Note:From the abstract: "In this perspective article, we provide new insights into the potential role of exosomal lncRNA after spaceflight. We analyzed the transcriptional profile of exosomes isolated from peripheral blood plasma of three astronauts who flew on various Shuttle missions between 1998–2001 by RNA-sequencing. Computational analysis of the transcriptome of these exosomes identified 27 differentially expressed lncRNAs with a Log2fold change, with molecular, cellular, and clinical implications." This article is part of Research Topic "RNA-Chromatin Interactions: Biology, Mechanism, Disease and Therapeutics" (https://www.frontiersin.org/research-topics/25076/rna-chromatin-interactions-biology-mechanism-disease-and-therapeutics#articles). Additional articles will be forthcoming and may be found in the link to the Research Topic. This article may be obtained online without charge.
Journal Impact Factor:4.599
Funding:"This work is supported by the Translational Research Institute through NASA Cooperative Agreement NNX16AO69A (to DG), the Translational Research Institute for Space Health funds FIP0005 (to DG.), National Aeronautics and Space Administration grant 80NSSC19K1079 (to DG), American Heart Association Career Development Award 18CDA34110277 and startup funds from the Ohio State University Medical Center (to VG.), National Institutes of Health grant R01 HL133554 and American Heart Association 18IPA34170321 (to LH), NIH 5T32HL007824-22, and the Cardiovascular Medical Research and Education Fund (CMREF) (to LH and MB). Work was also performed under the auspices of the U.S. Department of Energy by Lawrence Livermore National Laboratory under contract DE-AC52-07NA27344."
Parker CW, Teixeira MM, Singh NK, Raja HA, Cank KB, Spigolon G, Oberlies NH, Barker BM, Stajich JE, Mason CE, Venkateswaran K.
Genomic characterization ofParengyodontium torokiisp. nov., a biofilm-forming fungus isolated from Mars 2020 Assembly Facility.
Funding:"This work was funded by the Translational Research Institute for Space Health through Cooperative Agreement NNX16AO69A, the National Science Foundation award number IOS-1907338, and the University of Colorado."
Demmig-Adams B, Polutchko SK, Zenir MC, Fourounjian P, Stewart JJ, López-Pozo M, Adams WW 3rd.
Intersections: Photosynthesis, abiotic stress, and the plant microbiome.
Note:This article may be obtained online without charge.
Journal Impact Factor:3.189
Funding:"This work was supported by the Translational Research Institute for Space Health through Cooperative Agreement NNX16AO69A, National Science Foundation award number IOS-1907338, and the University of Colorado."
Pena D, Suescun J, Schiess M, Ellmore TM, Giancardo L.
Toward a multimodal computer-aided diagnostic tool for Alzheimer's disease conversion.
Funding:"…LG was supported by a Learning Healthcare Award funded by the UTHealth Center for Clinical and Translational Science (CCTS), the Translational Research Institute through NASA Cooperative Agreement NNX16AO69A, NIH grants UL1TR003167 and R01NS121154, and a Cancer Prevention and Research Institute of Texas grant (RP 170668)."
Kaplonek P, Fischinger S, Cizmeci D, Bartsch YC, Kang J, Burke JS, Shin SA, Dayal D, Martin P, Mann C, Amanat F, Julg B, Nilles EJ, Musk ER, Menon AS, Krammer F, Saphire EO, Carfi A, Alter G.
mRNA-1273 vaccine-induced antibodies maintain Fc-effector functions across SARS-CoV-2 variants of concern.
Note:This article may be obtained online without charge.
Journal Impact Factor:31.745
Funding:"…We acknowledge support from the Ragon Institute of MGH, MIT, and Harvard, the Massachusetts Consortium on Pathogen Readiness (MassCPR), the NIH (3R37AI080289-11S1, R01AI146785, U19AI42790-01, U19AI135995-02, U19AI42790-01, 1U01CA260476 – 01, CIVIC75N93019C00052), the Gates Foundation Global Health Vaccine Accelerator Platform funding (OPP1146996 and INV-001650), Translational Research Institute for Space Health through NASA Cooperative Agreement (NNX16AO69A), and the Musk Foundation."
Note:ISS results. From the abstract: "This work is a review of the experiments carried out in the Russian segment of the ISS (inside and outside) from 2005 to 2016 on the effect of the space flight factor on the resting stages of organisms. In outer space, ultraviolet, a wide range of high and low temperatures, cosmic radiation, altered gravity, modified electromagnetic field, vacuum, factors of technical origin, ultrasound, microwave radiation, etc. and their combination determine the damaging effect on living organisms." This article may be obtained online without charge.
Nijhuis J, Schmidt S, Tran NN, Hessel V.
Microfluidics and macrofluidics in space: ISS-proven fluidic transport and handling concepts.
