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NASA Spaceline Current Awareness List # 970 8 October 2021 (Space Life Science Research Results)

Status Report From: Spaceline
Posted: Friday, October 8, 2021

SPACELINE Current Awareness Lists are distributed via listserv and are available on the NASA Task Book website at https://taskbook.nasaprs.com/Publication/spaceline.cfm. Please send any correspondence to Shawna Byrd, SPACELINE Current Awareness Senior Editor, SPACELINE@nasaprs.com.
 
Papers deriving from NASA support:
 
1
Ison C, Neilsen C, DeBerardinis J, Trabia MB, Dufek JS.
Use of pressure-measuring insoles to characterize gait parameters in simulated reduced-gravity conditions.
Sensors (Basel). 2021 Sep 17;21(18):6244.
https://pubmed.ncbi.nlm.nih.gov/34577451
Note: An AlterG Treadmill and Medilogic pressure measuring insole system were used in this study. This article is part of Special Issue "Sensors and Musculoskeletal Dynamics to Evaluate Human Movement" (https://www.mdpi.com/journal/sensors/special_issues/Musculoskeletal_Dynamics). Additional articles will be forthcoming and may be found in the link to the Special Issue. This article may be obtained online without charge.
Journal Impact Factor: 3.576
Funding: "This research was partially supported by the Nevada NASA Space Grant Consortium (NVSGC)."
 
2
Matar M, Gokoglu SA, Prelich MT, Gallo CA, Iqbal AK, Britten RA, Prabhu RK, Myers JG Jr.
Machine learning models to predict cognitive impairment of rodents subjected to space radiation.
Front Syst Neurosci. 2021 Sep 13;15:713131.
https://pubmed.ncbi.nlm.nih.gov/34588962
PI: R.A. Britten
Note: This article may be obtained online without charge.
Journal Impact Factor: 4.8
Funding: "The investigation generating the data used in this study was funded by NASA grant support NNX14AE73G."
 
3
Rosa-Caldwell ME, Mortreux M, Kaiser UB, Sung DM, Bouxsein ML, Dunlap KR, Greene NP, Rutkove SB.
The estrous cycle and skeletal muscle atrophy: Investigations in rodent models of muscle loss.
Exp Physiol. 2021 Sep 26. Online ahead of print.
https://pubmed.ncbi.nlm.nih.gov/34569104
PIs: M.E. Rosa-Caldwell, S.B. Rutkove 
Note: Hindlimb unloading study.
Journal Impact Factor: 2.969
Funding: "HHS | National Institutes of Health (NIH): Nicholas P Greene, R15AR069913; HHS | National Institutes of Health (NIH): Nicholas P Greene, R01AR075794-01A1; HHS| National Institutes of Health (NIH): Ursula B Kaiser, R37HD19938; HHS | National Institutes of Health (NIH): Nicholas P Greene, P20GM125503; National Aeronautics and Space Administration (NASA): Megan E Rosa-Caldwell, 80NSSC21K0311; National Aeronautics and Space Administration (NASA): Seward B Rutkove, 80NSSC19K1598."
 
_______________________________________________________
 
 
Other papers of interest:
 
1
Mortimer JC, Gilliham M.
SpaceHort: Redesigning plants to support space exploration and on-Earth sustainability.
Curr Opin Biotechnol. 2022 Feb;73:246-52. Review. Available online 23 September 2021.
https://pubmed.ncbi.nlm.nih.gov/34563931
Note: From the article: "Here, we have outlined the potential for designed plants to support Space exploration, not only as a source of food, but as part of a broader biomanufacturing strategy." This article may be obtained online without charge.
 
2
Neilson BN, Craig CM, Altman GC, Travis AT, Vance JA, Klein MI.
Can the biophilia hypothesis be applied to long-duration human space flight? A mini-review.
Front Psychol. 2021 Sep 9;12:703766. Review.
https://pubmed.ncbi.nlm.nih.gov/34566783
Note: From the introduction: "A theory called biophilia suggests that humans have an innate propensity for nature, and there may be an evolutionary benefit to such a propensity. " This article is part of Research Topic "Biophilic Design Rationale: Theory, Methods, and Applications" (https://www.frontiersin.org/research-topics/15369/biophilic-design-rationale-theory-methods-and-applications#articles). Additional articles will be forthcoming and may be found in the link to the Research Topic. This article may be obtained online without charge.
 
