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NASA Spaceline Current Awareness List #931 8 January 2021 (Space Life Science Research Results)

Status Report From: Spaceline
Posted: Friday, January 8, 2021

SPACELINE Current Awareness Lists are distributed via listserv and are available on the NASA Task Book website athttps://taskbook.nasaprs.com/Publication/spaceline.cfm. Please send any correspondence to Robyn Ertwine, SPACELINE Current Awareness Senior Editor, SPACELINE@nasaprs.com.

 

 

Papers deriving from NASA support:

 

1

Shaka S, Carpo N, Tran V, Espinosa-Jeffrey A.

Behavior of astrocytes derived from human neural stem cells flown onto space and their progenies.

Appl Sci. 2020 Jan;11(1):41.

https://www.mdpi.com/2076-3417/11/1/41

PI: A. Espinosa-Jeffrey

Note: ISS results. The article belongs to the Special Issue "Advances in Space Biology: Cell Behavior in Microgravity," available at https://www.mdpi.com/journal/applsci/special_issues/Space_Biology. This article is featured on the cover of the January 2021 issue (https://www.mdpi.com/2076-3417/11/1) and may be obtained online without charge.

Journal Impact Factor: 2.474

Funding: "We thank NASA Space Biology for Grant: NNX15AB43G; The IDDRC Cell Culture Core is supported by NIH/NICHD grant number U54HD087101-05."

 

2

Vyas RJ, Young M, Murray MC, Predovic M, Lim S, Jacobs NM, Mason SS, Zanello SB, Taibbi G, Vizzeri G, Parsons-Wingerter P.

Decreased vascular patterning in the retinas of astronaut crew members as new measure of ocular damage in spaceflight-associated neuro-ocular syndrome.

Invest Ophthalmol Vis Sci. 2020 Dec 1;61(14):34.

https://pubmed.ncbi.nlm.nih.gov/33372980

PI: P. Parsons-Wingerter

Note: ISS results. This article may be obtained online without charge.

Journal Impact Factor: 3.470

Funding: "Supported by the National Aeronautics and Space Administration (NASA) with Grant NNJ12ZSA002N by the Human Research Program (HRP) and additional support by the HRP Space Radiation and Vascular Centennial Challenge Programs to P.P.W."

 

3

Hammel P, Zenhausern F.

RB620 and RB621 antibodies recognize a peptide of the SARS-CoV-2 E protein by ELISA.

Antib Rep. 2020 Aug 24;3(4):e238.

https://oap.unige.ch/journals/abrep/article/view/238

Note: This article may be obtained online without charge.

Journal Impact Factor: Not available for this journal

Funding: "This work was co-sponsored by NASA TRISH contract #NNX16AO69A/CAT0001."

 

4

Marchetti A, Zenhausern F.

The RB621 antibody recognizes the envelope E protein from SARS-CoV-2 by immunofluorescence.

Antib Rep. 2020 Aug 26;3(4):e239.

https://oap.unige.ch/journals/abrep/article/view/239

Note: This article may be obtained online without charge.

Journal Impact Factor: Not available for this journal

Funding: "This work was co-sponsored by NASA TRISH contract #NNX16AO69A/CAT0001."

 

5

Tyson TL, Feick NH, Cravalho PF, Flynn-Evans EE, Stone LS.

Dose-dependent sensorimotor impairment in human ocular tracking after acute low-dose alcohol administration.

J Physiol. 2020 Dec 17. Online ahead of print.

https://pubmed.ncbi.nlm.nih.gov/33332605

Journal Impact Factor: 4.547

Funding: "This work was supported by the Force Health Protection Program of the Office of Naval Research (SAA2 402925-1, Contract Award no. N0001418IP00050) and in part by NASA cooperative agreement NNX17AE07A. We also thank NASA's Human Research Program for support during the writing of this article."

 

6

Douglas GL, Cooper MR, Wu H, Gaza R, Guida P, Young M.

Impact of galactic cosmic ray simulation on nutritional content of foods.

Life Sci Space Res. 2021 Feb;28:22-5.

http://www.sciencedirect.com/science/article/pii/S2214552420300869

PI: G.L. Douglas

Note: This article may be obtained online without charge.

Journal Impact Factor: 2.453

Funding: "This work was funded by the Human Health Countermeasures Element of the Human Research Program at the NASA Johnson Space Center."

 

7

Keiser AA, Kramár EA, Dong T, Shanur S, Pirodan M, Ru N, Acharya MM, Baulch JE, Limoli CL, Wood MA.

Systemic HDAC3 inhibition ameliorates impairments in synaptic plasticity caused by simulated galactic cosmic radiation exposure in male mice.

Neurobiol Learn Mem. 2020 Dec 23. Online ahead of print.

https://pubmed.ncbi.nlm.nih.gov/33359392  

PIs: C.L. Limoli/M.M. Acharya/J.E. Baulch/NSCOR

Journal Impact Factor: 2.768

Funding: "This work was supported by funding from the National Institutes of Health (T32 AG000096 (AAK); R01 DA047981 and DA025922 (MAW); NASA Specialized Center of Research (NSCOR) grant NNX15AI22G (CLL)."

