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NASA Spaceline Current Awareness List #876 29 November 2019 (Space Life Science Research Results)

Status Report From: Spaceline
Posted: Friday, November 29, 2019

SPACELINE Current Awareness Lists are distributed via listserv and are available on the NASA Task Book website at https://taskbook.nasaprs.com/Publication/spaceline.cfm. Please send any correspondence to Robyn Ertwine, SPACELINE Current Awareness Senior Editor, SPACELINE@nasaprs.com.

 

 

Papers deriving from NASA support:

 

1

Agha NH, Baker FL, Kunz HE, Spielmann G, Mylabathula PL, Rooney BV, Mehta SK, Pierson DL, Laughlin MS, Markofski MM, Crucian BE, Simpson RJ.

Salivary antimicrobial proteins and stress biomarkers are elevated during a 6-month mission to the International Space Station.

J Appl Physiol (1985). 2019 Nov 21. [Epub ahead of print]

https://www.ncbi.nlm.nih.gov/pubmed/31751178

PI: R.J. Simpson

Note: ISS results.

Journal Impact Factor: 3.140

Funding: "This work was supported by NASA Grants NNX12AB48G, NNX16AB29G, and NNX16AG02G to R. J. Simpson."

 

2

Clement G, Boyle RD, Gunga H-C.

Editorial: The effects of altered gravity on physiology.

Front Physiol. 2019 Nov 27;10:1447.

https://www.frontiersin.org/article/10.3389/fphys.2019.01447

Note: The authors introduce the Frontiers in Physiology Research Topic "The Effects of Altered Gravity on Physiology," which examines various methods for studying the effects of altered gravity on sensorimotor, musculoskeletal, cardiopulmonary, and cerebrovascular responses in humans and rodents. The collection contains 11 studies, which have been cited in previous SPACELINE Current Awareness Lists. A full list of articles in this Research Topic can be found at: https://www.frontiersin.org/research-topics/8565/the-effects-of-altered-gravity-on-physiology#articles. The articles may be obtained online without charge.

Journal Impact Factor: 3.201

Funding: "This work was supported by the NASA/NAG2-945/Neurolab/STS-95 and NIH/NIDCD P01 DC01837 (to RB)."

 

3

Petersen LG, Hargens A, Bird EM, Ashari N, Saalfeld J, Petersen JCG.

Mobile lower body negative pressure suit as an integrative countermeasure for spaceflight.

Aerosp Med Hum Perform. 2019 Dec 1;90(12):993-9.

https://www.ncbi.nlm.nih.gov/pubmed/31747995

PI: L.G. Petersen

Journal Impact Factor: 0.889

Funding: "This work was supported by NASA grant: 80NSSC19K0020 entitled "Mobile Gravity Suit (an integrative countermeasure device)" for Lonnie G. Petersen and the Novo Nordic foundation fellowship: NNF15OC0019196, likewise for Lonnie G. Petersen."

 

4

Stenger MB, Laurie SS, Sadda SR, Sadun AA, Macias BR, Huang AS.

Focus on the optic nerve head in spaceflight-associated neuro-ocular syndrome.

Ophthalmology. 2019 Dec;126(12):1604-6.

https://www.ncbi.nlm.nih.gov/pubmed/31759496

PIs: M.B. Stenger, B.R. Macias, S.S. Laurie

Note: This article may be obtained online without charge.

Journal Impact Factor: 7.732

Funding: "Funding from NASA grants (Principal Investigator [M.B.S.]: grant no. NNJ11ZSA002NA, Principal Investigator [B.R.M.]: grant no. 80JSC017N0001-BPBA, Principal Investigator [S.S.L.]: grant no. NNJ14ZSA001N-MIXEDTOPICS) and an unrestricted grant from Research to Prevent Blindness to UCLA (New York, NY)."

 

5

Beheshti A, Stevenson K, Vanderburg C, Ravi D, McDonald JT, Christie AL, Shigemori K, Jester H, Weinstock DM, Evens AM.

Identification of circulating serum multi-microRNA signatures in human DLBCL models.

Sci Rep. 2019 Nov 20;9(1):17161.

https://www.ncbi.nlm.nih.gov/pubmed/31748664

Note: This article may be obtained online without charge.

Journal Impact Factor: 4.011

Funding: "The research was support in part by NCI R01 CA164311-01A1." A. Beheshti is affiliated with NASA Ames Research Center.