3
Dong H-S, Shen Q-B, Lan H-Y, Zhao W, Cao P, Chen P.
Fecal bile acids profile of crewmembers consuming the same space food in a spacecraft simulator.
Front Physiol. 2021 Oct 1;12:593226.
https://www.frontiersin.org/article/10.3389/fphys.2021.593226
Note: This article is part of Research Topic "Aerospace Health and Safety: Today and the Future" (https://www.frontiersin.org/research-topics/10667/aerospace-health-and-safety-today-and-the-future#articles). The Research Topic also includes articles from previous Current Awareness Lists #873 https://doi.org/10.3389/fphys.2019.01366, #893 https://doi.org/10.3389/fphys.2020.00299, #897 https://doi.org/10.3389/fpubh.2020.00119, #907 https://doi.org/10.3389/fphys.2020.00837, #910 https://doi.org/10.3389/fphys.2020.00781, #911 https://doi.org/10.3389/fphys.2020.00960, #918 https://doi.org/10.3389/fpubh.2020.00327, #936 https://doi.org/10.3389/fphys.2020.577325, #940 https://doi.org/10.3389/fphys.2021.643943, #942  https://doi.org/10.3389/fphys.2021.651977, and #969 https://doi.org/10.3389/fphys.2021.712628. Additional articles will be forthcoming and may be found in the link to the Research Topic. This article may be obtained online without charge.
 
4
Romano LE, Aronne G.
The world smallest plants (Wolffia Sp.) as potential species for bioregenerative life support systems in space.
Plants (Basel). 2021 Sep 13;10(9):1896. Review.
https://pubmed.ncbi.nlm.nih.gov/34579428
Note: From the abstract: "We reviewed the scientific literature on duckweed (Lemnaceae) and reported available information on plant biological traits, nutritional features, biomass production, and space applications, especially of the genus Wolffia. Results confirmed that the smallest existing higher plants are the best candidate for space BLSS [bioregenerative life support systems]. We discussed needs for further research before criticalities to be addressed to finalize the adoption of Wolffia species for space missions." This article is part of Special Issue "Duckweed: Research Meets Applications" (https://www.mdpi.com/journal/plants/special_issues/duckweed). Additional articles will be forthcoming and may be found in the link to the Special Issue. This article may be obtained online without charge.
 
5
Zhao S, Zhao J, Sui D, Wang T, Zheng T, Zhao C, Zhu Y.
Modular robotic limbs for astronaut activities assistance.
Sensors (Basel). 2021 Sep 21;21(18):6305.
https://pubmed.ncbi.nlm.nih.gov/34577512
Note: This article is part of Section "Sensors and Robotics" (https://www.mdpi.com/journal/sensors/sections/robotics). This article may be obtained online without charge.
 
6
Buravkova L, Larina I, Andreeva E, Grigoriev A.
Microgravity effects on the matrisome.
Cells. 2021 Sep;10(9):2226. Review.
https://pubmed.ncbi.nlm.nih.gov/34571874
Note: Spaceflight missions (including ISS) and various microgravity simulation methods results. This article is part of Section "Cell Microenvironment" (https://www.mdpi.com/journal/cells/sections/Cell_Microenvironment). This article may be obtained online without charge.
 
7
Ludtka C, Moore E, Allen JB.
The effects of simulated microgravity on macrophage phenotype.
Biomedicines. 2021 Sep 12;9(9):1205.
https://pubmed.ncbi.nlm.nih.gov/34572391
Note: A rotating wall vessel bioreactor was used in this study. This article and the article below (Li et al.) are part of Topic "Translation from Microgravity Research to Earth Application" (https://www.mdpi.com/topics/microgravity_research). Additional articles will be forthcoming and may be found in the link to the Topic. This article may be obtained online without charge.
 
8
Li C, Liu Y, Li Y, Tai R, Sun Z, Wu Q, Liu Y, Sun C.
Collagen XV promotes ER stress-induced inflammation through activating integrin β1/FAK signaling pathway and M1 macrophage polarization in adipose tissue.
Int J Mol Sci. 2021 Sep 16;22(18):9997.
https://pubmed.ncbi.nlm.nih.gov/34576160
Note: This article and the article above (Ludtka et al.) are part of Topic "Translation from Microgravity Research to Earth Application" (https://www.mdpi.com/topics/microgravity_research). Additional articles will be forthcoming and may be found in the link to the Topic. This article may be obtained online without charge.
 
9
Singh R, Rajput M, Singh RP.
Simulated microgravity triggers DNA damage and mitochondria-mediated apoptosis through ROS generation in human promyelocytic leukemic cells.
Mitochondrion. 2021 Sep 24;S1567-7249(21)00132-X. Online ahead of print.
https://pubmed.ncbi.nlm.nih.gov/34571251
Note: A rotary cell culture system was used in this study.
 
