge.

Journal Impact Factor: 2.129

Funding: "LL, MD, MG, and SZ are supported by KBR’s Human Health and Performance Contract NNJ15HK11B through the National Aeronautics and Space Administration. LL and PR are also supported in part by NASA Human Research Program Directed Projects Identification and Validation of BHP Standard Measures in HERA for Transport and CBS Operational Performance Measures (P. G. Roma, PI). GD and AW are supported by NASA’s Human Health and Performance Directorate and Human Research Program."

 

10

St Hilaire MA, Kristal BS, Rahman SA, Sullivan JP, Quackenbush J, Duffy JF, Barger LK, Gooley JJ, Czeisler CA, Lockley SW.

Using a single daytime performance test to identify most individuals at high-risk for performance impairment during extended wake.

Sci Rep. 2019 Nov 13;9(1):16681.

https://www.ncbi.nlm.nih.gov/pubmed/31723161

PIs: S.W. Lockley, C.A. Czeisler

Note: This article may be obtained online without charge.

Journal Impact Factor: 4.011

Funding: "This work was funded by NASA #NNX14AK53G. LKB also was supported by NASA grant NCC9–119. JQ also was supported by 5R01HL111759. The data included in the present analyses were collected with support from the National Space Biomedical Research Institute (HPF01301), the National Institute of Mental Health (R01MH45130), the National Institute of Neurological Disorders and Stroke (R01NS36590), Brigham and Women’s Hospital General Clinical Research Center grant M01RR02635, and Clinical Translational Science Award UL1RR025758 to Harvard University and Brigham and Women’s Hospital from the National Center for Research Resources."

 

11

Robertson JM, Dias RD, Gupta A, Marshburn T, Lipsitz SR, Pozner CN, Doyle TE, Smink DS, Musson DM, Yule S.

Medical event management for future deep space exploration missions to Mars.

J Surg Res. 2020 Feb;246:305-14. Epub 2019 Nov 12.

https://www.ncbi.nlm.nih.gov/pubmed/31731248

PI: S. Yule

Journal Impact Factor: 1.872

Funding: "This work was supported by the National Space Biomedical Research Institute-National Aeronautics and Space Administration (HPF04501)."

______________________________________________________

 

 

Other papers of interest:

 

1

Dirks ML, Miotto PM, Goossens GH, Senden JM, Petrick HL, van Kranenburg J, van Loon LJC, Holloway GP.

Short-term bed rest-induced insulin resistance cannot be explained by increased mitochondrial H2O2 emission.

J Physiol. 2019 Nov 12. [Epub ahead of print]

https://www.ncbi.nlm.nih.gov/pubmed/31721213

Note: Bed rest study.

 

2

Goswami N, van Loon JWA, Roessler A, Blaber AP, White O.

Editorial: Gravitational physiology, aging and medicine.

Front Physiol. 2019 Oct 25;10:1338.

https://www.ncbi.nlm.nih.gov/pubmed/31708798

Note: The authors introduce the Frontiers in Physiology Research Topic "Gravitational Physiology, Aging and Medicine," which examines effects of gravitational changes on human physiology, with applications to geriatrics and clinical medicine. The Research Topic is also aimed at promoting national and international networks that include activities used to stimulate student-oriented learning. A full list of articles in this Research Topic can be found at: https://www.frontiersin.org/research-topics/5201/gravitational-physiology-aging-and-medicine#articles. The articles may be obtained online without charge.

 

3

Kienast C, Gunga H-C, Steinach M.

Neuropeptide Y - Its role in human performance and extreme environments.

REACH. 2019 Nov 15. [Article in Press] Review.

http://www.sciencedirect.com/science/article/pii/S2352309319300161

 

4

Kurose T, Takahashi S, Otsuka T, Nakagawa K, Imura T, Sueda T, Yuge L.

Simulated microgravity-cultured mesenchymal stem cells improve recovery following spinal cord ischemia in rats.

Stem Cell Res. 2019 Oct 15;41:101601.

https://www.ncbi.nlm.nih.gov/pubmed/31731179

Note: A 3D clinostat was used. This article may be obtained online without charge.

 

5

Liu P, Li D, Li W, Wang D.

Mitochondrial unfolded protein response to microgravity stress in nematode Caenorhabditis elegans.

Sci Rep. 2019 Nov 11;9(1):16474.

https://www.ncbi.nlm.nih.gov/pubmed/31712608

Note: Centrifugation was used. This article may be obtained online without charge.

 

6

Po A, Giuliani A, Masiello MG, Cucina A, Catizone A, Ricci G, Chiacchiarini M, Tafani M, Ferretti E, Bizzarri M.

Phenotypic transitions enacted by simulated microgravity do not alter coherence in gene transcription profile.

npj Microgravity. 2019 Nov 21;5(1):27.

https://www.nature.com/articles/s41526-019-0088-x

Note: A Random Positioning Machine was used. This article may be obtained online without charge.

 

7

Aleci C.

From international ophthalmology to space ophthalmology: The threats to vision on the way to Moon and Mars colonization.

Int Ophthalmol. 2019 Nov 13. [Epub ahead of print] Review.

https://www.ncbi.nlm.nih.gov/pubmed/31722052

 

8

Liphardt AM, Bolte V, Eckstein F, Wirth W, Brüggemann G-P, Niehoff A.

Response of thigh muscle cross-sectional area to 21-days of bed rest with exercise and nutrition countermeasures.

Transl Sports Med. 2019 Nov 14. [Article in Press]

https://onlinelibrary.wiley.com/doi/abs/10.1002/tsm2.122

Note: Bed rest study. This article may be obtained online without charge.