 

6

Panesar SS, Kliot M, Parrish R, Fernandez-Miranda J, Cagle Y, Britz GW.

Promises and perils of artificial intelligence in neurosurgery.

Neurosurgery. 2019 Nov 21. [Epub ahead of print]

https://www.ncbi.nlm.nih.gov/pubmed/31748800

Journal Impact Factor: 4.605

Funding: No funding cited. Y. Cagle is affiliated with NASA Ames Research Center.

 

7

Plante I, Slaba T, Shavers Z, Hada M.

A bi-exponential repair algorithm for radiation-induced double-strand breaks: Application to simulation of chromosome aberrations.

Genes (Basel). 2019 Nov 16;10(11):E936.

https://www.ncbi.nlm.nih.gov/pubmed/31744120

PI: M. Hada

Note: This article may be obtained online without charge.

Journal Impact Factor: 3.331

Funding: "This research was funded by NASA Space Radiation Program (NNX16AR97G for MH), NASA Human Health and Performance Contract (HHPC) number NNJ15HK11B."

 

8

Habiba K, Aziz K, Sanders K, Santiago CM, Mahadevan LSK, Makarov V, Weiner BR, Morell G, Krishnan S.

Enhancing colorectal cancer radiation therapy efficacy using silver nanoprisms decorated with graphene as radiosensitizers.

Sci Rep. 2019 Nov 19;9(1):17120.

https://www.ncbi.nlm.nih.gov/pubmed/31745177       

Note: This article may be obtained online without charge.

Journal Impact Factor: 4.011

Funding: "This research was funded in part by U54 UPR-MD Anderson Cancer Center Partnership Program (NIH U54 CA096297/CA096300), NIH/NCI T32 Cancer Nanotechnology Fellowship to K.H., the MD Anderson CCSG grant P30 CA16672, NASA Grants (80NSSC19M0049, NNX15AK43A, and NNX15AI11H), and the John E. and Dorothy J. Harris endowed professorship to S.K."

 

9

Johnson CD, LaGoy AD, Pepping GJ, Eagle SR, Beethe AZ, Bower JL, Alfano CA, Simpson RJ, Connaboy C.

Action boundary proximity effects on perceptual-motor judgments.

Aerosp Med Hum Perform. 2019 Dec 1;90(12):1000-8.

https://www.ncbi.nlm.nih.gov/pubmed/31747996

PI: C.A. Alfano

Journal Impact Factor: 0.889

Funding: "This study was funded by the National Aeronautics and Space Administration; grant number NNX15AC13G."

______________________________________________________

 

 

Other papers of interest:

 

1

Nassef MZ, Kopp S, Melnik D, Corydon TJ, Sahana J, Krüger M, Wehland M, Bauer TJ, Liemersdorf C, Hemmersbach R, Infanger M, Grimm D.

Short-term microgravity influences cell adhesion in human breast cancer cells.

Int J Mol Sci. 2019 Nov 15;20(22):5730.

https://www.ncbi.nlm.nih.gov/pubmed/31731625

Note: Parabolic flight. A centrifuge and a random positioning machine also were used. This article may be obtained online without charge.

 

2

Cristofaro F, Pani G, Pascucci B, Mariani A, Balsamo M, Donati A, Mascetti G, Rea G, Rizzo AM, Visai L.

The NATO project: Nanoparticle-based countermeasures for microgravity-induced osteoporosis.

Sci Rep. 2019 Nov 20;9(1):17141.

https://www.ncbi.nlm.nih.gov/pubmed/31748575

Note: ISS results. A Random Positioning Machine was used for ground studies. This article may be obtained online without charge.

 

3

Liu J, Fang W, Jia F, Song H, Lou X, Li L, Yang H, Tan R, Shi T, Wu J, Zhou L, Wang Y, Gu J.

The anesthesia and coping strategies of medical care for astronauts in Shenzhou Eleven spaceship.

Clin Med Res. 2019 Sep;8(5):119-24.

http://www.sciencepublishinggroup.com/journal/paperinfo?journalid=151&doi=10.11648/j.cmr.20190805.15

Note: Shenzhou 11 results. This article may be obtained online without charge.

 

4

Li Y, Ren Y, Xu Y, Li P, Qu X.

[Study on mould removal technology with negative pressure suction in manned spacecraft].

