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NASA Spaceline Current Awareness List #886 14 February 2020 (Space Life Science Research Results)

Status Report From: Spaceline
Posted: Friday, February 14, 2020

SPACELINE Current Awareness Lists are distributed via listserv and are available on the NASA Task Book website athttps://taskbook.nasaprs.com/Publication/spaceline.cfm. Please send any correspondence to Robyn Ertwine, SPACELINE Current Awareness Senior Editor, SPACELINE@nasaprs.com.

 

Papers deriving from NASA support:

 

1

Díez J, Moreno G, Del Peral L, Adams JH Jr, Rodriguez Frías MD, Manjón JL.

Fuligo septica spores onboard of a stratospheric NASA balloon and its complete in vitro life cycle.

Astrobiology. 2020 Feb 6. [Epub ahead of print]

https://www.ncbi.nlm.nih.gov/pubmed/32027169

Note: Balloon flight results.

Journal Impact Factor: 3.768

Funding: "This work was partially supported by the Spanish Government MICINN and MINECO under projects AYA2009-06037-E/AYA, AYA-ESP 2010-19082, AYA2011-29489-C03-01 and AYA2011-29489-C03-02, AYA-ESP2012-39115-C03-01 and AYA-ESP2012-39115-C03-03, AYA-ESP 2013-47816-C4, MINECO/FEDER-UNAH13-4E-2741, CSD2009-00064 (Consolider MULTIDARK), AEI FPA2017-90566-REDC Multidark, FPA2017-90714-REDT CPAN, by the Comunidad de Madrid under projects S2009/ESP-1496, S2013/ICE-2822, and P2018/NMT-4291 and the University of Alcalá GC2016-003 Alcalá University project. We also want to acknowledge NASA Grant NNX13AH53G for supporting the participation of Dr. J.H.A. in the balloon flight campaign."

 

2

Shelhamer M, Bloomberg J, LeBlanc A, Prisk GK, Sibonga J, Smith SM, Zwart SR, Norsk P.

Selected discoveries from human research in space that are relevant to human health on Earth.

npj Microgravity. 2020 Feb 12;6(1):5. 

https://www.nature.com/articles/s41526-020-0095-y

Note: The authors provide evidence that in the course of research studying the physiological effects of spaceflight that is primarily focused on maintaining astronaut health in space, discoveries have also been made that have a broader impact on fundamental scientific understanding of basic physiological processes, providing a foundation for enhancing healthcare on Earth. This article may be obtained online without charge.

Journal Impact Factor: 3.111

Funding: "AL was supported by numerous NASA grants and contracts. GKP was supported by numerous NASA contracts, grants, and through a cooperative agreement with the National Space Biomedical Research Institute. JS's science expertise for this report was supported by the Human Health Countermeasures Element of the NASA Human Research Program. Nutrition research support was provided by the Human Health Countermeasures Element of the Human Research Program (S.S. and S.Z.). Support from NNX16A069A, NASA Cooperative Agreement to Baylor College of Medicine for the Translational Research Institute for Space Health (TRISH), is gratefully acknowledged (P.N.)."

 

3

Lee AG, Mader TH, Gibson CR, Tarver W, Rabiei P, Riascos RF, Galdamez LA, Brunstetter TJ.

Spaceflight associated neuro-ocular syndrome (SANS) and the neuro-ophthalmologic effects of microgravity: A review and an update.

npj Microgravity. 2020 Feb 7;6(1):7. Review.

https://www.ncbi.nlm.nih.gov/pubmed/32047839

Note: This article may be obtained online without charge.

Journal Impact Factor: 3.111

Funding: No funding cited. W. Tarver is affiliated with NASA Johnson Space Center.

 

4

Nelson ES, Myers JG Jr, Lewandowski BE, Ethier CR, Samuels BC.

Acute effects of posture on intraocular pressure.

