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NASA Spaceline 27 March 2009 Current Space Life Science Awareness

Status Report From: Spaceline
Posted: Thursday, May 28, 2009

The abstract in PubMed or at the publisher's site is linked when available and will open in a new window.



  1. Tuday EC, Nyhan D, Shoukas AA, Berkowitz DE. Simulated microgravity induced aortic remodeling. J Appl Physiol. 2009 Mar 19. [Epub ahead of print] (PI: A.A. Shoukas)


  2. Caiozzo VJ, Haddad F, Lee SM, Baker M, Paloski WH, Baldwin KM. Artificial gravity as a countermeasure to microgravity: A pilot study examining the effects on knee extensor and plantar flexor muscle groups. J Appl Physiol. 2009 Mar 12. [Epub ahead of print] (PI: K.M. Baldwin)


  3. Cook JS, Ray CA. Modulation of muscle sympathetic nerve activity to muscle heating during dynamic exercise. Am J Physiol Regul Integr Comp Physiol. 2009 Mar 11. [Epub ahead of print] (PI: C.A. Ray)


  4. Hu S, Kim MH, McClellan GE, Cucinotta FA. Modeling the acute health effects of astronauts from exposure to large solar particle events. Health Phys. 2009 Apr;96(4):465-76. (PI: F.A. Cucinotta)


  5. Gridley DS, Pecaut MJ, Rizvi A, Coutrakon GB, Luo-Owen X, Makinde AY, Slater JM. Low-dose, low-dose-rate proton radiation modulates CD4(+) T cell gene expression. Int J Radiat Biol. 2009 Mar 12:1-12. [Epub ahead of print] (PI: D.S. Gridley)


  6. Lackner JR, DiZio P. Control and calibration of multi-segment reaching movements. Adv Exp Med Biol. 2009;629:681-98. Review. (PIs: J.R. Lackner, L.R. Young)


  7. Inan OT, Etemadi M, Sanchez ME, Marcu O, Bhattacharya S, Kovacs GT. A miniaturized video system for monitoring the locomoter activity of walking Drosophila melanogaster in space and terrestrial settings. IEEE Trans Biomed Eng. 2008 Oct 3. [Epub ahead of print]


  8. Leitz G, Kang BH, Schoenwaelder ME, Staehelin LA. Statolith sedimentation kinetics and force transduction to the cortical endoplasmic reticulum in gravity-sensing Arabidopsis columella cells. Plant Cell. 2009 Mar 10. [Epub ahead of print] (PI: L.A. Staehelin) Note: This article may be obtained online without charge.




Other papers of interest:



  1. Lohmeier TE, Hildebrandt DA, Dwyer TM, Iliescu R, Irwin ED, Cates AW, Rossing MA. Prolonged activation of the baroreflex decreases arterial pressure even during chronic adrenergic blockade. Hypertension. 2009 Mar 9. [Epub ahead of print]


  2. Ogoh S, Fisher JP, Young CN, Raven PB, Fadel PJ. Transfer function characteristics of the neural and peripheral arterial baroreflex arcs at rest and during post exercise muscle ischemia in humans. Am J Physiol Heart Circ Physiol. 2009 Mar 13. [Epub ahead of print]


  3. Goswami N, Roessler A, Lackner HK, Schneditz D, Grasser E, Hinghofer-Szalkay HG. Heart rate and stroke volume response patterns to augmented orthostatic stress. Clin Auton Res. 2009 Mar 7. [Epub ahead of print]


  4. Cooke J, Carew S, O'Connor M, Costelloe A, Sheehy T, Lyons D. Sitting and standing blood pressure measurements are not accurate for the diagnosis of orthostatic hypotension. QJM. 2009 Mar 9. [Epub ahead of print]


  5. Low DA, Wingo JE, Keller DM, Davis SL, Cui J, Zhang R, Crandall CG. Dynamic cerebral autoregulation during passive heat stress in humans. Am J Physiol Regul Integr Comp Physiol. 2009 Mar 11. [Epub ahead of print]


