NASA Spaceline Current Awareness List #690 18 March 2016

Status Report From: Spaceline
Posted: Friday, March 18, 2016

Editor's note: NASA's various life sciences programs have prepared the SPACELINE Current Awareness updates since 1999 covering all aspects of space life science, gravitational biology, space medicine, and human factors. NASA does not maintain a website - nor does it have an  archive of this resource online. However, SpaceRef does have a complete archive of SPACELINE updates all the way back to 1999 that can be accessed here:

Papers deriving from NASA support:




Bigley AB, Rezvani K, Shah N, Sekine T, Balneger N, Pistillo M, Agha N, Kunz H, Bollard CM, O'Connor DP, Simpson RJ.

Latent CMV infection enhances anti-tumor cytotoxicity through accumulation of NKG2C+ NK-cells in healthy humans.

Clin Exp Immunol. 2016 Mar 3. [Epub ahead of print]

PIs: R.J. Simpson; A.B. Bigley, NSBRI Postdoctoral Fellowship Program

Journal Impact Factor: 3.037

Funding: "This work was supported by National Space Biomedical Research Institute through NASA NCC 9-58 to A.B. Bigley and NASA grants NNX12AB48G and NNJ14ZSA001N-FLAGSHIP to R.J. Simpson."



Hendry JH, Niwa O, Barcellos-Hoff MH, Globus RK, Harrison JD, Martin MT, Seed TM, Shay JW, Story MD, Suzuki K, Yamashita S.

ICRP Publication 131: Stem cell biology with respect to carcinogenesis aspects of radiological protection.

Ann ICRP. 2016 Mar 8. [Epub ahead of print]

Note: See also the monograph by the same title, PubMed PMID 26637346 ( which appeared in Current Awareness List #677. This article may be obtained online without charge.

Journal Impact Factor: Not available for this journal

Funding: No funding cited. R.K. Globus is at NASA Ames Research Center.



Koturbash I, Miousse IR, Sridharan V, Nzabarushimana E, Skinner CM, Melnyk SB, Pavliv O, Hauer-Jensen M, Nelson GA, Boerma M.

Radiation-induced changes in DNA methylation of repetitive elements in the mouse heart.

Mutat Res. 2016 Mar 2;787:43-53. [Epub ahead of print]

PIs: G.A. Nelson/NSCOR; M. Boerma/I. Koturbash/M. Hauer-Jensen/G.A. Nelson/NSBRI Center for Research on Cardiac, Vascular, and Acute Effects of Space Radiation

Journal Impact Factor: 3.68

Funding: "This work was supported by National Aeronautics and Space Administration [NNX10AD59G]; National Space Biomedical Research Institute [RE03701 through NCC 9–58]; the National Institutes of Health [CA148679 to MB, R37 CA71382 to MHJ, 1P20GM109005, and Clinical and Translational Science AwardUL1TR000039 and KL2TR000063], US Veterans Administration, the Arkansas Biosciences Institute (ABI), ABI Grant for Core Metabolomics Laboratory, and ACH Foundation Grants for studies of metabolic changes in children with Autism and patients with Down Syndrome."



Locke PA, Weil MM.

Personalized cancer risk assessments for space radiation exposures.

Front Oncol. 2016 Feb 22;6:38.

PI: M.M. Weil

Note: This article may be obtained online without charge.

Journal Impact Factor: Not available for this journal

Funding: "Research by MW is supported by grants NNX12AB54G and NNX15AK13G from the National Aeronautics and Space Administration."



Vasterling JJ, Deming C.

Evaluating the evidence and viability of occupational social support countermeasures delivered prior to long-duration spaceflight to enhance behavioral health.

Houston, TX: NASA Johnson Space Center, 2016 Mar. 68 p. NASA/TM-2016-218601.

Note: This article may be obtained online without charge.

Journal Impact Factor: Not applicable

Funding: "This project was funded by the NASA Human Research Program (HRP), Behavioral Health and Performance (BHP) Group."



Other papers of interest:



Zhang S, Zheng D, Wu Y, Lin W, Chen Z, Meng L, Liu J, Zhou Y.

Simulated microgravity using a rotary culture system compromises the in vitro development of mouse preantral follicles.

PLoS One. 2016 Mar 10;11(3):e0151062.

Note: A rotating wall vessel was used. This article may be obtained online without charge.



Bozzini C, Picasso EO, Champin GM, Alippi RM, Bozzini CE.

Structural and material mechanical quality of femoral shafts in rats exposed to simulated high altitude from infancy to adulthood.

High Alt Med Biol. 2016 Mar;17(1):50-3. Epub 2016 Mar 7.



Kim HW, Rhee MS.

Influence of low-shear modeled microgravity on heat resistance, membrane fatty acid composition, and heat stress-related gene expression in Escherichia coli O157:H7 ATCC 35150, 43889, 43890, and 43895.