PLoS One. 2020 Feb 6;15(2):e0226915.

https://www.ncbi.nlm.nih.gov/pubmed/32027692

PI: C.R. Ethier

Note: The authors examined data from 36 independent datasets from 30 articles on intraocular pressure response to postural change. This article may be obtained online without charge.

Journal Impact Factor: 11.048

Funding: "NASA's Human Research Program (http://www.nasa.gov/hrp) supported this work through the Cross-Cutting Computational Modeling Project and NASA grant numbers NNX13AP91G and NNX16AT06G. Research to Prevent Blindness provided a grant to the University of Alabama at Birmingham."

 

5

Mertens CJ, Slaba TC.

Characterization of solar energetic particle radiation dose to astronaut crew on deep-space exploration missions.

Space Weather. 2019 Dec;17(12):1650-8.

https://agupubs.onlinelibrary.wiley.com/doi/abs/10.1029/2019SW002363

Note: This article may be obtained online without charge.

Journal Impact Factor: 3.69

Funding: "This work was supported by the Human Research Program and the Advanced Exploration Systems Division within the NASA Human Exploration and Operations Mission Directorate."

 

Please Note: The second edition of Principles of Clinical Medicine for Space Flight (New York: Springer, 2019. 939 p.) has recently been published. Edited by Michael Barratt, Ellen Baker, and the late Sam Pool, the 30 chapters in this edition incorporate knowledge learned through continuous human presence aboard the International Space Station since the first edition was published in 2008. The book is available at:https://link.springer.com/book/10.1007/978-1-4939-9889-0. Individual chapters are listed below.

 

1

Barratt MR.

Physical and bioenvironmental aspects of human space flight.

In: Barratt MR, Baker ES, Pool SL, eds. Principles of Clinical Medicine for Space Flight. New York: Springer, 2019. p. 3-37.

https://link.springer.com/chapter/10.1007/978-1-4939-9889-0_1

Funding: No funding cited. The author is affiliated with NASA Johnson Space Center.

 

2

Jones JA, Karouia F, Pinsky L, Cristea O.

Radiation and radiation disorders.

In: Barratt MR, Baker ES, Pool SL, eds. Principles of Clinical Medicine for Space Flight. New York: Springer, 2019. p. 39-108.

https://link.springer.com/chapter/10.1007/978-1-4939-9889-0_2

Funding: No funding cited. F. Karouia is affiliated with NASA Johnson Space Center.

 

3

Beck G, Law J, Bacal K, Barratt MR.

Hypoxia, hypercarbia, and atmospheric control.

In: Barratt MR, Baker ES, Pool SL, eds. Principles of Clinical Medicine for Space Flight. New York: Springer, 2019. p. 109-51.

https://link.springer.com/chapter/10.1007/978-1-4939-9889-0_3

Funding: No funding cited. M.R. Barratt is affiliated with NASA Johnson Space Center.

 

4

James JT, Ryder VE.

Health effects of atmospheric contamination.

In: Barratt MR, Baker ES, Pool SL, eds. Principles of Clinical Medicine for Space Flight. New York: Springer, 2019. p. 153-74.

https://link.springer.com/chapter/10.1007/978-1-4939-9889-0_4

Funding: No funding cited. The authors are affiliated with NASA Johnson Space Center.

 

5

Danielson RW, Allen CS, Limardo JG, Clark JB.

Acoustic and auditory issues.

In: Barratt MR, Baker ES, Pool SL, eds. Principles of Clinical Medicine for Space Flight. New York: Springer, 2019. p. 175-200.

https://link.springer.com/chapter/10.1007/978-1-4939-9889-0_5

Funding: No funding cited. R.W. Danielson, C.S. Allen, and J.G. Limardo are affiliated with NASA Johnson Space Center.

 

6

Taddeo TA, Gilmore S, Armstrong CW.

Spaceflight medical systems.

In: Barratt MR, Baker ES, Pool SL, eds. Principles of Clinical Medicine for Space Flight. New York: Springer, 2019. p. 201-31.

https://link.springer.com/chapter/10.1007/978-1-4939-9889-0_6

Funding: No funding cited. The authors are affiliated with NASA Johnson Space Center.

