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NASA Spaceline Current Awareness List #1,000 20 May 2022 (Space Life Science Research Results)

Status Report From: Spaceline
Posted: Friday, May 20, 2022

SPACELINE Current Awareness Lists are distributed via listserv and are available on the NASA Task Book website at https://taskbook.nasaprs.com/Publication/spaceline.cfm. Please send any correspondence to Shawna Byrd, SPACELINE Current Awareness Senior Editor, SPACELINE@nasaprs.com.
 
Call for articles to cite in the weekly lists: Authors at NASA Centers and NASA PIs—do you have an article that has recently published or will publish in the upcoming weeks within a peer-reviewed journal and is in the scope of space life sciences? If so, send it our way! Send your article to the email address mentioned above. Articles received by Wednesday will appear within that week's list—articles received after Wednesday will appear the following week.
 
Papers deriving from NASA support:
 
1
Siamwala JH, Macias BR, Healey R, Bennett B, Hargens AR.
Spaceflight-associated vascular remodeling and gene expression in mouse calvaria.
Front Physiol. 2022 May 13;13:893025.
https://doi.org/10.3389/fphys.2022.893025
PI: A.R. Hargens
Note: STS-131 and BION-M1 mission results. This article and an article below (Desruelle et al.) in the "Other" section are part of Research Topic "Physiology in extreme conditions: Adaptations and unexpected reactions, Volume II" (https://www.frontiersin.org/research-topics/29492/physiology-in-extreme-conditions-adaptations-and-unexpected-reactions-volume-ii#articles). Additional articles will be forthcoming and may be found in the link to the Research Topic. This article may be obtained online without charge.
Journal Impact Factor: 4.566
Funding: "AH is a recipient of the following grant: NASA NNX09AP11G; Rodent Spine Deconditioning after 30 Days of Microgravity. JS is a recipient of the following grants: COBRE P20 GM103652 pilot sub grant, National Institute of General Medical Sciences, National Institutes of Health; Rhode Island Foundation grant 20190594, Alzheimer's Administrative Supplement grant, and TEAM UTRA grant from Brown University."
 
2
Reyes DP, Masterova KS, Walton M, Kerstman EL, Antonsen EL.
Assessment of sex-dependent medical outcomes during spaceflight.
J Womens Health (Larchmt). 2022 May 12. Online ahead of print.
https://pubmed.ncbi.nlm.nih.gov/35549913
Note: From the abstract: "In this study sex-differences in medical outcomes during spaceflight are reviewed and probabilistic risk assessment (PRA) is used to assess the impact on spaceflight missions of varying lengths."
Journal Impact Factor: 2.681
Funding: E.L. Antonsen is affiliated with NASA Johnson Space Center.
 
3
Wostyn P, Mader TH, Gibson CR, Nedergaard M.
Does long-duration exposure to microgravity lead to dysregulation of the brain and ocular glymphatic systems?
Eye Brain. 2022 May 4;14:49-58. Review.
https://pubmed.ncbi.nlm.nih.gov/35546965
Note: From the abstract: "Spaceflight-associated neuro-ocular syndrome (SANS) has been well documented in astronauts both during and after long-duration spaceflight and is characterized by the development of optic disc edema, globe flattening, choroidal folds, and hyperopic refractive error shifts. The exact mechanisms underlying these ophthalmic abnormalities remain unclear. New findings regarding spaceflight-associated alterations in cerebrospinal fluid spaces, specifically perivascular spaces, may shed more light on the pathophysiology of SANS. The preliminary results of a recent brain magnetic resonance imaging study show that perivascular spaces enlarge under prolonged microgravity conditions, and that the amount of fluid in perivascular spaces is linked to SANS. The exact pathophysiological mechanisms underlying enlargement of perivascular spaces in space crews are currently unclear. Here, we speculate that the dilation of perivascular spaces observed in long-duration space travelers may result from impaired cerebral venous outflow and compromised cerebrospinal fluid resorption, leading to obstruction of glymphatic perivenous outflow and increased periarterial cerebrospinal fluid inflow, respectively." This article may be obtained online without charge.
Journal Impact Factor: 3.93
Funding: C.R. Gibson is affiliated with NASA Space Medicine Operations Division.
 