Appl Environ Microbiol. 2016 Mar 4. [Epub ahead of print]

Note: A Rotary Cell Culture System and a High Aspect-Ratio Vessel were used.



Gabriel BM, Hamilton DL, Tremblay AM, Wackerhage H.

The Hippo signal transduction network for exercise physiologists.

J Appl Physiol (1985). 2016 Mar 3:jap.01076.2015. [Epub ahead of print]



Hasumura T, Meguro S.

Exercise quantity-dependent muscle hypertrophy in adult zebrafish (Danio rerio).

J Comp Physiol B. 2016 Mar 7. [Epub ahead of print]

Note: Researchers studied exercise duration and gene expression in zebrafish skeletal muscle to determine the effects of exercise intensity and velocity during swimming.



Heidlauf T, Klotz T, Rode C, Altan E, Bleiler C, Siebert T, Röhrle O.

A multi-scale continuum model of skeletal muscle mechanics predicting force enhancement based on actin-titin interaction.

Biomech Model Mechanobiol. 2016 Mar 3. [Epub ahead of print]

Note: From the abstract: "This work presents the first biophysically based continuum-mechanical model of skeletal muscle that considers, in addition to actin–myosin interactions, force enhancement based on actin–titin interactions."



Jensen BR, Hovgaard-Hansen L, Cappelen KL.

Muscle activation and estimated relative joint force during running with weight support on a lower-body positive pressure treadmill.

J Appl Biomech. 2016 Mar 8. [Epub ahead of print]



Nielsen RO, Schjerling P, Tesch P, Stål P, Langberg H.

Collagen content in the vastus lateralis and the soleus muscle following a 90-day bed rest period with or without resistance exercises.

Muscles Ligaments Tendons J. 2015 Oct;5(4):305-9.

Note: Bed rest study. This article may be obtained online without charge.



Jung H, Akkus O.

Activation of intracellular calcium signaling in osteoblasts colocalizes with the formation of post-yield diffuse microdamage in bone matrix.

Bonekey Rep. 2016 Mar 2;5:778.



Pacheco-Costa R, Davis HM, Atkinson EG, Katchburian E, Plotkin LI, Reginato RD.

Osteocytic connexin 43 is not required for the increase in bone mass induced by intermittent PTH administration in male mice.

J Musculoskelet Neuronal Interact. 2016 Mar;16(1):45-57.

Note: This article may be obtained online without charge.



Shi J, Lee S, Uyeda M, Tanjaya J, Kim JK, Pan HC, Reese P, Stodieck L, Lin A, Ting K, Kwak JH, Soo C.

Guidelines for dual energy x-ray absorptiometry analysis of trabecular bone-rich regions in mice: Improved precision, accuracy and sensitivity for assessing longitudinal bone changes.

Tissue Eng Part C Methods. 2016 Mar 9. [Epub ahead of print]

Note: From the abstract: "The purpose of this study is to define a novel method for accurately analyzing trabecular bone-rich regions in mice via DXA. This method will be utilized to analyze scans obtained from the International Space Station in an upcoming study of microgravity-induced bone loss."



Xu H, Liu R, Ning D, Zhang J, Yang R, Riquelme MA, Li J, Jiang JX, Shang P.

Biological responses of osteocytic connexin 43 hemichannels to simulated microgravity.

J Orthop Res. 2016 Mar 4. [Epub ahead of print]

Note: A random positioning machine was used.



Walenta S, Mueller-Klieser W.

Differential superiority of heavy charged-particle irradiation to X-rays: Studies on biological effectiveness and side effect mechanisms in multicellular tumor and normal tissue models.

Front Oncol. 2016 Feb 25;6:30. Review.

Note: This article may be obtained online without charge.



Wang J, Lewis RF.

Abnormal tilt perception during centrifugation in patients with vestibular migraine.

J Assoc Res Otolaryngol. 2016 Mar 8. [Epub ahead of print]

Note: A rotating chair was used.



Balint T, Hall A.

How to design and fly your humanly space object in space?

Acta Astronaut. 2016 Jun-Jul;123:71-85.

Note: From the Introduction: "In this paper we revisit and advance the list of artistic and design considerations for future space missions, including the roles of cybernetics, perception and cognition. We will illustrate aspects of these considerations through a physical artifact, a "cybernetic astronaut chair," which will serve as a discussion point. We will also outline approaches related to a human centered interactive habitat, advancing the current state of practice, which to date mainly focuses on fulfilling basic physiological and related functional needs."



Wyatt T, Baum B, Charras G.

A question of time: Tissue adaptation to mechanical forces.

Curr Opin Cell Biol. 2016 Mar 2;38:68-73. Review. [Epub ahead of print]



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