 

7

Campbell MR, Billica RD.

Surgical capabilities.

In: Barratt MR, Baker ES, Pool SL, eds. Principles of Clinical Medicine for Space Flight. New York: Springer, 2019. p. 233-52.

https://link.springer.com/chapter/10.1007/978-1-4939-9889-0_7

 

8

Melton S, Simmons SC, Smith BA, Hamilton DR.

Telemedicine.

In: Barratt MR, Baker ES, Pool SL, eds. Principles of Clinical Medicine for Space Flight. New York: Springer, 2019. p. 253-71.

https://link.springer.com/chapter/10.1007/978-1-4939-9889-0_8

Funding: No funding cited. S. Melton and B.A. Smith are affiliated with NASA Johnson Space Center.

 

9

Sargsyan AE.

Diagnostic imaging in space medicine.

In: Barratt MR, Baker ES, Pool SL, eds. Principles of Clinical Medicine for Space Flight. New York: Springer, 2019. p. 273-326.

https://link.springer.com/chapter/10.1007/978-1-4939-9889-0_9

Funding: No funding cited. The author is affiliated with NASA Johnson Space Center.

 

10

Johnston SL 3rd, Smart KT, Pattarini JM.

Medical evacuation risk and crew transport.

In: Barratt MR, Baker ES, Pool SL, eds. Principles of Clinical Medicine for Space Flight. New York: Springer, 2019. p. 327-53.

https://link.springer.com/chapter/10.1007/978-1-4939-9889-0_10

Funding: No funding cited. S.L. Johnston 3rd and J.M. Pattarini are affiliated with NASA Johnson Space Center.

 

11

Gray GW, Johnston SL 3rd, Saary J, Cook T.

Medical evaluations and standards.

In: Barratt MR, Baker ES, Pool SL, eds. Principles of Clinical Medicine for Space Flight. New York: Springer, 2019. p. 357-66.

https://link.springer.com/chapter/10.1007/978-1-4939-9889-0_11

Funding: No funding cited. S.L. Johnston 3rd is affiliated with NASA Johnson Space Center.

 

12

Baker ES, Barratt MR, Sams CF, Wear ML.

Human response to space flight.

In: Barratt MR, Baker ES, Pool SL, eds. Principles of Clinical Medicine for Space Flight. New York: Springer, 2019. p. 367-411.

https://link.springer.com/chapter/10.1007/978-1-4939-9889-0_12

Funding: No funding cited. M.R. Barratt, C.F. Sams, and M.L. Wear are affiliated with NASA Johnson Space Center.

 

13

Smith SM, Lane HW, Zwart SR.

Spaceflight metabolism and nutritional support.

In: Barratt MR, Baker ES, Pool SL, eds. Principles of Clinical Medicine for Space Flight. New York: Springer, 2019. p. 413-39.

https://link.springer.com/chapter/10.1007/978-1-4939-9889-0_13

Funding: No funding cited. The authors are affiliated with NASA Johnson Space Center.

 

14

Ortega HJJ, Harm DL, Reschke MF.

Space and entry motion sickness.

In: Barratt MR, Baker ES, Pool SL, eds. Principles of Clinical Medicine for Space Flight. New York: Springer, 2019. p. 441-56.

https://link.springer.com/chapter/10.1007/978-1-4939-9889-0_14

Funding: No funding cited. D.L. Harm and M.F. Reschke are affiliated with NASA Johnson Space Center.

 

15

Marshburn TH, Lindgren KN, Moynihan S.

Acute care.

In: Barratt MR, Baker ES, Pool SL, eds. Principles of Clinical Medicine for Space Flight. New York: Springer, 2019. p. 457-80.

https://link.springer.com/chapter/10.1007/978-1-4939-9889-0_15

Funding: No funding cited. The authors are affiliated with NASA Johnson Space Center.

 

16

Pilmanis AA, Clark JB.

Decompression-related disorders.