4
Paul A-L, Elardo SM, Ferl R.
Plants grown in Apollo lunar regolith present stress-associated transcriptomes that inform prospects for lunar exploration.
Commun Biol. 2022 May 12;5:382.
https://pubmed.ncbi.nlm.nih.gov/35552509
PI: A-L. Paul
Note: Apollo 11, 12, and 17 results. From the abstract: "The extent to which plants can enhance human life support on other worlds depends on the ability of plants to thrive in extraterrestrial environments using in-situ resources. Using samples from Apollo 11, 12, and 17, we show that the terrestrial plant Arabidopsis thaliana germinates and grows in diverse lunar regoliths. However, our results show that growth is challenging; the lunar regolith plants were slow to develop and many showed severe stress morphologies." This article may be obtained online without charge.
Journal Impact Factor: 6.268
Funding: "We thank the members of the UF Space Plants Lab, particularly Jordan Callaham, Natasha Haveman, and Brandon Califar for their support. We thank the NASA AARB (formerly CAPTEM), the NASA Johnson Space Center Curation staff for the allocation of the Apollo samples for this work, and Charles Walkinshaw for insightful discussions. We also thank UF Research and UF-IFAS Communications, particularly Tyler L. Jones for his plant photography. And finally, the UF ICBR Gene Expression (RRID:SCR_019145), NextGen Sequencing (RRID:SCR_019152), and Bioinformatics (RRID:SCR_019120) cores, for their services. Funding for this work included National Aeronautics and Space Administration grant NNX14AT24G (A-LP, RJF), University of Florida Office of Research - Retuned IDC (A-LP, RJF), and National Aeronautics and Space Administration grant 80NSSC19K0752 (SME)."
 
5
Buonanno M, Gonon G, Pandey BN, Azzam EI.
The intercellular communications mediating radiation-induced bystander effects and their relevance to environmental, occupational, and therapeutic exposures.
Int J Radiat Biol. 2022 May 13;1-59. Review. Online ahead of print.
https://pubmed.ncbi.nlm.nih.gov/35559659
PI: E.I. Azzam
Journal Impact Factor: 2.694
Funding: "This work received support from the National Institutes of Health (Grants CA92262 and CA049062), the National Aeronautics and Space Administration (grants NNJ06HD91G and NNX15AD62G), the US department of Energy Low Dose Radiation Research program (DE-FG02-02ER63447), the New Jersey Commission on Cancer Research (Grant No. 02-1081-CCR-S2), and the Federal Nuclear Science and Technology program at Canadian Nuclear Laboratories (project FST-51320.50.19.06)."
 
6
Werneth CM, Slaba TC, Huff JL, Patel ZS, Simonsen LC.
Medical countermeasure requirements to meet NASA's space radiation permissible exposure limits for a Mars mission scenario.
Health Phys. 2022 May 13. Online ahead of print.
https://pubmed.ncbi.nlm.nih.gov/35551137
Note: From the abstract: "Results from this study provide important information regarding MCM [medical countermeasure] requirements needed to meet NASA limits for planned Mars missions. Insight into the types of countermeasures expected to yield greatest reductions in crew risk is also gained."
Journal Impact Factor: 1.316
Funding: "This work was supported by the Human Research Program of the Human Exploration and Operations Mission Directorate of the National Aeronautics and Space Administration (CMW, JLH, TCS, LCS) and by the Human Health and Performance contract NNJ15HK11B (ZSP)."
 
7
Macklin BL, Lin YY, Emmerich K, Wisniewski E, Polster BM, Konstantopoulos K, Mumm JS, Gerecht S.
Intrinsic epigenetic control of angiogenesis in induced pluripotent stem cell-derived endothelium regulates vascular regeneration.
npj Regen Med. 2022 May 12;7:28.
https://pubmed.ncbi.nlm.nih.gov/35551465
PI: S. Gerecht
Note: This article may be obtained online without charge.
Journal Impact Factor: 10.364
Funding: "Funding for this work was made possible by a NRSA F31 predoctoral fellowship F31HL143972 from NHLBI (awarded to BM), a T32 training award 5T32EY007143-25 and NRSA F31 predoctoral fellowship F31EY032790 from NEI (awarded to KE), and FA9550-20-1-0356 from the Air Force, RAD0102 from the Translational Research Institute through NASA Cooperative Agreement NNX16AO69A; and U54 CA210173-01 from NCI (awarded to SG)."
 
8
Hilditch CJ, Flynn-Evans EE.
Fatigue, schedules, sleep, and sleepiness in U.S. commercial pilots during COVID-19.
Aerosp Med Hum Perform. 2022 May 1;93(5):433-41.
https://pubmed.ncbi.nlm.nih.gov/35551720
Journal Impact Factor: 1.904
Funding: "Cassie J. Hilditch is supported by the NASA Airspace Operations and Safety Program, System-Wide Safety."
 