  6. Capulli M, Rufo A, Teti A, Rucci N. Global transcriptome analysis in mouse calvarial osteoblasts highlights sets of genes regulated by modeled microgravity and identifies a "mechanoresponsive osteoblast gene signature." J Cell Biochem. 2009 Mar 13. [Epub ahead of print] Note: From abstract: "We finally matched our transcriptome results with other public global gene profiles obtained in loading and unloading conditions, identifying 10 shared regulated genes which could represent an 'osteoblast mechanoresponsive gene signature.' "


  7. Furuichi Y, Masuda K, Takakura H, Hotta N, Ishida K, Katayama K, Iwase S, Akima H. Effect of intensive interval training during unloading on muscle deoxygenation kinetics. Int J Sports Med. 2009 Mar 19. [Epub ahead of print]


  8. Siu PM, Alway SE. Response and adaptation of skeletal muscle to denervation stress: The role of apoptosis in muscle loss. Front Biosci. 2009 Jan 1;14:432-52.


  9. Klossner S, Durieux AC, Freyssenet D, Flueck M. Mechano-transduction to muscle protein synthesis is modulated by FAK. Eur J Appl Physiol. 2009 Mar 18. [Epub ahead of print]


  10. Michael KE, Dumbauld DW, Burns KL, Hanks SK, Garcia AJ. FAK modulates cell adhesion strengthening via integrin activation. Mol Biol Cell. 2009 Mar 18. [Epub ahead of print] Note: This article may currently be obtained online without charge.


  11. Clement G, Fraysse MJ, Deguine O. Mental representation of space in vestibular patients with otolithic or rotatory vertigo. Neuroreport. 2009 Mar 25;20(5):457-61.


  12. Krishnamoorthy V, Hsu WL, Kesar TM, Benoit DL, Banala SK, Perumal R, Sangwan V, Binder-Macleod SA, Agrawal SK, Scholz JP. Gait training after stroke: A pilot study combining a gravity-balanced orthosis, functional electrical stimulation, and visual feedback. J Neurol Phys Ther. 2008 Dec;32(4):192-202.


  13. Bender JA, Frye MA. Invertebrate solutions for sensing gravity. Curr Biol. 2009 Mar 10;19(5):R186-90. Note: No abstract. From paper: "Just as we mammals have evolved highly acute sensory mechanisms to detect gravity acting on our bodies and appendages, so have invertebrates developed these capacities. For invertebrates, perceiving gravity's pull presents a number of fascinating challenges, which are accentuated by their diminutive stature. For tiny animals, the gravitational force can be vanishingly small, requiring exquisite sensitivity in order to measure it. Invertebrates have correlates of each of the gravity-sensing systems found in humans, some by shared ancestry and some by convergent evolution. Additional exotic solutions highlight the performance demands of invertebrate locomotion. Here we will discuss strategies for gravity detection by invertebrates during terrestrial, aquatic, and aerial locomotion. Notwithstanding the obvious architectural and developmental disparities, we shall, where possible, compare their solutions to our own."


  14. Veland IR, Awan A, Pedersen LB, Yoder BK, Christensen ST. Primary cilia and signaling pathways in mammalian development, health and disease. Nephron Physiol. 2009;111(3):p39-53. Epub 2009 Mar 10. Note: This article may be obtained online without charge.


  15. Rangaswami H, Marathe N, Zhuang S, Chen Y, Yeh JC, Frangos JA, Boss GR, Pilz RB. Type II cGMP-dependent protein kinase mediates osteoblast mechanotransduction. J Biol Chem. 2009 Mar 11. [Epub ahead of print] Note: This article may currently be obtained online without charge.


  16. Glossop JR, Cartmell SH. Effect of fluid flow-induced shear stress on human mesenchymal stem cells: Differential gene expression of IL1B and MAP3K8 in MAPK signaling. Gene Expr Patterns. 2009 Jan 19. [Epub ahead of print]


  17. Durachko DM, Cosgrove DJ. Measuring plant cell wall extension (creep) induced by acidic pH and by alpha-expansin. J Vis Exp. 2009 Mar 11;(25):1263. doi: 10.3791/1263. Note: This journal, the Journal of Visualized Experiments, contains online videos along with text. Take a look at this paper/video, available currently without cost, by former PI Daniel Cosgrove.





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