In: Barratt MR, Baker ES, Pool SL, eds. Principles of Clinical Medicine for Space Flight. New York: Springer, 2019. p. 481-518.

https://link.springer.com/chapter/10.1007/978-1-4939-9889-0_16

 

17

Dervay J, Sanders RW, Thompson MS, Snow TJ.

Medical aspects of extravehicular activity.

In: Barratt MR, Baker ES, Pool SL, eds. Principles of Clinical Medicine for Space Flight. New York: Springer, 2019. p. 519-43.

https://link.springer.com/chapter/10.1007/978-1-4939-9889-0_17

Funding: No funding cited. J. Dervay and R.W. Sanders are affiliated with NASA Johnson Space Center.

 

18

Jones JA, Pietrzyk RA, Cristea O, Whitson PA.

Renal and genitourinary concerns.

In: Barratt MR, Baker ES, Pool SL, eds. Principles of Clinical Medicine for Space Flight. New York: Springer, 2019. p. 545-79.

https://link.springer.com/chapter/10.1007/978-1-4939-9889-0_18

Funding: No funding cited. R.A. Pietrzyk and P.A. Whitson are affiliated with NASA Johnson Space Center.

 

19

Shackelford LC.

Musculoskeletal response to space flight.

In: Barratt MR, Baker ES, Pool SL, eds. Principles of Clinical Medicine for Space Flight. New York: Springer, 2019. p. 581-607.

https://link.springer.com/chapter/10.1007/978-1-4939-9889-0_19

Funding: No funding cited. L.C. Shackelford is affiliated with NASA Johnson Space Center.

 

20

Lee SMC, Scheuring RA, Guilliams ME, Kerstman EL.

Physical performance, countermeasures, and postflight reconditioning.

In: Barratt MR, Baker ES, Pool SL, eds. Principles of Clinical Medicine for Space Flight. New York: Springer, 2019. p. 609-58.

https://link.springer.com/chapter/10.1007/978-1-4939-9889-0_20

Funding: No funding cited. S.M.C. Lee, R.A. Scheuring, and M.E. Guilliams are affiliated with NASA Johnson Space Center.

 

21

Sams CF, Crucian BE, Pierson DL.

Immunology and microbiology.

In: Barratt MR, Baker ES, Pool SL, eds. Principles of Clinical Medicine for Space Flight. New York: Springer, 2019. p. 659-71.

https://link.springer.com/chapter/10.1007/978-1-4939-9889-0_21

Funding: No funding cited. The authors are affiliated with NASA Johnson Space Center.

 

22

Hamilton DR.

Cardiovascular aspects of space flight.

In: Barratt MR, Baker ES, Pool SL, eds. Principles of Clinical Medicine for Space Flight. New York: Springer, 2019. p. 673-710.

https://link.springer.com/chapter/10.1007/978-1-4939-9889-0_22

 

23

Clark JB, Bloomberg JJ, Bacal K.

Neurologic concerns.

In: Barratt MR, Baker ES, Pool SL, eds. Principles of Clinical Medicine for Space Flight. New York: Springer, 2019. p. 711-46.

https://link.springer.com/chapter/10.1007/978-1-4939-9889-0_23

Funding: No funding cited. J.J. Bloomberg is affiliated with NASA Johnson Space Center.

 

24

Jennings RT, Baker ES.

Gynecologic and reproductive considerations.

In: Barratt MR, Baker ES, Pool SL, eds. Principles of Clinical Medicine for Space Flight. New York: Springer, 2019. p. 747-60.

https://link.springer.com/chapter/10.1007/978-1-4939-9889-0_24

 

25

Sipes WE, Flynn CF, Beven GE.

Behavioral health and performance support.

In: Barratt MR, Baker ES, Pool SL, eds. Principles of Clinical Medicine for Space Flight. New York: Springer, 2019. p. 761-92.

https://link.springer.com/chapter/10.1007/978-1-4939-9889-0_25

Funding: No funding cited. G.E. Bevan is affiliated with NASA Johnson Space Center.

