Funding:"Part of the research described in this publication was carried out at the Jet Propulsion Laboratory, California Institute of Technology, under a contract with NASA. We thank researchers associated with Biotechnology and Planetary Protection group at JPL for their facility support. Government sponsorship acknowledged. This research was funded by 2012 Space Biology NNH12ZTT001N grant number 19-12829-26 under task order NNN13D111T awarded to K.V."
Morsi A, Massa GD, Morrow RC, Wheeler RM, Mitchell CA.
Comparison of two controlled-release fertilizer formulations for cut-and-come-again harvest yield and mineral content ofLactuca sativaL. cv. Outredgeous grown under International Space Station environmental conditions.
Funding:"This work was supported by the National Aeronautics and Space Administration [grant 80NSSC17K0546 to John Z. Kiss] and by the Spanish Plan Estatal de Investigaci´on Científica y Desarrollo Tecnol´ogico [Grant RTI2018-099309-B-I00, co-funded by EU-ERDF, to F. Javier Medina]."
Trudel G, Shahin N, Ramsay T, Laneuville O, Louati H.
Hemolysis contributes to anemia during long-duration space flight.
Funding:"We thank all 14 participants, who generously consented to the collection of these specimens in addition to their other mission duties, as well as the NASA Increment Science Coordinators at JSC and Reta Warren at the JSC Clinical Laboratory for the care of the blood samples…"
Aronne G, Muthert LWF, Izzo LG, Romano LE, Iovane M, Capozzi F, Manzano A, Ciska M, Herranz R, Medina FJ, Kiss JZ, van Loon JJWA.
A novel device to study altered gravity and light interactions in seedling tropisms.
Note:A random positioning machine and large diameter centrifuge were used in this study.
Journal Impact Factor:2.082
Funding:"Authors acknowledge Andrea Buonanno's contribution to create all parts of the ROOTROPS device in CATIA V5. We would also like to thank Mr. Alan Dowson from ESA-ESTEC TEC-MMG LIS Lab for his support in preparation and during this study. This work was supported by the ESA-HRE CORA contract #4000127705/19/NL/PG/pt. Financial support was also provided by ESA-TEC contract #4000116223/16/NL/KML/hh to Jack J.W.A. van Loon, by Spanish Agencia Estatal de Investigaci´on (grant RTI2018–099309-B-I00, co-funded by EU-ERDF) to F. Javier Medina, and by NASA (grant 80NSSC17K0546) to John Z. Kiss."
Izzo LG, Romano LE, Muthert LWF, Iovane M, Capozzi F, Manzano A, Ciska M, Herranz R, Medina FJ, Kiss JZ, van Loon JJWA, Aronne G.
Interaction of gravitropism and phototropism in roots ofBrassica oleracea.
Note:A random positioning machine and large diameter centrifuge were used in this study.
Journal Impact Factor:5.545
Funding:"Authors acknowledge Andrea Buonanno's contribution to create all parts of the ROOTROPS device in CATIA V5. We would also like to thank Mr. Alan Dowson from ESA-ESTEC TEC- MMG LIS Lab for his support in preparation and during this study. This work was supported by the ESA-HRE CORA contract #4000127705/19/NL/PG/pt. Financial support was also provided by ESA-TEC contract #4000116223/16/NL/KML/hh to Jack J.W.A. van Loon, by Spanish Agencia Estatal de Investigación (Grant RTI2018-099309-B-I00, co-funded by EU- ERDF) to F. Javier Medina, and by NASA (Grant 80NSSC17K0546) to John Z. Kiss."
Braveboy-Wagner J, Sharoni Y, Lelkes PI.
Nutraceuticals synergistically promote osteogenesis in cultured 7F2 osteoblasts and mitigate inhibition of differentiation and maturation in simulated microgravity.
Note:A random positioning machine was used in this study. This article may be obtained online without charge.
Journal Impact Factor:5.924
Funding:"This study was supported, in part, by NASA Grant/Contract 80NSSC18K1480 (P.I.L., P.I.) and a Dissertation Completion Grant from the Temple Graduate School (JBW). Y.S. acknowledges funding by Lycored Ltd., Beer Sheva, Israel (grant number 89964661). Publication of this article was funded in part by the Temple University Libraries Open Access Publishing Fund."