9
Ajala C, Hasenstein KH.
Transcription profile of auxin related genes during positively gravitropic hypocotyl curvature of Brassica rapa.
Plants (Basel). 2022 Apr 28;11(9):1191.
https://pubmed.ncbi.nlm.nih.gov/35567192
PI: K.H. Hasenstein
Note: This article is part of Special Issue "Advances in Plant Physiology and Ecophysiology" (https://www.mdpi.com/journal/plants/special_issues/A_PPE). This article may be obtained online without charge.
Journal Impact Factor: 3.935
Funding: "This research was partially supported by NASA grants NNX10AP91G and 80NSSC17K0344."
 
10
Blachowicz A, Mhatre S, Singh NK, Wood JM, Parker CW, Ly C, Butler D, Mason CE, Venkateswaran K.
The isolation and characterization of rare mycobiome associated with spacecraft assembly cleanrooms.
Front Microbiol. 2022 Apr 26;13:777133.
https://pubmed.ncbi.nlm.nih.gov/35558115
Note: From the abstract: "This study is a first step in characterizing cultivable and viable fungal populations in cleanrooms to assess fungal potential as biocontaminants during interplanetary explorations. The outcomes of this and future studies could be implemented in other cleanrooms that require reducing microbial burden, like intensive care units, operating rooms, or cleanrooms in the semiconducting and pharmaceutical industries." This article may be obtained online without charge.
Journal Impact Factor: 5.640
Funding: "This research was supported by the NASA Planetary Protection Office 15-PPR15-0001 awarded to KV which also supported the postdoctoral fellowship for AB, SM, and CP."
 
11
Jamison DA Jr, Anand Narayanan S, Trovão NS, Guarnieri JW, Topper MJ, Moraes-Vieira PM, Zaksas V, Singh KK, Wurtele ES, Beheshti A.
A comprehensive SARS-CoV-2 and COVID-19 review, Part 1: Intracellular overdrive for SARS-CoV-2 infection.
Eur J Hum Genet. 2022 May 16;1-10. Review.
https://pubmed.ncbi.nlm.nih.gov/35577935
PI: A. Beheshti
Note: This article may be obtained online without charge.
Journal Impact Factor: 4.246
Funding: "This work was supported by supplemental funds for COVID-19 research from Translational Research Institute of Space Health through NASA Cooperative Agreement NNX16AO69A (T-0404) to AB, and by a NASA Space Biology Postdoctoral Fellowship (80NSSC19K0426) to SAN. MJT is a recipient of The Evelyn Grollman Glick Scholar Award and supported by research funding from The Dr. Miriam and Sheldon G. Adelson Medical Research Foundation, Van Andel Research Institute through the Van Andel Research Institute – Stand Up To Cancer Epigenetics Dream Team. Stand Up To Cancer is a program of the Entertainment Industry Foundation, administered by AACR, and Specialized Program of Research Excellence (SPORE) program, through the National Cancer Institute (NCI), grant P50CA254897."
 
___________________________________________________
 
 
Other papers of interest:
 
1
Chi Y, Wang X, Li F, Zhang Z, Tan P.
Aerospace technology improves fermentation potential of microorganisms.
Front Microbiol. 2022 Apr 29;13:896556. Review.
https://pubmed.ncbi.nlm.nih.gov/35572688
Note: From the abstract: "It is highly possible to obtain high-quality microbial products in appreciable amounts, as aerospace technology is advancing continuously. Genome-wide genetic variations in microorganisms can be triggered by space microgravity and radiation. Mutation rate is high, mutant range is wide, and final mutant character is stable. Therefore, space microorganism breeding is growing to be a new and promising area in microbial science and has greatly propelled the development of fermentation technology."
 
2
Duri LG, Pannico A, Petropoulos SA, Caporale AG, Adamo P, Graziani G, Ritieni A, De Pascale S, Rouphael Y.
Bioactive compounds and antioxidant activity of lettuce grown in different mixtures of monogastric-based manure with Lunar and Martian soils.
Front Nutr. 2022 Apr 29;9:890786.
https://pubmed.ncbi.nlm.nih.gov/35571954
Note: This article is part of Research Topic "The Chemistry of Food in the Advent of Sustainable Diets" (https://www.frontiersin.org/research-topics/16100/the-chemistry-of-food-in-the-advent-of-sustainable-diets#articles). Additional articles will be forthcoming and may be found in the link to the Research Topic. This article may be obtained online without charge.
 