 

26

Johnston SL 3rd, Whitmire A, Marshburn TH, Putcha L.

Sleep, circadian rhythms, and fatigue management in space flight operations.

In: Barratt MR, Baker ES, Pool SL, eds. Principles of Clinical Medicine for Space Flight. New York: Springer, 2019. p. 793-813.

https://link.springer.com/chapter/10.1007/978-1-4939-9889-0_26

Funding: No funding cited. The authors are affiliated with NASA Johnson Space Center.

 

27

Wotring VE.

Spaceflight pharmacology.

In: Barratt MR, Baker ES, Pool SL, eds. Principles of Clinical Medicine for Space Flight. New York: Springer, 2019. p. 815-40.

https://link.springer.com/chapter/10.1007/978-1-4939-9889-0_27

Funding: No funding cited. V.E. Wotring is affiliated with NASA Johnson Space Center.

 

28

Mader TH, Gibson CR, Manuel FK.

Ophthalmologic concerns.

In: Barratt MR, Baker ES, Pool SL, eds. Principles of Clinical Medicine for Space Flight. New York: Springer, 2019. p. 841-59.

https://link.springer.com/chapter/10.1007/978-1-4939-9889-0_28

Funding: No funding cited. C.R. Gibson is affiliated with NASA Johnson Space Center.

 

29

Hodapp MH, Jeske AH.

Dental considerations.

In: Barratt MR, Baker ES, Pool SL, eds. Principles of Clinical Medicine for Space Flight. New York: Springer, 2019. p. 861-84.

https://link.springer.com/chapter/10.1007/978-1-4939-9889-0_29

 

30

Banks RW, Auñón SM, Harding R, Mumbower A.

Spacecraft accident investigation.

In: Barratt MR, Baker ES, Pool SL, eds. Principles of Clinical Medicine for Space Flight. New York: Springer, 2019. p. 885-904.

https://link.springer.com/chapter/10.1007/978-1-4939-9889-0_30

Funding: No funding cited. S.M. Auñón is affiliated with NASA Johnson Space Center.

______________________________________________________

 

 

Other papers of interest:

 

1

Liemersdorf C, Lichterfeld Y, Hemmersbach R, Hauslage J.

The MAPHEUS module CellFix for studying the influence of altered gravity on the physiology of single cells.

Rev Sci Instrum. 2020 Jan 1;91(1):014101.

https://www.ncbi.nlm.nih.gov/pubmed/32012597

Note: MAPHEUS sounding rocket results.

 

2

Ichijo T, Shimazu T, Nasu M.

Microbial monitoring in the International Space Station and its application on Earth.

Biol Pharm Bull. 2020 Feb 1;43(2):254-7. Review.

https://www.ncbi.nlm.nih.gov/pubmed/32009114

Note: ISS results. This article may be obtained online without charge.

 

3

Chen B, Li GQ, Li Y, Cho J-L, Jiaping W, Jianyi G, Deng Y, Li Y.

Label-free quantitative proteomics of rat liver exposed to simulated microgravity.

Acta Astronaut. 2020 Feb 5. [Article in Press]

http://www.sciencedirect.com/science/article/pii/S0094576520300 692

Note: Hindlimb unloading study.

 

4

Melnik D, Sahana J, Corydon TJ, Kopp S, Nassef MZ, Wehland M, Infanger M, Grimm D, Krüger M.

Dexamethasone inhibits spheroid formation of thyroid cancer cells exposed to simulated microgravity.

Cells. 2020 Feb 5;9(2):E367.

https://www.ncbi.nlm.nih.gov/pubmed/32033410

Note: A random positioning machine was used. This article may be obtained online without charge.

 

5

Kim HR, Yun SH, Hong GS, Cho JH, Shim JH, Kim TY.

Experiments on proliferation of the mesenchymal stem cells under simulated microgravity environment.