Space Med Med Eng. 2019;2019(4):313-8. Chinese.

http://caod.oriprobe.com/articles/57462580/Study_on_Mould_Removal_Technology_with_Negative_Pr.htm 

 

5

Mulder MB, Eidelson SA, Buzzelli MD, Gross KR, Batchinsky AI, Convertino VA, Schulman CI, Namias N, Proctor KG.

Exercise-induced changes in compensatory reserve and heart rate complexity.

Aerosp Med Hum Perform. 2019 Dec 1;90(12):1009-15.

https://www.ncbi.nlm.nih.gov/pubmed/31747997

 

6

Honda T, Nakayama R, Kawahara Y, Yuge L, Ueda K.

Kaposi's sarcoma-associated herpesvirus is cell-intrinsically controlled in latency in microgravity.

Virus Res. 2020 Jan 15;276:197821. Epub 2019 Nov 19.

https://www.ncbi.nlm.nih.gov/pubmed/31756357

Note: A 3D-clinostat was used.

 

7

Shykoff BE, Lee RL.

Risks from breathing elevated oxygen.

Aerosp Med Hum Perform. 2019 Dec 1;90(12):1041-9. Review.

https://www.ncbi.nlm.nih.gov/pubmed/31748001

 

8

Krusche T, Limmer M, Jendrusch G, Platen P.

Influence of natural hypobaric hypoxic conditions on dynamic visual performance.

High Alt Med Biol. 2019 Nov 20. [Epub ahead of print]

https://www.ncbi.nlm.nih.gov/pubmed/31746645

 

9

Counts BR, Fix DK, Hetzler KL, Carson JA.

The effect of estradiol administration on muscle mass loss and cachexia progression in female ApcMin/+ mice.

Front Endocrinol (Lausanne). 2019 Nov 1;10:720.

https://www.ncbi.nlm.nih.gov/pubmed/31736871

Note: This article may be obtained online without charge.

 

10

Kilroe SP, Fulford J, Holwerda AM, Jackman SR, Lee BP, Gijsen AP, van Loon LJC, Wall BT.

Short-term muscle disuse induces a rapid and sustained decline in daily myofibrillar protein synthesis rates.

Am J Physiol Endocrinol Metab. 2019 Nov 19. [Epub ahead of print]

https://www.ncbi.nlm.nih.gov/pubmed/31743039

Note: Leg immobilization accomplished with bracing.

 

11

Zhang L, Soulakova J, St Pierre Schneider B.

Mild hypobaric hypoxia effects on murine skeletal muscle morphology and macrophages and well-being.

Aerosp Med Hum Perform. 2019 Dec 1;90(12):1050-4.

https://www.ncbi.nlm.nih.gov/pubmed/31748002

 

12

Bevelacqua JJ, Mortazavi SMJ.

Poor understanding of radiation profiles in deep space causes inaccurate findings and misleading conclusions.

J Biomed Phys Eng. 2019 Oct;9(5):587-8.

https://www.ncbi.nlm.nih.gov/pubmed/31750273

Note: This article may be obtained online without charge.

 

13

Zabihi A, Tello J, Incerti S, Francis Z, Forozani G, Semsarha F, Moslehi A, Bernal MA.

Determination of fast neutron RBE using a fully mechanistic computational model.

Appl Radiat Isot. 2019 Nov 2. [Epub ahead of print]

https://www.ncbi.nlm.nih.gov/pubmed/31735447

 

14

Dixon JB, Clark TK.

Sensorimotor impairment from a new analog of spaceflight-altered neurovestibular cues.

J Neurophysiol. 2019 Nov 20. [Epub ahead of print]

https://www.ncbi.nlm.nih.gov/pubmed/31747329

Note: From the Introduction: "Here, we propose a novel ground-based approach to produce sustained replication of the neurovestibular cues experienced in microgravity, in a single plane by restraining the head to keep gravity out of the plane of interest. Translation and rotation stimulation, typically experienced in microgravity, is produced through the base of a motorized wheelchair attached to a recumbent bed that persons lie on during exposure."

 

15

Hageman KN, Chow MR, Roberts D, Boutros PJ, Tooker A, Lee K, Felix S, Pannu SS, Haque R, Della Santina CC.

Binocular 3D otolith-ocular reflexes: Responses of chinchillas to prosthetic electrical stimulation targeting the utricle and saccule.

J Neurophysiol. 2019 Nov 20. [Epub ahead of print]

https://www.ncbi.nlm.nih.gov/pubmed/31747349

 

16

Hageman KN, Chow MR, Roberts D, Della Santina CC.

