Note:ISS results. From the abstract: "Here, I review findings from our NASA Twins Study and Telomeres investigations, highlighting potential mechanistic roles of chronic space radiation exposure in changes in telomere length and persistent DNA damage responses associated with long-duration spaceflight." This article may be obtained online without charge.
Journal Impact Factor:2.368
Funding:"Astronaut studies were supported by NASA: NNX14AH51G [all Twins Study principal investigators (PIs)]; NNX14AB02G and 80NSSC19K0434 (S.M.B.). Funding for the prostate cancer studies was provided through a philanthropic gift to the Baylor Scott & White Central Texas Foundation, Temple, TX, USA, and the Colorado Office of Economic Development and International Trade (OEDIT) Advanced Industry (AI) Bioscience Proof of Concept (POC) award program, Colorado State University (CSU) Ventures. Graduate student fellowships awarded by CSU’s Program of Research and Scholarly Excellence (PRSE), and the Cancer Biology and Comparative Oncology (CB&CO) PRSE to support quantitative Cell and Molecular Biology (qCMB) studies, are also gratefully acknowledged."
Gurubhagavatula I, Barger LK, Barnes CM, Basner M, Boivin DB, Dawson D, Drake CL, Flynn-Evans EE, Mysliwiec V, Patterson PD, Reid KJ, Samuels C, Shattuck NL, Kazmi U, Carandang G, Heald JL, Van Dongen HPA.
Guiding principles for determining work shift duration and addressing the effects of work shift duration on performance, safety, and health.
Sleep. 2021 Jul 15;zsab161. Online ahead of print.
Note:From the abstract: "Dose loading of cosmonaut's representative body organs beyond the Earth's magnetosphere was calculated for various scenarios of departure from a reference orbit in space vehicles of different design. Calculation of contribution to the equivalent doses from protons and electrons of Earth's radiations belts and galactic cosmic rays (GCR) demonstrated that, irrespective of vehicle design, during solar minimum and growing activity the equivalent dose does not exceed the established limit for a single exposure to 150 mSv. However, radiation exposure may vary at times depending on the traverse trajectory."
Note:SIRIUS 19 isolation and confinement analog mission results. From the abstract: "The paper presents the results of examination of 6 volunteers (3 males and 3 females) in a 120-day isolation study aimed to simulate a mission to the Moon."
Ilyin VK, Komissarova DV, Usanova NА, Morozova YA.
[Investigations of microflora from professional test-subjects and volunteers for isolation studies of up to 20 days in duration.]
Note:From the abstract: "Microbiocenosis in the upper respiration tracts and intestine was investigated in experienced test-subjects who could, possibly, have adapted to stresses during chamber studies of 8 to 10 days in duration faster than first-timers. The eubiotic index was used to assess positive and negative shifts in microbiota. The intestinal microflora in experienced subjects turned out to be more plastic and adapted much faster compared to the inexperienced counterparts. In both groups, the microbiota composition was compromised slightly at the end of acute adaptation and then stabilized."
Nakajima S, Nagata M, Ikehata A.
Mechanism for enhancing the growth of mung bean seedlings under simulated microgravity.
Note:The microgravity modeling method was not identified in the English abstract.From the abstract: "In this investigation, we used several optimized models of co-culturing mesenchymal stromal cells (MSCs) and hematopoietic stem and progenitor cells (HSPCs) to analyze the HSPCs suspension fractions following 7-day modeling of the effects of microgravity."
MacLean MK, Ferris DP.
Human muscle activity and lower limb biomechanics of overground walking at varying levels of simulated reduced gravity and gait speeds.
Note:From the abstract: "The authors review recent experimental data about relative biological effectiveness (RBE) of low absorbed doses (0.01–0.5 Gy) from fast neutrons and accelerated multicharged ions currently accepted as career limits for cosmonauts from the standpoint of late effects risk mitigation."
A forty-year journey from "classical" biophysics and radiobiology to hadrontherapy, space radiation and low dose rate underground radiobiology.
Int J Radiat Biol. 2021 Jul 14;1-12. Review. Online ahead of print.
Note:From the abstract: "The paper analyzes approaches used in cognitive sciences to explore imagination of 2D and 3D virtual scenes and thus to get insight into the psychological aspects of spatial orientation."
Soldatov PE, Shulaguin YA, Tyurin-Kuzmin АY, Dyachenko AI.
[Endurance of hypoxic hypoxia after preliminary breathing of normoxic mixtures containing argon or krypton.]