10
Fayat R, Delgado Betancourt V, Goyallon T, Petremann M, Liaudet P, Descossy V, Reveret L, Dugué GP.
Inertial measurement of head tilt in rodents: Principles and applications to vestibular research.
Sensors (Basel). 2021 Sep 21;21(18):6318.
https://pubmed.ncbi.nlm.nih.gov/34577524
Note: Head tilt study. This article is part of Special Issue "Advances in Inertial Sensors" (https://www.mdpi.com/journal/sensors/special_issues/iertial_sensors). Additional articles will be forthcoming and may be found in the link to the Special Issue. This article may be obtained online without charge.
 
11
Tyganov SA, Mochalova EP, Melnikov IY, Vikhlyantsev IM, Ulanova AD, Sharlo KA, Mirzoev TM, Shenkman BS.
NOS [nitric oxide synthase]-dependent effects of plantar mechanical stimulation on mechanical characteristics and cytoskeletal proteins in rat soleus muscle during hindlimb suspension.
Faseb J. 2021 Oct;35(10):e21905.
https://pubmed.ncbi.nlm.nih.gov/34569672
Note: Hindlimb unloading study.
 
12
Shin TH, Nithiyanandam S, Lee DY, Kwon DH, Hwang JS, Kim SG, Jang YE, Basith S, Park S, Mo JS, Lee G.
Analysis of nanotoxicity with integrated omics and mechanobiology.
Nanomaterials (Basel). 2021 Sep;11(9):2385. Review.
https://pubmed.ncbi.nlm.nih.gov/34578701
Note: From the abstract: "Here, we review the integration of omics, ML [machine learning], and mechanobiology for evaluating nanotoxicity." This article is part of Special Issue "From Measurements to Predictive Models: Recent Advancements in Nanosafety Research" (https://www.mdpi.com/journal/nanomaterials/special_issues/advancement_nanosafety). Additional articles will be forthcoming and may be found in the link to the Special Issue. This article may be obtained online without charge.
 
13
Salvadego D, Grassi B, Keramidas ME, Eiken O, McDonnell AC, Mekjavic IB.
Heterogeneity of human adaptations to bed rest and hypoxia: A retrospective analysis within the skeletal muscle oxidative function.
Am J Physiol Regul Integr Comp Physiol. 2021 Sep 29. Online ahead of print.
https://pubmed.ncbi.nlm.nih.gov/34585615
Note: Bed rest study. From the abstract: "This retrospective study was designed to analyse the interindividual variability in the responses of different variables characterizing the skeletal muscle oxidative function to normoxic (N-BR) and hypoxic (H-BR) bed rests, and to a hypoxic ambulatory confinement (H-AMB) of 10 and 21 days."
 
14
Bouchard AL, Dsouza C, Julien C, Rummler M, Gaumond MH, Cermakian N, Willie BM.
Bone adaptation to mechanical loading in mice is affected by circadian rhythms.
Bone. 2022 Jan;154:116218. Available online 24 September 2021.
https://pubmed.ncbi.nlm.nih.gov/34571201
 
15
Lau P, Beijer Å, Rosenberger A, Schoenau E, Clemen CS, Zange J, Rittweger J.
Effects of six-week resistance training with or without vibration on metabolic markers of bone metabolism.
Int J Environ Res Public Health. 2021 Sep 18;18(18):9860.
https://pubmed.ncbi.nlm.nih.gov/34574778
Note: This article is part of Special Issue "Sports Medicine and Sports Science" (https://www.mdpi.com/journal/ijerph/special_issues/sports_medicine_science). Additional articles will be forthcoming and may be found in the link to the Special Issue. This article may be obtained online without charge.
 
16
Bastos AR, Raquel Maia F, Miguel Oliveira J, Reis RL, Correlo VM.
Influence of gellan gum-hydroxyapatite spongy-like hydrogels on human osteoblasts under long-term osteogenic differentiation conditions.
Mater Sci Eng C Mater Biol Appl. 2021 Oct;129:112413.
https://pubmed.ncbi.nlm.nih.gov/34579922
 
17
Calaf GM, Crispin LA, Roy D, Aguayo F, Muñoz JP, Bleak TC.
Gene signatures induced by ionizing radiation as prognostic tools in an in vitro experimental breast cancer model.
Cancers (Basel). 2021 Sep 12;13(18):4571. Review.
https://pubmed.ncbi.nlm.nih.gov/34572798
Note: This article may be obtained online without charge.
 