Note:From the abstract: "Recently, three different microfluidics-suitable fluid behavior phenomena have been studied on the ISS that might further facilitate the manipulation of fluids in space: capillary-driven flow, thermocapillary Marangoni forces, and electrolytic gas evolution-driven flow. Furthermore, attention is drawn for strategies to eliminate unwanted bubbles from liquid bodies in space, as they can damage sensitive equipment: Mesh-screen capillarity and open wedge channels have been identified as promising approaches. Finally, the relevance of fluid handling in space is illustrated with everyday activities during space missions, such as drinking, plant watering, and gathering biometric data." This article is part of Research Topic "Technologies for handling, preparation, and liquid-based analysis of fluidic samples in space" (https://www.frontiersin.org/research-topics/18491/technologies-for-handling-preparation-and-liquid-based-analysis-of-fluidic-samples-in-space#articles). The Research Topic also includes an article from previous Current Awareness List #981https://doi.org/10.3389/frspt.2021.797518. Additional articles will be forthcoming and may be found in the link to the Research Topic. This article may be obtained online without charge.
Bogomolov VV, Polyakov AV, Matsnev EI, Popova II, Kovachevich IV, Alferova IV, Repenkova LG, Sigaleva EE.
Diagnosis and treatment of ENT diseases in Russian cosmonauts during missions to the Orbital Station MIR and ISS.
Note:From the abstract: "This review summarizes all known cardiovascular diseases related to human spaceflight and focusses on the cardiovascular changes related to human spaceflight (in vivo [e.g., head-down bed rest studies]) as well as cellular and molecular changes (in vitro [e.g., random positioning machine])." This article and the two articles below (Cortés-Sánchez et al. and Hammer et al.) are part of Topic "Translation from Microgravity Research to Earth Application" (https://www.mdpi.com/topics/microgravity_research). The Topic also includes articles from previous Current Awareness List #970https://doi.org/10.3390/ijms22189997andhttps://doi.org/10.3390/biomedicines9091205, and #976https://doi.org/10.3390/ijms222111759. Additional articles will be forthcoming and may be found in the link to the Topic. This article may be obtained online without charge.
Cortés-Sánchez JL, Callant J, Krüger M, Sahana J, Kraus A, Baselet B, Infanger M, Baatout S, Grimm D.
Cancer studies under space conditions: Finding answers abroad.
Note:From the abstract: "In this review article, we discuss the current state of knowledge in cancer research under real and simulated microgravity conditions and point out further research directions in this field. Outer space is an extremely hostile environment for human life, with radiation, microgravity, and vacuum posing significant hazards." This article, the article above (Baran et al.), and the article below (Hammer et al.), are part of Topic "Translation from Microgravity Research to Earth Application" (https://www.mdpi.com/topics/microgravity_research). This article may be obtained online without charge.
Hammer A, Cerretti G, Ricciardi DA, Schiffmann D, Maranda S, Kummer R, Zumbühl C, Rattenbacher-Kiser KF, von Arx S, Ammann S, Strobl F, Berkane R, Stolz A, Stelzer EHK, Egli M, Schleiff E, Wuest SL, Böhmer M.
Retrograde analysis of calcium signaling by CaMPARI2 shows cytosolic calcium in chondrocytes is unaffected by parabolic flights.
Note:Parabolic flight results.This article and the two articles above (Baran et al. and Cortés-Sánchez et al.) are part of Topic "Translation from Microgravity Research to Earth Application" (https://www.mdpi.com/topics/microgravity_research). This article may be obtained online without charge.
Hughes L, Hackney KJ, Patterson SD.
Optimization of exercise countermeasures to spaceflight using blood flow restriction.
Aerosp Med Hum Perform. 2022 Jan;93(1):32-45. Review.
Note:From the abstract: "Blood flow restriction exercise is a low intensity exercise strategy that requires minimal equipment and can elicit positive training benefits across multiple physiological systems. This method of exercise training has potential as a strategy to optimize exercise countermeasures during spaceflight and reconditioning in terrestrial and partial gravity environments. The possible applications of blood flow restriction exercise during spaceflight are discussed herein."
Space research and new concepts in the physiology of movements.
Note:Parabolic flight results.This article is part of Special Issue "Frontiers in Extremophiles: From Life at Edge on Earth to Space Exploration" (https://www.mdpi.com/journal/life/special_issues/CEE2022). Additional articles will be forthcoming and may be found in the link to the Topic. This article may be obtained online without charge.
Shi S, Li J, Li E, Guo W, He Y, Wang J, Zhang Y, Yue L, Wei L.
Simulated microgravity increases the permeability of HUVEC monolayer through up-regulation of Rap1GAP and decreased Rap2 activation.
Note:Hindlimb unloading study. This article is part of Special Issue "Craniofacial Bone and Dental Genetics, Metabolism, Aging, and Disorders" (https://www.mdpi.com/journal/genes/special_issues/Bone_Genetics). Additional articles will be forthcoming and may be found in the link to the Special Issue. This article may be obtained online without charge.
Joushomme A, Garenne A, Dufossée M, Renom R, Ruigrok HJ, Chappe YL, Canovi A, Patrignoni L, Hurtier A, Poulletier de Gannes F, Lagroye I, Lévêque P, Lewis N, Priault M, Arnaud-Cormos D, Percherancier Y.
Label-free study of the global cell behavior during exposure to environmental radiofrequency fields in the presence or absence of pro-apoptotic or pro-autophagic treatments.
Note:From the abstract: "In this work, a 3D composite scaffold is designed using bioprinting technology and synergistic hemostasis mechanisms of cellulose nanofibrils (TCNFs), chitosan, and casein to control blood loss in traumatic hemorrhage."