Trans Korean Soc Mech Eng B. 2020 Jan;44(1):45-50. Korean.

http://www.dbpia.co.kr/journal/articleDetail?nodeId=NODE09287085&language=ko_KR#

Note: A random positioning machine was used.

 

6

Arc-Chagnaud C, Py G, Fovet T, Roumanille R, Demangel R, Pagano AF, Delobel P, Blanc S, Jasmin BJ, Blottner D, Salanova M, Gomez-Cabrera M-C, Viña J, Brioche T, Chopard A. 

Evaluation of an antioxidant and anti-inflammatory cocktail against human hypoactivity-induced skeletal muscle deconditioning.

Front Physiol. 2020 Feb 12;11:71.

https://www.frontiersin.org/article/10.3389/fphys.2020.00071

Note: Head-down tilt bed rest study. This article may be obtained online without charge.

 

7

Dideriksen K, Reitelseder S, Agergaard J, Boesen AP, Aas SN, Raastad T, Holm L.

Muscle protein breakdown is impaired during immobilization compared to during a subsequent retraining period in older men: No effect of anti-inflammatory medication.

Pflugers Arch. 2020 Feb 5. [Epub ahead of print]

https://www.ncbi.nlm.nih.gov/pubmed/32025814

Note: Leg immobilization was accomplished via casting. This article may be obtained online without charge.

 

8

Mañas-Garcia L, Bargalló N, Gea J, Barreiro E.

Muscle phenotype, proteolysis, and atrophy signaling during reloading in mice: Effects of curcumin on the gastrocnemius.

Nutrients. 2020 Jan 31;12(2):E388.

https://www.ncbi.nlm.nih.gov/pubmed/32024036

Note: Hindlimb immobilization study. This article may be obtained online without charge.

 

9

Zhang B, Chen L, Bai YG, Song JB, Cheng JH, Ma HZ, Ma J, Xie MJ.

miR-137 and its target T-type CaV 3.1 channel modulate dedifferentiation and proliferation of cerebrovascular smooth muscle cells in simulated microgravity rats by regulating calcineurin/NFAT pathway.

Cell Prolif. 2020 Feb 8. [Epub ahead of print]

https://www.ncbi.nlm.nih.gov/pubmed/32034930

Note: Hindlimb unloading study. This article may be obtained online without charge.

 

10

Parajuli A, Pei S, Zhao H, Martinez JR, Lu XL, Liu XS, Farach-Carson MC, Kirn-Safran CB, Wang L.

Trabecular bone deficit and enhanced anabolic response to re-ambulation after disuse in perlecan-deficient skeleton.

Biomolecules. 2020 Jan 29;10(2):E198.

https://www.ncbi.nlm.nih.gov/pubmed/32013135

Note: Hindlimb unloading study. This article may be obtained online without charge.

 

11

Sen B, Paradise CR, Xie Z, Sankaran J, Uzer G, Styner M, Meyer M, Dudakovic A, van Wijnen AJ, Rubin J.

β-catenin preserves the stem state of murine bone marrow stromal cells through activation of EZH2.

J Bone Miner Res. 2020 Feb 5. [Epub ahead of print]

https://www.ncbi.nlm.nih.gov/pubmed/32022326

 

12

Mishra OP, Popov AV, Pietrofesa RA, Hwang WT, Andrake M, Nakamaru-Ogiso E, Christofidou-Solomidou M.

Radiation activates myeloperoxidase (MPO) to generate active chlorine species (ACS) via a dephosphorylation mechanism: Inhibitory effect of LGM2605.

Biochim Biophys Acta Gen Subj. 2020 Feb 5. [Epub ahead of print]

https://www.ncbi.nlm.nih.gov/pubmed/32035161

 

13

Paul JO, Funmilola OA, Ayegba AS.

Microgravity and infertility.

Int J Trend Sci Res Develop. 2019 Oct;3(6):190-5. Review.

https://www.ijtsrd.com/other-scientific-research-area/other/29408/microgravity-and-infertility/jaiyeola-o-paul

Note: This article may be obtained online without charge.

// end //

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