18
Dalvi SG, Gaikwad HD, Hasabnis S, Suprasanna P.
Electron beam irradiated chitosan elicits enhanced biochemical responses for resistance to purple blotch disease (Alternaria porri) in onion (Allium cepa).
Int J Radiat Biol. 2021 Sep 29:1-17. Online ahead of print.
https://pubmed.ncbi.nlm.nih.gov/34587466
 
19
Li X, Chen L, Zhou H, Gu S, Wu Y, Wang B, Zhang M, Ding N, Sun J, Pang X, Lu D.
LsrB, the hub of ABC transporters involved in the membrane damage mechanisms of heavy ion irradiation in Escherichia coli.
Int J Radiat Biol. 2021 Oct 1:1-27. Online ahead of print.
https://pubmed.ncbi.nlm.nih.gov/34597255
Note: From the abstract: "Ionizing radiation, especially heavy-ion (HI) beams, has been widely used in biology and medicine. However, the mechanism of membrane damage by such radiation remains primarily uncharacterized."
 
20
Manisaligil YA, Gumustekin M, Micili SC, Ural C, Cavdar Z, Sisman G, Yurt A.
The role of small GTPase Rac1 in ionizing radiation-induced testicular damage.
Int J Radiat Biol. 2021 Oct 1:1-27. Online ahead of print.
https://pubmed.ncbi.nlm.nih.gov/34597250
 
21
Ramchander S, Andrew Peter Leon MT, Souframanien J, Arumugam Pillai M.
Genetic diversity, allelic variation and marker trait associations in gamma irradiated mutants of rice (Oryza sativa L.).
Int J Radiat Biol. 2021 Sep 29;1-31. Online ahead of print.
https://pubmed.ncbi.nlm.nih.gov/34587459
 
22
Sharma V, Thakur M.
Gamma irradiations induced morphological and biochemical variations in in vitro regenerated ginger (Zingiber officinale Rosc.)- an invaluable medicinal spice.
Int J Radiat Biol. 2021 Oct 1;1-26. Online ahead of print.
https://pubmed.ncbi.nlm.nih.gov/34597254
 
23
Vinithashri G, Manonmani S, Akilan M, Anand G, Meena S, Bhuvaneswari K, John JA.
Early flowering, good grain quality mutants through gamma rays and EMS [Ethyl Methane Sulphonate] for enhancing per day productivity in rice (Oryza sativa L.).
Int J Radiat Biol. 2021 Oct 1;1-19. Online ahead of print.
https://pubmed.ncbi.nlm.nih.gov/34597257
 
24
Zhang J, Peng Z, Liu Q, Yang G, Zhou L, Li W, Wang H, Chen Z, Guo T.
Time course analysis of genome-wide identification of mutations induced by and genes expressed in response to carbon ion beam irradiation in rice (Oryza sativa L.).
Genes (Basel). 2021 Sep 9;12(9):1391.
https://pubmed.ncbi.nlm.nih.gov/34573373
Note: This article is part of Special Issue "Mechanisms of DNA Damage, Repair and Mutagenesis" (https://www.mdpi.com/journal/genes/special_issues/Mechanisms_Repair_Mutagenesis). Additional articles will be forthcoming and may be found in the link to the Special Issue. This article may be obtained online without charge.
 
25
Harris F, Dobbs J, Atkins D, Ippolito JA, Stewart JE.
Soil fertility interactions with Sinorhizobium-legume symbiosis in a simulated Martian regolith; effects on nitrogen content and plant health.
PLoS One. 2021 Sep 29;16(9):e0257053.
https://pubmed.ncbi.nlm.nih.gov/34587163
Note: Press release for this article from the SpaceRef website: "To explore a possible role for symbiotic nitrogen-fixing bacteria in astroagriculture, the researchers grew clover in man-made regolith that closely matches that of Mars. They inoculated some of the plants with the microbe Sinorhizobium meliloti, which is commonly found in clover root nodules on Earth. Previous research had shown that clover can be grown in regolith, but had not explored inoculation with nitrogen- fixers." For the full press release go to http://spaceref.com/space-biology/clover-growth-in-mars-like-soils-boosted-by-bacterial-symbiosis.html. This article may be obtained online without charge.
 
26
Alcantara-Thome M, Miguel-Puga JA, Jauregui-Renaud K.
Anxiety and motion sickness susceptibility may influence the ability to update orientation in the horizontal plane of healthy subjects.
Front Integr Neurosci. 2021 Sep;15:742100.
https://pubmed.ncbi.nlm.nih.gov/34594190
Note: This article is part of Research Topic "Role of the Vestibular System in the Perception of Time and Space" (https://www.frontiersin.org/research-topics/20823/role-of-the-vestibular-system-in-the-perception-of-time-and-space#articles). Additional articles will be forthcoming and may be found in the link to the Research Topic. This article may be obtained online without charge.
 

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