Call for articles to cite in the weekly lists:Authors at NASA Centers and NASA PIs—do you have an article that has recently published or will publish in the upcoming weeks within a peer-reviewed journal and is in the scope of space life sciences?If so, send it our way! Send your article to the email address mentioned above. Articles received by Wednesday will appear within that week's list—articles received after Wednesday will appear the following week.
Funding:"AH is a recipient of the following grant: NASA NNX09AP11G; Rodent Spine Deconditioning after 30 Days of Microgravity. JS is a recipient of the following grants: COBRE P20 GM103652 pilot sub grant, National Institute of General Medical Sciences, National Institutes of Health; Rhode Island Foundation grant 20190594, Alzheimer's Administrative Supplement grant, and TEAM UTRA grant from Brown University."
Reyes DP, Masterova KS, Walton M, Kerstman EL, Antonsen EL.
Assessment of sex-dependent medical outcomes during spaceflight.
J Womens Health (Larchmt). 2022 May 12. Online ahead of print.
Note:From the abstract: "In this study sex-differences in medical outcomes during spaceflight are reviewed and probabilistic risk assessment (PRA) is used to assess the impact on spaceflight missions of varying lengths."
Journal Impact Factor:2.681
Funding:E.L. Antonsen is affiliated with NASA Johnson Space Center.
Wostyn P, Mader TH, Gibson CR, Nedergaard M.
Does long-duration exposure to microgravity lead to dysregulation of the brain and ocular glymphatic systems?
Note:From the abstract: "Spaceflight-associated neuro-ocular syndrome (SANS) has been well documented in astronauts both during and after long-duration spaceflight and is characterized by the development of optic disc edema, globe flattening, choroidal folds, and hyperopic refractive error shifts. The exact mechanisms underlying these ophthalmic abnormalities remain unclear. New findings regarding spaceflight-associated alterations in cerebrospinal fluid spaces, specifically perivascular spaces, may shed more light on the pathophysiology of SANS. The preliminary results of a recent brain magnetic resonance imaging study show that perivascular spaces enlarge under prolonged microgravity conditions, and that the amount of fluid in perivascular spaces is linked to SANS. The exact pathophysiological mechanisms underlying enlargement of perivascular spaces in space crews are currently unclear. Here, we speculate that the dilation of perivascular spaces observed in long-duration space travelers may result from impaired cerebral venous outflow and compromised cerebrospinal fluid resorption, leading to obstruction of glymphatic perivenous outflow and increased periarterial cerebrospinal fluid inflow, respectively." This article may be obtained online without charge.
Journal Impact Factor:3.93
Funding:C.R. Gibson is affiliated with NASA Space Medicine Operations Division.
Paul A-L, Elardo SM, Ferl R.
Plants grown in Apollo lunar regolith present stress-associated transcriptomes that inform prospects for lunar exploration.
Note:Apollo 11, 12, and 17 results. From the abstract: "The extent to which plants can enhance human life support on other worlds depends on the ability of plants to thrive in extraterrestrial environments using in-situ resources. Using samples from Apollo 11, 12, and 17, we show that the terrestrial plantArabidopsis thalianagerminates and grows in diverse lunar regoliths. However, our results show that growth is challenging; the lunar regolith plants were slow to develop and many showed severe stress morphologies." This article may be obtained online without charge.
Journal Impact Factor:6.268
Funding:"We thank the members of the UF Space Plants Lab, particularly Jordan Callaham, Natasha Haveman, and Brandon Califar for their support. We thank the NASA AARB (formerly CAPTEM), the NASA Johnson Space Center Curation staff for the allocation of the Apollo samples for this work, and Charles Walkinshaw for insightful discussions. We also thank UF Research and UF-IFAS Communications, particularly Tyler L. Jones for his plant photography. And finally, the UF ICBR Gene Expression (RRID:SCR_019145), NextGen Sequencing (RRID:SCR_019152), and Bioinformatics (RRID:SCR_019120) cores, for their services. Funding for this work included National Aeronautics and Space Administration grant NNX14AT24G (A-LP, RJF), University of Florida Office of Research - Retuned IDC (A-LP, RJF), and National Aeronautics and Space Administration grant 80NSSC19K0752 (SME)."
Buonanno M, Gonon G, Pandey BN, Azzam EI.
The intercellular communications mediating radiation-induced bystander effects and their relevance to environmental, occupational, and therapeutic exposures.
Int J Radiat Biol. 2022 May 13;1-59. Review. Online ahead of print.
Funding:"This work received support from the National Institutes of Health (Grants CA92262 and CA049062), the National Aeronautics and Space Administration (grants NNJ06HD91G and NNX15AD62G), the US department of Energy Low Dose Radiation Research program (DE-FG02-02ER63447), the New Jersey Commission on Cancer Research (Grant No. 02-1081-CCR-S2), and the Federal Nuclear Science and Technology program at Canadian Nuclear Laboratories (project FST-51320.50.19.06)."
Werneth CM, Slaba TC, Huff JL, Patel ZS, Simonsen LC.
Medical countermeasure requirements to meet NASA's space radiation permissible exposure limits for a Mars mission scenario.
Note:From the abstract: "Results from this study provide important information regarding MCM [medical countermeasure] requirements needed to meet NASA limits for planned Mars missions. Insight into the types of countermeasures expected to yield greatest reductions in crew risk is also gained."