Cromwell RL, Huff JL, Simonsen LC, Patel ZS.
Earth-based research analogs to investigate space-based health risks.
Note:Various Earth-based analogs used to simulate the unique physiological and behavioral effects associated with spaceflight are reviewed in this article. This article may be obtained online without charge.
Journal Impact Factor:1.4
Funding:"This review was supported by the Translational Research Institute for Space Health (TRISH) at the Baylor College of Medicine (R.L.C.; Z.S.P.—The Red Risk School); through the NASA Human Health and Performance Contract #NNJ15HK11B (Z.S.P.); and NASA directly ( J.L.H. and L.C.S.)."
Kumar K, Datta K, Fornace AJ Jr, Suman S.
Total body proton and heavy-ion irradiation causes cellular senescence and promotes pro-osteoclastogenic activity in mouse bone marrow.
Funding:"Financial support from the following sources is gratefully acknowledged: National Aeronautics and Space Administration, Human Research Program (NASA/HRP) 80NSSC18K0864 (BDL); 80NSSC21K0679 (MNC); National Institute of Allergy and Infectious Diseases (NIAID) 2U19AI067773 (IS)."
Wang C, Sani ES, Gao W.
Wearable bioelectronics for chronic wound management.
Adv Funct Mater. 2021 Dec 26;2111022. Review. Online ahead of print.
Funding:"This project was supported by the National Institutes of Health grant R01HL155815, Office of Naval Research grants N00014‐21‐1‐2483 and N00014‐21‐1‐2845, the Translational Research Institute for Space Health through NASA NNX16AO69A, and Rothenberg Innovation Initiative (RI2) and Rosen Center for Bioengineering at California Institute of Technology."
Jahng JWS, Wu JC.
Cardiac reprogramming via chromatin remodeling by CRISPR activation.
PI:J.W.S. Jahng, TRISH Postdoctoral Fellowship Program
Journal Impact Factor:11.454
Funding:"The current work is supported by National Institute of Health (NIH) grants R01 HL126527, R01 HL130020, and R01 HL146990 (J.C.W.), and the Translational Research Institute for Space Health (TRISH) through Cooperative Agreement NNX16AO69A (J.W.S.J)."
Huang Y, Harris BS, Minami SA, Jung S, Shah PS, Nandi S, McDonald KA, Faller R.
SARS-CoV-2 spike binding to ACE2 is stronger and longer ranged due to glycan interaction.
Note:This article may be obtained online without charge.
Journal Impact Factor:4.033
Funding:"Y.H. and R.F. were partially supported by the National Science Foundation under grant CBET 1911267. S.A.M. and S.J. were partially supported by a COVID-19 Research Accelerator Funding Track award by the UC Davis Office of Research (https://covid19research.ucdavis.edu/tags/craft). B.S.H. was partially supported by the Laboratory Directed Research and Development program of Lawrence Livermore National Laboratory, under the auspices of the U.S. Department of Energy by Lawrence Livermore National Laboratory under contract DE-AC52-07NA27344. K.A.M. and S.N. were partially supported by NASA Space Technology Research (award NNX17AJ31G) and by the Translational Research Institute through NASA (grant NNX16AO69A)."
Note:Chinese spacelab Tiangong-2 mission results. This article is part of Special Issue "Biotic and Abiotic Stress Effects on Plant Structure and Physiology" (https://www.mdpi.com/journal/ijms/special_issues/Plant_Structure_Physiology). Additional articles will be forthcoming and may be found in the link to the Special Issue.This article may be obtained online without charge.
Note:From the abstract: "In this review, we provide a summary of the existing knowledge about current space food products, the impact of radiation and storage on food composition, the identification of radiolytic biomarkers and identify gaps in our knowledge that are specific in relation to the effect of the cosmic radiation on food in space."
Wuest SL, Cerretti G, Wadsworth JL, Follonier C, Rattenbacher-Kiser KF, Bradley T, Egli M, Ille F.
Cytosolic calcium and membrane potential in articular chondrocytes during parabolic flight.
Acta Astronaut. 2022 Jan 17. Online ahead of print.