3
Huyan T, Li M, Chen W, Zhou X, Pei D, Shang P, Wu C.
Simulated microgravity promotes oxidative stress-induced apoptosis in ARPE-19 cells associated with Nrf2 signaling pathway.
Acta Astronaut. 2022 May 13. Online ahead of print.
https://doi.org/10.1016/j.actaastro.2022.05.012
Note: A random positioning machine was used in this study.
 
4
Linossier MT, Peurière L, Fernandez P, Normand M, Beck A, Bareille M-P, Bonneau C, Gauquelin-Koch G, Vico L.
DI-5-cuffs: Bone remodelling and associated metabolism markers in humans after five days of dry immersion to simulate microgravity.
Front Physiol. 2022 Apr 27;13:801448.
https://pubmed.ncbi.nlm.nih.gov/35574450
Note: Dry immersion results.
 
5
Orr S, Casler J, Rhoades J, de León P.
Effects of walking, running, and skipping under simulated reduced gravity using the NASA Active Response Gravity Offload System (ARGOS).
Acta Astronaut. 2022 May 13. Online ahead of print.
https://doi.org/10.1016/j.actaastro.2022.05.014
Note: The NASA Active Response Gravity Offload System was used in this study to simulate reduced gravity.
 
6
Pradhan GN, Galvan-Garza RC, Perez AM, Stepanek J, Cevette MJ.
Visual vestibular conflict mitigation in virtual reality using galvanic vestibular stimulation.
Aerosp Med Hum Perform. 2022 May 1;93(5):406-14.
https://pubmed.ncbi.nlm.nih.gov/35551727
Note: From the abstract: "Virtual reality (VR) is an effective technique to reduce cost and increase fidelity in training programs. In VR, visual and vestibular cues are often in conflict, which may result in simulator-induced motion sickness. The purpose of this study is to investigate the integration of Galvanic Vestibular Stimulation (GVS) with a VR flight training simulator by assessing flight performance, secondary task performance, simulator sickness and presence."
 
7
Orlov OI, Belakovskiy MS, Kussmaul AR, Tomilovskaya ES.
Using the possibilities of Russian space medicine for terrestrial healthcare.
Front Physiol. 2022 May 13;13:921487.
https://doi.org/10.3389/fphys.2022.921487
Note: This article is part of Research Topic "Space Countermeasures and Medicine - Implementation into Earth medicine and Rehabilitation" (https://www.frontiersin.org/research-topics/29370/space-countermeasures-and-medicine---implementation-into-earth-medicine-and-rehabilitation#articles). The Research Topic also includes an article from previous Current Awareness List #997 https://doi.org/10.3389/fphys.2022.897694. Additional articles will be forthcoming and may be found in the link to the Research Topic. This article may be obtained online without charge.
 
8
Li B, Zhao L, Zhang S, Cai H, Xu L, An B, Wang R, Liu G, He Y, Jiao C, Liu L, Xu Y.
The mutational, epigenetic, and transcriptional effects between mixed high-energy particle field (CR) and 7Li-Ion beams (LR) radiation in wheat M1 seedlings.
Front Plant Sci. 2022 May 11;13:878420.
https://doi.org/10.3389/fpls.2022.878420
Note: This article is part of Research Topic "Higher Plants, Algae and Cyanobacteria in Space Environments, Volume II" (https://www.frontiersin.org/research-topics/30023/higher-plants-algae-and-cyanobacteria-in-space-environments-volume-ii#articles). Additional articles will be forthcoming and may be found in the link to the Research Topic. This article may be obtained online without charge.
 
9
Xu D, Li H, Katsube T, Huang G, Liu J, Wang B, Zhang H.
Effects of concurrent exposure to chronic restraint-induced stress and total-body iron ion radiation on induction of kidney injury in mice.
Int J Mol Sci. 2022 Apr 27;23(9):4866.
https://pubmed.ncbi.nlm.nih.gov/35563256
Note: This article is part of Special Issue "Biological Effects of Low Dose and Low Dose-Rate Ionizing Radiation Exposure" (https://www.mdpi.com/journal/ijms/special_issues/Low_Dose). This article may be obtained online without charge.
 
10
Blocker A, Lostroscio K, Carey SL.
Biomechanics of healthy subjects during exercise on a simulated vibration isolation and stabilization system.
Life Sci Space Res. 2022 May 14. Online ahead of print.
https://doi.org/10.1016/j.lssr.2022.05.003
Note: From the abstract: "With long-term space flights being planned for the moon and Mars, proper countermeasures must be taken to facilitate human health in microgravity environments. Exercise is a vital countermeasure used to prevent bone and muscle loss, among other health interests. Future exploration missions encourage creating an exercise device that is both compact and can be used to properly execute exercise by the astronauts. Current design considerations include interfacing an exercise device with a vibration isolation and stabilization (VIS) system, which is necessary for protecting the spacecraft and sensitive experiments from harmful vibrations developed during repetitive exercise. This human factor study assesses the feasibility of a VIS system exercise device by using the Computer Assistive Rehabilitation Environment (CAREN) to simulate characteristics of the system."
 