Journal Impact Factor:1.316
Funding:"This work was supported by the Human Research Program of the Human Exploration and Operations Mission Directorate of the National Aeronautics and Space Administration (CMW, JLH, TCS, LCS) and by the Human Health and Performance contract NNJ15HK11B (ZSP)."
Macklin BL, Lin YY, Emmerich K, Wisniewski E, Polster BM, Konstantopoulos K, Mumm JS, Gerecht S.
Intrinsic epigenetic control of angiogenesis in induced pluripotent stem cell-derived endothelium regulates vascular regeneration.
Note:This article may be obtained online without charge.
Journal Impact Factor:10.364
Funding:"Funding for this work was made possible by a NRSA F31 predoctoral fellowship F31HL143972 from NHLBI (awarded to BM), a T32 training award 5T32EY007143-25 and NRSA F31 predoctoral fellowship F31EY032790 from NEI (awarded to KE), and FA9550-20-1-0356 from the Air Force, RAD0102 from the Translational Research Institute through NASA Cooperative Agreement NNX16AO69A; and U54 CA210173-01 from NCI (awarded to SG)."
Hilditch CJ, Flynn-Evans EE.
Fatigue, schedules, sleep, and sleepiness in U.S. commercial pilots during COVID-19.
Note:From the abstract: "This study is a first step in characterizing cultivable and viable fungal populations in cleanrooms to assess fungal potential as biocontaminants during interplanetary explorations. The outcomes of this and future studies could be implemented in other cleanrooms that require reducing microbial burden, like intensive care units, operating rooms, or cleanrooms in the semiconducting and pharmaceutical industries." This article may be obtained online without charge.
Journal Impact Factor:5.640
Funding:"This research was supported by the NASA Planetary Protection Office 15-PPR15-0001 awarded to KV which also supported the postdoctoral fellowship for AB, SM, and CP."
Note:This article may be obtained online without charge.
Journal Impact Factor:4.246
Funding:"This work was supported by supplemental funds for COVID-19 research from Translational Research Institute of Space Health through NASA Cooperative Agreement NNX16AO69A (T-0404) to AB, and by a NASA Space Biology Postdoctoral Fellowship (80NSSC19K0426) to SAN. MJT is a recipient of The Evelyn Grollman Glick Scholar Award and supported by research funding from The Dr. Miriam and Sheldon G. Adelson Medical Research Foundation, Van Andel Research Institute through the Van Andel Research Institute – Stand Up To Cancer Epigenetics Dream Team. Stand Up To Cancer is a program of the Entertainment Industry Foundation, administered by AACR, and Specialized Program of Research Excellence (SPORE) program, through the National Cancer Institute (NCI), grant P50CA254897."
Note:From the abstract: "It is highly possible to obtain high-quality microbial products in appreciable amounts, as aerospace technology is advancing continuously. Genome-wide genetic variations in microorganisms can be triggered by space microgravity and radiation. Mutation rate is high, mutant range is wide, and final mutant character is stable. Therefore, space microorganism breeding is growing to be a new and promising area in microbial science and has greatly propelled the development of fermentation technology."
Duri LG, Pannico A, Petropoulos SA, Caporale AG, Adamo P, Graziani G, Ritieni A, De Pascale S, Rouphael Y.
Bioactive compounds and antioxidant activity of lettuce grown in different mixtures of monogastric-based manure with Lunar and Martian soils.
Note: From the abstract: "Virtual reality (VR) is an effective technique to reduce cost and increase fidelity in training programs. In VR, visual and vestibular cues are often in conflict, which may result in simulator-induced motion sickness. The purpose of this study is to investigate the integration of Galvanic Vestibular Stimulation (GVS) with a VR flight training simulator by assessing flight performance, secondary task performance, simulator sickness and presence."
Note:From the abstract: "With long-term space flights being planned for the moon and Mars, proper countermeasures must be taken to facilitate human health in microgravity environments. Exercise is a vital countermeasure used to prevent bone and muscle loss, among other health interests. Future exploration missions encourage creating an exercise device that is both compact and can be used to properly execute exercise by the astronauts. Current design considerations include interfacing an exercise device with a vibration isolation and stabilization (VIS) system, which is necessary for protecting the spacecraft and sensitive experiments from harmful vibrations developed during repetitive exercise. This human factor study assesses the feasibility of a VIS system exercise device by using the Computer Assistive Rehabilitation Environment (CAREN) to simulate characteristics of the system."
Kramer KEP, Anderson EE.
Hyperventilation-induced hypocapnia in an aviator.
Note:From the abstract: "Here, we describe a case of an aviator who experienced tingling extremities, confusion, and loss of consciousness during a flight. The aviator incorrectly believed he was experiencing hypoxia and continued to take multiple steps to troubleshoot the wrong underlying problem for his symptoms. Evaluation after landing suggested this was instead a stress-induced hyperventilation that resulted in symptomatic hypocapnia."
Note: NASA Task Load Index was used in this study. From the abstract: "Studies examining the potential of augmented reality (AR) to improve assembly tasks are often unrepresentative of real assembly line conditions and assess mental workload only through subjective measurements and leads to conflicting results. We proposed a study directly carried out in industrial settings, to compare the impact of AR-based instructions to computerized instructions, on assembly effectiveness (completion time and errors) and mental workload using objective (eye tracking), subjective (NASA-TLX) and behavioral measurements (dual task paradigm)."