 

8

Simonsen LC, Slaba TC, Guida P, Rusek A.

The galactic cosmic ray simulator at the NASA Space Radiation Research Laboratory.

THREE. 2020 Dec 16.

https://three.jsc.nasa.gov/articles/GalacticCosmicRaySimulator.cfm

Note: This article may be obtained online without charge.

Journal Impact Factor: Not applicable to this publication

Funding: No funding cited. L.S. Simonsen and T.C. Slaba are affiliated with NASA Langley Research Center.

 

9

McKeen P, Cullinane C, Rhodes R, Stirling L.

Analysis of the relationship between hip joint flexion/extension and torques in the Mark III space suit using a computational dynamics model.

Comput Methods Biomech Biomed Engin. 2020 Dec 18. Online ahead of print.

https://pubmed.ncbi.nlm.nih.gov/33337914

Journal Impact Factor: 1.502

Funding: "This work was supported in part by NASA NCC 9-58, NASA Award NNX15AR20G, and NSTRF NNX15AP51H." L.R. Young was the principal investigator for the NSBRI training grant under NCC 9-58.

 

10

Sawin C.

The Skylab Medical Experiments Altitude Test (SMEAT).

Aerosp Med Hum Perform. 2021 Jan 1;92(1):58-60.

https://pubmed.ncbi.nlm.nih.gov/33357277

Note: SMEAT was a 56-d Skylab mission simulation, conducted in an altitude chamber in the summer of 1972 to test mission preparations and observe physiological changes resulting from the planned atmosphere at 5 psia.

Journal Impact Factor: 0.889

Funding: No funding cited. C. Sawin was affiliated with NASA Johnson Space Center.

______________________________________________________

 

 

Other papers of interest:

 

1

Fukuda APM, Camandona VL, Francisco KJM, Rios-Anjos RM, Lucio do Lago C, Ferreira-Junior JR.

Simulated microgravity accelerates aging in Saccharomyces cerevisiae.

Life Sci Space Res. 2021 Feb;28:32-40.

http://www.sciencedirect.com/science/article/pii/S2214552420300882

Note: A clinostat was used.

 

2

Shpakov AV, Artamonov AA, Voronov AV, Plotnikov EV, Puchkova AA, Orlov DO.

Human locomotion strategies under changed bodyweight support.

Aerosp Med Hum Perform. 2021 Jan 1;92(1):4-10.

https://pubmed.ncbi.nlm.nih.gov/33357266

 

3

Šket R, Deutsch L, Prevoršek Z, Mekjavić IB, Plavec J, Rittweger J, Debevec T, Eiken O, Stres B.

Systems view of deconditioning during spaceflight simulation in the PlanHab project: The departure of urine 1H-NMR metabolomes from healthy state in young males subjected to bedrest inactivity and hypoxia.

Front Physiol. 2020 Dec 7;11:532271.

https://pubmed.ncbi.nlm.nih.gov/33364971

Note: Bed rest study. PlanHab is the Planetary Habitat simulation project supported by the European Union and the European Space Agency (ESA) (registration number NCT02637921 at https://clinicaltrials.gov/). This article may be obtained online without charge.

 

4

Chen Y, Xue F, Russo A, Wan Y.

Proteomic analysis of extracellular vesicles derived from MDA-MB-231 cells in microgravity.

Protein J. 2021 Jan 2. Online ahead of print.

https://pubmed.ncbi.nlm.nih.gov/33387250

Note: A 3-D clinostat was used.

 

5

Liu L, Cheng Y, Wang J, Ding Z, Halim A, Luo Q, Song G.

Simulated microgravity suppresses osteogenic differentiation of mesenchymal stem cells by inhibiting oxidative phosphorylation.

Int J Mol Sci. 2020 Dec 21;21(24):9747.

https://pubmed.ncbi.nlm.nih.gov/33371243

Note: A 2-D clinostat was used. This article may be obtained online without charge.

 

6

Ricci G, Cucina A, Proietti S, Dinicola S, Ferranti F, Cammarota M, Filippini A, Bizzarri M, Catizone A.

Microgravity induces transient EMT in human keratinocytes by early down-regulation of E-cadherin and cell-adhesion remodeling.

Appli Sci. 2021 Jan;11(1):110.

https://www.mdpi.com/2076-3417/11/1/110

Note: A Random Positioning Machine was used. The article belongs to the Special Issue "Advances in Space Biology: Cell Behavior in Microgravity," available at https://www.mdpi.com/journal/applsci/special_issues/Space_Biology. This article may be obtained online without charge.

 

7

Ottestad W, Hansen TA, Ksin JI.

Hypobaric decompression and white matter hyperintensities: An evaluation of the NATO standard.

Aerosp Med Hum Perform. 2021 Jan 1;92(1):39-42. Review.

https://pubmed.ncbi.nlm.nih.gov/33357271

 

8

Ganse B, Bosutti A, Drey M, Degens H.

Sixty days of head-down tilt bed rest with or without artificial gravity do not affect the neuromuscular secretome.