11
Kramer KEP, Anderson EE.
Hyperventilation-induced hypocapnia in an aviator.
Aerosp Med Hum Perform. 2022 May 1;93(5):470-1.
https://pubmed.ncbi.nlm.nih.gov/35551718
Note: From the abstract: "Here, we describe a case of an aviator who experienced tingling extremities, confusion, and loss of consciousness during a flight. The aviator incorrectly believed he was experiencing hypoxia and continued to take multiple steps to troubleshoot the wrong underlying problem for his symptoms. Evaluation after landing suggested this was instead a stress-induced hyperventilation that resulted in symptomatic hypocapnia."
 
12
Miskovic V, Malafronte E, Minetti C, Machrafi H, Varon C, Iorio CS.
Thermotropic liquid crystals for temperature mapping.
Front Bioeng Biotechnol. 2022 May 12;10:806362.
https://doi.org/10.3389/fbioe.2022.806362
Note: This article is part of Research Topic "Wound Management and Healing in Space" (https://www.frontiersin.org/research-topics/14877/wound-management-and-healing-in-space#articles). The Research Topic also includes articles from previous Current Awareness Lists #958 https://doi.org/10.3389/fbioe.2021.679650, #972 https://doi.org/10.3389/fbioe.2021.720091, #973 https://doi.org/10.3389/fbioe.2021.720217 and https://doi.org/10.3389/fbioe.2021.716184, #995 https://doi.org/10.3389/fbioe.2022.666434, and #998 https://doi.org/10.3389/fbioe.2022.873384. Additional articles will be forthcoming and may be found in the link to the Research Topic. This article may be obtained online without charge.
 
13
Desruelle A-V, Maistre Sd, Gaillard S, Richard S, Tardive C, Martin J-C, Blatteau J-E, Boussuges A, Rives S, Risso J-J, Vallee N.
Cecal metabolomic fingerprint of unscathed rats: Does it reflect the good response to a provocative decompression?
Front Physiol. 2022 May 17;13:882944.
https://doi.org/10.3389/fphys.2022.882944
Note: This article and an article above (Siamwala et al.) in the "NASA" section are part of Research Topic "Physiology in extreme conditions: Adaptations and unexpected reactions, Volume II" (https://www.frontiersin.org/research-topics/29492/physiology-in-extreme-conditions-adaptations-and-unexpected-reactions-volume-ii#articles). This article may be obtained online without charge.
 
14
Goldie C, Stork B, Bernhardt K, Gaydos SJ, Kelley AM.
Obstructive sleep apnea among army aircrew.
Aerosp Med Hum Perform. 2022 May 1;93(5):415-20.
https://pubmed.ncbi.nlm.nih.gov/35551721
 
15
McHill AW, Hull JT, Klerman EB.
Chronic circadian disruption and sleep restriction influence subjective hunger, appetite, and food preference.
Nutrients. 2022 Apr 26;14(9):1800.
https://pubmed.ncbi.nlm.nih.gov/35565768
Note: This article is part of Special Issue "Nutrition, Circadian Disruption and Cardiometabolic Health" (https://www.mdpi.com/journal/nutrients/special_issues/circadian_cardiometabolic). Additional articles will be forthcoming and may be found in the link to the Special Issue. This article may be obtained online without charge.
 
16
Drouot M, Le Bigot N, Bricard E, Bougrenet JL, Nourrit V.
Augmented reality on industrial assembly line: Impact on effectiveness and mental workload.
Appl Ergon. 2022 Sep;103:103793.
https://pubmed.ncbi.nlm.nih.gov/35561532
Note: NASA Task Load Index was used in this study. From the abstract: "Studies examining the potential of augmented reality (AR) to improve assembly tasks are often unrepresentative of real assembly line conditions and assess mental workload only through subjective measurements and leads to conflicting results. We proposed a study directly carried out in industrial settings, to compare the impact of AR-based instructions to computerized instructions, on assembly effectiveness (completion time and errors) and mental workload using objective (eye tracking), subjective (NASA-TLX) and behavioral measurements (dual task paradigm)."
 

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