 

9

Liphardt AM, Windahl SH, Sehic E, Hannemann N, Gustafsson KL, Bozec A, Schett G, Engdahl C.

Changes in mechanical loading affect arthritis-induced bone loss in mice.

Bone. 2019 Nov 9. [Epub ahead of print]

https://www.ncbi.nlm.nih.gov/pubmed/31715339

 

10

Pei S, Parthasarathy S, Parajuli A, Martinez J, Lv M, Jiang S, Wu D, Wei S, Lu XL, Farach-Carson MC, Kirn-Safran CB, Wang L.

Perlecan/Hspg2 deficiency impairs bone's calcium signaling and associated transcriptome in response to mechanical loading.

Bone. 2020 Feb;131:115078. Epub 2019 Nov 9.

https://www.ncbi.nlm.nih.gov/pubmed/31715337

 

11

Sasaki F, Hayashi M, Mouri Y, Nakamura S, Adachi T, Nakashima T.

Mechanotransduction via the Piezo1-Akt pathway underlies Sost suppression in osteocytes.

Biochem Biophys Res Commun. 2019 Nov 7. [Epub ahead of print]

https://www.ncbi.nlm.nih.gov/pubmed/31708103

 

12

Wu D, Zhou X, Zheng C, He Y, Yu L, Qiu G, Wu Z, Wu J, Liu Y.

The effects of simulated +Gz and microgravity on intervertebral disc degeneration in rabbits.

Sci Rep. 2019 Nov 12;9(1):16608.

https://www.ncbi.nlm.nih.gov/pubmed/31719640

Note: Hindlimb unloading and centrifugation were used. This article may be obtained online without charge.

 

13

El-Jaby S, Lewis BJ, Tomi L.

A commentary on the impact of modelling results to inform mission planning and shield design.

Life Sci Space Res. 2019 Nov 16. [Article in Press]

http://www.sciencedirect.com/science/article/pii/S2214552419301397

Note: The authors reply to: Slaba TC, Singleterry R. Correct modeling results are needed to inform mission planning and shield design, Life Sci Space Res. 2019 Nov 16. [Article in Press], https://www.sciencedirect.com/science/article/abs/pii/S2214552419301385. See #8 in the NASA section of this List.

 

14

Fahl WE, Jermusek F, Guerin T, Albrecht DM, Fahl CJS, Dreischmeier E, Benedict C, Back S, Eickhoff J, Halberg RB.

Impact of the PrC-210 radioprotector molecule on cancer deaths in p53-deficient-/- mice.

Radiat Res. 2019 Nov 18. [Epub ahead of print]

https://www.ncbi.nlm.nih.gov/pubmed/31738662

 

15

Brauns K, Werner A, Gunga HC, Maggioni MA, Dinges DF, Stahn A.

Electrocortical evidence for impaired affective picture processing after long-term immobilization.

Sci Rep. 2019 Nov 12;9(1):16610.

https://www.ncbi.nlm.nih.gov/pubmed/31719552

Note: Bed rest study. This article may be obtained online without charge.

 

16

Lloro V, Giovannoni LM, Lozano-de Luaces V, Lloro I, Manzanares MC.

Is oral health affected in long period space missions only by microgravity? A systematic review.

Acta Astronaut. 2019 Nov 15. [Article in Press] Review.

http://www.sciencedirect.com/science/article/pii/S0094576519313943

Note: The review included articles published between 1969 and 2018. Spaceflight durations ranged from less than 30 days to more than 220 days.

 

17

Desiderio A, Salzano AM, Scaloni A, Massa S, Pimpinella M, De Coste V, Pioli C, Nardi L, Benvenuto E, Villani ME.

Effects of simulated space radiations on the tomato root proteome.

Front Plant Sci. 2019 Oct 24;10:1334.

https://www.ncbi.nlm.nih.gov/pubmed/31708949

Note: This article may be obtained online without charge.

 

18

Liao CY, Bassham DC.

Combating stress: The interplay between hormone signaling and autophagy in plants.

J Exp Bot. 2019 Nov 14. [Epub ahead of print] Review.

https://www.ncbi.nlm.nih.gov/pubmed/31725881

 

19

Park CH, Seo C, Park YJ, Youn JH, Roh J, Moon J, Kim SK.

BES1 directly binds to the promoter of the ACC oxidase 1 gene to regulate gravitropic response in the roots of Arabidopsis thaliana.

Plant Signal Behav. 2019 Nov 13. [Epub ahead of print]

https://www.ncbi.nlm.nih.gov/pubmed/31718454

Note: Seedlings were rotated 90º to track gravitropic response.

 

20

Swarup R, Bhosale R.

Developmental roles of AUX1/LAX auxin influx carriers in plants.

Front Plant Sci. 2019 Oct 28;10:1306. Review.

https://www.ncbi.nlm.nih.gov/pubmed/31719828

Note: This article may be obtained online without charge.

 

21

Argentati C, Morena F, Tortorella I, Bazzucchi M, Porcellati S, Emiliani C, Martino S.

Insight into mechanobiology: How stem cells feel mechanical forces and orchestrate biological functions.

Int J Mol Sci. 2019 Oct 26;20(21):E5337. Review.

https://www.ncbi.nlm.nih.gov/pubmed/31717803

Note: This article may be obtained online without charge.

 

22

Bonnet CT, Davin T, Baudry S.

Interaction between eye and body movements to perform visual tasks in upright stance.

Hum Mov Sci. 2019 Dec;68:102541.

https://www.ncbi.nlm.nih.gov/pubmed/31731211

Note: The NASA Task Load Index was used.

...

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