Note:From the abstract: "This is a review of the current state of knowledge of the effects of weightlessness on human proprioception. Two aspects have been highlighted: the sense of limb position and performance in sensorimotor tasks."
Dai TX, Son HN, Chi HNQ, Huy HNQ, Minh NT, Tram NTT, Huyen NTT, Quan TM, Chung DC, Nhung TH, Minh TT, Diem TH, Mai NTP, Long LT.
Simulated microgravity induces the proliferative inhibition and morphological changes in porcine granulosa cells.
Note:From the abstract: "We summarize the findings over the recent 3 years on µg-induced changes in the proteome of protists, plants, rodent and human cells. Considering the thematic orientation of microgravity-related publications in that time frame, we focus on medicine-associated findings such as the µg-induced antibiotic resistance of bacteria, the myocardial consequences of µg-induced calpain activation and the role of MMP13 in osteoarthritis. All these point to the fact that µg is an extreme stressor that could not be evolutionarily addressed on Earth."
Tran KN, Choi J-I.
Mimic microgravity effect on muscle transcriptome under ionizing radiation.
Note:Head-down tilt test study. This article may be obtained online without charge.
Bjursten H, Oudin Åström D, Nozohoor S, Ahmad K, Tang M, Bjurbom M, Hansson EC, Jeppsson A, Joost Holdflod Møller C, Jormalainen M, Juvonen T, Mennander A, Olsen PS, Olsson C, Ahlsson A, Oudin A, Pan E, Raivio P, Wickbom A, Sjögren J, Geirsson A, Gudbjartsson T, Zindovic I.
Once after a full moon: Acute type A aortic dissection and lunar phases.
Interact Cardiovasc Thorac Surg. 2022 Jan 6;34(1):105-10. Available online 27 August 2021.
Note:From the abstract: "Acute type A aortic dissection (ATAAD) is a rare but severe condition, routinely treated with emergent cardiac surgery. Many surgeons have the notion that patients with ATAAD tend to come in clusters, but no studies have examined these observations. This investigation was undertaken to study the potential association between the lunar cycle and the incidence of ATAAD." This article may be obtained online without charge.
Brocca L, Rossi M, Canepari M, Bottinelli R, Pellegrino MA.
Exercise preconditioning blunts early atrogenes expression and atrophy in gastrocnemius muscle of hindlimb unloaded mice.
Note:From the abstract: "Inhibitory control, the ability to inhibit impulsive responses and irrelevant stimuli, enables high level functioning and activities of daily living. The Simon task probes inhibition using interfering stimuli, i.e., cues spatially presented on the opposite side of the indicated response; incongruent response times (RT) are slower than congruent RTs. Operational applicability of the Simon task beyond finger/hand manipulations and visual/auditory cues is unclear, but important to consider as new technologies provide tactile cues and require motor responses from the lower extremity (e.g., exoskeletons). In this study, twenty participants completed the Simon task under four conditions, each combination of two cue (visual/tactile) and response (upper/lower-extremity) modalities."
Note:From the abstract: "Deployable lunar structures have been and are being developed as an appropriate solution to the volumetric limitations of cargo mission flights. A deployable lunar habitat consisting of linear and planar elements connected through simple movable joints is introduced. This new structure is made of some linear units consisting of two types of scissor-like elements (SLE): 1) a modified polar scissor-like element and 2) a closed-loop of angulated scissor-like elements. After conducting theoretical research on lunar habitats, the evaluation criteria of transformable lunar structures are derived and then many new concepts are evaluated. The design considerations of such structures are discussed, and a proper form for these habitat types is selected. An experimental study is run to assess the best deployment strategy for the whole structure. By introducing the dimensional properties of the lunar habitats through physical and digital modeling process per crewmember, the derived alternatives from the previous stage are analyzed and the best transformation strategy that meets the aforementioned considerations is developed."
Vinogradova OL, Tomilovskaya ES, Kozlovskaya IB.
Gravity as a factor in evolutionary adaptation of animals to living on the Earth.
Note:From the abstract: "The review considers the current ideas about the role of the gravitational factor in activities of the sensorimotor and cardiovascular systems, as well as new basic problems and questions of space medicine and physiology."