The research fills in one of the major gaps in our understanding about the origins of life: how single molecules were able to join together to create the self-replicating long chain molecules of RNA, the precursors of DNA. It "sheds new light on the earliest steps of evolution," write Armen Mulkidjanian and his colleagues from Osnabr¸ck University, Germany and National Institutes of Health, USA.

With no ozone layer the primordial Earth was a hostile place. This was especially true for long-chain molecules that would be broken up by UV radiation, which was at 100 times today's level. Most existing theories about how life evolved involve hiding the first life forms away from the light. Instead, Mulkidjanian and his colleagues have investigated the idea that high levels of UV light hitting the primordial earth were vital to RNA's survival.

The researchers used computer-modelling technology to assess the ability of RNA to form from its constituent parts, sugar phosphates and nitrogenous bases, with and without high levels of UV light. They found that the ability of nitrogenous bases to absorb and disperse UV radiation could protect the backbone of primordial RNA from breaks. Under high levels of UV, RNA molecules were more stable than other large molecules and the small molecules that join together to create the RNA. This gave RNA molecules a selective advantage, so that their levels then increased through the simulated process of natural selection. Moreover, part of the energy from the absorbed UV light could have driven the elongation of RNA chains.

"The suggested mechanism turns the high UV levels on primordial Earth from a perceived obstacle to the origin of life into the selective factor that, in fact, might have driven the whole process", write the authors.

"It seems quite unlikely that the extremely effective UV-quenching by all major nitrogenous bases is just incidental. We can assume that these bases were selected to perform the UV-protecting function before they became involved in the maintenance and transfer of genetic information. In this (primordial) world the nitrogenous bases served just as protecting units. Accordingly these units were replaceable and variable. Exactly this variability could have paved the way to the variability of the future genomes".

Three of the four nitrogenous bases that protected RNA from UV on primordial Earth are the same as those that make up the genetic code of DNA. Ironically, the ability of DNA to absorb UV light is now responsible for many skin cancer deaths. When the bases of DNA absorb UV light they often suffer structural damage, although the DNA backbone remains intact. If this damage occurs within a gene it can lead to the alteration of that gene, which may cause cancer.

Upon publication on Wednesday 28th May at 13:00 GMT, this article will be freely available online via http://www.biomedcentral.com/bmcevolbiol, according to BioMed Central's policy of open access to research articles:

Survival of the fittest before the beginning of life
Selection of the first oligonucleotide-like polymers by UV light
Armen Y. Mulkidjanian, Dmitry A. Cherepanov, Michael Y. Galperin
BMC Evolutionary Biology

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Contact the authors:
Dr. Mulkidjanian can be contacted by phone on +49-541-969-2871 or by email at mulkidjanian@biologie.uni-osnabrueck.de.

Dr. Galperin can be contacted by phone on +1-301-435-5910 or by email at galperin@ncbi.nlm.nih.gov.

For any further information please contact Gemma Bradley by email at press@biomedcentral.com or by phone on +44-0-20-732-30323 x2331.

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