Exp Cell Res. 2020 Dec 29. Online ahead of print.

https://pubmed.ncbi.nlm.nih.gov/33385417

Note: Bed rest study, part of AGBRESA, the European Space Agency Artificial Gravity Bed Rest study.

 

9

Gritsyna YV, Ulanova AD, Popova SS, Bobylev AG, Zhalimov VK, Nemirovskaya TL, Shenkman BS, Vikhlyantsev IM.

Inhibition of histone deacetylases 4 and 5 reduces titin proteolysis and prevents reduction of TTN gene expression in atrophied rat soleus muscle after seven-day hindlimb unloading.

Dokl Biochem Biophys. 2020 Nov;495(1):338-41.

https://pubmed.ncbi.nlm.nih.gov/33368047

Note: Hindlimb unloading study.

 

10

Hao J, Siu K-C.

External visual perturbation impacts muscle activation while walking on incline treadmill.

Acta Astronaut. 2021 Mar;180:482-8. Epub 2020 Dec 30.

http://www.sciencedirect.com/science/article/pii/S009457652030789X

 

11

Brent MB, Brüel A, Thomsen JS.

A systematic review of animal models of disuse-induced bone loss.

Calcif Tissue Int. 2021 Jan 1. Online ahead of print. Review.

https://pubmed.ncbi.nlm.nih.gov/33386477

 

12

Takahashi I, Matsuzaki T, Kuroki H, Hoso M.

Disuse atrophy of articular cartilage induced by unloading condition accelerates histological progression of osteoarthritis in a post-traumatic rat model.

Cartilage. 2020 Dec 27. Online ahead of print.

https://pubmed.ncbi.nlm.nih.gov/33356503

Note: Hindlimb unloading study.

 

13

Oluwafemi FA, Abdelbaki R, Lai JCY, Mora-Almanza JG, Afolayan EM.

A review of astronaut mental health in manned missions: Potential interventions for cognitive and mental health challenges.

Life Sci Space Res. 2020 Feb;28:26-31. Review.

http://www.sciencedirect.com/science/article/pii/S2214552420300870

Note: From the abstract: "...this paper reviews the effects of isolation/confinement on psychological and cognitive health; impact of radiation and microgravity on cognitive health; and implications of disturbances to the circadian rhythm and sleep in space."

 

14

Mendt S, Gunga H-C, Felsenberg D, Belavy DL, Steinach M, Stahn AC.

Regular exercise counteracts circadian shifts in core body temperature during long-duration bed rest.

npj Microgravity. 2021 Jan 5;7(1):1.

https://www.nature.com/articles/s41526-020-00129-1

Note: Head-down tilt bed rest study, part of the Berlin Bed Rest Study 2. This article may be obtained online without charge.

 

15

Lim HK, Ji K, Woo YS, Han DU, Lee DH, Nam SG, Jang KM.

Test-retest reliability of the virtual reality sickness evaluation using electroencephalography (EEG).

Neurosci Lett. 2021 Jan;743:135589.

https://pubmed.ncbi.nlm.nih.gov/33359731

Note: This article may be obtained online without charge.

 

16

Vanhaelewyn L, Van Der Straeten D, De Coninck B, Vandenbussche F.

Ultraviolet radiation from a plant perspective: The plant-microorganism context.

Front Plant Sci. 2020 Dec 15;11:597642.

https://pubmed.ncbi.nlm.nih.gov/33384704

Note: This article may be obtained online without charge.

 

17

Ferranti F, Bianco MD, Pacelli C.

Advantages and limitations of current microgravity platforms for space biology research.

Appl Sci. 2021 Jan;11(1):68.

https://www.mdpi.com/2076-3417/11/1/68

Note: From the abstract: "This review provides a critical analysis of current ground-based and spaceflight facilities." The article belongs to the Special Issue "Advances in Space Biology: Cell Behavior in Microgravity," available at https://www.mdpi.com/journal/applsci/special_issues/Space_Biology. This article may be obtained online without charge.

 

18

Hoogendoorn ME, Brinkman S, Spijkstra JJ, Bosman RJ, Margadant CC, Haringman J, de Keizer NF.

The objective nursing workload and perceived nursing workload in Intensive Care Units: Analysis of association.

Int J Nurs Stud. 2021 Feb;114:103852.

https://pubmed.ncbi.nlm.nih.gov/33360666

Note: The NASA Task Load Index was used.

 

19

Lebet RM, Hasbani NR, Sisko MT, Agus MSD, Nadkarni VM, Wypij D, Curley MAQ.

Nurses' perceptions of workload burden in pediatric critical care.

Am J Crit Care. 2021 Jan 1;30(1):27-35.

https://pubmed.ncbi.nlm.nih.gov/33385203

Note: The NASA Task Load Index was used.

 

20

Rainieri G, Fraboni F, Russo G, Tul M, Pingitore A, Tessari A, Pietrantoni L.

Visual scanning techniques and mental workload of helicopter pilots during simulated flight.

Aerosp Med Hum Perform. 2021 Jan 1;92(1):11-9.

https://pubmed.ncbi.nlm.nih.gov/33357267

Note: The NASA Task Load Index was used.

...

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