Binocular 3D otolith-ocular reflexes: Responses of normal chinchillas to tilt and translation.

J Neurophysiol. 2019 Nov 20. [Epub ahead of print]

https://www.ncbi.nlm.nih.gov/pubmed/31747360

 

17

Hicks KL, Wisner SR, Cox BC, Stone JS.

Atoh1 is required in supporting cells for regeneration of vestibular hair cells in adult mice.

Hear Res. 2020 Jan;385:107838. Epub 2019 Nov 7.

https://www.ncbi.nlm.nih.gov/pubmed/31751832

 

18

Wang C, Zhao X, Yao Q, Wang Y, Wu Q, Liu S, Guo D, Jia H.

[Simulation study on a vestibular perception model for space orientation].

Space Med Med Eng. 2019;2019(4):299-305. Chinese.

http://caod.oriprobe.com/articles/57462577/Simulation_Study_on_A_Vestibular_Perception_Model_.htm  

 

19

Lešková A, Zvarík M, Araya T, Giehl RFH.

Nickel toxicity targets cell wall-related processes and PIN2-mediated auxin transport to inhibit root elongation and gravitropic responses in Arabidopsis.

Plant Cell Physiol. 2019 Nov 21. [Epub ahead of print]

https://www.ncbi.nlm.nih.gov/pubmed/31750 920

 

20

Pastor-Cantizano N, Ko DK, Angelos E, Pu Y, Brandizzi F.

Functional diversification of ER stress responses in Arabidopsis.

Trends Biochem Sci. 2019 Nov 18. [Epub ahead of print] Review.

https://www.ncbi.nlm.nih.gov/pubmed/31753702

 

21

Sinclair SA, Friml J.

Defying gravity: A plant's quest for moisture.

Cell Res. 2019 Nov 19. [Epub ahead of print]

https://www.ncbi.nlm.nih.gov/pubmed/31745287

Note: This article may be obtained online without charge.

 

22

Rouphael Y, Petropoulos SA, El-Nakhel C, Pannico A, Kyriacou MC, Giordano M, Troise AD, Vitaglione P, De Pascale S.

Reducing energy requirements in future bioregenerative life support systems (BLSSs): Performance and bioactive composition of diverse lettuce genotypes grown under optimal and suboptimal light conditions.

Front Plant Sci. 2019 Oct 30;10:1305.

https://www.ncbi.nlm.nih.gov/pubmed/31736990

Note: This article may be obtained online without charge.

 

23

Liu D, Yang H, Luo S, Ran Q, Shang K, Ma J.

[Research progress of spacesuit joint technology based on gait walking].

Space Med Med Eng. 2019;2019(4):370-6. Chinese.

http://caod.oriprobe.com/articles/57462573/Research_Progress_of_Spacesuit_Joint_Technology_Ba.htm

 

24

Zhang P, Liu X, Ma R.

[Modeling and simulation of active upper limb-assisted exoskeleton in extravehicular spacesuit].

Space Med Med Eng. 2019;2019(4):319-25. Chinese.

http://caod.oriprobe.com/articles/57462571/Modeling_and_Simulation_of_Active_Upper_Limb_assis.htm

 

25

Amselem S.

Remote controlled autonomous microgravity lab platforms for drug research in space.

Pharm Res. 2019 Nov 18;36(12):183. Review.

https://www.ncbi.nlm.nih.gov/pubmed/31741058

Note: From the Introduction: "In this article the traditionally available microgravity platforms as well as emerging microgravity enabling tools for drug research are reviewed. A special emphasis is put on novel miniaturized, unmanned, remote-controlled microgravity lab platforms based on microfluidics and lab-on-chips that have been recently launched successfully to space on nanosatellites."

 

26

Gerull W, Zihni A, Awad M.

Operative performance outcomes of a simulator-based robotic surgical skills curriculum.

Surg Endosc. 2019 Nov 15. [Epub ahead of print]

https://www.ncbi.nlm.nih.gov/pubmed/31732857

Note: The NASA Task Load Index was used.

 

27

Hess S, Dubach M, Meboldt M, Foggensteiner L.

Evaluating patient safety and ease of use of a novel connection-assist device for peritoneal dialysis.

Patient Prefer Adherence. 2019 Oct 29;13:1785-90.

https://www.ncbi.nlm.nih.gov/pubmed/31754299

Note: The NASA Task Load Index was used. This article may be obtained online without charge.

...

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